Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics

Molecular Pharmacology

Volumn 59, Issue 4, 2001, Pages 684-691

  Sunami, Akihiko ^a   Glaaser, Ian W ^a   Fozzard, Harry A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LOCAL ANESTHETIC AGENT; OMEGA CONOTOXIN; SODIUM CHANNEL; TOXIN; TRIMETHYLAMMONIUM SALT DERIVATIVE;

ARTICLE; BINDING AFFINITY; BINDING SITE; LOCAL ANESTHESIA; MEMBRANE POTENTIAL; MUTATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN STRUCTURE; SKELETAL MUSCLE; SODIUM CURRENT; STEADY STATE;

EID: 0035056966     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.59.4.684     Document Type: Article

References (39)

1. Is there a second external lidocaine binding site on mammalian cardiac cells?
2. Molecular localization of an ion-binding site within the pore of mammalian sodium channels
3. Molecular motions within the pore of voltage-dependent sodium channels
4. Thermal motions of surface α-helices in the D-galactose chemosensory receptor: Detection by disulfide trapping
5. + channel fast inactivation
6. + channel localized by mutant cycle analysis
7. Chimeric study of sodium channels from rat skeletal and cardiac muscle
8. + channel revealed by cysteine mutagenesis
9. + conduction and selectivity
10. + channel mutant: Possible localization of a binding site at the outer vestibule
11. 2+ in the voltage-gated sodium channel
12. Molecular basis for pharmacological differences between brain and cardiac sodium channels
13. Calcium channel characteristics conferred on the sodium channel by single mutations
14. Local anesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction
15. On the use of thiol-modifying agents to determine channel topology
16. Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels
17. + channel
18. Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channel
19. + channel pore
20. + channel
21. A critical role for transmembrane segment IVS6 of the sodium channel α subunit in fast inactivation
22. + channels modulate binding affinity and stereoselectivity of local anesthetic enantiomers
23. + channel
24. + channels by local anesthetics
25. + channels
26. A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties
27. Local anesthetics: Effect of pH on use-dependent block of sodium channels in frog muscle
28. Conformations of disulfide bridges in proteins
29. Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics
30. The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine
31. +, and molecular sieving
32. Sodium channel selectivity filter regulates antiarrhythmic drug binding
33. A critical residue for isoform differences in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel
34. Altered ionic selectivity of the sodium channel revealed by cysteine mutations within the pore
35. + channel pores revealed by single- and double-cysteine replacements
36. + channels
37. + channels resistant to batrachotoxin
38. + channels derived from point mutations in transmembrane segment D4-S6