Structural basis for the unique biological function of small GTPase RHEB

Journal of Biological Chemistry

Volumn 280, Issue 17, 2005, Pages 17093-17100

  Yu, Yadong ^a   Li, Sheng ^a   Xu, Xiang ^a   Li, Yong ^b   Guan, Kunliang ^b   Arnold, Eddy ^c   Ding, Jianping ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; HYDROLYSIS; LIVING SYSTEMS STUDIES; PROTEINS;

BIOLOGICAL FUNCTIONS; CELL GROWTH; RAPAMYCIN; TUMOR SUPPRESSOR PROTEINS;

ENZYMES;

ARGININE; GLYCINE; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RAS PROTEIN; RHEB PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; ASPARAGINE; GUANOSINE TRIPHOSPHATE; MAGNESIUM; MAMMALIAN TARGET OF RAPAMYCIN; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; NEUROPEPTIDE; PROTEIN KINASE; REPRESSOR PROTEIN; RHEB PROTEIN, HUMAN; TUBERIN; TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN;

ALPHA HELIX; ARTICLE; BINDING SITE; BIOCHEMISTRY; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME STRUCTURE; GENE INSERTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HYDROLYSIS; MEDIATOR RELEASE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; REACTION ANALYSIS; STEREOSPECIFICITY; TUBEROUS SCLEROSIS; AMINO ACID SEQUENCE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN DATABASE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

MAMMALIA;

AMINO ACID SEQUENCE; ARGININE; ASPARAGINE; BINDING SITES; CATALYTIC DOMAIN; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DATABASES, PROTEIN; GTP PHOSPHOHYDROLASES; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HUMANS; HYDROLYSIS; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MONOMERIC GTP-BINDING PROTEINS; NEUROPEPTIDES; PROTEIN CONFORMATION; PROTEIN KINASES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RAS PROTEINS; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR PROTEINS; X-RAY DIFFRACTION;

EID: 20444442724     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501253200     Document Type: Article

References (41)

1. Yamagata, K., Sanders, L. K., Kaufmann, W. E., Yee, W., Barnes, C. A., Nathans, D., and Worley, P. F. (1994) J. Biol. Chem. 269, 16333-16339
2. Mizuki, N., Kimura, M., Ohno, S., Miyata, S., Sato, M., Ando, H., Ishihara, M., Goto, K., Watanabe, S., Yamazaki, M., Ono, A., Taguchi, S., Okumura, K., Nogami, M., Taguchi, T., Ando, A., and Inoko, H. (1996) Genomics 34, 114-118
3. Aspuria, P.-J., and Tamanoi, F. (2004) Cell. Signal. 16, 1105-1112
4. Gao, X., Zhang, Y., Arrazola, P., Hino, O., Kobayashi, T., Yeung, R. S., Ru, B., and Pan, D. (2002) Nat. Cell Biol. 4, 699-704
5. Inoki, K., Li, Y., Zhu, T., Wu, J., and Guan, K. L. (2002) Nat. Cell Biol. 4, 648-657
6. Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., and Cantley, L. C. (2002) Mol. Cell 10, 151-162
7. Tee, A. R., Fingar, D. C., Manning, B. D., Kwiatkowski, D. J., Cantley, L. C., and Blenis, J. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 13571-13576
8. Castro, A. F., Rebhun, J. F., Clark, G. J., and Quilliam, L. A. (2003) J. Biol. Chem. 278, 32493-32496
9. Garami, A., Zwartkruis, F. J., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., Kozma, S. C., Hafen, E., Bos, J. L., and Thomas, G. (2003) Mol. Cell 11, 1457-1466
10. Inoki, K., Li, Y., Xu, T., and Guan, K. L. (2003) Genes Dev. 17, 1829-1834
11. Manning, B. D., and Cantley, L. C. (2003) Trends Biochem. Sci. 28, 573-576
12. Saucedo, L. J., Gao, X., Chiarelli, D. A., Li, L., Pan, D., and Edgar, B. A. (2003) Nat. Cell Biol. 5, 566-571
13. Stocker, H., Radimerski, T., Schindelholz, B., Wittwer, F., Belawat, P., Daram, P., Breuer, S., Thomas, G., and Hafen, E. (2003) Nat. Cell Biol. 5, 559-565
14. Pan, D., Dong, J., Zhang, Y., and Gao, X. (2004) Trends Cell Biol. 14, 78-85
15. Patel, P. H., Thapar, N., Guo, L., Martinez, M., Maris, J., Gau, C. L., Lengyel, J. A., and Tamanoi, F. (2003) J. Cell Sci. 116, 3601-3610
16. Tee, A. R., Manning, B. D., Roux, P. P., Cantley, L. C., and Blenis, J. (2003) Curr. Biol. 13, 1259-1268
17. Zhang, Y., Gao, X., Saucedo, L. J., Ru, B., Edgar, B. A., and Pan, D. (2003) Nat. Cell Biol. 5, 578-581
18. Li, Y., Corradetti, M. N., Inoki, K., and Guan, K. L. (2004) Trends Biochem. Sci. 29, 32-38
19. Povey, S., Burley, M. W., Attwood, J., Benham, F., Hunt, D., Jeremiah, S. J., Franklin, D., Gillett, G., Malas, S., Robson, E. B., Tippett, P., Edwards, J. H., Kwiatkowski, D. J., Super, M., Mueller, R., Fryer, A., Clarke, A., Webb, D., and Osborne, J. (1994) Ann. Hum. Genet. 58, 107-127
20. Maheshwar, M. M., Cheadle, J. P., Jones, A. C., Myring, J., Fryer, A. E., Harris, P. C., and Sampson, J. R. (1997) Hum. Mol. Genet. 6, 1991-1996
21. Gomez, M. R. (1999) Tuberous Sclerosis, 3rd Ed., Oxford University Press, Oxford
22. Sparagana, S. P., and Roach, E. S. (2000) Curr. Opin. Neurol. 13, 115-119
23. Maheshwar, M. M., Sandford, R., Nellist, M., Cheadle, J. P., Sgotto, B., Vaudin, M., and Sampson, J. R. (1996) Hum. Mol. Genet. 5, 131-137
24. Li, Y., Inoki, K., and Guan, K. L. (2004) Mol. Cell. Biol. 24, 7965-7975
25. Rittinger, K., Walker, P. A., Eccleston, J. F., Smerdon, S. J., and Gamblin, S. J. (1997) Nature 389, 673-674
26. Scheffzek, K., Ahmadian, M. R., Kabsch, W., Wiesmuller, L., Lautwein, A., Schmitz, F., and Wittinghofer, A. (1997) Science 277, 333-338
27. Vetter, I. R., and Wittinghofer, A. (2001) Science 294, 1299-1304
28. Clark, G. J., Kinch, M. S., Rogers-Graham, K., Sebti, S. M., Hamilton, A. D., and Der, C. J. (1997) J. Biol. Chem. 272, 10608-10615
29. Daumke, O., Weyand, M., Chakrabarti, P. P., Vetter, I. R., and Wittinghofer, A. (2004) Nature 429, 197-201
30. Im, E., von Lintig, F. C., Chen, J., Zhuang, S., Qui, W., Chowdhury, S., Worley, P. F., Boss, G. R., and Pilz, R. B. (2002) Oncogene 21, 6356-6365
31. Yu, Y., Chang, Y., Li, S., Hu, H., Huang, Q., and Ding, J. (2004) Acto Crystallogr. Sect. D 60, 1883-1887
32. Brunger, A. T., Adams, P. D., Clore, G. M., Delano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J.-S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D 54, 905-921
33. Cherfils, J., Menetrey, J., Le Bras, G., Janoueix-Lerosey, I., de Gunzburg, J., Garel, J. R., and Auzat, I. (1997) EMBO J. 16, 5582-5591
34. Nassar, N., Horn, G., Herrmann, C., Scherer, A., McCormick, F., and Wittinghofer, A. (1995) Nature 375, 554-560
35. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. Sect. A 47, 110-119
36. Wittinghofer, A. (1999) in GTPase (Hall, A., ed) Oxford University Press, Oxford
37. Barbacid, M. (1987) Annu. Rev. Biochem. 56, 779-827
38. Krengel, U., Schlichting, L., Scherer, A., Schumann, R., Frech, M., John, J., Kabsch, W., Pai, E. F., and Wittinghofer, A. (1990) Cell 62, 539-548
39. Nassar, N., Horn, G., Herrmann, C., Block, C., Janknecht, R., and Wittinghofer, A. (1996) Nat. Struct. Biol. 3, 723-729
40. Pai, E. F., Krengel, U., Petsko, G. A., Goody, R. S., Kabsch, W., and Wittinghofer, A. (1990) EMBO J. 9, 2351-2359
41. Reuther, G. W., and Der, C. J. (2000) Curr. Opin. Cell Biol. 12, 157-165