Methods for a Randomized Trial of Weight-Supported Treadmill Training Versus Conventional Training for Walking During Inpatient Rehabilitation after Incomplete Traumatic Spinal Cord Injury

Neurorehabilitation and Neural Repair

Volumn 17, Issue 3, 2003, Pages 153-167

  Dobkin, Bruce H ^a   Apple, David ^a   Barbeau, Hugues ^a   Basso, Michele ^a   Behrman, Andrea ^a   Deforge, Dan ^a   Ditunno, John ^a   Dudley, Gary ^a   Elashoff, Robert ^a   Fugate, Lisa ^a   Harkema, Susan ^a   Saulino, Michael ^a   Scott, Michael ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Locomotor training; Motor learning; Neurologic rehabilitation; Spinal cord

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EVIDENCE BASED MEDICINE; HOSPITAL PATIENT; HUMAN; INTERMETHOD COMPARISON; LOCOMOTION; MAJOR CLINICAL STUDY; MOBILIZATION; MULTICENTER STUDY; PHYSIOTHERAPIST; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SPINAL CORD INJURY; TASK PERFORMANCE; TRAINING; TREADMILL EXERCISE; TREATMENT OUTCOME; WALKING; WALKING SPEED; WEIGHT BEARING;

EXERCISE TEST; HUMANS; INPATIENTS; MULTICENTER STUDIES; OUTCOME ASSESSMENT (HEALTH CARE); PATIENT SELECTION; PHYSICAL THERAPY MODALITIES; PROSPECTIVE STUDIES; RANDOMIZED CONTROLLED TRIALS; SAMPLE SIZE; SPINAL CORD INJURIES; WALKING;

EID: 0043030235     PISSN: 15459683     EISSN: 15526844     Source Type: Journal    
DOI: 10.1177/0888439003255508     Document Type: Article

References (42)

1. Dobkin B. The clinical science of neurologic rehabilitation. New York: Oxford University Press; 2003.
2. Marino R, Barros T, Bioering-Sorensen F, et al. International standards for neurological classification of spinal cord injury. 6th ed. J Spinal Cord Me 2003; 26(suppl 1): S49-S56.
3. Stover S, DeVivo M, Go B. History, implementation, and cur rent status of the national spinal cord injury database. Arch Phys Med Rehabil 1999; 80: 1365-1371.
4. Dobkin B, Apple D, Barbeau H, Saulino M, Fugate L, Scott M. Randomized trial of body weight-supported treadmill training after acute spinal cord injury. Neurorehabil Neural Repair 1999; 13: 50.
5. Barbeau H, Fung J. New experimental approaches in the treatment of spastic gait disorders. Med Sport Sci 1992; 36: 234-246.
6. Barbeau H, McCrea D, O'Donovan M, Rossignol S, Grill W, Lemay M. Tapping into spinal circuits to restore motor function. Brain Res Rev 1999; 30: 27-51.
7. Dobkin B. Overview of treadmill locomotor training with partial body weight support: a neurophysiologically sound approach whose time has come for randomized clinical trials. Neurorehabil Neural Repair 1999; 13: 157-165.
8. Wernig A, Nanassy A, Miller S. Maintenance of locomotor abilities following Laufband (treadmill) therapy in paraand tetraplegic persons: follow-up studies. Spinal Cord 1998; 36: 744-749.
9. Dietz V, Wirz M, Curt A, Colombo G. Locomotor patterns in paraplegic patients: training effects and recovery of spinal cord function. Spinal Cord 1998; 36: 380-390.
10. Tillakaratne N, de Leon R, Hoang T, Roy R, Edgerton V, Tobin A. Use-dependent modulation of inhibitory capacity in the feline lumbar spinal cord. J Neurosci 2002; 22: 3130-3143.
11. Schmidt B, Jordan L. The role of serotonin in reflex modulation and locomotor rhythm production in the mammalian spinal cord. Brain Res Bull 2001; 53: 689-710.
12. Kakulas B. A review of the neuropathology of human spinal cord injury with emphasis on special features. J Spinal Cord Med 1999; 22: 119-124.
13. Blight A. Remyelination, revascularization, and recovery of function in experimental spinal cord injury. In: Seil F, editor. Spinal cord injury. New York: Raven; 1993, p. 91-104.
14. Belanger M, Drew T, Provencher J, Rossignol S. A comparison of treadmill locomotion in adult cats before and after spinal transection. J Neurophysiol 1996; 76: 471-491.
15. Bouyer L, Whelan P, Pearson K, Rossignol S. Adaptive locomotor plasticity in chronic spinal cats after ankle extensors neurectomy. J Neurosci 2001; 21: 3531-3541.
16. de Leon R, Hodgson J, Roy R, Edgerton V. Locomotor capacity attributable to step training versus spontaneous recovery after spinalization in adult cats. J Neurophysiol 1998; 79: 1329-1340.
17. Dimitrijevic M, Gerasimenko Y, Pinter M. Evidence for a spinal central pattern generator in humans. Ann NY Acad Sci 1998; 860: 360-376.
18. Duysens J, Van de Crommert H. Neural control of locomotion: The central pattern generator from cats to humans. Gait and Posture 1998; 7: 131-141.
19. Tresch M, Saltiel P, Bizzi E. The construction of movement by the spinal cord. Nature Neurosci 1999; 2: 162-167.
20. Harkema S, Hurley S, Patel U, Dobkin B, Edgerton V. Human lumbosacral spinal cord interprets loading during stepping. J Neurophysiol 1997; 77: 797-811.
21. Armstrong D. The supraspinal control of mammalian locomotion. J Physiol 1988; 405: 1-37.
22. Dobkin B, Harkema S, Requejo P, Edgerton V. Modulation of locomotor-like EMG activity in subjects with complete and incomplete chronic spinal cord injury. J Neurologic Rehabil 1995; 9: 183-190.
23. Dobkin B. Spinal and supraspinal plasticity after incomplete spinal cord injury: correlations between functional magnetic resonance imaging and engaged locomotor networks. In: Seil F, editor. Progress in brain research. Vol. 128. Amsterdam: Elsevier; 2000. p. 99-111.
24. Graziano M, Taylor C, Moore T. Complex movements evoked by microstimulation of precentral cortex. Neuron 2002; 34: 841-851.
25. Merzenich M, Recanzone G, Jenkins W, Nudo R. How the brain functionally rewires itself. In: Arbib M, Robinson J, editors. Natural and artificial parallel computations. Cambridge (MA): MIT Press; 1990, p. 170-198.
26. Schwab M. Repairing the injured spinal cord. Science 2002; 295: 1029-1031.
27. Barbeau H, Fung J. The role of rehabilitation in the recovery of walking in the neurological population. Curr Opin Neurol 2001; 14: 735-740.
28. Dobkin B. Functional rewiring of brain and spinal cord after injury: the three R's of neural repair and neurological rehabilitation. Curr Opin Neurol 2000; 13: 655-659.
29. Edgerton V, de Leon R, Harkema S, et al. Retraining the injured spinal cord. J Physiol 2001; 533: 15-22.
30. Edgerton V, Harkema S, Dobkin B. Retraining the human spinal cord. In: Lin V, editor. Spinal cord medicine: principles and practice. New York: Demos Medical; 2003. p. 817-828.
31. Waters R, Adkins R, Yakura J, Vogil D. Prediction of ambulatory performance based on motor scores derived from standards of the American Spinal Injury Association. Arch Phys Med Rehabil 1994; 75: 756-760.
32. Waters R, Yakura J, Adkins R, Barnes G. Determinants of gait performance following spinal cord injury. Arch Phys Med Rehabil 1989; 70: 811-818.
33. Fiedler R, Granger C, Russell C. UDSMR: follow-up data on patients discharged in 1994-1996. Am J Phys Med Rehabil 2000; 79: 184-192.
34. Behrman A, Harkema S. Locomotion training after human spinal cord injury: a series of case studies. Phys Ther 2000; 80: 688-700.
35. Pohl P, Duncan P, Perera S, et al. Influence of stroke-related impairments on performance in 6-minute walk test. J Rehabil Res Develop 2002; 39: 439-444.
36. Berg K, Maki B, Williams J, Holliday P, Wood-Dauphinee S. Clinical laboratory measures of postural balance in an elderly population. Arch Phys Med Rehabil 1992; 73: 1073-1080.
37. Ditunno J, Ditunno P, Graziani V, et al. Walking index for spinal cord injury (WISCI): an international multicenter validity and reliability study. Spinal Cord 2000; 38: 234-243.
38. Ditunno P, Ditunno J. Walking index for spinal cord injury scale revision (WISCI II). Spinal Cord 2001; 39: 654-656.
39. Ware J. Measuring patient's views: the optimum outcome measure. BMJ 1993; 306: 1429-1430.
40. Vickrey B, Hays R, Genovese B, Myers L, Ellison G. Comparison of a generic to disease-targeted health-related quality-of-life measures for multiple sclerosis. J Clin Epidemiol 1997; 50: 557-569.
41. Korner-Bitensky N, Wood-Dauphinee S, Siemiatycki J, Shapiro S, Becker R. Health-related information postdischarge: telephone versus face-to-face interviewing. Arch Phys Med Rehabil 1994; 75: 1287-1296.
42. Brashear A, Gordon M, Elovic E, Kassicieh D, Group BS. Intramuscular injection of botulinum toxin for the treatment of wrist and finger spasticity after a stroke. New Engl J Med 2002; 347: 395-400.