Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase IIα in vitro and in cultured cells

Biochemistry

Volumn 44, Issue 10, 2005, Pages 3972-3981

  Vélez Cruz, Renier ^a   Riggins, James N ^a   Daniels, J Scott ^a   Cai, Hongliang ^a   Guengerich, F Peter ^a   Marnett, Lawrence J ^a   Osheroff, Neil ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY CHROMATOGRAPHY; CATALYSIS; CELL CULTURE; CHEMICAL BONDS; ENZYMES; PHYSIOLOGY;

CATALYTIC CYCLES; CULTURED HUMAN CELLS; HUMAN TOPOISOMERASE; LESIONS;

DNA;

1,N 2 ETHENODEOXYGUANOSINE; 1,N 2 PROPANODEOXYGUANOSINE; 3,N 4 ETHENO 2' RIBOCYTIDINE; 3,N 4 ETHENODEOXYCYTIDINE; CHLOROACETALDEHYDE; CYTIDINE DERIVATIVE; DEOXYRIBOSE; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; GUANOSINE DERIVATIVE; PYRIMIDO[1,2 A]PURIN 10(3H)ONE DEOXYRIBOSE; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; DNA ADDUCT; DNA BINDING; DNA CLEAVAGE; DNA DAMAGE; DNA STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL;

ACETALDEHYDE; ALKYLATING AGENTS; ANTIGENS, NEOPLASM; CELL LINE, TUMOR; CELL SURVIVAL; DEOXYGUANOSINE; DNA ADDUCTS; DNA DAMAGE; DNA REPAIR; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; HUMANS; MYELOID-LYMPHOID LEUKEMIA PROTEIN; PROTO-ONCOGENES; TRANSCRIPTION FACTORS;

EID: 14844345208     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0478289     Document Type: Article

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