Oncogenic BRAFV600E induces expression of neuronal differentiation marker MAP2 in melanoma cells by promoter demethylation and down-regulation of transcription repressor HES1

Journal of Biological Chemistry

Volumn 285, Issue 1, 2010, Pages 242-254

  Maddodi, Nityanand ^a   Bhat, Kumar M R ^a,c   Devi, Sulochana ^a   Zhang, Su Chun ^a   Setaluri, Vijayasaradhi ^a,b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b Manipal University ^*  (United States)

^c KASTURBA MEDICAL COLLEGE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CYTIDINE; DEMETHYLATION; DENDRITIC MICROTUBULES; DOWN-REGULATION; ECTOPIC EXPRESSIONS; EPIGENETIC MECHANISMS; HYPERACTIVATION; IN-VITRO; MELANOMA CELLS; MELANOMA TUMORS; METASTATIC MELANOMA; MICROTUBULE ASSOCIATED PROTEIN; MITOTIC SPINDLE; MOLECULAR MECHANISM; NEURONAL DIFFERENTIATION; PROMOTER ACTIVITIES; TUMOR PROGRESSIONS;

CELL CULTURE; CELL DEATH; CHEMICAL REACTIONS; DENDRIMERS; DERMATOLOGY; GROWTH KINETICS; ONCOLOGY; SIGNALING; TRANSCRIPTION; TUMORS;

GENE EXPRESSION REGULATION;

5 AZA 2' DEOXYCYTIDINE; B RAF KINASE; MICROTUBULE ASSOCIATED PROTEIN 2; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR HES 1; AZACITIDINE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BIOLOGICAL MARKER; BRAF PROTEIN, HUMAN; HES1 PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; MAP2 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MUTANT PROTEIN;

ARTICLE; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DISEASE COURSE; DNA METHYLATION; DOWN REGULATION; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENE MUTATION; HUMAN; HUMAN CELL; MELANOMA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR GROWTH; AMINO ACID SUBSTITUTION; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; DNA RESPONSIVE ELEMENT; DRUG EFFECT; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; MELANOMA; METABOLISM; MOUSE; NERVE CELL; TUMOR CELL LINE;

AMINO ACID SUBSTITUTION; ANIMALS; AZACITIDINE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CPG ISLANDS; DNA METHYLATION; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; MAP KINASE SIGNALING SYSTEM; MELANOMA; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MUTANT PROTEINS; NEURONS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS B-RAF; RESPONSE ELEMENTS; TRANSCRIPTION, GENETIC;

EID: 73649104787     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.068668     Document Type: Article

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