Pharmacokinetics of gastrodin and its metabolite p-hydroxybenzyl alcohol in rat blood, brain and bile by microdialysis coupled to LC-MS/MS

Journal of Pharmaceutical and Biomedical Analysis

Volumn 48, Issue 3, 2008, Pages 909-917

  Lin, Lei Chwen ^a,b   Chen, Yen Fei ^a   Lee, Wen Chuan ^a   Wu, Yu Tse ^a   Tsai, Tung Hu ^a,c  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^c TAIPEI CITY HOSPITAL   (Taiwan)

Author keywords

Gastrodia elata Blume; Gastrodin; Herbal medicine; Microdialysis; Pharmacokinetics

Indexed keywords

4 HYDROXYBENZYL ALCOHOL; AMMONIUM HYDROXIDE; DRUG METABOLITE; GASTRODIN; METHANOL; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; GASTRODIA ELATA; HERBAL MEDICINE; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BENZYL ALCOHOLS; BILE; BRAIN; CALIBRATION; CHROMATOGRAPHY, LIQUID; GLUCOSIDES; MALE; MICRODIALYSIS; MOLECULAR STRUCTURE; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TIME FACTORS;

EID: 53049100124     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.07.013     Document Type: Article

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