Heterodimeric GTPase Core of the SRP Targeting Complex

Science

Volumn 303, Issue 5656, 2004, Pages 373-377

  Focia, Pamela J ^a   Shepotinovskaya, Irina V ^a   Seidler, James A ^a   Freymann, Douglas M ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CONFORMATIONS; MOLECULAR STRUCTURE; NUCLEIC ACIDS;

COTRANSLATIONAL TARGETING;

ENZYMES;

GUANOSINE TRIPHOSPHATASE; NUCLEOTIDE; SIGNAL RECOGNITION PARTICLE;

ENZYME;

ALLOSTERISM; ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; MEMBRANE; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; PROTEIN TARGETING; THERMUS AQUATICUS;

AMINO ACID MOTIFS; BACTERIAL PROTEINS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; GUANOSINE TRIPHOSPHATE; HETEROTRIMERIC GTP-BINDING PROTEINS; HYDROGEN BONDING; HYDROPHOBICITY; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL RECOGNITION PARTICLE; THERMUS;

NEGIBACTERIA; THERMUS; THERMUS AQUATICUS;

EID: 0346373753     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1090827     Document Type: Article

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37. We thank C. W. Carter, S. McGovern, U. D. Ramirez, and S. R. Sprang for critical reading of this manuscript, and Panchika Prangkio for her contribution. This work was supported by grant GM58500 from the NIH. Portions of this work were performed at the DuPont-Northwestern-Dow Collaborative Access Team (DND-CAT) Synchrotron Research Center, Sector 5, and BioCARS, Sector 14, of the Advanced Photon Source (APS) at Argonne National Laboratory. Use of the APS was supported by the U.S. Department of Energy, Basic Energy Sciences, Office of Science, under Contract No. W-31-109-Eng-38. DND-CAT was supported by DuPont, Dow, the state of Illinois, and the NSF. Use of the BioCARS was supported by NIH, National Center for Research Resources, under grant number RR07707. Support from the R. H. Lurie Comprehensive Cancer Center of Northwestern University to the Structural Biology Facility is acknowledged. Coordinates and structure factors have been deposited with the Protein Data Bank and assigned accession code 1OKK.