PR3 and Elastase Alter PAR1 Signaling and Trigger vWF Release via a Calcium-Independent Mechanism from Glomerular Endothelial Cells

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Tull, Samantha P ^a   Bevins, Anne ^a   Kuravi, Sahithi Jyothsna ^a   Satchell, Simon C ^b   Al Ani, Bahjat ^c   Young, Stephen P ^a   Harper, Lorraine ^a   Williams, Julie M ^b   Rainger, George Ed ^a   Savage, Caroline O S ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c KING KHALID UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; ELASTASE; MYELOBLASTIN; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 3; SMALL INTERFERING RNA; THROMBIN; TRYPSIN; VON WILLEBRAND FACTOR;

ARTICLE; CALCIUM SIGNALING; CELL FUNCTION; CELL SURFACE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME MECHANISM; FLOW CYTOMETRY; GENE SILENCING; GLOMERULAR ENDOTHELIAL CELL; GLOMERULONEPHRITIS; HUMAN; HUMAN CELL; PHENOTYPE; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

CALCIUM; ENDOTHELIAL CELLS; HEK293 CELLS; HUMANS; KIDNEY GLOMERULUS; MYELOBLASTIN; PANCREATIC ELASTASE; PROTEOLYSIS; RECEPTOR, PAR-1; SIGNAL TRANSDUCTION; VON WILLEBRAND FACTOR;

EID: 84865584004     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043916     Document Type: Article

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