siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy

Anticancer Research

Volumn 32, Issue 7, 2012, Pages 2479-2485

  Separovic, Duska ^a   Breen, Paul ^a   Joseph, Nicholas ^a   Bielawski, Jacek ^b   Pierce, Jason S ^b   Van Buren, Eric ^a   Gudz, Tatyana I ^b,c  

^a WAYNE STATE UNIVERSITY   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

, dihydroceramide; Apoptosis; Ceramide; Ceramide synthase 1; Head and neck squamous carcinomas cells UM SCC 22A; PDT; Sphingolipids

Indexed keywords

CASPASE 3; CERAMIDE DERIVATIVE; CERAMIDE SYNTHASE 1; PHTHALOCYANINE DERIVATIVE; SMALL INTERFERING RNA; SPHINGOLIPID; SYNTHETASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL DEATH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME REGULATION; FLOW CYTOMETRY; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LIPID ANALYSIS; MASS SPECTROMETRY; MOLECULARLY TARGETED THERAPY; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPECTROFLUOROMETRY;

APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CASPASE 3; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOWN-REGULATION; GENE KNOCKDOWN TECHNIQUES; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOBLOTTING; MEMBRANE POTENTIAL, MITOCHONDRIAL; MEMBRANE PROTEINS; PEPTIDE HYDROLASES; PHOTOCHEMOTHERAPY; RNA, SMALL INTERFERING; SPHINGOLIPIDS; SPHINGOSINE N-ACYLTRANSFERASE; TRANSFECTION; TRYPAN BLUE;

EID: 84865695462     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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