Development of a novel assay for human tyrosyl DNA phosphodiesterase 2

Analytical Biochemistry

Volumn 416, Issue 1, 2011, Pages 112-116

  Adhikari, Sanjay ^a   Karmahapatra, Soumendra K ^a   Elias, Hadi ^a   Dhopeshwarkar, Priyanka ^a   Scott Williams, R ^b   Byers, Stephen ^a   Uren, Aykut ^a   Roy, Rabindra ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

DNA repair; Enzyme assay; High throughput screening; Kinetics; TDP2

Indexed keywords

CHEMOTHERAPY; COLORIMETRY; ENZYME KINETICS; ENZYMES; ESTERS; OLIGONUCLEOTIDES; PH EFFECTS;

DNA REPAIR; ENZYMATIC MECHANISMS; ENZYME ASSAYS; HIGH THROUGHPUT SCREENING; PHOSPHODIESTERASE ACTIVITY; SODIUM ORTHOVANADATE; STEADY-STATE KINETICS; TDP2;

DNA;

4 NITROPHENYLTHYMIDINE 5' PHOSPHATE; CHROMOGENIC SUBSTRATE; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; SODIUM CHLORIDE; TYROSYL DNA PHOSPHODIESTERASE 1; TYROSYL DNA PHOSPHODIESTERASE 2; TYROSYL DNA PHOSPHODIESTERASE 2 INHIBITOR; UNCLASSIFIED DRUG; VANADATE SODIUM;

ARTICLE; CALORIMETRY; CHEMICAL STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; HYDROLYSIS KINETICS; PH MEASUREMENT; PRIORITY JOURNAL; REACTION OPTIMIZATION; SCREENING TEST; STEADY STATE;

EID: 79959758050     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2011.05.008     Document Type: Article

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