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Volumn 221, Issue 3, 2007, Pages 349-362

Interactive toxicity of inorganic mercury and trichloroethylene in rat and human proximal tubules: Effects on apoptosis, necrosis, and glutathione status

Author keywords

Apoptosis; Human proximal tubular cells; Inorganic mercury; Interactive toxicity; Necrosis; Rat proximal tubular cells; Trichloroethylene

Indexed keywords

GLUTATHIONE; GLUTATHIONE TRANSFERASE ALPHA; LACTATE DEHYDROGENASE; MERCURY; TRICHLOROETHYLENE;

EID: 34249811198     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.03.023     Document Type: Article
Times cited : (23)

References (45)
  • 2
    • 0022448371 scopus 로고
    • The effect of depletion of nonprotein sulfhydryls by diethyl maleate plus buthionine sulfoximine on renal uptake of mercury in the rat
    • Baggett J.M., and Berndt W.O. The effect of depletion of nonprotein sulfhydryls by diethyl maleate plus buthionine sulfoximine on renal uptake of mercury in the rat. Toxicol. Appl. Pharmacol. 83 (1986) 556-562
    • (1986) Toxicol. Appl. Pharmacol. , vol.83 , pp. 556-562
    • Baggett, J.M.1    Berndt, W.O.2
  • 6
    • 32944464498 scopus 로고    scopus 로고
    • Cysteine conjugate β-lyases
    • Cooper A.J.L., and Pinto J.T. Cysteine conjugate β-lyases. Amino Acids 30 (2006) 1-15
    • (2006) Amino Acids , vol.30 , pp. 1-15
    • Cooper, A.J.L.1    Pinto, J.T.2
  • 7
    • 0033975309 scopus 로고    scopus 로고
    • Metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-l-cysteine in freshly isolated human proximal tubular cells
    • Cummings B.S., and Lash L.H. Metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-l-cysteine in freshly isolated human proximal tubular cells. Toxicol. Sci. 53 (2000) 458-466
    • (2000) Toxicol. Sci. , vol.53 , pp. 458-466
    • Cummings, B.S.1    Lash, L.H.2
  • 8
    • 0034618720 scopus 로고    scopus 로고
    • Cytotoxicity of trichloroethylene and S-(1,2-dichlorovinyl)-l-cysteine in primary cultures of rat renal proximal tubular and distal tubular cells
    • Cummings B.S., Zangar R.C., Novak R.F., and Lash L.H. Cytotoxicity of trichloroethylene and S-(1,2-dichlorovinyl)-l-cysteine in primary cultures of rat renal proximal tubular and distal tubular cells. Toxicology 150 (2000) 83-98
    • (2000) Toxicology , vol.150 , pp. 83-98
    • Cummings, B.S.1    Zangar, R.C.2    Novak, R.F.3    Lash, L.H.4
  • 9
    • 0034056796 scopus 로고    scopus 로고
    • Expression of glutathione-dependent enzymes and cytochrome P450s in freshly isolated and primary cultures of proximal tubular cells from human kidney
    • Cummings B.S., Lasker J.M., and Lash L.H. Expression of glutathione-dependent enzymes and cytochrome P450s in freshly isolated and primary cultures of proximal tubular cells from human kidney. J. Pharmacol. Exp. Ther. 293 (2000) 677-685
    • (2000) J. Pharmacol. Exp. Ther. , vol.293 , pp. 677-685
    • Cummings, B.S.1    Lasker, J.M.2    Lash, L.H.3
  • 10
    • 0033958342 scopus 로고    scopus 로고
    • Role of cytochrome P450 and glutathione S-transferase α in metabolism and cytotoxicity of trichloroethylene in rat kidney
    • Cummings B.S., Parker J.C., and Lash L.H. Role of cytochrome P450 and glutathione S-transferase α in metabolism and cytotoxicity of trichloroethylene in rat kidney. Biochem. Pharmacol. 59 (2000) 531-543
    • (2000) Biochem. Pharmacol. , vol.59 , pp. 531-543
    • Cummings, B.S.1    Parker, J.C.2    Lash, L.H.3
  • 11
    • 0026346879 scopus 로고
    • Consideration of the target organ toxicity of trichloroethylene in terms of metabolite toxicity and pharmacokinetics
    • Davidson I.W., and Beliles R.P. Consideration of the target organ toxicity of trichloroethylene in terms of metabolite toxicity and pharmacokinetics. Drug Metab. Rev. 23 (1991) 493-599
    • (1991) Drug Metab. Rev. , vol.23 , pp. 493-599
    • Davidson, I.W.1    Beliles, R.P.2
  • 12
    • 0028335663 scopus 로고
    • Role of extracellular glutathione and γ-glutamyltranspeptidase in the disposition and kidney toxicity of inorganic mercury in rats
    • de Ceaurriz J., Payan J.P., Morel G., and Brondeau M.T. Role of extracellular glutathione and γ-glutamyltranspeptidase in the disposition and kidney toxicity of inorganic mercury in rats. J. Appl. Toxicol. 14 (1994) 201-206
    • (1994) J. Appl. Toxicol. , vol.14 , pp. 201-206
    • de Ceaurriz, J.1    Payan, J.P.2    Morel, G.3    Brondeau, M.T.4
  • 13
    • 0022492563 scopus 로고
    • Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity
    • Elfarra A.A., Jakobson I., and Anders M.W. Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity. Biochem. Pharmacol. 35 (1986) 283-288
    • (1986) Biochem. Pharmacol. , vol.35 , pp. 283-288
    • Elfarra, A.A.1    Jakobson, I.2    Anders, M.W.3
  • 14
    • 0027327828 scopus 로고
    • Effect of different renal glutathione levels on renal mercury disposition and excretion in the rat
    • Girardi G., and Elias M.M. Effect of different renal glutathione levels on renal mercury disposition and excretion in the rat. Toxicology 81 (1993) 57-67
    • (1993) Toxicology , vol.81 , pp. 57-67
    • Girardi, G.1    Elias, M.M.2
  • 15
    • 20844440373 scopus 로고    scopus 로고
    • Molecular mechanisms of enhanced renal cell division in protection against S-(1,2-dichlorovinyl)-l-cysteine-induced acute renal failure and death
    • Korrapati M.C., Lock E.A., and Mehendale H.M. Molecular mechanisms of enhanced renal cell division in protection against S-(1,2-dichlorovinyl)-l-cysteine-induced acute renal failure and death. Am. J. Physiol. 289 (2005) F175-F185
    • (2005) Am. J. Physiol. , vol.289
    • Korrapati, M.C.1    Lock, E.A.2    Mehendale, H.M.3
  • 16
    • 33746639614 scopus 로고    scopus 로고
    • Preplaced cell division: a critical mechanism of autoprotection against S-(1,2-dichlorovinyl)-l-cysteine-induced acute renal failure and death in mice
    • Korrapati M.C., Chilakapati J., Lock E.A., Latendresse J.R., Warbritton A., and Mehendale H.M. Preplaced cell division: a critical mechanism of autoprotection against S-(1,2-dichlorovinyl)-l-cysteine-induced acute renal failure and death in mice. Am. J. Physiol. 291 (2006) F439-F455
    • (2006) Am. J. Physiol. , vol.291
    • Korrapati, M.C.1    Chilakapati, J.2    Lock, E.A.3    Latendresse, J.R.4    Warbritton, A.5    Mehendale, H.M.6
  • 17
    • 0024455217 scopus 로고
    • Isolation of two distinct populations of cells from rat kidney cortex and their use in the study of chemical-induced toxicity
    • Lash L.H., and Tokarz J.J. Isolation of two distinct populations of cells from rat kidney cortex and their use in the study of chemical-induced toxicity. Anal. Biochem. 182 (1989) 271-279
    • (1989) Anal. Biochem. , vol.182 , pp. 271-279
    • Lash, L.H.1    Tokarz, J.J.2
  • 18
    • 0026695858 scopus 로고
    • Mercuric chloride-induced cytotoxicity and compensatory hypertrophy in rat kidney proximal tubular cells
    • Lash L.H., and Zalups R.K. Mercuric chloride-induced cytotoxicity and compensatory hypertrophy in rat kidney proximal tubular cells. J. Pharmacol. Exp. Ther. 261 (1992) 819-829
    • (1992) J. Pharmacol. Exp. Ther. , vol.261 , pp. 819-829
    • Lash, L.H.1    Zalups, R.K.2
  • 19
    • 0030358841 scopus 로고    scopus 로고
    • Alterations in renal cellular glutathione metabolism after in vivo administration of a subtoxic dose of mercuric chloride
    • Lash L.H., and Zalups R.K. Alterations in renal cellular glutathione metabolism after in vivo administration of a subtoxic dose of mercuric chloride. J. Biochem. Toxicol. 11 (1996) 1-9
    • (1996) J. Biochem. Toxicol. , vol.11 , pp. 1-9
    • Lash, L.H.1    Zalups, R.K.2
  • 20
    • 0029166099 scopus 로고
    • Glutathione-dependent metabolism of trichloroethylene in isolated liver and kidney cells of rats and its role in mitochondrial and cellular toxicity
    • Lash L.H., Xu Y., Elfarra A.A., Duescher R.J., and Parker J.C. Glutathione-dependent metabolism of trichloroethylene in isolated liver and kidney cells of rats and its role in mitochondrial and cellular toxicity. Drug Metab. Dispos. 23 (1995) 846-853
    • (1995) Drug Metab. Dispos. , vol.23 , pp. 846-853
    • Lash, L.H.1    Xu, Y.2    Elfarra, A.A.3    Duescher, R.J.4    Parker, J.C.5
  • 21
    • 0029416940 scopus 로고
    • Susceptibility of primary cultures of proximal tubular and distal tubular cells from rat kidney to chemically induced toxicity
    • Lash L.H., Tokarz J.J., and Pegouske D.M. Susceptibility of primary cultures of proximal tubular and distal tubular cells from rat kidney to chemically induced toxicity. Toxicology 103 (1995) 85-103
    • (1995) Toxicology , vol.103 , pp. 85-103
    • Lash, L.H.1    Tokarz, J.J.2    Pegouske, D.M.3
  • 22
    • 0031837835 scopus 로고    scopus 로고
    • Role of extracellular thiols in uptake and distribution of inorganic mercury in rat renal proximal and distal tubular cells
    • Lash L.H., Putt D.A., and Zalups R.K. Role of extracellular thiols in uptake and distribution of inorganic mercury in rat renal proximal and distal tubular cells. J. Pharmacol. Exp. Ther. 285 (1998) 1039-1050
    • (1998) J. Pharmacol. Exp. Ther. , vol.285 , pp. 1039-1050
    • Lash, L.H.1    Putt, D.A.2    Zalups, R.K.3
  • 23
    • 0031919247 scopus 로고    scopus 로고
    • Glutathione conjugation of trichloroethylene in rats and mice: sex-, species-, and tissue-dependent differences
    • Lash L.H., Qian W., Putt D.A., Jacobs K., Elfarra A.A., Krause R.J., and Parker J.C. Glutathione conjugation of trichloroethylene in rats and mice: sex-, species-, and tissue-dependent differences. Drug Metab. Dispos. 26 (1998) 12-19
    • (1998) Drug Metab. Dispos. , vol.26 , pp. 12-19
    • Lash, L.H.1    Qian, W.2    Putt, D.A.3    Jacobs, K.4    Elfarra, A.A.5    Krause, R.J.6    Parker, J.C.7
  • 24
    • 0032718791 scopus 로고    scopus 로고
    • Influence of exogenous thiols on inorganic mercury-induced injury in renal proximal and distal tubular cells from normal and uninephrectomized rats
    • Lash L.H., Putt D.A., and Zalups R.K. Influence of exogenous thiols on inorganic mercury-induced injury in renal proximal and distal tubular cells from normal and uninephrectomized rats. J. Pharmacol. Exp. Ther. 291 (1999) 492-502
    • (1999) J. Pharmacol. Exp. Ther. , vol.291 , pp. 492-502
    • Lash, L.H.1    Putt, D.A.2    Zalups, R.K.3
  • 25
    • 0033534408 scopus 로고    scopus 로고
    • Identification of S-(1,2-dichlorovinyl)glutathione in the blood of human volunteers exposed to trichloroethylene
    • Lash L.H., Putt D.A., Abbas R., Brashear W.T., Parker J.C., and Fisher J.W. Identification of S-(1,2-dichlorovinyl)glutathione in the blood of human volunteers exposed to trichloroethylene. J. Toxicol. Environ. Health 56 (1999) 1-21
    • (1999) J. Toxicol. Environ. Health , vol.56 , pp. 1-21
    • Lash, L.H.1    Putt, D.A.2    Abbas, R.3    Brashear, W.T.4    Parker, J.C.5    Fisher, J.W.6
  • 26
    • 0032963856 scopus 로고    scopus 로고
    • Glutathione conjugation of trichloroethylene in human liver and kidney: Kinetics and individual variation
    • Lash L.H., Lipscomb J.C., Putt D.A., and Parker J.C. Glutathione conjugation of trichloroethylene in human liver and kidney: Kinetics and individual variation. Drug Metab. Dispos. 27 (1999) 351-359
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 351-359
    • Lash, L.H.1    Lipscomb, J.C.2    Putt, D.A.3    Parker, J.C.4
  • 27
    • 0033945538 scopus 로고    scopus 로고
    • Modes of action of trichloroethylene for kidney tumorigenesis
    • Lash L.H., Parker J.C., and Scott C.S. Modes of action of trichloroethylene for kidney tumorigenesis. Environ. Health Perspect. 108 Suppl. 2 (2000) 225-240
    • (2000) Environ. Health Perspect. , vol.108 , Issue.SUPPL. 2 , pp. 225-240
    • Lash, L.H.1    Parker, J.C.2    Scott, C.S.3
  • 29
    • 0035079862 scopus 로고    scopus 로고
    • Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences
    • Lash L.H., Qian W., Putt D.A., Hueni S.E., Elfarra A.A., Krause R.J., and Parker J.C. Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences. J. Pharmacol. Exp. Ther. 297 (2001) 155-164
    • (2001) J. Pharmacol. Exp. Ther. , vol.297 , pp. 155-164
    • Lash, L.H.1    Qian, W.2    Putt, D.A.3    Hueni, S.E.4    Elfarra, A.A.5    Krause, R.J.6    Parker, J.C.7
  • 30
    • 0035891527 scopus 로고    scopus 로고
    • Apoptosis, necrosis and cell proliferation induced by S-(1,2-dichlorovinyl)-l-cysteine in primary cultures of human proximal tubular cells
    • Lash L.H., Hueni S.E., and Putt D.A. Apoptosis, necrosis and cell proliferation induced by S-(1,2-dichlorovinyl)-l-cysteine in primary cultures of human proximal tubular cells. Toxicol. Appl. Pharmacol. 177 (2001) 1-16
    • (2001) Toxicol. Appl. Pharmacol. , vol.177 , pp. 1-16
    • Lash, L.H.1    Hueni, S.E.2    Putt, D.A.3
  • 31
    • 20444459421 scopus 로고    scopus 로고
    • Molecular markers of trichloroethylene-induced toxicity in human kidney cells
    • Lash L.H., Putt D.A., Hueni S.E., and Horwitz B.P. Molecular markers of trichloroethylene-induced toxicity in human kidney cells. Toxicol. Appl. Pharmacol. 206 (2005) 157-168
    • (2005) Toxicol. Appl. Pharmacol. , vol.206 , pp. 157-168
    • Lash, L.H.1    Putt, D.A.2    Hueni, S.E.3    Horwitz, B.P.4
  • 32
    • 0027164227 scopus 로고
    • 2 formation and oxidative stress in vivo and in vitro in rat kidney mitochondria
    • 2 formation and oxidative stress in vivo and in vitro in rat kidney mitochondria. Biochem. Pharmacol. 45 (1993) 2017-2024
    • (1993) Biochem. Pharmacol. , vol.45 , pp. 2017-2024
    • Lund, B.-O.1    Miller, D.M.2    Woods, J.S.3
  • 33
    • 0027476076 scopus 로고
    • Dose-dependent induction or depression of cysteine conjugate (-lyase in rat kidney by N-acetyl-S-(1,2,3,4,4-pentachloro-1,3-butadienyl)-l-cysteine
    • MacFarlane M., Schofield M., Parker N., Roelandt L., David M., Lock E.A., King L.J., Goldfarb P.S., and Gibson G.G. Dose-dependent induction or depression of cysteine conjugate (-lyase in rat kidney by N-acetyl-S-(1,2,3,4,4-pentachloro-1,3-butadienyl)-l-cysteine. Toxicology 77 (1993) 133-144
    • (1993) Toxicology , vol.77 , pp. 133-144
    • MacFarlane, M.1    Schofield, M.2    Parker, N.3    Roelandt, L.4    David, M.5    Lock, E.A.6    King, L.J.7    Goldfarb, P.S.8    Gibson, G.G.9
  • 34
    • 0006989879 scopus 로고
    • Enzymatic isolation and serum-free culture of human renal cells
    • Jones G.E. (Ed), Humana Press, Inc., Totowa, NJ Chapter 32
    • Todd J.H., McMartin K.E., and Sens D.A. Enzymatic isolation and serum-free culture of human renal cells. In: Jones G.E. (Ed). Methods in Molecular Medicine: Human Cell Culture Protocols (1995), Humana Press, Inc., Totowa, NJ Chapter 32
    • (1995) Methods in Molecular Medicine: Human Cell Culture Protocols
    • Todd, J.H.1    McMartin, K.E.2    Sens, D.A.3
  • 35
    • 0037446429 scopus 로고    scopus 로고
    • Renal injury and repair following S-(1,2-dichlorovinyl)-l-cysteine administration to mice
    • Vaidya V.S., Shankar K., Lock E.A., Bucci T.J., and Mehendale H.M. Renal injury and repair following S-(1,2-dichlorovinyl)-l-cysteine administration to mice. Toxicol. Appl. Pharmacol. 188 (2003) 110-121
    • (2003) Toxicol. Appl. Pharmacol. , vol.188 , pp. 110-121
    • Vaidya, V.S.1    Shankar, K.2    Lock, E.A.3    Bucci, T.J.4    Mehendale, H.M.5
  • 36
    • 0038155371 scopus 로고    scopus 로고
    • Role of tissue repair in survival from S-(1,2-dichlorovinyl)-l-cysteine-induced acute renal tubular necrosis in the mouse
    • Vaidya V.S., Shankar K., Lock E.A., Bucci T.J., and Mehendale H.M. Role of tissue repair in survival from S-(1,2-dichlorovinyl)-l-cysteine-induced acute renal tubular necrosis in the mouse. Toxicol. Sci. 74 (2003) 215-227
    • (2003) Toxicol. Sci. , vol.74 , pp. 215-227
    • Vaidya, V.S.1    Shankar, K.2    Lock, E.A.3    Bucci, T.J.4    Mehendale, H.M.5
  • 37
    • 0242468781 scopus 로고    scopus 로고
    • Molecular mechanisms of renal tissue repair in survival from acute renal tubule necrosis: role of ERK1/2 pathway
    • Vaidya V.S., Shankar K., Lock E.A., Dixon D., and Mehendale H.M. Molecular mechanisms of renal tissue repair in survival from acute renal tubule necrosis: role of ERK1/2 pathway. Toxicol. Pathol. 31 (2003) 604-618
    • (2003) Toxicol. Pathol. , vol.31 , pp. 604-618
    • Vaidya, V.S.1    Shankar, K.2    Lock, E.A.3    Dixon, D.4    Mehendale, H.M.5
  • 38
    • 0028788285 scopus 로고
    • Up-regulation of glutathione synthesis in rat kidney by methyl mercury: relationship to mercury-induced oxidative stress
    • Woods J.S., and Ellis M.E. Up-regulation of glutathione synthesis in rat kidney by methyl mercury: relationship to mercury-induced oxidative stress. Biochem. Pharmacol. 50 (1995) 1719-1724
    • (1995) Biochem. Pharmacol. , vol.50 , pp. 1719-1724
    • Woods, J.S.1    Ellis, M.E.2
  • 39
    • 0026703404 scopus 로고
    • Enhancement of γ-glutamylcysteine synthetase mRNA in rat kidney by methyl mercury
    • Woods J.S., Davis H.A., and Baer R.P. Enhancement of γ-glutamylcysteine synthetase mRNA in rat kidney by methyl mercury. Arch. Biochem. Biophys. 296 (1992) 350-353
    • (1992) Arch. Biochem. Biophys. , vol.296 , pp. 350-353
    • Woods, J.S.1    Davis, H.A.2    Baer, R.P.3
  • 40
    • 0025770073 scopus 로고
    • Method for studying the in vivo accumulation of inorganic mercury in segments of the nephron in the kidneys of rats treated with mercuric chloride
    • Zalups R.K. Method for studying the in vivo accumulation of inorganic mercury in segments of the nephron in the kidneys of rats treated with mercuric chloride. J. Pharmacol. Methods 26 (1991) 89-104
    • (1991) J. Pharmacol. Methods , vol.26 , pp. 89-104
    • Zalups, R.K.1
  • 41
    • 0026026695 scopus 로고
    • Autometallographic localization of inorganic mercury in the kidneys of rats: effect of unilateral nephrectomy and compensatory renal growth
    • Zalups R.K. Autometallographic localization of inorganic mercury in the kidneys of rats: effect of unilateral nephrectomy and compensatory renal growth. Exp. Mol. Pathol. 54 (1991) 10-21
    • (1991) Exp. Mol. Pathol. , vol.54 , pp. 10-21
    • Zalups, R.K.1
  • 42
    • 0027310179 scopus 로고
    • Early aspects of the intrarenal distribution of mercury after the intravenous administration of mercuric chloride
    • Zalups R.K. Early aspects of the intrarenal distribution of mercury after the intravenous administration of mercuric chloride. Toxicology 79 (1993) 215-228
    • (1993) Toxicology , vol.79 , pp. 215-228
    • Zalups, R.K.1
  • 43
    • 0025034266 scopus 로고
    • Effects of uninephrectomy and mercuric chloride on renal glutathione homeostasis
    • Zalups R.K., and Lash L.H. Effects of uninephrectomy and mercuric chloride on renal glutathione homeostasis. J. Pharmacol. Exp. Ther. 254 (1990) 962-970
    • (1990) J. Pharmacol. Exp. Ther. , vol.254 , pp. 962-970
    • Zalups, R.K.1    Lash, L.H.2
  • 44
    • 84954974005 scopus 로고
    • Recent advances in understanding the renal transport and toxicity of mercury
    • Zalups R.K., and Lash L.H. Recent advances in understanding the renal transport and toxicity of mercury. J. Toxicol. Environ. Health 42 (1994) 1-44
    • (1994) J. Toxicol. Environ. Health , vol.42 , pp. 1-44
    • Zalups, R.K.1    Lash, L.H.2
  • 45
    • 0030963110 scopus 로고    scopus 로고
    • Depletion of glutathione in the kidney and the renal disposition of administered inorganic mercury
    • Zalups R.K., and Lash L.H. Depletion of glutathione in the kidney and the renal disposition of administered inorganic mercury. Drug Metab. Dispos. 25 (1997) 516-523
    • (1997) Drug Metab. Dispos. , vol.25 , pp. 516-523
    • Zalups, R.K.1    Lash, L.H.2


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