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Volumn 32, Issue 3, 2012, Pages 753-760

Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells

Author keywords

Apoptosis; Ceramide; Ceramide synthase 6; Dihydroceramide; Head and neck squamous carcinoma; PDT; Sphingolipids; UM SCC 22A cells

Indexed keywords

CERAMIDE; CERAMIDE SYNTHASE 6; SMALL INTERFERING RNA; SPHINGOLIPID; TRYPAN BLUE; UNCLASSIFIED DRUG;

EID: 84858780894     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (22)

References (29)
  • 1
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: Lessons from sphingolipids
    • DOI 10.1038/nrm2329, PII NRM2329
    • Hannun YA and Obeid LM: Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol 9: 139-150, 2008. (Pubitemid 351158911)
    • (2008) Nature Reviews Molecular Cell Biology , vol.9 , Issue.2 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 2
    • 78649850282 scopus 로고    scopus 로고
    • Inhibition of ceramide biosynthesis preserves photoreceptor structure and function in a mouse model of retinitis pigmentosa
    • Strettoi E, Gargini C, Novelli E, Sala G, Piano I, Gasco P and Ghidoni R: Inhibition of ceramide biosynthesis preserves photoreceptor structure and function in a mouse model of retinitis pigmentosa. Proc Natl Acad Sci USA 107: 18706-18711, 2010.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 18706-18711
    • Strettoi, E.1    Gargini, C.2    Novelli, E.3    Sala, G.4    Piano, I.5    Gasco, P.6    Ghidoni, R.7
  • 3
    • 84856305649 scopus 로고    scopus 로고
    • Acyl chain specificity of ceramide synthases is determined within a region of 150 residues in the Tram-Lag-CLN8 (TLC) domain
    • Tidhar R, Ben-Dor S, Wang E, Kelly S, Merrill AH Jr. and Futerman AH: Acyl chain specificity of ceramide synthases is determined within a region of 150 residues in the Tram-Lag-CLN8 (TLC) domain. J Biol Chem 287: 3197-3206, 2012.
    • (2012) J Biol Chem , vol.287 , pp. 3197-3206
    • Tidhar, R.1    Ben-Dor, S.2    Wang, E.3    Kelly, S.4    Merrill Jr., A.H.5    Futerman, A.H.6
  • 4
  • 6
    • 61349193762 scopus 로고    scopus 로고
    • Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells
    • White-Gilbertson S, Mullen T, Senkal C, Lu P, Ogretmen B, Obeid L and Voelkel-Johnson C: Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells. Oncogene 28: 1132-1141, 2009.
    • (2009) Oncogene , vol.28 , pp. 1132-1141
    • White-Gilbertson, S.1    Mullen, T.2    Senkal, C.3    Lu, P.4    Ogretmen, B.5    Obeid, L.6    Voelkel-Johnson, C.7
  • 10
    • 0036384177 scopus 로고    scopus 로고
    • A role for the de novo sphingolipids in apoptosis of photosensitized cells
    • Wispriyono B, Schmelz E, Pelayo H, Hanada K and Separovic D: A role for the de novo sphingolipids in apoptosis of photosensitized cells. Exp Cell Res 279: 153-165, 2002.
    • (2002) Exp Cell Res , vol.279 , pp. 153-165
    • Wispriyono, B.1    Schmelz, E.2    Pelayo, H.3    Hanada, K.4    Separovic, D.5
  • 11
    • 2542501763 scopus 로고    scopus 로고
    • De novo ceramide accumulation due to inhibition of its conversion to complex sphingolipids in apoptotic photosensitized cells
    • DOI 10.1074/jbc.M311974200
    • Dolgachev V, Farooqui MS, Kulaeva OI, Tainsky MA, Nagy B, Hanada K and Separovic D: De novo ceramide accumulation due to inhibition of its conversion to complex sphingolipids in apoptotic photosensitized cells. J Biol Chem 279: 23238-23249, 2004. (Pubitemid 38685631)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.22 , pp. 23238-23249
    • Dolgachev, V.1    Farooqui, M.S.2    Kulaeva, O.I.3    Tainsky, M.A.4    Nagy, B.5    Hanada, K.6    Separovic, D.7
  • 12
    • 0043065270 scopus 로고    scopus 로고
    • Reactive oxygen species generation is independent of de novo sphingolipids in apoptotic photosensitized cells
    • DOI 10.1016/S0014-4827(03)00235-0
    • Dolgachev V, Nagy B, Taffe B, Hanada K and Separovic D: Reactive oxygen species generation is independent of de novo sphingolipids in apoptotic photosensitized cells. Exp Cell Res 288: 425-436, 2003. (Pubitemid 36959958)
    • (2003) Experimental Cell Research , vol.288 , Issue.2 , pp. 425-436
    • Dolgachev, V.1    Nagy, B.2    Taffe, B.3    Hanada, K.4    Separovic, D.5
  • 13
    • 78649937863 scopus 로고    scopus 로고
    • Photodynamic therapy-induced apoptosis
    • Gewritz DA, Grant S and Holt SE (eds.). New Jersey, Humana Press
    • Oleinick N, Morris R and Nieminen AL: Photodynamic therapy-induced apoptosis. In: Apoptosis, Senescence, and Cancer. Gewritz DA, Grant S and Holt SE (eds.). New Jersey, Humana Press., pp. 557-578, 2007.
    • (2007) Apoptosis, Senescence, and Cancer , pp. 557-578
    • Oleinick, N.1    Morris, R.2    Nieminen, A.L.3
  • 14
    • 33745537921 scopus 로고    scopus 로고
    • Photodynamic therapy and antitumour immunity
    • Castano AP, Mroz P and Hamblin MR: Photodynamic therapy and antitumour immunity. Nat Rev Cancer 6: 535-545, 2006.
    • (2006) Nat Rev Cancer , vol.6 , pp. 535-545
    • Castano, A.P.1    Mroz, P.2    Hamblin, M.R.3
  • 15
    • 1542510617 scopus 로고    scopus 로고
    • Choice of Oxygen-Conserving Treatment Regimen Determines the Inflammatory Response and Outcome of Photodynamic Therapy of Tumors
    • DOI 10.1158/0008-5472.CAN-03-3513
    • Henderson BW, Gollnick SO, Snyder JW, Busch TM, Kousis PC, Cheney RT and Morgan J: Choice of oxygen-conserving treatment regimen determines the inflammatory response and outcome of photodynamic therapy of tumors. Cancer Res 64: 2120-2126, 2004. (Pubitemid 38339462)
    • (2004) Cancer Research , vol.64 , Issue.6 , pp. 2120-2126
    • Henderson, B.W.1    Gollnick, S.O.2    Snyder, J.W.3    Busch, T.M.4    Kousis, P.C.5    Cheney, R.T.6    Morgan, J.7
  • 17
    • 77955241980 scopus 로고    scopus 로고
    • Silencing heat shock protein 27 decreases metastatic behavior of human head and neck squamous cell cancer cells in vitro
    • Zhu Z, Xu X, Yu Y, Graham M, Prince ME, Carey TE and Sun D: Silencing heat shock protein 27 decreases metastatic behavior of human head and neck squamous cell cancer cells in vitro. Mol Pharm 7: 1283-1290, 2010.
    • (2010) Mol Pharm , vol.7 , pp. 1283-1290
    • Zhu, Z.1    Xu, X.2    Yu, Y.3    Graham, M.4    Prince, M.E.5    Carey, T.E.6    Sun, D.7
  • 18
    • 42649083647 scopus 로고    scopus 로고
    • Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage
    • Separovic D, Semaan L, Tarca AL, Awad Maitah MY, Hanada K, Bielawski J, Villani M and Luberto C: Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage. Exp Cell Res 314: 1860-1868, 2008.
    • (2008) Exp Cell Res , vol.314 , pp. 1860-1868
    • Separovic, D.1    Semaan, L.2    Tarca, A.L.3    Awad Maitah, M.Y.4    Hanada, K.5    Bielawski, J.6    Villani, M.7    Luberto, C.8
  • 19
    • 74149088291 scopus 로고    scopus 로고
    • Increased ceramide accumulation correlates with down-regulation of the autophagy protein ATG-7 in MCF-7 cells sensitized to photodamage
    • Separovic D, Kelekar A, Nayak AK, Tarca AL, Hanada K, Pierce JS and Bielawski J: Increased ceramide accumulation correlates with down-regulation of the autophagy protein ATG-7 in MCF-7 cells sensitized to photodamage. Arch Biochem Biophys 494: 101-105, 2010.
    • (2010) Arch Biochem Biophys , vol.494 , pp. 101-105
    • Separovic, D.1    Kelekar, A.2    Nayak, A.K.3    Tarca, A.L.4    Hanada, K.5    Pierce, J.S.6    Bielawski, J.7
  • 20
    • 0027374638 scopus 로고
    • A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5',6,6'-tetrachloro- 1,1',3,3'-tetraethylbenzimidazolcarbocyanine iodide (JC-1)
    • DOI 10.1006/bbrc.1993.2438
    • Cossarizza A, Baccarani-Contri M, Kalashnikova G and Franceschi C: A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′- tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine iodide (JC-1). Biochem Biophys Res Commun 197: 40-45, 1993. (Pubitemid 23358874)
    • (1993) Biochemical and Biophysical Research Communications , vol.197 , Issue.1 , pp. 40-45
    • Cossarizza, A.1    Baccarani-Contri, M.2    Kalashnikova, G.3    Franceschi, C.4
  • 21
    • 0032112125 scopus 로고    scopus 로고
    • Association of Ceramide Accumulation with Photodynamic Treatment-Induced Cell Death
    • Separovic D, Mann KJ and Oleinick NL: Association of ceramide accumulation with photodynamic treatment-induced cell death. Photochem Photobiol 68: 101-109, 1998. (Pubitemid 128472339)
    • (1998) Photochemistry and Photobiology , vol.68 , Issue.1 , pp. 101-109
    • Separovic, D.1    Mann, K.J.2    Oleinick, N.L.3
  • 22
    • 84860515463 scopus 로고    scopus 로고
    • C16-ceramide analog combined with Pc 4 photodynamic therapy evokes enhanced total ceramide accumulation, promotion of DEVDase activation in the absence of apoptosis, and augmented overall cell killing
    • Separovic D, Saad ZH, Edwin EA, Bielawski J, Pierce JS, Buren EV and Bielawska A: C16-ceramide analog combined with Pc 4 photodynamic therapy evokes enhanced total ceramide accumulation, promotion of DEVDase activation in the absence of apoptosis, and augmented overall cell killing. J Lipids 2011: 1-9, 2010.
    • (2010) J Lipids , vol.2011 , pp. 1-9
    • Separovic, D.1    Saad, Z.H.2    Edwin, E.A.3    Bielawski, J.4    Pierce, J.S.5    Buren, E.V.6    Bielawska, A.7
  • 23
    • 0035861589 scopus 로고    scopus 로고
    • Photodynamic therapy-induced apoptosis in epidermoid carcinoma cells. Reactive oxygen species and mitochondrial inner membrane permeabilization
    • Lam M, Oleinick NL and Nieminen AL: Photodynamic therapy-induced apoptosis in epidermoid carcinoma cells. Reactive oxygen species and mitochondrial inner membrane permeabilization. J Biol Chem 276: 47379-47386, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 47379-47386
    • Lam, M.1    Oleinick, N.L.2    Nieminen, A.L.3
  • 24
    • 75149176725 scopus 로고    scopus 로고
    • Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways
    • Senkal CE, Ponnusamy S, Bielawski J, Hannun YA and Ogretmen B: Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J 24: 296-308, 2010.
    • (2010) FASEB J , vol.24 , pp. 296-308
    • Senkal, C.E.1    Ponnusamy, S.2    Bielawski, J.3    Hannun, Y.A.4    Ogretmen, B.5
  • 26
  • 27
    • 23944483995 scopus 로고    scopus 로고
    • Mammalian Lass6 and its related family members regulate synthesis of specific ceramides
    • DOI 10.1042/BJ20050291
    • Mizutani Y, Kihara A and Igarashi Y: Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J 390: 263-271, 2005. (Pubitemid 41192252)
    • (2005) Biochemical Journal , vol.390 , Issue.1 , pp. 263-271
    • Mizutani, Y.1    Kihara, A.2    Igarashi, Y.3
  • 29
    • 79955533796 scopus 로고    scopus 로고
    • Ceramide synthase-dependent ceramide generation and programmed cell death: Involvement of salvage pathway in regulating postmitochondrial events
    • Mullen TD, Jenkins RW, Clarke CJ, Bielawski J, Hannun YA and Obeid LM: Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events. J Biol Chem 286: 15929-15942, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 15929-15942
    • Mullen, T.D.1    Jenkins, R.W.2    Clarke, C.J.3    Bielawski, J.4    Hannun, Y.A.5    Obeid, L.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.