Small-molecule Klotho enhancers as novel treatment of neurodegeneration

Future Medicinal Chemistry

Volumn 4, Issue 13, 2012, Pages 1671-1679

  Abraham, Carmela R ^a   Chen, Cidi ^a   Cuny, Gregory D ^b,c   Glicksman, Marcie A ^b   Zeldich, Ella ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b The Harvard Center for Neurodegeneration & Repair   (United States)

^c UNIVERSITY OF HOUSTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CENTRAL NERVOUS SYSTEM AGENTS; KLOTHO ENHANCER; KLOTHO PROTEIN; LUCIFERASE; MESSENGER RNA; MYELIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; CELL LOSS; COGNITIVE DEFECT; DOWN REGULATION; HAPLORHINI; HIGH THROUGHPUT SCREENING; HUMAN; MICROARRAY ANALYSIS; MOLECULAR WEIGHT; MULTIPLE SCLEROSIS; NERVE DEGENERATION; NEURAL STEM CELL; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RHESUS MONKEY; RODENT; UPREGULATION; WHITE MATTER;

AGING; ANIMALS; BRAIN; DRUG DISCOVERY; GENE EXPRESSION REGULATION; GLUCURONIDASE; HEK293 CELLS; HUMANS; MACACA MULATTA; NEURODEGENERATIVE DISEASES; RNA, MESSENGER; SMALL MOLECULE LIBRARIES; TRANSCRIPTIONAL ACTIVATION;

EID: 84865761463     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.12.134     Document Type: Article

References (48)

1. Selkoe D, Mandelkow E, Holtzman D. Deciphering Alzheimer disease. Cold Spring Harb. Perspect. Med. 2(1), a011460 (2012).
2. Sloane JA, Hollander W, Moss MB, Rosene DL, Abraham CR. Increased microglial activation and protein nitration in white matter of the aging monkey. Neurobiol. Aging 20(4), 395-405 (1999).
3. Sloane JA, Hollander W, Roseane DL, Moss MB, Kemper T, Abraham CR. Astrocytic hypertrophy and altered GFAP degradation with age in subcortical white matter of the rhesus monkey. Brain Res. 862(1-2), 1-10 (2000).
4. Hollander W, Jaffe R, Abraham CR. Activation of early components of complement targets myelin and oligodendrocytes in the aged rhesus monkey brain. Neurobiol. Aging 27(4), 633-644 (2006).
5. Sloane JA, Hinman JD, Lubonia M, Hollander W, Abraham CR. Age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 in the rhesus monkey. J. Neurochem. 84(1), 157-168 (2003).
6. Hinman JD, Duce JA, Siman RA, Hollander W, Abraham CR. Activation of calpain-1 in myelin and microglia in the white matter of the aged rhesus monkey. J. Neurochem. 89(2), 430-441 (2004).
7. Hinman JD, Peters A, Cabral H et al. Age-related molecular reorganization at the node of Ranvier. J. Comp. Neurol. 495(4), 351-362 (2006).
8. Peters A, C Sethares. Aging and the myelinated fibers in prefrontal cortex and corpus callosum of the monkey. J. Comp. Neurol. 442(3), 277-291 (2002).
9. Franklin R. Why does remyelination fail in multiple sclerosis? Nat. Rev. Neurosci. 3(9), 705-714 (2002).
10. Chang A, Tourtellotte WW, Rudick R, Trapp BD. Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. N. Engl. J. Med. 346(3), 165-173 (2002).
11. Wolswijk G. Oligodendrocyte precursor cells in chronic multiple sclerosis lesions. Mult. Scler. 3(2), 168-169 (1997).
12. Wolswijk G. Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells. J. Neurosci. 18(2), 601-609 (1998).
13. Mi S, Miller RH, Tang W et al. Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells. Ann. Neurol. 65(3), 304-315 (2009).
14. Kuro-o M, Matsumura Y, Aizawa H et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390(6655), 45-51 (1997).
15. Kurosu H, Yamamoto M, Clark JD et al. Suppression of aging in mice by the hormone Klotho. Science 309(5742), 1829-1833 (2005).
16. Zhao Y, Banerjee S, Dey N et al. Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation. Diabetes 60(7), 1907-1916 (2011).
17. Liu F, Wu S, Ren H, Gu J. Klotho suppresses RIG-I-mediated senescence-associated inflammation. Nat. Cell Biol. 13(3), 254-262 (2011).
18. Wolf I, Levanon-Cohen S, Bose S et al. Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer. Oncogene 27(56), 7094-7105 (2008).
19. Chen CD, Podvin S, Gillespie E, Leeman SE, Abraham CR. Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc. Natl Acad. Sci. USA 104(50), 19796-19801 (2007).
20. Imura A, Iwano A, Tohyama O et al. Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett. 565(1-3), 143-147 (2004).
21. Liu H, Fergusson MM, Castilho RM et al. Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317(5839), 803-806 (2007).
22. Kuro-o M. Klotho. Pflugers Arch. Eur. J. Physiol. 459(2), 333-343 (2010).
23. Kuro-o M. Klotho and the aging process. Korean J. Int. Med. 26(2), 113-122 (2011).
24. Chang Q, Hoefs S, van der Kemp AW et al. The b-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 310(5747), 490-493 (2005).
25. Cha SK, Ortega B, Kurosu H, Rosenblatt KP, Kuro-O M, Huang CL. Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc. Natl Acad. Sci. USA 105(28), 9805-9810 (2008).
26. Thurston RD, Larmonier CB, Majewski PM et al. Tumor necrosis factor and interferon-g down-regulate Klotho in mice with colitis. Gastroenterology 138(4), 1384-1394, 1394 e1-e2 (2010).
27. Witkowski JM, Soroczyńska-Cybula M, Bryl E, Smoleńska Z, Jóźwik A. Klotho - a common link in physiological and rheumatoid arthritis-related aging of human CD4+ lymphocytes. J. Immunol. 178(2), 771-777 (2007).
28. Maekawa Y, Ishikawa K, Yasuda O et al. Klotho suppresses TNF-a-induced expression of adhesion molecules in the endothelium and attenuates NF-kB activation. Endocrine 35(3), 341-346 (2009).
29. Moreno JA, Izquierdo MC, Sanchez-Niño MD et al. The inflammatory cytokines TWEAK and TNFa reduce renal klotho expression through NFkB. J. Am. Soc. Nephrol. 22(7), 1315-1325 (2011).
30. Ichikawa S, Imel EA, Kreiter ML et al. A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis. J. Clin. Invest. 117(9), 2684-2691 (2007).
31. Kosakai A, Ito D, Nihei Y et al. Degeneration of mesencephalic dopaminergic neurons in klotho mouse related to vitamin D exposure. Brain Res. 1382, 109-117 (2011).
32. Yoshida T, Fujimori T, Nabeshima Y. Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1a-hydroxylase gene. Endocrinology 143(2), 683-689 (2002).
33. Cha SK, Hu MC, Kurosu H et al. Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho. Mol. Pharmacol. 76(1), 38-46 (2009).
34. Hu MC, Shi M, Zhang J et al. Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J. 24(9), 3438-3450 (2010).
35. Hu MC, Shi M, Zhang J et al. Klotho deficiency causes vascular calcification in chronic kidney disease. J. Am. Soc. Nephrol. 22(1), 124-136 (2011).
36. Doi S, Zou Y, Togao O et al. Klotho inhibits transforming growth factor-b1 (TGF-b1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J. Biol. Chem. 286(10), 8655-8665 (2011).
37. Arking DE, Becker DM, Yanek LR et al. KLOTHO allele status and the risk of early-onset occult coronary artery disease. Am. J. Hum. Genet. 72(5), 1154-1161 (2003).
38. Deary IJ, Harris SE, Fox HC et al. KLOTHO genotype and cognitive ability in childhood and old age in the same individuals. Neurosci. Lett. 378(1), 22-27 (2005).
39. Nagai T, Yamada K, Kim HC et al. Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress. FASEB J. 17(1), 50-52 (2003).
40. Houlihan LM, Harris SE, Luciano M et al. Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936. Genes Brain Behav. 8(2), 238-247 (2009).
41. Duce JA, Podvin S, Hollander W, Kipling D, Rosene DL, Abraham CR. Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey. Glia 56(1), 106-117 (2008).
42. Hinman JD, Abraham CR. What's behind the decline? The role of white matter in brain aging. Neurochem. Res. 32(12), 2023-2031 (2007).
43. King GD, Rosene DL, Abraham CR. Promoter methylation and age-related downregulation of Klotho in rhesus monkey. Age doi:10.1007/s11357-011-9315-4 (2011) (Epub ahead of print).
44. Shiozaki M, Yoshimura K, Shibata M et al. Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice. Neuroscience 152(4), 924-941 (2008).
45. King GD, Chen C, Huang MM et al. Identification of novel small molecules that elevate Klotho expression. Biochem. J. 441(1), 453-461 (2012).
46. Urakawa I, Yamazaki Y, Shimada T et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444(7120), 770-774 (2006).
47. Oncomine. oncomine.org
48. Allen Institute for Brain Science. Allen brain atlas. www.brain-map.org