The Largely Normal Response to Toll-Like Receptor 7 and 9 Stimulation and the Enhanced Expression of SIGIRR by B Cells in Systemic Lupus Erythematosus

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Zhu, Yun Yan ^a   Su, Yin ^b   Li, Zhan Guo ^b   Zhang, Yu ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD19 ANTIGEN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; SINGLE IMMONOGLOBULIN INTERLEUKIN 1 RECEPTOR RELATED MOLECULE; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

ADULT; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; B-LYMPHOCYTES; CASE-CONTROL STUDIES; CELL PROLIFERATION; DEMOGRAPHY; FEMALE; HUMANS; IMMUNOGLOBULIN G; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, INTERLEUKIN-1; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 9;

EID: 84865579687     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044131     Document Type: Article

References (43)

1. Mok CC, Lau CS, (2003) Pathogenesis of systemic lupus erythematosus. J Clin Pathol 56: 481-490.
2. Klinman DM, Shirai A, Ishigatsubo Y, Conover J, Steinberg AD, (1991) Quantitation of IgM- and IgG-secreting B cells in the peripheral blood of patients with systemic lupus erythematosus. Arthritis Rheum 34: 1404-1410.
3. Liossis SN, Kovacs B, Dennis G, Kammer GM, Tsokos GC, (1996) B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events. J Clin Invest 98: 2549-2557.
4. Meyer-Bahlburg A, Rawlings DJ, (2008) B cell autonomous TLR signaling and autoimmunity. Autoimmun Rev 7: 313-316.
5. Avalos AM, Busconi L, Marshak-Rothstein A, (2010) Regulation of autoreactive B cell responses to endogenous TLR ligands. Autoimmunity 43: 76-83.
6. Hanten JA, Vasilakos JP, Riter CL, Neys L, Lipson KE, et al. (2008) Comparison of human B cell activation by TLR7 and TLR9 agonists. BMC Immunol 9: 39.
7. Bernasconi NL, Onai N, Lanzavecchia A, (2003) A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood 101: 4500-4504.
8. Bourke E, Bosisio D, Golay J, Polentarutti N, Mantovani A, (2003) The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells. Blood 102: 956-963.
9. Leadbetter EA, Rifkin IR, Hohlbaum AM, Beaudette BC, Shlomchik MJ, et al. (2002) Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416: 603-607.
10. Lau CM, Broughton C, Tabor AS, Akira S, Flavell RA, et al. (2005) RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med 202: 1171-1177.
11. Berland R, Fernandez L, Kari E, Han JH, Lomakin I, et al. (2006) Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice. Immunity 25: 429-440.
12. Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, et al. (2006) Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25: 417-428.
13. Pisitkun P, Deane JA, Difilippantonio MJ, Tarasenko T, Satterthwaite AB, et al. (2006) Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 312: 1669-1672.
14. Subramanian S, Tus K, Li QZ, Wang A, Tian XH, et al. (2006) A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci U S A 103: 9970-9975.
15. Fairhurst AM, Hwang SH, Wang A, Tian XH, Boudreaux C, et al. (2008) Yaa autoimmune phenotypes are conferred by overexpression of TLR7. Eur J Immunol 38: 1971-1978.
16. Ehlers M, Fukuyama H, McGaha TL, Aderem A, Ravetch JV, (2006) TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. Journal of Experimental Medicine 203: 553-561.
17. Wu X, Peng SL, (2006) Toll-like receptor 9 signaling protects against murine lupus. Arthritis Rheum 54: 336-342.
18. Liew FY, Xu D, Brint EK, O'Neill LA, (2005) Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol 5: 446-458.
19. Garlanda C, Anders HJ, Mantovani A, (2009) TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization. Trends Immunol 30: 439-446.
20. Thomassen E, Renshaw BR, Sims JE, (1999) Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. Cytokine 11: 389-399.
21. Polentarutti N, Rol GP, Muzio M, Bosisio D, Camnasio M, et al. (2003) Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. Eur Cytokine Netw 14: 211-218.
22. Huang X, Hazlett LD, Du W, Barrett RP, (2006) SIGIRR promotes resistance against Pseudomonas aeruginosa keratitis by down-regulating type-1 immunity and IL-1R1 and TLR4 signaling. J Immunol 177: 548-556.
23. Wald D, Qin J, Zhao Z, Qian Y, Naramura M, et al. (2003) SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 4: 920-927.
24. Lech M, Kulkarni OP, Pfeiffer S, Savarese E, Krug A, et al. (2008) Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens. J Exp Med 205: 1879-1888.
25. Lech M, Garlanda C, Mantovani A, Kirschning CJ, Schlondorff D, et al. (2007) Different roles of TiR8/Sigirr on toll-like receptor signaling in intrarenal antigen-presenting cells and tubular epithelial cells. Kidney Int 72: 182-192.
26. Garlanda C, Riva F, Polentarutti N, Buracchi C, Sironi M, et al. (2004) Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. Proc Natl Acad Sci U S A 101: 3522-3526.
27. Drexler SK, Kong P, Inglis J, Williams RO, Garlanda C, et al. (2010) SIGIRR/TIR-8 Is an Inhibitor of Toll-like Receptor Signaling in Primary Human Cells and Regulates Inflammation in Models of Rheumatoid Arthritis. Arthritis and Rheumatism 62: 2249-2261.
28. Zhang C, Wu X, Zhao Y, Deng Z, Qian G, (2011) SIGIRR inhibits toll-like receptor 4, 5, 9-mediated immune responses in human airway epithelial cells. Mol Biol Rep 38: 601-609.
29. Lech M, Skuginna V, Kulkarni OP, Gong J, Wei T, et al. (2010) Lack of SIGIRR/TIR8 aggravates hydrocarbon oil-induced lupus nephritis. J Pathol 220: 596-607.
30. Papadimitraki ED, Choulaki C, Koutala E, Bertsias G, Tsatsanis C, et al. (2006) Expansion of toll-like receptor 9-expressing B cells in active systemic lupus erythematosus: implications for the induction and maintenance of the autoimmune process. Arthritis Rheum 54: 3601-3611.
31. Komatsuda A, Wakui H, Iwamoto K, Ozawa M, Togashi M, et al. (2008) Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Clin Exp Immunol 152: 482-487.
32. Nakano S, Morimoto S, Suzuki J, Nozawa K, Amano H, et al. (2008) Role of pathogenic auto-antibody production by Toll-like receptor 9 of B cells in active systemic lupus erythematosus. Rheumatology (Oxford) 47: 145-149.
33. Migita K, Miyashita T, Maeda Y, Nakamura M, Yatsuhashi H, et al. (2007) Toll-like receptor expression in lupus peripheral blood mononuclear cells. J Rheumatol 34: 493-500.
34. Wu O, Chen GP, Chen H, Li XP, Xu JH, et al. (2009) The expressions of Toll-like receptor 9 and T-bet in circulating B and T cells in newly diagnosed, untreated systemic lupus erythematosus and correlations with disease activity and laboratory data in a Chinese population. Immunobiology 214: 392-402.
35. Rui LX, Vinuesa CG, Blasioli J, Goodnow CC, (2003) Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling. Nature Immunology 4: 594-600.
36. Zeuner RA, Klinman DM, Illei G, Yarboro C, Ishii KJ, et al. (2003) Response of peripheral blood mononuclear cells from lupus patients to stimulation by CpG oligodeoxynucleotides. Rheumatology (Oxford) 42: 563-569.
37. Anderson CC, Rahimpour R, Sinclair NR, (1994) Lipopolysaccharide-induced IgM production is not suppressed by antigen receptor ligation in B cells from some autoimmune strains of mice. Immunol Res 13: 10-20.
38. Salata M, Golbus J, Richardson BC, (1988) Diminished response to an inhibitory signal in lymphocytes from patients with systemic lupus erythematosus. Clin Exp Immunol 71: 439-444.
39. Xiao H, Gulen MF, Qin J, Yao J, Bulek K, et al. (2007) The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis. Immunity 26: 461-475.
40. Bulek K, Swaidani S, Qin J, Lu Y, Gulen MF, et al. (2009) The essential role of single Ig IL-1 receptor-related molecule/Toll IL-1R8 in regulation of Th2 immune response. J Immunol 182: 2601-2609.
41. Adib-Conquy M, Adrie C, Fitting C, Gattolliat O, Beyaert R, et al. (2006) Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients. Crit Care Med 34: 2377-2385.
42. Gulen MF, Kang Z, Bulek K, Youzhong W, Kim TW, et al. (2010) The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity 32: 54-66.
43. Muzio M, Scielzo C, Bertilaccio MT, Frenquelli M, Ghia P, et al. (2009) Expression and function of toll like receptors in chronic lymphocytic leukaemia cells. Br J Haematol 144: 507-516.