Age-related molecular reorganization at the node of Ranvier

Journal of Comparative Neurology

Volumn 495, Issue 4, 2006, Pages 351-362

  Hinman, Jason D ^a   Peters, Alan ^a,b   Cabral, Howald ^c   Rosene, Douglas L ^a,b   Hollander, William ^a   Rasband, Matthew N ^d   Abraham, Carmela R ^a,e  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^d UNIVERSITY OF CONNECTICUT   (United States)

^e Department of Biochemistry K620 ^*  (United States)

Author keywords

Aging; Caspr; Channels; Juxtaparanode; Monkey; Paranode

Indexed keywords

ION CHANNEL; MYELIN; POTASSIUM CHANNEL; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT POTASSIUM CHANNEL KV1.2;

ACTION POTENTIAL; AGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; MONKEY; MYELIN SHEATH; MYELINATION; NERVE CONDUCTION; NERVE FIBER; NERVE FIBER MEMBRANE; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RANVIER NODE; ULTRASTRUCTURE;

AGING; ANIMALS; BRAIN; CELL ADHESION MOLECULES, NEURONAL; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; KV1.2 POTASSIUM CHANNEL; MACACA MULATTA; MICROSCOPY, ELECTRON, TRANSMISSION; MYELIN SHEATH; OPTIC NERVE; RANVIER'S NODES; RATS;

EID: 33644866554     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.20886     Document Type: Article

References (57)

1. Albert M. 1993. Neuropsychological and neurophysiological changes in healthy adult humans across the age range. Neurobiol Aging 14:623-625.
2. Arroyo EJ, Xu T, Poliak S, Watson M, Peles E, Scherer SS. 2001. Internodal specializations of myelinated axons in the central nervous system. Cell Tissue Res 305:53-66.
3. Arroyo EJ, Xu T, Grinspan J, Lambert S, Levinson SR, Brophy PJ, Peles E, Scherer SS. 2002. Genetic dysmyelination alters the molecular architecture of the nodal region. J Neurosci 22:1726-1737.
4. Bhat MA, Rios JC, Lu Y, Garcia-Fresco GP, Ching W, St. Martin M, Li J, Einheber S, Chesler M, Rosenbluth J, Salzer JL, Bellen HJ. 2001. Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin. Neuron 30:369-383.
5. Boiko T, Rasband MN, Levinson SR, Caldwell JH, Mandel G, Trimmer JS, Matthews G. 2001. Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon. Neuron 30:91-104.
6. Bostock H, Sears TA, Sherratt RM. 1981. The effects of 4-aminopyridine and tetraethylammonium ions on normal and demyelinated mammalian nerve fibres. J Physiol 313:301-315.
7. Boyle ME, Berglund EO, Murai KK, Weber L, Peles E, Ranscht B. 2001. Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve. Neuron 30:385-397.
8. Chang YM, Rosene DL, Killiany RJ, Mangiamele LA, Luebke JI. 2004. Increased action potential firing rates of layer 2/3 pyramidal cells in the prefrontal cortex are significantly related to cognitive performance in aged monkeys. Cereb Cortex (in press).
9. Chiu SY. 1991. Functions and distribution of voltage-gated sodium and potassium channels in mammalian Schwann cells. Glia 4:541-558.
10. Chiu SY, Ritchie JM. 1980. Potassium channels in nodal and internodal axonal membrane of mammalian myelinated fibres. Nature 284:170-171.
11. Craner MJ, Lo AC, Black JA, Waxman SG. 2003. Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination. Brain 126:1552-1561.
12. + channels. J Neurophysiol 87:1376-1385.
13. Dupree JL, Coetzee T, Blight A, Suzuki K, Popko B. 1998. Myelin galactolipids are essential for proper node of Ranvier formation in the CNS. J Neurosci 18:1642-1649.
14. Einheber S, Zanazzi G, Ching W, Scherer S, Milner TA, Peles E, Salzer JL. 1997. The axonal membrane protein Caspr, a homologue of neurexin IV, is a component of the septate-like paranodal junctions that assemble during myelination. J Cell Biol 139:1495-1506.
15. Felts PA, Baker TA, Smith KJ. 1997. Conduction in segmentally demyelinated mammalian central axons. J Neurosci 17:7267-7277.
16. Fischer CA, Morell P. 1974. Turnover of proteins in myelin and myelin-like material of mouse brain. Brain Res 74:51-65.
17. Gollan L, Salomon D, Salzer JL, Peles E. 2003. Caspr regulates the processing of contactin and inhibits its binding to neurofascin. J Cell Biol 163:1213-1218.
18. Herndon JG, Moss MB, Rosene DL, Killiany RJ. 1997. Patterns of cognitive decline in aged rhesus monkeys. Behav Brain Res 87:25-34.
19. Hinman JD, Duce JA, Siman RA, Hollander W, Abraham CR. 2004. Activation of calpain-1 in myelin and microglia in the white matter of the aged rhesus monkey. J Neurochem 89:430-441.
20. Ishibashi T, Dupree JL, Ikenaka K, Hirahara Y, Honke K, Peles E, Popko B, Suzuki K, Nishino H, Baba H. 2002. A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation. J Neurosci 22:6507-6514.
21. Ishibashi T, Ikenaka K, Shimizu T, Kagawa T, Baba H. 2003. Initiation of sodium channel clustering at the node of Ranvier in the mouse optic nerve. Neurochem Res 28:117-125.
22. Karimi-Abdolrezaee S, Eftekharpour E, Fehlings MG. 2004. Temporal and spatial patterns of Kv1.1 and Kv1.2 protein and gene expression in spinal cord white matter after acute and chronic spinal cord injury in rats: implications for axonal pathophysiology after neurotrauma. Eur J Neurosci 19:577-589.
23. Kazarinova-Noyes K, Shrager P. 2002. Molecular constituents of the node of Ranvier. Mol Neurobiol 26:167-182.
24. Knox CA, Kokmen E, Dyck PJ. 1989. Morphometric alteration of rat myelinated fibers with aging. J Neuropathol Exp Neurol 48:119-139.
25. Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
26. Lajtha A, Toth J, Fujimoto K, Agrawal HC. 1977. Turnover of myelin proteins in mouse brain in vivo. Biochem J 164:323-329.
27. Lappe-Siefke C, Goebbels S, Gravel M, Nicksch E, Lee J, Braun PE, Griffiths IR, Nave KA. 2003. Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat Genet 33:366-374.
28. Marcus J, Popko B. 2002. Galactolipids are molecular determinants of myelin development and axo-glial organization. Biochim Biophys Acta 1573:406-413.
29. Moore TL, Killiany RJ, Herndon JG, Rosene DL, Moss MB. 2003. Impairment in abstraction and set shifting in aged rhesus monkeys. Neurobiol Aging 24:125-134.
30. + channels after chronic spinal cord injury. Eur J Neurosci 12:491-506.
31. Peles E, Nativ M, Lustig M, Grumet M, Schilling J, Martinez R, Plowman GD, Schlessinger J. 1997. Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions. EMBO J 16:978-988.
32. Peters A. 2002. Structural changes in the normally aging cerebral cortex of primates. Prog Brain Res 136:455-465.
33. Peters A, Sethares C. 2002. Aging and the myelinated fibers in prefrontal cortex and corpus callosum of the monkey. J Comp Neurol 442:277-291.
34. Peters A, Sethares C. 2003. Is there remyelination during aging of the primate central nervous system? J Comp Neurol 460:238-254.
35. Peters A, Sethares C, Killiany RJ. 2001. Effects of age on the thickness of myelin sheaths in monkey primary visual cortex. J Comp Neurol 435:241-248.
36. Poliak S, Gollan L, Salomon D, Berglund EO, Ohara R, Ranscht B, Peles E. 2001. Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon. J Neurosci 21:7568-7575.
37. Rasband MN. 2004. It's "juxta" potassium channel! J Neurosci Res 76:749-757.
38. + channels in spinal cord. J Comp Neurol 429:166-176.
39. Rasband MN, Trimmer JS, Schwarz TL, Levinson SR, Ellisman MH, Schachner M, Shrager P. 1998. Potassium channel distribution, clustering, and function in remyelinating rat axons. J Neurosci 18:36-47.
40. + channel distribution and clustering in developing and hypomyelinated axons of the optic nerve. J Neurocytol 28:319-331.
41. Rasband MN, Kagawa T, Park EW, Ikenaka K, Trimmer JS. 2003. Dysregulation of axonal sodium channel isoforms after adult-onset chronic demyelination. J Neurosci Res 73:465-470.
42. + channel alpha- and beta-subunit polypeptides in rat brain. J Neurosci 15:5360-5371.
43. Rios JC, Rubin M, St. Martin M, Downey RT, Einheber S, Rosenbluth J, Levinson SR, Bhat M, Salzer JL. 2003. Paranodal interactions regulate expression of sodium channel subtypes and provide a diffusion barrier for the node of Ranvier. J Neurosci 23:7001-7011.
44. Rosene DL, Rhodes KJ. 1990. Cryoprotection and freezing methods for controlling ice crystal artifact in frozen sections of fixed and unfixed brain tissue. In: Conn PM, editor. Methods in neuroscience. New York: Academic Press, p 360-385.
45. Sabri MI, Bone AH, Davison AN. 1974. Turnover of myelin and other structural proteins in the developing rat brain. Biochem J 142:499-507.
46. Sandell JH, Peters A. 2001. Effects of age on nerve fibers in the rhesus monkey optic nerve. J Comp Neurol 429:541-553.
47. Sandell JH, Peters A. 2003. Disrupted myelin and axon loss in the anterior commissure of the aged rhesus monkey. J Comp Neurol 466:14-30.
48. Schafer DP, Bansal R, Hedstrom KL, Pfeiffer SE, Rasband MN. 2004. Does paranode formation and maintenance require partitioning of neurofascin 155 into lipid rafts? J Neurosci 24:3176-3185.
49. Sloane JA, Hinman JD, Lubonia M, Hollander W, Abraham CR. 2003. Age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 in the rhesus monkey. J Neurochem 84:157-168.
50. Sugiyama I, Tanaka K, Akita M, Yoshida K, Kawase T, Asou H. 2002. Ultrastructural analysis of the paranodal junction of myelinated fibers in 31-month-old rats. J Neurosci Res 70:309-317.
51. Suzuki A, Hoshi T, Ishibashi T, Hayashi A, Yamaguchi Y, Baba H. 2004. Paranodal axoglial junction is required for the maintenance of the Nav1.6-type sodium channel in the node of Ranvier in the optic nerves but not in peripheral nerve fibers in the sulfatide-deficient mice. Glia 46:274-283.
52. Targ EF, Kocsis JD. 1985. 4-Aminopyridine leads to restoration of conduction in demyelinated rat sciatic nerve. Brain Res 328:358-361.
53. Targ EF, Kocsis JD. 1986. Action potential characteristics of demyelinated rat sciatic nerve following application of 4-aminopvridine. Brain Res 363:1-9.
54. Vabnick I, Trimmer JS, Schwarz TL, Levinson SR, Risal D, Shrager P. 1999. Dynamic potassium channel distributions during axonal development prevent aberrant firing patterns. J Neurosci 19:747-758.
55. + channels in terminal and juxtaparanodal regions of neurons. Nature 365:75-79.
56. Waxman SG. 2001. Acquired channelopathies in nerve injury and MS. Neurology 56:1621-1627.
57. Wolswijk G, Balesar R. 2003. Changes in the expression and localization of the paranodal protein Caspr on axons in chronic multiple sclerosis. Brain 126:1638-1649.