Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na+ Channels

Journal of Medicinal Chemistry

Volumn 46, Issue 24, 2003, Pages 5238-5248

  Franchini, Carlo ^a   Carocci, Alessia ^a   Catalano, Alessia ^a   Cavalluzzi, Maria M ^a   Corbo, Filomena ^a   Lentini, Giovanni ^a   Scilimati, Antonio ^a   Tortorella, Paolo ^b   Camerino, Diana Conte ^a   De Luca, Annamaria ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 METHYLPHENOXY) 1 PHENYLETHANAMINE; DRUG ANALOG; MEXILETINE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; TOCAINIDE; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EVALUATION; OPTICAL ROTATION; SODIUM CURRENT; STEREOCHEMISTRY; VOLTAGE CLAMP;

ANIMALS; ION CHANNEL GATING; MEXILETINE; MUSCLE FIBERS; MUSCLE, SKELETAL; PATCH-CLAMP TECHNIQUES; PHENETHYLAMINES; PHENYL ETHERS; RANA ESCULENTA; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0242439310     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030865y     Document Type: Article

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