Activation of c-Jun N-terminal kinase is essential for mitochondrial membrane potential change and apoptosis induced by doxycycline in melanoma cells

British Journal of Pharmacology

Volumn 160, Issue 5, 2010, Pages 1171-1184

  Shieh, Jiunn Min ^a   Huang, Tur Fu ^b   Hung, Chi Feng ^c   Chou, Kuan Hsien ^c   Tsai, Yih Jeng ^d   Wu, Wen Bin ^c  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^d SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Apoptosis; ASK; Caspase; Doxycycline; Free radical; JNK; Melanoma; Mitochondria; ROS; Tetracycline

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; APOPTOSIS SIGNAL REGULATING KINASE 1; CASPASE 3; CASPASE 7; CASPASE 9; CYTOCHROME C; DOXYCYCLINE HYCLATE; MATRIX METALLOPROTEINASE; MINOCYCLINE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; DOXYCYCLINE; SCAVENGER;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ASSAY; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HUMAN TISSUE; MELANOMA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL SURVIVAL; DRUG EFFECTS; DRUG SCREENING; MELANOMA; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; TUMOR CELL LINE; UPREGULATION;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; DOXYCYCLINE; DRUG SCREENING ASSAYS, ANTITUMOR; FREE RADICAL SCAVENGERS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASE 5; MELANOMA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MINOCYCLINE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 77953226760     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00746.x     Document Type: Article

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