Pyrrolidine dithiocarbamate-zinc(II) and -copper(II) complexes induce apoptosis in tumor cells by inhibiting the proteasomal activity

Toxicology and Applied Pharmacology

Volumn 231, Issue 1, 2008, Pages 24-33

  Milacic, Vesna ^a   Chen, Di ^a   Giovagnini, Lorena ^b   Diez, Alejandro ^c   Fregona, Dolores ^b   Dou, Q Ping ^a  

^a KARMANOS CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PADOVA   (Italy)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Calpain; Copper; Proteasome inhibitor; Pyrrolidine dithiocarbamate; Zinc

Indexed keywords

CALPAIN; CASPASE 3; COPPER COMPLEX; PROTEASOME; PYRROLIDINE DITHIOCARBAMATE; PYRROLIDINE DITHIOCARBAMATE COPPER COMPLEX; PYRROLIDINE DITHIOCARBAMATE ZINC COMPLEX; ZINC COMPLEX;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PROSTATE CANCER;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CALCIUM-BINDING PROTEINS; CALPAIN; CASPASE 3; CELL LINE, TUMOR; CHYMOTRYPSIN; COPPER; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; IN SITU NICK-END LABELING; KINETICS; PROTEASOME ENDOPEPTIDASE COMPLEX; PYRROLIDINES; RABBITS; TETRAZOLIUM SALTS; THIAZOLES; THIOCARBAMATES; TIME FACTORS; ZINC;

EID: 48649110541     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.03.009     Document Type: Article

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