Complexed plasma elastase as an in vivo marker for leukocyte activation in antineutrophil cytoplasmic antibody-associated vasculitis

Arthritis and Rheumatism

Volumn 40, Issue 9, 1997, Pages 1680-1684

  Haubitz, M ^a   Schulzeck, P ^a   Schellong, S ^a   Schulze, M ^a   Koch, K M ^a   Brunkhorst, R ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; ELASTASE; NEUTROPHIL CYTOPLASMIC ANTIBODY;

ADOLESCENT; ADULT; AGED; ANTIBODY TITER; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; LEUKOCYTE ACTIVATION; LYSOSOME; MALE; PATHOGENESIS; POLYMYOSITIS; PRIORITY JOURNAL; VASCULITIS; WEGENER GRANULOMATOSIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALPHA 1-ANTITRYPSIN; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CYCLOPHOSPHAMIDE; FEMALE; GRANULOCYTES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LEUKOCYTE ELASTASE; MALE; METHYLPREDNISOLONE; MIDDLE AGED; PANCREATIC ELASTASE; PREDNISOLONE; RECURRENCE; VASCULITIS; WEGENER GRANULOMATOSIS;

EID: 0030771395     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780400918     Document Type: Article

References (28)

1. Van der Woude FJ, Rasmussen N, Lobatto S, Wilk A, Permin H, van Es LA, van der Giessen M, van der Hem GK, The TH: Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis. Lancet 1:425-429, 1985
2. Falk RJ, Jennette JC: Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med 318:1651-1657, 1988
3. Gross WL, Schmitt WH, Csernok E: ANCA and associated diseases: immunodiagnostic and pathogenetic aspects. Clin Exp Immunol 91:1-12, 1993
4. Cohen Tervaert JW, van der Woude FJ, Fauci AS, Ambrus JL, Velosa J, Keane WF, Meijer S, van der Giessen M, van der Hem GK, The TH, Vallenberg GM: Association between active Wegener's granulomatosis and anticytoplasmic antibodies. Arch Intern Med 149:2461-2465, 1989
5. Nölle B, Specks U, Lüdemann J, Rohrbach MS, DeRemee RA, Gross WL: Anticytoplasmic autoantibodies: their immunodiagnostic value in Wegener's granulomatosis. Ann Intern Med 111:28-40, 1989
6. Csernok E, Ernst M, Schmitt W, Bainton DF, Gross WL: Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo. Clin Exp Immunol 95:244-250, 1994
7. Falk RJ, Terrell RS, Charles LA, Jennette JC: Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci U S A 87:4115-4119, 1990
8. Ohlsson K, Ohlsson I: The extracellular release of granulocyte collagenase and elastase during phagocytosis and inflammatory processes. Scand J Haematol 19:145-152, 1977
9. Kargi HA, Campbell EJ, Kuhn C: Elastase and cathepsin G of human monocytes: heterogeneity and subcellular localization to peroxidase-positive granules. J Histochem Cytochem 38:1179-1186, 1990
10. Jennette JC, Falk RJ, Andrassy K, Bacon PA, Churg J, Gross WL, Hagen EC, Hoffman GS, Hunder GG, Kallenberg CGB, McCluskey RT, Sinico RA, Rees AJ, van Es LA, Waldherr R, Wiik A: Nomenclature of systemic vasculitides: proposal of an international consensus conference. Arthritis Rheum 37:187-192, 1994
11. Leavitt RY, Fauci AS, Bloch DA, Michel BA, Hunder GG, Arend WP, Calabrese LH, Fries JF, Lie JT, Lightfoot RW Jr, Masi AT, McShane DJ, Mills JA, Stevens MB, Wallace SL, Zvaifler NJ: The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis. Arthritis Rheum 33:1101-1107, 1990
12. Luqmani RA, Bacon PA, Moots RJ, Janssen BA, Pall A, Emery P, Savage C, Adu D: Birmingham Vasculitis Activity Score (BVAS) in systemic necrotizing vasculitis. QJM 87:671-678, 1994
13. Neumann S, Gunzer G, Hennrich N, Lang H: "PMN elastase assay": enzyme immunoassay for human polymorphonuclear elastase complexed with α1-proteinase inhibitor. J Clin Chem Biochem 22:693-697, 1984
14. Lüdemann J, Utecht B, Gross WL: Detection and quantitation of anti-neutrophil cytoplasmic antibodies in Wegener's granulomatosis by ELISA using affinity-purified antigen. J Immunol Methods 114:167-174, 1988
15. Koderisch J, Andrassy K, Rassmussen N, Hartmann M, Tilgen W: "False positive" anti-neutrophil cytoplasmic antibodies in HIV infection. Lancet 335:1227-1228, 1990
16. Kerr GS, Fleisher TA, Hallahan CW, Leavitt RY, Fauci AS, Hoffman GS: Limited prognostic value of changes in antineutrophil cytoplasmic antibody titer in patients with Wegener's granulomatosis. Arthritis Rheum 36:365-371, 1993
17. Savage CO, Pottinger BE, Gaskin G, Pusey CD, Pearson JD: Autoantibodies developing to mycloperoxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity toward cultured endothelial cells. Am J Pathol 141:335-342, 1992
18. Gordon M, Luqmani RA, Adu D, Greaves I, Richards N, Michael J, Emery P, Howie AJ, Bacon, PA: Relapses in patients with a systemic vasculitis. QJM 86:779-789, 1993
19. Phan SH, Gannon DE, Ward PA, Karmiol S: Mechanism of neutrophil-induced xanthine dehydrogenase to xanthin oxidase conversion in endothelial cells: evidence of a role for elastase. Am J Respir Cell Mol Biol 6:270-278, 1992
20. Ballieux BE, Hiemstra PS, Klar MN, Hagan EC, van Es LA, van der Woude F, Daha MR: Detachment and cytolysis of human endothelial cells by proteinase 3. Eur J Immunol 24:3211-3215, 1994
21. Berger SP, Seelen MAJ, Hiemstra PS, Heemskerk E, van der Woude FJ, Daha MR: The neutrophil enzymes proteinase 3 and elastase enhance the production of IL-8 by endothelial cells in culture. J Am Soc Nephrol 7:694-701, 1996
22. Trocme SD, Bartley GB, Campbell RJ, Gleich GJ, Leiferman KM: Eosinophil and neutrophil degranulation in ophthalmic lesions of Wegener's granulomatosis. Arch Ophthalmol 109:1585-1589, 1991
23. Brouwer E, Huitema MG, Mulder AH, Heeringa P, van Goor H, Tervaert, JWC, Weening JJ, Kallenberg CGM: Neutrophil activation in vitro and in vivo in Wegener's granulomatosis. Kidney Int 45:1120-1131, 1994
24. Brouwer E, Huitema MG, Klok PA, de Weerd H, Tervaert JWC, Weening JJ, Kallenberg CGM: Antimyeloperoxidase-associated proliferative glomerulonephritis: an animal model. J Exp Med 177:905-914, 1993
25. Lasson A, Balldin G, Ohlsson K: Leucocyte elastase α1-proteinase inhibitor complexes may diagnose pancreatic abscesses early. Scand J Clin Lab Invest 21:220-221, 1986
26. Adeyemi EO, Neumann S, Chadwick VS, Hodgson HJF, Pepys MB: Circulating human elastase in patients with inflammatory diseases. Gut 26:1300-1306, 1985
27. Kuramitsu K, Yoshida A: Plasma and synovial fluid levels of granulocytal elastase-alpha-1-protease inhibitor complex in patients with rheumatoid arthritis. Rheumatol Int 10:51-56, 1990
28. Nuijens JH, Abbink JJ, Wachtfogel YT, Colman RW, Eermberg A, Dors D, Kamp AJ, Strackvan Schündel RJ, Thüs LG, Hack CE: Plasma elastase α1-antitrypsin and lactoferrin in sepsis: evidence for neutrophils as mediators in fatal sepsis. J Lab Clin Med 119:159-168, 1992