Anti-angiogenic actions of pyrrolidine dithiocarbamate, a nuclear factor kappa B inhibitor

Angiogenesis

Volumn 12, Issue 4, 2009, Pages 365-379

  Morais, Christudas ^a,b   Gobe, Glenda ^b   Johnson, David W ^b   Healy, Helen ^a  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Angiogenesis; Interleukin 8; Monocyte chemoattractant protein 1; Nuclear factor kappa B; Protein microarray; Pyrrolidine dithiocarbamate; Renal cell carcinoma; Vascular endothelial growth factor

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; EPIDERMAL GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; PYRROLIDINE DITHIOCARBAMATE; RANTES; VASCULOTROPIN;

ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; AORTA; ARTICLE; CANCER CELL CULTURE; CELL ADHESION; CONTROLLED STUDY; ENDOTHELIUM CELL; EX VIVO STUDY; FEMALE; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MICROARRAY; RAT; TUMOR VASCULARIZATION;

AMINO ACID SEQUENCE; ANGIOGENESIS INHIBITORS; ANIMALS; AORTA; APOPTOSIS; CARCINOMA, RENAL CELL; CELL DIVISION; CELL LINE, TUMOR; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; ENDOTHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KIDNEY NEOPLASMS; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; NF-KAPPA B; ORGAN CULTURE TECHNIQUES; PEPTIDES; PROLINE; RATS; RATS, SPRAGUE-DAWLEY; THIOCARBAMATES; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 71249149845     PISSN: 09696970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10456-009-9158-0     Document Type: Article

References (71)

1. RH Weiss PY Lin 2006 Kidney cancer: identification of novel targets for therapy Kidney Int 69 224 232 10.1038/sj.ki.5000065 1:CAS:528: DC%2BD28XksVKqtg%3D%3D 16408110 (Pubitemid 43323071)
2. F Bussolino A Mantovani G Persico 1997 Molecular mechanisms of blood vessel formation Trends Biochem Sci 22 251 256 10.1016/S0968-0004(97)01074-8 1:CAS:528:DyaK2sXks1yksL8%3D 9255066 (Pubitemid 27310945)
3. JK Min KY Han EC Kim YM Kim SW Lee OH Kim KW Kim YS Gho YG Kwon 2004 Capsaicin inhibits in vitro and in vivo angiogenesis Cancer Res 64 644 651 10.1158/0008-5472.CAN-03-3250 1:CAS:528:DC%2BD2cXmsVahsg%3D%3D 14744780 (Pubitemid 38120905)
4. JW Slaton K Inoue P Perrotte AK El-Naggar DA Swanson IJ Fidler CP Dinney 2001 Expression levels of genes that regulate metastasis and angiogenesis correlate with advanced pathological stage of renal cell carcinoma Am J Pathol 158 735 743 1:STN:280:DC%2BD3M7psVCisg%3D%3D 11159211
5. A Takahashi H Sasaki SJ Kim K Tobisu T Kakizoe T Tsukamoto Y Kumamoto T Sugimura M Terada 1994 Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis Cancer Res 54 4233 4237 1:CAS:528: DyaK2cXltVGmt7w%3D 7518352
6. N Rioux-Leclercq P Fergelot S Zerrouki E Leray F Jouan P Bellaud JI Epstein JJ Patard 2007 Plasma level and tissue expression of vascular endothelial growth factor in renal cell carcinoma: a prospective study of 50 cases Hum Pathol 38 1489 1495 10.1016/j.humpath.2007.02.014 1:CAS:528: DC%2BD2sXhtVOgu77N 17597181 (Pubitemid 47418959)
7. MM Baldewijns VL Thijssen GG Van den Eynden SJ Van Laere AM Bluekens T Roskams H van Poppel AP De Bruine AW Griffioen PB Vermeulen 2007 High-grade clear cell renal cell carcinoma has a higher angiogenic activity than low-grade renal cell carcinoma based on histomorphological quantification and qRT-PCR mRNA expression profile Br J Cancer 96 1888 1895 10.1038/sj.bjc.6603796 1:CAS:528:DC%2BD2sXmtlyqtb0%3D 17505508 (Pubitemid 46912016)
8. S Fukata K Inoue M Kamada C Kawada M Furihata Y Ohtsuki T Shuin 2005 Levels of angiogenesis and expression of angiogenesis-related genes are prognostic for organ-specific metastasis of renal cell carcinoma Cancer 103 931 942 10.1002/cncr.20887 1:CAS:528:DC%2BD2MXisVensrs%3D 15685621 (Pubitemid 40270069)
9. E Cenni F Perut D Granchi S Avnet I Amato ML Brandi A Giunti N Baldini 2007 Inhibition of angiogenesis via FGF-2 blockage in primitive and bone metastatic renal cell carcinoma Anticancer Res 27 315 319 1:CAS:528: DC%2BD2sXjs1Wnsb0%3D 17352248
10. L Xu R Tong DM Cochran RK Jain 2005 Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model Cancer Res 65 5711 5719 10.1158/0008-5472.CAN-04-4313 1:CAS:528:DC%2BD2MXlslOqsLY%3D 15994946 (Pubitemid 40911174)
11. D Kedar CH Baker JJ Killion CP Dinney IJ Fidler 2002 Blockade of the epidermal growth factor receptor signaling inhibits angiogenesis leading to regression of human renal cell carcinoma growing orthotopically in nude mice Clin Cancer Res 8 3592 3600 1:CAS:528:DC%2BD38XpsVCgtbg%3D 12429651
12. LS Angelo M Talpaz R Kurzrock 2002 Autocrine interleukin-6 production in renal cell carcinoma: evidence for the involvement of p53 Cancer Res 62 932 940 1:CAS:528:DC%2BD38Xht1Kqs74%3D 11830554
13. B Konig F Steinbach B Janocha A Drynda M Stumm C Philipp EP Allhoff W Konig 1999 The differential expression of proinflammatory cytokines IL-6, IL-8 and TNF-alpha in renal cell carcinoma Anticancer Res 19 1519 1524 1:CAS:528:DyaK1MXjvFKjs7Y%3D 10365136
14. A Horiguchi M Sumitomo J Asakuma T Asano R Zheng T Asano DM Nanus M Hayakawa 2006 Leptin promotes invasiveness of murine renal cancer cells via extracellular signal-regulated kinases and rho dependent pathway J Urol 176 1636 1641 10.1016/j.juro.2006.06.040 1:CAS:528:DC%2BD28XhtVCht7fI 16952706 (Pubitemid 44316854)
15. M Oya M Ohtsubo A Takayanagi M Tachibana N Shimizu M Murai 2001 Constitutive activation of nuclear factor-kappaB prevents TRAIL-induced apoptosis in renal cancer cells Oncogene 20 3888 3896 10.1038/sj.onc.1204525 1:CAS:528:DC%2BD3MXlt1KrsLY%3D 11439352 (Pubitemid 32646199)
16. M Oya A Takayanagi A Horiguchi R Mizuno M Ohtsubo K Marumo N Shimizu M Murai 2003 Increased nuclear factor-kappa B activation is related to the tumor development of renal cell carcinoma Carcinogenesis 24 377 3784 10.1093/carcin/24.3.377 1:CAS:528:DC%2BD3sXjslagsL8%3D 12663495 (Pubitemid 36432631)
17. MS Hayden S Ghosh 2004 Signaling to NF-kappaB Genes Dev 18 2195 2224 10.1101/gad.1228704 1:CAS:528:DC%2BD2cXnslCntbY%3D 15371334 (Pubitemid 39209568)
18. S Huang CA Pettaway H Uehara CD Bucana IJ Fidler 2001 Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis Oncogene 20 4188 4197 10.1038/sj.onc.1204535 1:CAS:528:DC%2BD3MXls1WltbY%3D 11464285 (Pubitemid 32762193)
19. S Huang JB Robinson A Deguzman CD Bucana IJ Fidler 2000 Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8 Cancer Res 60 5334 5339 1:CAS:528: DC%2BD3cXns1ehsL8%3D 11034066
20. N Mukaida S Okamoto Y Ishikawa K Matsushima 1994 Molecular mechanism of interleukin-8 gene expression J Leukoc Biol 56 554 558 1:CAS:528: DyaK2cXmvFymtb0%3D 7525815
21. G Djordjevic K Matusan-Ilijas E Sinozic G Damante D Fabbro B Grahovac K Lucin N Jonjic 2008 Relationship between vascular endothelial growth factor and nuclear factor-kappaB in renal cell tumors Croat Med J 49 608 617 10.3325/cmj.2008.5.608 18925694
22. I Meteoglu IH Erdogdu N Meydan M Erkus S Barutca 2008 NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues J Exp Clin Cancer Res 27 53 10.1186/1756-9966-27-53 18928570
23. AM Roccaro T Hideshima N Raje S Kumar K Ishitsuka H Yasui N Shiraishi D Ribatti B Nico A Vacca F Dammacco PG Richardson KC Anderson 2006 Bortezomib mediates antiangiogenesis in multiple myeloma via direct and indirect effects on endothelial cells Cancer Res 66 184 191 10.1158/0008-5472.CAN-05-1195 1:CAS:528:DC%2BD28XhsFWhtw%3D%3D 16397231 (Pubitemid 43166024)
24. L Levine JA Lucci III B Pazdrak JZ Cheng YS Guo CM Townsend Jr MR Hellmich 2003 Bombesin stimulates nuclear factor kappa B activation and expression of proangiogenic factors in prostate cancer cells Cancer Res 63 3495 3502 1:CAS:528:DC%2BD3sXltVGrtLc%3D 12839933
25. SP Tabruyn AW Griffioen 2008 NF-kappa B: a new player in angiostatic therapy Angiogenesis 11 101 106 10.1007/s10456-008-9094-4 1:CAS:528: DC%2BD1cXjsFWksbk%3D 18283548
26. SP Tabruyn C Sabatel NQ Nguyen C Verhaeghe K Castermans L Malvaux AW Griffioen JA Martial I Struman 2007 The angiostatic 16K human prolactin overcomes endothelial cell anergy and promotes leukocyte infiltration via nuclear factor-kappaB activation Mol Endocrinol 21 1422 1429 10.1210/me.2007-0021 1:CAS:528:DC%2BD2sXmtlKltLo%3D 17405903 (Pubitemid 46984747)
27. R Schreck B Meier DN Mannel W Droge PA Baeuerle 1992 Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells J Exp Med 175 1181 1194 10.1084/jem.175.5.1181 1:CAS:528:DyaK38XhvVyjsb8%3D 1314883
28. JS Woods ME Ellis FJ Dieguez-Acuna J Corral 1999 Activation of NF-kappaB in normal rat kidney epithelial (NRK52E) cells is mediated via a redox-insensitive, calcium-dependent pathway Toxicol Appl Pharmacol 154 219 227 10.1006/taap.1998.8583 1:CAS:528:DyaK1MXhtlOksbk%3D 9931281 (Pubitemid 29085233)
29. KG Daniel D Chen S Orlu QC Cui FR Miller QP Dou 2005 Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells Breast Cancer Res 7 R897 R908 10.1186/bcr1322 1:CAS:528:DC%2BD2MXht1WmsrvJ 16280039
30. R Chinery JA Brockman MO Peeler Y Shyr RD Beauchamp RJ Coffey 1997 Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: a p53-independent induction of p21WAF1/CIP1 via C/EBPbeta Nat Med 3 1233 1241 10.1038/nm1197-1233 1:CAS:528:DyaK2sXntFanu7s%3D 9359698
31. Q Li YY Yu ZG Zhu YB Ji Y Zhang BY Liu XH Chen YZ Lin 2005 Effect of NF-kappaB constitutive activation on proliferation and apoptosis of gastric cancer cell lines Eur Surg Res 37 105 110 10.1159/000084541 1:CAS:528: DC%2BD2MXktlKktbs%3D 15905616 (Pubitemid 40864173)
32. L Malaguarnera MR Pilastro R DiMarco C Scifo M Renis MC Mazzarino A Messina 2003 Cell death in human acute myelogenous leukemic cells induced by pyrrolidinedithiocarbamate Apoptosis 8 539 545 10.1023/A:1025550726803 1:CAS:528:DC%2BD3sXmvVOmurc%3D 14601560 (Pubitemid 37247996)
33. J Lee I Duk Jung C Gyo Park JW Han H Young Lee 2006 Autotaxin stimulates urokinase-type plasminogen activator expression through phosphoinositide 3-kinase-Akt-nuclear [corrected] factor kappa B signaling cascade in human melanoma cells Melanoma Res 16 445 452 10.1097/01.cmr.0000232293.14408.a4 1:CAS:528:DC%2BD28XhtVWntr7L 17013094 (Pubitemid 44511225)
34. GH Liu SR Wang B Wang BH Kong 2006 Inhibition of nuclear factor-kappaB by an antioxidant enhances paclitaxel sensitivity in ovarian carcinoma cell line Int J Gynecol Cancer 16 1777 1782 10.1111/j.1525-1438.2006.00652.x 1:STN:280:DC%2BD28nhvVSiug%3D%3D 17009971 (Pubitemid 44470035)
35. M Donadelli E Dalla Pozza C Costanzo MT Scupoli P Piacentini A Scarpa M Palmieri 2006 Increased stability of P21(WAF1/CIP1) mRNA is required for ROS/ERK-dependent pancreatic adenocarcinoma cell growth inhibition by pyrrolidine dithiocarbamate Biochim Biophys Acta 1763 917 926 10.1016/j.bbamcr.2006.05.015 1:CAS:528:DC%2BD28XptlyrtL0%3D 16904205 (Pubitemid 44332597)
36. D Chen F Peng QC Cui KG Daniel S Orlu J Liu QP Dou 2005 Inhibition of prostate cancer cellular proteasome activity by a pyrrolidine dithiocarbamate-copper complex is associated with suppression of proliferation and induction of apoptosis Front Biosci 10 2932 2939 10.2741/1749 1:CAS:528:DC%2BD2MXntFGitr0%3D 15970547
37. YJ Nai ZW Jiang ZM Wang N Li JS Li 2007 Prevention of cancer cachexia by pyrrolidine dithiocarbamate (PDTC) in colon 26 tumor-bearing mice JPEN J Parenter Enteral Nutr 31 18 25 10.1177/014860710703100118 1:CAS:528: DC%2BD2sXhtVCrs78%3D 17202436
38. SP Bach R Chinery ST O'Dwyer CS Potten RJ Coffey AJ Watson 2000 Pyrrolidinedithiocarbamate increases the therapeutic index of 5-fluorouracil in a mouse model Gastroenterology 118 81 89 10.1016/S0016-5085(00)70416-1 1:CAS:528:DC%2BD3cXlt1Omuw%3D%3D 10611156
39. C Morais B Pat G Gobe DW Johnson H Healy 2006 Pyrrolidine dithiocarbamate exerts anti-proliferative and pro-apoptotic effects in renal cell carcinoma cell lines Nephrol Dial Transplant 21 3377 3388 10.1093/ndt/gfl543 1:CAS:528:DC%2BD2sXivFClug%3D%3D 16998220 (Pubitemid 44817085)
40. H Sasaki L Zhu S Fukuda N Maulik 2000 Inhibition of NF kappa B activation by pyrrolidine dithiocarbamate prevents in vivo hypoxia/reoxygenation-mediated myocardial angiogenesis Int J Tissue React 22 93 100 1:STN:280: DC%2BD3M7lsVWgsA%3D%3D 11199341
41. A Yoshida S Yoshida T Ishibashi M Kuwano H Inomata 1999 Suppression of retinal neovascularization by the NF-kappaB inhibitor pyrrolidine dithiocarbamate in mice Invest Ophthalmol Vis Sci 40 1624 1629 1:STN:280:DyaK1M3osFyrsA%3D%3D 10359349
42. Gu JW, Young E, Busby B, Covington J, Tan W, Johnson JW (2009) Oral administration of pyrrolidine dithiocarbamate (PDTC) inhibits VEGF expression, tumor angiogenesis and growth of breast cancer in female mice. Cancer Biol Ther 8:514-521 (Epub ahead of print)
43. I Vucenik A Passaniti MI Vitolo K Tantivejkul P Eggleton AM Shamsuddin 2004 Anti-angiogenic activity of inositol hexaphosphate (IP6) Carcinogenesis 25 2115 2123 10.1093/carcin/bgh232 1:CAS:528:DC%2BD2cXhtVWgs7zJ 15297368 (Pubitemid 39534848)
44. EM Boyle Jr JC Kovacich TG Canty Jr EN Morgan E Chi ED Verrier TH Pohlman 1998 Inhibition of nuclear factor-kappa B nuclear localization reduces human E-selectin expression and the systemic inflammatory response Circulation 98 II282 II288 9852915
45. L Huang L Verstrepen K Heyninck A Wullaert H Revets P De Baetselier R Beyaert 2008 ABINs inhibit EGF receptor-mediated NF-kappaB activation and growth of EGF receptor-overexpressing tumour cells Oncogene 27 6131 6140 10.1038/onc.2008.208 1:CAS:528:DC%2BD1cXht1Cms7vP 18622428
46. G Sethi KS Ahn MM Chaturvedi BB Aggarwal 2007 Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha Oncogene 26 7324 7332 10.1038/sj.onc.1210544 1:CAS:528:DC%2BD2sXhtlWjtrzO 17533369 (Pubitemid 350115978)
47. H Zhang G Ma M Dong M Zhao X Shen Z Ma K Guo 2006 Epidermal growth factor promotes invasiveness of pancreatic cancer cells through NF-kappaB-mediated proteinase productions Pancreas 32 101 109 10.1097/01.mpa.0000191644.94301.be 1:CAS:528:DC%2BD28Xpt1yjuw%3D%3D 16340751
48. JH Distler C Hagen A Hirth U Muller-Ladner HM Lorenz A del Rosso BA Michel RE Gay R Nanagara K Nishioka M Matucci-Cerinic JR Kalden S Gay O Distler 2004 Bucillamine induces the synthesis of vascular endothelial growth factor dose-dependently in systemic sclerosis fibroblasts via nuclear factor-kappaB and simian virus 40 promoter factor 1 pathways Mol Pharmacol 65 389 399 10.1124/mol.65.2.389 1:CAS:528:DC%2BD2cXitFaks7o%3D 14742681 (Pubitemid 38134267)
49. CY Wu CJ Wang CC Tseng HP Chen MS Wu JT Lin H Inoue GH Chen 2005 Helicobacter pylori promote gastric cancer cells invasion through a NF-kappaB and COX-2-mediated pathway World J Gastroenterol 11 3197 3203 1:CAS:528:DC%2BD2MXmsFOgtb4%3D 15929167
50. M Hellmuth C Wetzler M Nold JH Chang S Frank J Pfeilschifter H Muhl 2002 Expression of interleukin-8, heme oxygenase-1 and vascular endothelial growth factor in DLD-1 colon carcinoma cells exposed to pyrrolidine dithiocarbamate Carcinogenesis 23 1273 1279 10.1093/carcin/23.8.1273 1:CAS:528: DC%2BD38Xms1KnsL8%3D 12151344
51. X Zhang M Yamashita H Uetsuki Y Kakehi 2002 Angiogenesis in renal cell carcinoma: evaluation of microvessel density, vascular endothelial growth factor and matrix metalloproteinases Int J Urol 9 509 514 10.1046/j.1442-2042.2002. 00511.x 1:CAS:528:DC%2BD3sXjtVKrsg%3D%3D 12410931 (Pubitemid 35365569)
52. M Eto S Naito 2006 Molecular targeting therapy for renal cell carcinoma Int J Clin Oncol 11 209 213 10.1007/s10147-006-0577-2 1:CAS:528: DC%2BD28XntVGju7Y%3D 16850127 (Pubitemid 44087119)
53. TE Hutson G Sonpavde MD Galsky 2006 Targeting growth factor and antiangiogenic pathways in clear-cell renal cell carcinoma: rationale and ongoing trials Clin Genitourin Cancer 5 Suppl 1 S31 S39 10.3816/CGC.2006.s.005 17239282
54. M Edgren B Lennernas A Larsson KM Kalkner 2001 Angiogenic factors: vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b-FGF) are not necessarily elevated in patients with advanced renal cell carcinoma Anticancer Res 21 1423 1429 1:STN:280:DC%2BD3MzivVymtg%3D%3D 11396226
55. WD Beecken W Bentas W Glienke J Linneweber D Jonas J Binder W Kramer 2002 Serum angiogenic activity: diagnostic relevance in renal cell carcinoma Eur Urol 42 364 369 10.1016/S0302-2838(02)00359-7 12361902 (Pubitemid 35175798)
56. N Ilan S Mahooti JA Madri 1998 Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis J Cell Sci 111 Pt 24 3621 3631 1:CAS:528:DyaK1MXmtlKnsg%3D%3D 9819353
57. MH Li ZH Miao WF Tan JM Yue C Zhang LP Lin XW Zhang J Ding 2004 Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation Clin Cancer Res 10 8266 8274 10.1158/1078-0432.CCR-04-0951 1:CAS:528:DC%2BD2cXhtFGjsrbK 15623602 (Pubitemid 40053386)
58. T Shinojima M Oya A Takayanagi R Mizuno N Shimizu M Murai 2007 Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha Carcinogenesis 28 529 536 10.1093/carcin/bgl143 1:CAS:528:DC%2BD2sXjslOgu7k%3D 16920734 (Pubitemid 46523348)
59. A Yoshida S Yoshida AK Khalil T Ishibashi H Inomata 1998 Role of NF-kappaB-mediated interleukin-8 expression in intraocular neovascularization Invest Ophthalmol Vis Sci 39 1097 1106 1:STN:280:DyaK1c3otFekug%3D%3D 9620068
60. C Munoz D Pascual-Salcedo MC Castellanos A Alfranca J Aragones A Vara JM Redondo MO de Landazuri 1996 Pyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF-kappa B and AP-1 transcription factors activity Blood 88 3482 3490 1:CAS:528:DyaK28XmsFKrtr0%3D 8896414
61. VG Keshamouni DA Arenberg RC Reddy MJ Newstead S Anthwal TJ Standiford 2005 PPAR-gamma activation inhibits angiogenesis by blocking ELR + CXC chemokine production in non-small cell lung cancer Neoplasia 7 294 301 10.1593/neo.04601 1:CAS:528:DC%2BD2MXjs1KrsL8%3D 15799829 (Pubitemid 40411641)
62. CH Yang IM Fang CP Lin CM Yang MS Chen 2005 Effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate on experimentally induced autoimmune anterior uveitis Invest Ophthalmol Vis Sci 46 1339 1347 10.1167/iovs.04-0640 15790900 (Pubitemid 41685874)
63. T Kuroda Y Kitadai S Tanaka X Yang N Mukaida M Yoshihara K Chayama 2005 Monocyte chemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment Clin Cancer Res 11 7629 7636 10.1158/1078-0432.CCR-05-0798 1:CAS:528: DC%2BD2MXhtF2is7bE 16278381 (Pubitemid 41611603)
64. H Nokihara Y Nishioka S Yano N Mukaida K Matsushima T Tsuruo S Sone 1999 Monocyte chemoattractant protein-1 gene modification of multidrug-resistant human lung cancer enhances antimetastatic effect of therapy with anti-P-glycoprotein antibody in SCID mice Int J Cancer 80 773 780 10.1002/(SICI)1097-0215(19990301)80:5<773::AID-IJC23>3.0.CO;2-E 1:CAS:528:DyaK1MXhtlSgtrg%3D 10048981 (Pubitemid 29066292)
65. DR Smith PJ Polverini SL Kunkel MB Orringer RI Whyte MD Burdick CA Wilke RM Strieter 1994 Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma J Exp Med 179 1409 1415 10.1084/jem.179.5.1409 1:CAS:528:DyaK2cXisVahtLg%3D 7513008
66. LF Lee RP Hellendall Y Wang JS Haskill N Mukaida K Matsushima JP Ting 2000 IL-8 reduced tumorigenicity of human ovarian cancer in vivo due to neutrophil infiltration J Immunol 164 2769 2775 1:CAS:528:DC%2BD3cXhsVKhtbs%3D 10679119
67. SC Tang JC Leung LY Chan AW Tsang KN Lai 2006 Activation of tubular epithelial cells in diabetic nephropathy and the role of the peroxisome proliferator-activated receptor-gamma agonist J Am Soc Nephrol 17 1633 1643 10.1681/ASN.2005101113 1:CAS:528:DC%2BD28XlvVemu74%3D 16687627 (Pubitemid 43794666)
68. LF Lee CC Schuerer-Maly AK Lofquist C van Haaften-Day JP Ting CM White BK Martin JS Haskill 1996 Taxol-dependent transcriptional activation of IL-8 expression in a subset of human ovarian cancer Cancer Res 56 1303 1308 1:CAS:528:DyaK28XhsFGntrs%3D 8640818
69. K Hirose M Hakozaki Y Nyunoya Y Kobayashi K Matsushita T Takenouchi A Mikata N Mukaida K Matsushima 1995 Chemokine gene transfection into tumour cells reduced tumorigenicity in nude mice in association with neutrophilic infiltration Br J Cancer 72 708 714 1:CAS:528:DyaK2MXotV2ktbs%3D 7669585
70. TS Collins LF Lee JP Ting 2000 Paclitaxel up-regulates interleukin-8 synthesis in human lung carcinoma through an NF-kappaB- and AP-1-dependent mechanism Cancer Immunol Immunother 49 78 84 10.1007/s002620050605 1:CAS:528:DC%2BD3cXktVyjtrw%3D 10823417 (Pubitemid 30431643)
71. A Gerber A Heimburg A Reisenauer A Wille T Welte F Buhling 2004 Proteasome inhibitors modulate chemokine production in lung epithelial and monocytic cells Eur Respir J 24 40 48 10.1183/09031936.04.00079203 1:CAS:528:DC%2BD2cXmsVanurg%3D 15293603 (Pubitemid 39029067)