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Volumn 33, Issue 3, 2012, Pages 459-471

Biomarkers in Asthma. A Real Hope to Better Manage Asthma

Author keywords

Asthma; Asthma management; Biomarkers

Indexed keywords

3 BROMOTYROSINE; ARGINASE; ARGININE; BIOLOGICAL MARKER; LEUKOTRIENE E4; LIPOXIN; METHYLARGININE DERIVATIVE; NITRIC OXIDE; S NITROSOGLUTATHIONE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RUNX2; TYROSINE; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 84865545734     PISSN: 02725231     EISSN: 15578216     Source Type: Journal    
DOI: 10.1016/j.ccm.2012.06.007     Document Type: Review
Times cited : (19)

References (139)
  • 1
    • 33746835022 scopus 로고    scopus 로고
    • Assessment of asthma severity and asthma control in children
    • Yawn B.P., Brenneman S.K., Allen-Ramey F.C., et al. Assessment of asthma severity and asthma control in children. Pediatrics 2006, 118:322-329.
    • (2006) Pediatrics , vol.118 , pp. 322-329
    • Yawn, B.P.1    Brenneman, S.K.2    Allen-Ramey, F.C.3
  • 2
    • 84865530993 scopus 로고    scopus 로고
    • National Heart Lung and Blood Institute. Expert panel report 3: guidelines for the diagnosis and management of asthma full report. Available at: Accessed July 2, 2012.
    • National Heart Lung and Blood Institute. Expert panel report 3: guidelines for the diagnosis and management of asthma full report. Available at: Accessed July 2, 2012. http://www.nhlbi.nih.gov/guidelines/asthma/asthgdln.pdf.
  • 3
    • 33845543076 scopus 로고    scopus 로고
    • The mouse trap: it still yields few answers in asthma
    • [discussion: 6-8]
    • Wenzel S., Holgate S.T. The mouse trap: it still yields few answers in asthma. Am J Respir Crit Care Med 2006, 174:1173-1176. [discussion: 6-8].
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 1173-1176
    • Wenzel, S.1    Holgate, S.T.2
  • 4
    • 2342590065 scopus 로고    scopus 로고
    • The global burden of asthma: executive summary of the GINA dissemination Committee report
    • Masoli M., Fabian D., Holt S., et al. The global burden of asthma: executive summary of the GINA dissemination Committee report. Allergy 2004, 59:469-478.
    • (2004) Allergy , vol.59 , pp. 469-478
    • Masoli, M.1    Fabian, D.2    Holt, S.3
  • 6
    • 33845987340 scopus 로고    scopus 로고
    • Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
    • Moore W.C., Bleecker E.R., Curran-Everett D., et al. Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol 2007, 119:405-413.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 405-413
    • Moore, W.C.1    Bleecker, E.R.2    Curran-Everett, D.3
  • 7
    • 15744397579 scopus 로고    scopus 로고
    • Do NHLBI lung function criteria apply to children? A cross-sectional evaluation of childhood asthma at National Jewish Medical and Research Center, 1999-2002
    • Paull K., Covar R., Jain N., et al. Do NHLBI lung function criteria apply to children? A cross-sectional evaluation of childhood asthma at National Jewish Medical and Research Center, 1999-2002. Pediatr Pulmonol 2005, 39:311-317.
    • (2005) Pediatr Pulmonol , vol.39 , pp. 311-317
    • Paull, K.1    Covar, R.2    Jain, N.3
  • 8
    • 33645306845 scopus 로고    scopus 로고
    • ATS Workshop Proceedings: exhaled nitric oxide and nitric oxide oxidative metabolism in exhaled breath condensate: executive summary
    • ATS Workshop Proceedings: exhaled nitric oxide and nitric oxide oxidative metabolism in exhaled breath condensate: executive summary. Am J Respir Crit Care Med 2006, 173:811-813.
    • (2006) Am J Respir Crit Care Med , vol.173 , pp. 811-813
  • 9
    • 33747756534 scopus 로고    scopus 로고
    • Asthma: defining of the persistent adult phenotypes
    • Wenzel S.E. Asthma: defining of the persistent adult phenotypes. Lancet 2006, 368:804-813.
    • (2006) Lancet , vol.368 , pp. 804-813
    • Wenzel, S.E.1
  • 10
    • 80054887543 scopus 로고    scopus 로고
    • The biochemistry of asthma
    • Gaston B. The biochemistry of asthma. Biochim Biophys Acta 2011, 1810:1017-1024.
    • (2011) Biochim Biophys Acta , vol.1810 , pp. 1017-1024
    • Gaston, B.1
  • 11
    • 52049087356 scopus 로고    scopus 로고
    • Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease
    • Anderson G.P. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet 2008, 372:1107-1119.
    • (2008) Lancet , vol.372 , pp. 1107-1119
    • Anderson, G.P.1
  • 12
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Leckie M.J., ten Brinke A., Khan J., et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000, 356:2144-2148.
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1    ten Brinke, A.2    Khan, J.3
  • 13
    • 52049089924 scopus 로고    scopus 로고
    • Inflammometry to assess airway diseases
    • Pavord I.D., Shaw D.E., Gibson P.G., et al. Inflammometry to assess airway diseases. Lancet 2008, 372:1017-1019.
    • (2008) Lancet , vol.372 , pp. 1017-1019
    • Pavord, I.D.1    Shaw, D.E.2    Gibson, P.G.3
  • 14
    • 20444505130 scopus 로고    scopus 로고
    • Genome screen for asthma and bronchial hyperresponsiveness: interactions with passive smoke exposure
    • Meyers D.A., Postma D.S., Stine O.C., et al. Genome screen for asthma and bronchial hyperresponsiveness: interactions with passive smoke exposure. J Allergy Clin Immunol 2005, 115:1169-1175.
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 1169-1175
    • Meyers, D.A.1    Postma, D.S.2    Stine, O.C.3
  • 15
    • 76149146032 scopus 로고    scopus 로고
    • Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program
    • Moore W.C., Meyers D.A., Wenzel S.E., et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010, 181:315-323.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 315-323
    • Moore, W.C.1    Meyers, D.A.2    Wenzel, S.E.3
  • 16
    • 79551500941 scopus 로고    scopus 로고
    • Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program
    • e1-13
    • Fitzpatrick A.M., Teague W.G., Meyers D.A., et al. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol 2010, 127:382-389. e1-13.
    • (2010) J Allergy Clin Immunol , vol.127 , pp. 382-389
    • Fitzpatrick, A.M.1    Teague, W.G.2    Meyers, D.A.3
  • 17
    • 0035177659 scopus 로고    scopus 로고
    • Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma
    • Woodruff P.G., Khashayar R., Lazarus S.C., et al. Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma. J Allergy Clin Immunol 2001, 108:753-758.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 753-758
    • Woodruff, P.G.1    Khashayar, R.2    Lazarus, S.C.3
  • 18
    • 0031657062 scopus 로고    scopus 로고
    • Sputum eosinophilia is more closely associated with airway responsiveness to bradykinin than methacholine in asthma
    • Polosa R., Renaud L., Cacciola R., et al. Sputum eosinophilia is more closely associated with airway responsiveness to bradykinin than methacholine in asthma. Eur Respir J 1998, 12:551-556.
    • (1998) Eur Respir J , vol.12 , pp. 551-556
    • Polosa, R.1    Renaud, L.2    Cacciola, R.3
  • 19
    • 0033954741 scopus 로고    scopus 로고
    • The relationship between airways inflammation and asthma severity
    • Louis R., Lau L.C., Bron A.O., et al. The relationship between airways inflammation and asthma severity. Am J Respir Crit Care Med 2000, 161:9-16.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 9-16
    • Louis, R.1    Lau, L.C.2    Bron, A.O.3
  • 20
    • 4444224765 scopus 로고    scopus 로고
    • Safety and application of induced sputum analysis in childhood asthma
    • Covar R.A., Spahn J.D., Martin R.J., et al. Safety and application of induced sputum analysis in childhood asthma. J Allergy Clin Immunol 2004, 114:575-582.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 575-582
    • Covar, R.A.1    Spahn, J.D.2    Martin, R.J.3
  • 21
    • 0031782865 scopus 로고    scopus 로고
    • Use of induced sputum to examine airway inflammation in childhood asthma
    • Gibson P.G. Use of induced sputum to examine airway inflammation in childhood asthma. J Allergy Clin Immunol 1998, 102:S100-101.
    • (1998) J Allergy Clin Immunol , vol.102
    • Gibson, P.G.1
  • 22
    • 36749095585 scopus 로고    scopus 로고
    • Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma
    • Berry M., Morgan A., Shaw D.E., et al. Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax 2007, 62:1043-1049.
    • (2007) Thorax , vol.62 , pp. 1043-1049
    • Berry, M.1    Morgan, A.2    Shaw, D.E.3
  • 23
    • 77951665424 scopus 로고    scopus 로고
    • Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes
    • e13
    • Hastie A.T., Moore W.C., Meyers D.A., et al. Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. J Allergy Clin Immunol 2010, 125:1028-1036. e13.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1028-1036
    • Hastie, A.T.1    Moore, W.C.2    Meyers, D.A.3
  • 24
    • 69249150516 scopus 로고    scopus 로고
    • T-helper type 2-driven inflammation defines major subphenotypes of asthma
    • Woodruff P.G., Modrek B., Choy D.F., et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 2009, 180:388-395.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 388-395
    • Woodruff, P.G.1    Modrek, B.2    Choy, D.F.3
  • 25
    • 80053084755 scopus 로고    scopus 로고
    • Lebrikizumab treatment in adults with asthma
    • Corren J., Lemanske R.F., Hanania N.A., et al. Lebrikizumab treatment in adults with asthma. N Engl J Med 2011, 365:1088-1098.
    • (2011) N Engl J Med , vol.365 , pp. 1088-1098
    • Corren, J.1    Lemanske, R.F.2    Hanania, N.A.3
  • 26
    • 0035340289 scopus 로고    scopus 로고
    • Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: characterization of pathways available to eosinophils for generating reactive nitrogen species
    • MacPherson J.C., Comhair S.A., Erzurum S.C., et al. Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: characterization of pathways available to eosinophils for generating reactive nitrogen species. J Immunol 2001, 166:5763-5772.
    • (2001) J Immunol , vol.166 , pp. 5763-5772
    • MacPherson, J.C.1    Comhair, S.A.2    Erzurum, S.C.3
  • 27
    • 0037105324 scopus 로고    scopus 로고
    • Eosinophil peroxidase produces hypobromous acid in the airways of stable asthmatics
    • Aldridge R.E., Chan T., van Dalen C.J., et al. Eosinophil peroxidase produces hypobromous acid in the airways of stable asthmatics. Free Radic Biol Med 2002, 33:847-856.
    • (2002) Free Radic Biol Med , vol.33 , pp. 847-856
    • Aldridge, R.E.1    Chan, T.2    van Dalen, C.J.3
  • 28
    • 0037335804 scopus 로고    scopus 로고
    • Local release of eosinophil peroxidase following segmental allergen provocation in asthma
    • Erpenbeck V.J., Hohlfeld J.M., Petschallies J., et al. Local release of eosinophil peroxidase following segmental allergen provocation in asthma. Clin Exp Allergy 2003, 33:331-336.
    • (2003) Clin Exp Allergy , vol.33 , pp. 331-336
    • Erpenbeck, V.J.1    Hohlfeld, J.M.2    Petschallies, J.3
  • 29
    • 0033596905 scopus 로고    scopus 로고
    • 3-Bromotyrosine and 3,5-dibromotyrosine are major products of protein oxidation by eosinophil peroxidase: potential markers for eosinophil-dependent tissue injury in vivo
    • Wu W., Chen Y., d'Avignon A., et al. 3-Bromotyrosine and 3,5-dibromotyrosine are major products of protein oxidation by eosinophil peroxidase: potential markers for eosinophil-dependent tissue injury in vivo. Biochemistry 1999, 38:3538-3548.
    • (1999) Biochemistry , vol.38 , pp. 3538-3548
    • Wu, W.1    Chen, Y.2    d'Avignon, A.3
  • 30
    • 3042675247 scopus 로고    scopus 로고
    • Urinary 3-bromotyrosine and 3-chlorotyrosine concentrations in asthmatic patients: lack of increase in 3-bromotyrosine concentration in urine and plasma proteins in aspirin-induced asthma after intravenous aspirin challenge
    • Mita H., Higashi N., Taniguchi M., et al. Urinary 3-bromotyrosine and 3-chlorotyrosine concentrations in asthmatic patients: lack of increase in 3-bromotyrosine concentration in urine and plasma proteins in aspirin-induced asthma after intravenous aspirin challenge. Clin Exp Allergy 2004, 34:931-938.
    • (2004) Clin Exp Allergy , vol.34 , pp. 931-938
    • Mita, H.1    Higashi, N.2    Taniguchi, M.3
  • 31
    • 79960446443 scopus 로고    scopus 로고
    • Urinary bromotyrosine measures asthma control and predicts asthma exacerbations in children
    • 248-255. e1
    • Wedes S.H., Wu W., Comhair S.A., et al. Urinary bromotyrosine measures asthma control and predicts asthma exacerbations in children. J Pediatr 2011, 159. 248-255. e1.
    • (2011) J Pediatr , vol.159
    • Wedes, S.H.1    Wu, W.2    Comhair, S.A.3
  • 32
    • 0032474233 scopus 로고    scopus 로고
    • Bronchodilator S-nitrosothiol deficiency in asthmatic respiratory failure
    • Gaston B., Sears S., Woods J., et al. Bronchodilator S-nitrosothiol deficiency in asthmatic respiratory failure. Lancet 1998, 351:1317-1319.
    • (1998) Lancet , vol.351 , pp. 1317-1319
    • Gaston, B.1    Sears, S.2    Woods, J.3
  • 33
    • 20444410779 scopus 로고    scopus 로고
    • Protection from experimental asthma by an endogenous bronchodilator
    • Que L.G., Liu L., Yan Y., et al. Protection from experimental asthma by an endogenous bronchodilator. Science 2005, 308:1618-1621.
    • (2005) Science , vol.308 , pp. 1618-1621
    • Que, L.G.1    Liu, L.2    Yan, Y.3
  • 34
    • 67650848555 scopus 로고    scopus 로고
    • S-nitrosoglutathione reductase: an important regulator in human asthma
    • Que L.G., Yang Z., Stamler J.S., et al. S-nitrosoglutathione reductase: an important regulator in human asthma. Am J Respir Crit Care Med 2009, 180:226-231.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 226-231
    • Que, L.G.1    Yang, Z.2    Stamler, J.S.3
  • 35
    • 0027515050 scopus 로고
    • Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways
    • Gaston B., Reilly J., Drazen J.M., et al. Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways. Proc Natl Acad Sci U S A 1993, 90:10957-10961.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 10957-10961
    • Gaston, B.1    Reilly, J.2    Drazen, J.M.3
  • 36
    • 33749353118 scopus 로고    scopus 로고
    • Buffering airway acid decreases exhaled nitric oxide in asthma
    • Gaston B., Kelly R., Urban P., et al. Buffering airway acid decreases exhaled nitric oxide in asthma. J Allergy Clin Immunol 2006, 118:817-822.
    • (2006) J Allergy Clin Immunol , vol.118 , pp. 817-822
    • Gaston, B.1    Kelly, R.2    Urban, P.3
  • 37
    • 77955302958 scopus 로고    scopus 로고
    • Direct regulation of striated muscle myosins by nitric oxide and endogenous nitrosothiols
    • Evangelista A.M., Rao V.S., Filo A.R., et al. Direct regulation of striated muscle myosins by nitric oxide and endogenous nitrosothiols. PloS One 2010, 5:e11209.
    • (2010) PloS One , vol.5
    • Evangelista, A.M.1    Rao, V.S.2    Filo, A.R.3
  • 38
    • 34247470682 scopus 로고    scopus 로고
    • Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2
    • Whalen E.J., Foster M.W., Matsumoto A., et al. Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell 2007, 129:511-522.
    • (2007) Cell , vol.129 , pp. 511-522
    • Whalen, E.J.1    Foster, M.W.2    Matsumoto, A.3
  • 39
    • 0033696551 scopus 로고    scopus 로고
    • S-nitrosoglutathione breakdown prevents airway smooth muscle relaxation in the guinea pig
    • Fang K., Johns R., Macdonald T., et al. S-nitrosoglutathione breakdown prevents airway smooth muscle relaxation in the guinea pig. Am J Physiol 2000, 279:L716-L721.
    • (2000) Am J Physiol , vol.279
    • Fang, K.1    Johns, R.2    Macdonald, T.3
  • 40
    • 84855400707 scopus 로고    scopus 로고
    • S-nitrosoglutathione reductase in human lung cancer
    • Marozkina N.V., Wei C., Yemen S., et al. S-nitrosoglutathione reductase in human lung cancer. Am J Respir Cell Mol Biol 2011, 46:63-70.
    • (2011) Am J Respir Cell Mol Biol , vol.46 , pp. 63-70
    • Marozkina, N.V.1    Wei, C.2    Yemen, S.3
  • 41
    • 0032522535 scopus 로고    scopus 로고
    • S-nitrosoglutathione is a substrate for rat alcohol dehydrogenase class III isoenzyme
    • Jensen D.E., Belka G.K., Du Bois G.C. S-nitrosoglutathione is a substrate for rat alcohol dehydrogenase class III isoenzyme. Biochem J 1998, 331(Pt 2):659-668.
    • (1998) Biochem J , vol.331 , Issue.PART 2 , pp. 659-668
    • Jensen, D.E.1    Belka, G.K.2    Du Bois, G.C.3
  • 42
    • 77955644592 scopus 로고    scopus 로고
    • Breath formate is a marker of airway S-nitrosothiol depletion in severe asthma
    • Greenwald R., Fitzpatrick A.M., Gaston B., et al. Breath formate is a marker of airway S-nitrosothiol depletion in severe asthma. PloS One 2010, 5:e11919.
    • (2010) PloS One , vol.5
    • Greenwald, R.1    Fitzpatrick, A.M.2    Gaston, B.3
  • 43
    • 0036529021 scopus 로고    scopus 로고
    • Acute effects of aerosolized S-nitrosoglutathione in cystic fibrosis
    • Snyder A.H., McPherson M.E., Hunt J.F., et al. Acute effects of aerosolized S-nitrosoglutathione in cystic fibrosis. Am J Respir Crit Care Med 2002, 165:922-926.
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 922-926
    • Snyder, A.H.1    McPherson, M.E.2    Hunt, J.F.3
  • 44
    • 33847749526 scopus 로고    scopus 로고
    • Airway nitric oxide release is reduced after PBS inhalation in asthma
    • Shin H.W., Shelley D.A., Henderson E.M., et al. Airway nitric oxide release is reduced after PBS inhalation in asthma. J Appl Physiol 2007, 102:1028-1033.
    • (2007) J Appl Physiol , vol.102 , pp. 1028-1033
    • Shin, H.W.1    Shelley, D.A.2    Henderson, E.M.3
  • 45
    • 1242276386 scopus 로고    scopus 로고
    • Oxidants and asthma
    • Caramori G., Papi A. Oxidants and asthma. Thorax 2004, 59:170-173.
    • (2004) Thorax , vol.59 , pp. 170-173
    • Caramori, G.1    Papi, A.2
  • 48
    • 71549136876 scopus 로고    scopus 로고
    • Redox control of asthma: molecular mechanisms and therapeutic opportunities
    • Comhair S.A., Erzurum S.C. Redox control of asthma: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal 2010, 12:93-124.
    • (2010) Antioxid Redox Signal , vol.12 , pp. 93-124
    • Comhair, S.A.1    Erzurum, S.C.2
  • 49
    • 0033406396 scopus 로고    scopus 로고
    • Allergen-induced synthesis of F(2)-isoprostanes in atopic asthmatics. Evidence for oxidant stress
    • Dworski R., Murray J.J., Roberts L.J., et al. Allergen-induced synthesis of F(2)-isoprostanes in atopic asthmatics. Evidence for oxidant stress. Am J Respir Crit Care Med 1999, 160:1947-1951.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1947-1951
    • Dworski, R.1    Murray, J.J.2    Roberts, L.J.3
  • 50
    • 0037115255 scopus 로고    scopus 로고
    • The isoprostanes: their role as an index of oxidant stress status in human pulmonary disease
    • Morrow J.D., Roberts L.J. The isoprostanes: their role as an index of oxidant stress status in human pulmonary disease. Am J Respir Crit Care Med 2002, 166:S25-S30.
    • (2002) Am J Respir Crit Care Med , vol.166
    • Morrow, J.D.1    Roberts, L.J.2
  • 51
    • 0037252642 scopus 로고    scopus 로고
    • Biomarkers of lipid peroxidation, airway inflammation and asthma
    • Wood L.G., Gibson P.G., Garg M.L. Biomarkers of lipid peroxidation, airway inflammation and asthma. Eur Respir J 2003, 21:177-186.
    • (2003) Eur Respir J , vol.21 , pp. 177-186
    • Wood, L.G.1    Gibson, P.G.2    Garg, M.L.3
  • 52
    • 81755165915 scopus 로고    scopus 로고
    • The pharmacogenetics and pharmacogenomics of asthma therapy
    • Tse S.M., Tantisira K., Weiss S.T. The pharmacogenetics and pharmacogenomics of asthma therapy. Pharmacogen J 2011, 11:383-392.
    • (2011) Pharmacogen J , vol.11 , pp. 383-392
    • Tse, S.M.1    Tantisira, K.2    Weiss, S.T.3
  • 53
    • 0031771523 scopus 로고    scopus 로고
    • Urinary mediators and asthma
    • Dworski R., Sheller J.R. Urinary mediators and asthma. Clin Exp Allergy 1998, 28:1309-1312.
    • (1998) Clin Exp Allergy , vol.28 , pp. 1309-1312
    • Dworski, R.1    Sheller, J.R.2
  • 54
    • 0024421581 scopus 로고
    • Pulmonary strategies of antioxidant defense
    • Heffner J.E., Repine J.E. Pulmonary strategies of antioxidant defense. Am Rev Respir Dis 1989, 140:531-554.
    • (1989) Am Rev Respir Dis , vol.140 , pp. 531-554
    • Heffner, J.E.1    Repine, J.E.2
  • 55
    • 0031028454 scopus 로고    scopus 로고
    • Decreased Cu, Zn-SOD activity in asthmatic airway epithelium: correction by inhaled corticosteroid in vivo
    • De Raeve H.R., Thunnissen F.B., Kaneko F.T., et al. Decreased Cu, Zn-SOD activity in asthmatic airway epithelium: correction by inhaled corticosteroid in vivo. Am J Physiol 1997, 272:L148-L154.
    • (1997) Am J Physiol , vol.272
    • De Raeve, H.R.1    Thunnissen, F.B.2    Kaneko, F.T.3
  • 56
    • 0343920015 scopus 로고    scopus 로고
    • Rapid loss of superoxide dismutase activity during antigen-induced asthmatic response
    • Comhair S.A., Bhathena P.R., Dweik R.A., et al. Rapid loss of superoxide dismutase activity during antigen-induced asthmatic response. Lancet 2000, 355:624.
    • (2000) Lancet , vol.355 , pp. 624
    • Comhair, S.A.1    Bhathena, P.R.2    Dweik, R.A.3
  • 57
    • 0036073157 scopus 로고    scopus 로고
    • Antioxidant responses to oxidant-mediated lung diseases
    • Comhair S.A., Erzurum S.C. Antioxidant responses to oxidant-mediated lung diseases. Am J Physiol 2002, 283:L246-L255.
    • (2002) Am J Physiol , vol.283
    • Comhair, S.A.1    Erzurum, S.C.2
  • 58
    • 79955764189 scopus 로고    scopus 로고
    • Detrimental effects of environmental tobacco smoke in relation to asthma severity
    • Comhair S.A., Gaston B.M., Ricci K.S., et al. Detrimental effects of environmental tobacco smoke in relation to asthma severity. PloS One 2011, 6:e18574.
    • (2011) PloS One , vol.6
    • Comhair, S.A.1    Gaston, B.M.2    Ricci, K.S.3
  • 59
    • 22644446038 scopus 로고    scopus 로고
    • Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma
    • Comhair S.A., Ricci K.S., Arroliga M., et al. Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma. Am J Respir Crit Care Med 2005, 172:306-313.
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 306-313
    • Comhair, S.A.1    Ricci, K.S.2    Arroliga, M.3
  • 60
    • 20044378676 scopus 로고    scopus 로고
    • Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity
    • Comhair S.A., Xu W., Ghosh S., et al. Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity. Am J Pathol 2005, 166:663-674.
    • (2005) Am J Pathol , vol.166 , pp. 663-674
    • Comhair, S.A.1    Xu, W.2    Ghosh, S.3
  • 61
    • 0033839993 scopus 로고    scopus 로고
    • Mice that overexpress Cu/Zn superoxide dismutase are resistant to allergen-induced changes in airway control
    • Larsen G.L., White C.W., Takeda K., et al. Mice that overexpress Cu/Zn superoxide dismutase are resistant to allergen-induced changes in airway control. Am J Physiol 2000, 279:L350-L359.
    • (2000) Am J Physiol , vol.279
    • Larsen, G.L.1    White, C.W.2    Takeda, K.3
  • 62
    • 33645961872 scopus 로고    scopus 로고
    • Nitrotyrosine proteome survey in asthma identifies oxidative mechanism of catalase inactivation
    • Ghosh S., Janocha A.J., Aronica M.A., et al. Nitrotyrosine proteome survey in asthma identifies oxidative mechanism of catalase inactivation. J Immunol 2006, 176:5587-5597.
    • (2006) J Immunol , vol.176 , pp. 5587-5597
    • Ghosh, S.1    Janocha, A.J.2    Aronica, M.A.3
  • 63
    • 0036140879 scopus 로고    scopus 로고
    • Expression and activity of pH-regulatory glutaminase in the human airway epithelium
    • Hunt J.F., Erwin E., Palmer L., et al. Expression and activity of pH-regulatory glutaminase in the human airway epithelium. Am J Respir Crit Care Med 2002, 165:101-107.
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 101-107
    • Hunt, J.F.1    Erwin, E.2    Palmer, L.3
  • 64
    • 33646554848 scopus 로고    scopus 로고
    • S-nitrosothiols regulate cell-surface pH buffering by airway epithelial cells during the human immune response to rhinovirus
    • Carraro S., Doherty J., Zaman K., et al. S-nitrosothiols regulate cell-surface pH buffering by airway epithelial cells during the human immune response to rhinovirus. Am J Physiol 2006, 290:L827-L832.
    • (2006) Am J Physiol , vol.290
    • Carraro, S.1    Doherty, J.2    Zaman, K.3
  • 65
    • 0034104692 scopus 로고    scopus 로고
    • Endogenous airway acidification. Implications for asthma pathophysiology
    • Hunt J.F., Fang K., Malik R., et al. Endogenous airway acidification. Implications for asthma pathophysiology. Am J Respir Crit Care Med 2000, 161:694-699.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 694-699
    • Hunt, J.F.1    Fang, K.2    Malik, R.3
  • 66
    • 79551574730 scopus 로고    scopus 로고
    • Determinants of exhaled breath condensate pH in a large population with asthma
    • Liu L., Teague W.G., Erzurum S., et al. Determinants of exhaled breath condensate pH in a large population with asthma. Chest 2011, 139:328-336.
    • (2011) Chest , vol.139 , pp. 328-336
    • Liu, L.1    Teague, W.G.2    Erzurum, S.3
  • 67
    • 33750592575 scopus 로고    scopus 로고
    • Epithelial damage and angiogenesis in the airways of children with asthma
    • Barbato A., Turato G., Baraldo S., et al. Epithelial damage and angiogenesis in the airways of children with asthma. Am J Respir Crit Care Med 2006, 174:975-981.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 975-981
    • Barbato, A.1    Turato, G.2    Baraldo, S.3
  • 68
    • 15844401603 scopus 로고    scopus 로고
    • Quantitative analysis of bronchial wall vascularity in the medium and small airways of patients with asthma and COPD
    • Hashimoto M., Tanaka H., Abe S. Quantitative analysis of bronchial wall vascularity in the medium and small airways of patients with asthma and COPD. Chest 2005, 127:965-972.
    • (2005) Chest , vol.127 , pp. 965-972
    • Hashimoto, M.1    Tanaka, H.2    Abe, S.3
  • 69
    • 34248176315 scopus 로고    scopus 로고
    • Th1- and Th2-dependent endothelial progenitor cell recruitment and angiogenic switch in asthma
    • Asosingh K., Swaidani S., Aronica M., et al. Th1- and Th2-dependent endothelial progenitor cell recruitment and angiogenic switch in asthma. J Immunol 2007, 178:6482-6494.
    • (2007) J Immunol , vol.178 , pp. 6482-6494
    • Asosingh, K.1    Swaidani, S.2    Aronica, M.3
  • 70
    • 0030973217 scopus 로고    scopus 로고
    • The codependence of angiogenesis and chronic inflammation
    • Jackson J.R., Seed M.P., Kircher C.H., et al. The codependence of angiogenesis and chronic inflammation. Faseb J 1997, 11:457-465.
    • (1997) Faseb J , vol.11 , pp. 457-465
    • Jackson, J.R.1    Seed, M.P.2    Kircher, C.H.3
  • 71
    • 33645233889 scopus 로고    scopus 로고
    • Vascular endothelial growth factor up-regulation and bronchial wall remodelling in asthma
    • Chetta A., Zanini A., Foresi A., et al. Vascular endothelial growth factor up-regulation and bronchial wall remodelling in asthma. Clin Exp Allergy 2005, 35:1437-1442.
    • (2005) Clin Exp Allergy , vol.35 , pp. 1437-1442
    • Chetta, A.1    Zanini, A.2    Foresi, A.3
  • 72
    • 31944439161 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-mediated induction of angiogenesis by human rhinoviruses
    • Psarras S., Volonaki E., Skevaki C.L., et al. Vascular endothelial growth factor-mediated induction of angiogenesis by human rhinoviruses. J Allergy Clin Immunol 2006, 117:291-297.
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 291-297
    • Psarras, S.1    Volonaki, E.2    Skevaki, C.L.3
  • 73
    • 33751105240 scopus 로고    scopus 로고
    • Vascular remodeling is airway generation-specific in a primate model of chronic asthma
    • Avdalovic M.V., Putney L.F., Schelegle E.S., et al. Vascular remodeling is airway generation-specific in a primate model of chronic asthma. Am J Respir Crit Care Med 2006, 174:1069-1076.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 1069-1076
    • Avdalovic, M.V.1    Putney, L.F.2    Schelegle, E.S.3
  • 74
    • 7044260315 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung
    • Lee C.G., Link H., Baluk P., et al. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nature Med 2004, 10:1095-1103.
    • (2004) Nature Med , vol.10 , pp. 1095-1103
    • Lee, C.G.1    Link, H.2    Baluk, P.3
  • 75
    • 11144277401 scopus 로고    scopus 로고
    • Human peripheral blood eosinophils induce angiogenesis
    • Puxeddu I., Alian A., Piliponsky A.M., et al. Human peripheral blood eosinophils induce angiogenesis. Int J Biochem Cell Biol 2005, 37:628-636.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 628-636
    • Puxeddu, I.1    Alian, A.2    Piliponsky, A.M.3
  • 76
    • 9244230028 scopus 로고    scopus 로고
    • Mast cell contribution to angiogenesis related to tumour progression
    • Ribatti D., Crivellato E., Roccaro A.M., et al. Mast cell contribution to angiogenesis related to tumour progression. Clin Exp Allergy 2004, 34:1660-1664.
    • (2004) Clin Exp Allergy , vol.34 , pp. 1660-1664
    • Ribatti, D.1    Crivellato, E.2    Roccaro, A.M.3
  • 77
    • 34249704141 scopus 로고    scopus 로고
    • Working hypothesis to redefine endothelial progenitor cells
    • Prater D.N., Case J., Ingram D.A., et al. Working hypothesis to redefine endothelial progenitor cells. Leukemia 2007, 21:1141-1149.
    • (2007) Leukemia , vol.21 , pp. 1141-1149
    • Prater, D.N.1    Case, J.2    Ingram, D.A.3
  • 78
    • 0031019745 scopus 로고    scopus 로고
    • Isolation of putative progenitor endothelial cells for angiogenesis
    • Asahara T., Murohara T., Sullivan A., et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997, 275:964-967.
    • (1997) Science , vol.275 , pp. 964-967
    • Asahara, T.1    Murohara, T.2    Sullivan, A.3
  • 79
    • 0028053173 scopus 로고
    • Increased nitric oxide in exhaled air of asthmatic patients
    • Kharitonov S.A., Yates D., Robbins R.A., et al. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994, 343:133-135.
    • (1994) Lancet , vol.343 , pp. 133-135
    • Kharitonov, S.A.1    Yates, D.2    Robbins, R.A.3
  • 81
    • 19444385389 scopus 로고    scopus 로고
    • Use of exhaled nitric oxide measurements to guide treatment in chronic asthma
    • Smith A.D., Cowan J.O., Brassett K.P., et al. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl J Med 2005, 352:2163-2173.
    • (2005) N Engl J Med , vol.352 , pp. 2163-2173
    • Smith, A.D.1    Cowan, J.O.2    Brassett, K.P.3
  • 82
    • 69149111410 scopus 로고    scopus 로고
    • Exhaled nitric oxide in pediatric asthma
    • Dinakar C. Exhaled nitric oxide in pediatric asthma. Curr Allergy Asthma Rep 2009, 9:30-37.
    • (2009) Curr Allergy Asthma Rep , vol.9 , pp. 30-37
    • Dinakar, C.1
  • 83
    • 14744296050 scopus 로고    scopus 로고
    • Exhaled nitric oxide in a population-based study of asthma and allergy in schoolchildren
    • Nordvall S.L., Janson C., Kalm-Stephens P., et al. Exhaled nitric oxide in a population-based study of asthma and allergy in schoolchildren. Allergy 2005, 60:469-475.
    • (2005) Allergy , vol.60 , pp. 469-475
    • Nordvall, S.L.1    Janson, C.2    Kalm-Stephens, P.3
  • 84
    • 7944232729 scopus 로고    scopus 로고
    • The Aerocrine exhaled nitric oxide monitoring system NIOX is cleared by the US Food and Drug Administration for monitoring therapy in asthma
    • Silkoff P.E., Carlson M., Bourke T., et al. The Aerocrine exhaled nitric oxide monitoring system NIOX is cleared by the US Food and Drug Administration for monitoring therapy in asthma. J Allergy Clin Immunol 2004, 114:1241-1256.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 1241-1256
    • Silkoff, P.E.1    Carlson, M.2    Bourke, T.3
  • 85
    • 77952206441 scopus 로고    scopus 로고
    • Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma
    • Dweik R.A., Sorkness R.L., Wenzel S., et al. Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. Am J Respir Crit Care Med 2010, 181:1033-1041.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 1033-1041
    • Dweik, R.A.1    Sorkness, R.L.2    Wenzel, S.3
  • 86
    • 0034120179 scopus 로고    scopus 로고
    • Molecular mechanisms of increased nitric oxide (NO) in asthma: evidence for transcriptional and post-translational regulation of NO synthesis
    • Guo F.H., Comhair S.A., Zheng S., et al. Molecular mechanisms of increased nitric oxide (NO) in asthma: evidence for transcriptional and post-translational regulation of NO synthesis. J Immunol 2000, 164:5970-5980.
    • (2000) J Immunol , vol.164 , pp. 5970-5980
    • Guo, F.H.1    Comhair, S.A.2    Zheng, S.3
  • 87
    • 0031761402 scopus 로고    scopus 로고
    • Characterization of inducible nitric oxide synthase expression in human airway epithelium
    • Guo F.H., Erzurum S.C. Characterization of inducible nitric oxide synthase expression in human airway epithelium. Environ Health Perspect 1998, 106(Suppl 5):1119-1124.
    • (1998) Environ Health Perspect , vol.106 , Issue.SUPPL 5 , pp. 1119-1124
    • Guo, F.H.1    Erzurum, S.C.2
  • 88
    • 0030865879 scopus 로고    scopus 로고
    • Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators
    • Guo F.H., Uetani K., Haque S.J., et al. Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators. J Clin Invest 1997, 100:829-838.
    • (1997) J Clin Invest , vol.100 , pp. 829-838
    • Guo, F.H.1    Uetani, K.2    Haque, S.J.3
  • 89
    • 34547557916 scopus 로고    scopus 로고
    • The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial
    • Shaw D.E., Berry M.A., Thomas M., et al. The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial. Am J Respir Crit Care Med 2007, 176:231-237.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 231-237
    • Shaw, D.E.1    Berry, M.A.2    Thomas, M.3
  • 90
    • 52049108262 scopus 로고    scopus 로고
    • Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial
    • Szefler S.J., Mitchell H., Sorkness C.A., et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet 2008, 372:1065-1072.
    • (2008) Lancet , vol.372 , pp. 1065-1072
    • Szefler, S.J.1    Mitchell, H.2    Sorkness, C.A.3
  • 91
    • 0037971329 scopus 로고    scopus 로고
    • Temporal association of nitric oxide levels and airflow in asthma after whole lung allergen challenge
    • [discussion: 5]
    • Khatri S.B., Hammel J., Kavuru M.S., et al. Temporal association of nitric oxide levels and airflow in asthma after whole lung allergen challenge. J Appl Physiol 2003, 95:436-440. [discussion: 5].
    • (2003) J Appl Physiol , vol.95 , pp. 436-440
    • Khatri, S.B.1    Hammel, J.2    Kavuru, M.S.3
  • 92
    • 0034526865 scopus 로고    scopus 로고
    • Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society
    • Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society. Am J Respir Crit Care Med 2000, 162:2341-2351.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 2341-2351
  • 93
    • 76149098409 scopus 로고    scopus 로고
    • Noninvasive markers of airway inflammation in asthma
    • Wedes S.H., Khatri S.B., Zhang R., et al. Noninvasive markers of airway inflammation in asthma. Clin Transl Sci 2009, 2:112-117.
    • (2009) Clin Transl Sci , vol.2 , pp. 112-117
    • Wedes, S.H.1    Khatri, S.B.2    Zhang, R.3
  • 94
    • 0030840381 scopus 로고    scopus 로고
    • Expired nitric oxide as a marker for childhood asthma
    • Nelson B.V., Sears S., Woods J., et al. Expired nitric oxide as a marker for childhood asthma. J Pediatr 1997, 130:423-427.
    • (1997) J Pediatr , vol.130 , pp. 423-427
    • Nelson, B.V.1    Sears, S.2    Woods, J.3
  • 95
    • 20444384766 scopus 로고    scopus 로고
    • Evaluation of oxidative-antioxidative status and the L-arginine-nitric oxide pathway in asthmatic patients
    • Ceylan E., Aksoy N., Gencer M., et al. Evaluation of oxidative-antioxidative status and the L-arginine-nitric oxide pathway in asthmatic patients. Respir Med 2005, 99:871-876.
    • (2005) Respir Med , vol.99 , pp. 871-876
    • Ceylan, E.1    Aksoy, N.2    Gencer, M.3
  • 96
    • 29644436252 scopus 로고    scopus 로고
    • Genetic polymorphisms in arginase I and II and childhood asthma and atopy
    • Li H., Romieu I., Sienra-Monge J.J., et al. Genetic polymorphisms in arginase I and II and childhood asthma and atopy. J Allergy Clin Immunol 2006, 117:119-126.
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 119-126
    • Li, H.1    Romieu, I.2    Sienra-Monge, J.J.3
  • 97
    • 3142757008 scopus 로고    scopus 로고
    • Decreased arginine bioavailability and increased serum arginase activity in asthma
    • Morris C.R., Poljakovic M., Lavrisha L., et al. Decreased arginine bioavailability and increased serum arginase activity in asthma. Am J Respir Crit Care Med 2004, 170:148-153.
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 148-153
    • Morris, C.R.1    Poljakovic, M.2    Lavrisha, L.3
  • 98
    • 52749084926 scopus 로고    scopus 로고
    • Alterations of the arginine metabolome in asthma
    • Lara A., Khatri S.B., Wang Z., et al. Alterations of the arginine metabolome in asthma. Am J Respir Crit Care Med 2008, 178:673-681.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 673-681
    • Lara, A.1    Khatri, S.B.2    Wang, Z.3
  • 99
    • 0042243556 scopus 로고    scopus 로고
    • Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis
    • Zimmermann N., King N.E., Laporte J., et al. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest 2003, 111:1863-1874.
    • (2003) J Clin Invest , vol.111 , pp. 1863-1874
    • Zimmermann, N.1    King, N.E.2    Laporte, J.3
  • 100
    • 33644769084 scopus 로고    scopus 로고
    • The arginine-arginase balance in asthma and lung inflammation
    • Zimmermann N., Rothenberg M.E. The arginine-arginase balance in asthma and lung inflammation. Eur J Pharmacol 2006, 533:253-262.
    • (2006) Eur J Pharmacol , vol.533 , pp. 253-262
    • Zimmermann, N.1    Rothenberg, M.E.2
  • 101
    • 32844458380 scopus 로고    scopus 로고
    • Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma
    • Maarsingh H., Leusink J., Bos I.S., et al. Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma. Respir Res 2006, 7:6.
    • (2006) Respir Res , vol.7 , pp. 6
    • Maarsingh, H.1    Leusink, J.2    Bos, I.S.3
  • 102
    • 4744342505 scopus 로고    scopus 로고
    • Arginine in asthma and lung inflammation
    • [discussion: 53S]
    • King N.E., Rothenberg M.E., Zimmermann N. Arginine in asthma and lung inflammation. J Nutr 2004, 134:2830S-2836S. [discussion: 53S].
    • (2004) J Nutr , vol.134
    • King, N.E.1    Rothenberg, M.E.2    Zimmermann, N.3
  • 103
    • 0028919209 scopus 로고
    • Arginase induction by suppressors of nitric oxide synthesis (IL-4, IL-10 and PGE2) in murine bone-marrow-derived macrophages
    • Corraliza I.M., Soler G., Eichmann K., et al. Arginase induction by suppressors of nitric oxide synthesis (IL-4, IL-10 and PGE2) in murine bone-marrow-derived macrophages. Biochem Biophys Res Commun 1995, 206:667-673.
    • (1995) Biochem Biophys Res Commun , vol.206 , pp. 667-673
    • Corraliza, I.M.1    Soler, G.2    Eichmann, K.3
  • 104
    • 0028916297 scopus 로고
    • Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines
    • Modolell M., Corraliza I.M., Link F., et al. Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines. Eur J Immunol 1995, 25:1101-1104.
    • (1995) Eur J Immunol , vol.25 , pp. 1101-1104
    • Modolell, M.1    Corraliza, I.M.2    Link, F.3
  • 105
    • 0035125111 scopus 로고    scopus 로고
    • Induction of arginases I and II in cornea during herpes simplex virus infection
    • Mistry S.K., Zheng M., Rouse B.T., et al. Induction of arginases I and II in cornea during herpes simplex virus infection. Virus Res 2001, 73:177-182.
    • (2001) Virus Res , vol.73 , pp. 177-182
    • Mistry, S.K.1    Zheng, M.2    Rouse, B.T.3
  • 106
    • 0033594888 scopus 로고    scopus 로고
    • Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase
    • Ito A., Tsao P.S., Adimoolam S., et al. Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 1999, 99:3092-3095.
    • (1999) Circulation , vol.99 , pp. 3092-3095
    • Ito, A.1    Tsao, P.S.2    Adimoolam, S.3
  • 107
    • 34447318645 scopus 로고    scopus 로고
    • Epithelial cell proliferation contributes to airway remodeling in severe asthma
    • Cohen L., E X., Tarsi J., et al. Epithelial cell proliferation contributes to airway remodeling in severe asthma. Am J Respir Crit Care Med 2007, 176:138-145.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 138-145
    • Cohen, L.1    E, X.2    Tarsi, J.3
  • 108
    • 0035016176 scopus 로고    scopus 로고
    • Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells
    • Li H., Meininger C.J., Hawker J.R., et al. Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells. Am J Physiol Endocrinol Metab 2001, 280:E75-E82.
    • (2001) Am J Physiol Endocrinol Metab , vol.280
    • Li, H.1    Meininger, C.J.2    Hawker, J.R.3
  • 109
    • 0025873423 scopus 로고
    • Polyamines: from molecular biology to clinical applications
    • Janne J., Alhonen L., Leinonen P. Polyamines: from molecular biology to clinical applications. Ann Med 1991, 23:241-259.
    • (1991) Ann Med , vol.23 , pp. 241-259
    • Janne, J.1    Alhonen, L.2    Leinonen, P.3
  • 110
    • 0027504024 scopus 로고
    • Role of ornithine as a proline precursor in healing wounds
    • Albina J.E., Abate J.A., Mastrofrancesco B. Role of ornithine as a proline precursor in healing wounds. J Surg Res 1993, 55:97-102.
    • (1993) J Surg Res , vol.55 , pp. 97-102
    • Albina, J.E.1    Abate, J.A.2    Mastrofrancesco, B.3
  • 111
    • 0014899683 scopus 로고
    • The relationship between the free pool of proline and collagen content in human liver cirrhosis
    • Kershenobich D., Fierro F.J., Rojkind M. The relationship between the free pool of proline and collagen content in human liver cirrhosis. J Clin Invest 1970, 49:2246-2249.
    • (1970) J Clin Invest , vol.49 , pp. 2246-2249
    • Kershenobich, D.1    Fierro, F.J.2    Rojkind, M.3
  • 112
    • 38849162254 scopus 로고    scopus 로고
    • Endogenous lipid mediators in the resolution of airway inflammation
    • Haworth O., Levy B.D. Endogenous lipid mediators in the resolution of airway inflammation. Eur Respir J 2007, 30:980-992.
    • (2007) Eur Respir J , vol.30 , pp. 980-992
    • Haworth, O.1    Levy, B.D.2
  • 113
    • 0030761053 scopus 로고    scopus 로고
    • Antileukotrienes in the treatment of asthma
    • O'Byrne P.M., Israel E., Drazen J.M. Antileukotrienes in the treatment of asthma. Ann Intern Med 1997, 127:472-480.
    • (1997) Ann Intern Med , vol.127 , pp. 472-480
    • O'Byrne, P.M.1    Israel, E.2    Drazen, J.M.3
  • 114
    • 33644885331 scopus 로고    scopus 로고
    • ALOX5 promoter genotype, asthma severity and LTC production by eosinophils
    • Kalayci O., Birben E., Sackesen C., et al. ALOX5 promoter genotype, asthma severity and LTC production by eosinophils. Allergy 2006, 61:97-103.
    • (2006) Allergy , vol.61 , pp. 97-103
    • Kalayci, O.1    Birben, E.2    Sackesen, C.3
  • 115
    • 37549003655 scopus 로고    scopus 로고
    • Effects of montelukast treatment and withdrawal on fractional exhaled nitric oxide and lung function in children with asthma
    • Montuschi P., Mondino C., Koch P., et al. Effects of montelukast treatment and withdrawal on fractional exhaled nitric oxide and lung function in children with asthma. Chest 2007, 132:1876-1881.
    • (2007) Chest , vol.132 , pp. 1876-1881
    • Montuschi, P.1    Mondino, C.2    Koch, P.3
  • 116
    • 77956378266 scopus 로고    scopus 로고
    • Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma
    • 545-551. e1-4
    • Rabinovitch N., Graber N.J., Chinchilli V.M., et al. Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma. J Allergy Clin Immunol 2010, 126. 545-551. e1-4.
    • (2010) J Allergy Clin Immunol , vol.126
    • Rabinovitch, N.1    Graber, N.J.2    Chinchilli, V.M.3
  • 117
    • 0032848512 scopus 로고    scopus 로고
    • Association of urinary leukotriene E4 excretion during aspirin challenges with severity of respiratory responses
    • Daffern P.J., Muilenburg D., Hugli T.E., et al. Association of urinary leukotriene E4 excretion during aspirin challenges with severity of respiratory responses. J Allergy Clin Immunol 1999, 104:559-564.
    • (1999) J Allergy Clin Immunol , vol.104 , pp. 559-564
    • Daffern, P.J.1    Muilenburg, D.2    Hugli, T.E.3
  • 118
    • 0027173832 scopus 로고
    • Differential effects of fluticasone propionate on allergen-evoked bronchoconstriction and increased urinary leukotriene E4 excretion
    • O'Shaughnessy K.M., Wellings R., Gillies B., et al. Differential effects of fluticasone propionate on allergen-evoked bronchoconstriction and increased urinary leukotriene E4 excretion. Am Rev Respir Dis 1993, 147:1472-1476.
    • (1993) Am Rev Respir Dis , vol.147 , pp. 1472-1476
    • O'Shaughnessy, K.M.1    Wellings, R.2    Gillies, B.3
  • 119
    • 0031797328 scopus 로고    scopus 로고
    • Urinary excretion of inflammatory mediators during allergen-induced early and late phase asthmatic reactions
    • O'Sullivan S., Roquet A., Dahlen B., et al. Urinary excretion of inflammatory mediators during allergen-induced early and late phase asthmatic reactions. Clin Exp Allergy 1998, 28:1332-1339.
    • (1998) Clin Exp Allergy , vol.28 , pp. 1332-1339
    • O'Sullivan, S.1    Roquet, A.2    Dahlen, B.3
  • 120
    • 1242351725 scopus 로고    scopus 로고
    • Increase in urinary leukotriene LTE4 levels in acute asthma: correlation with airflow limitation
    • Green S.A., Malice M.P., Tanaka W., et al. Increase in urinary leukotriene LTE4 levels in acute asthma: correlation with airflow limitation. Thorax 2004, 59:100-104.
    • (2004) Thorax , vol.59 , pp. 100-104
    • Green, S.A.1    Malice, M.P.2    Tanaka, W.3
  • 121
    • 0029853741 scopus 로고    scopus 로고
    • Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: a 6-month randomized multicenter trial. Zileuton Study Group
    • Liu M.C., Dube L.M., Lancaster J. Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: a 6-month randomized multicenter trial. Zileuton Study Group. J Allergy Clin Immunol 1996, 98:859-871.
    • (1996) J Allergy Clin Immunol , vol.98 , pp. 859-871
    • Liu, M.C.1    Dube, L.M.2    Lancaster, J.3
  • 122
    • 0029123159 scopus 로고
    • Effect of 5-lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma
    • Wenzel S.E., Trudeau J.B., Kaminsky D.A., et al. Effect of 5-lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma. Am J Respir Crit Care Med 1995, 152:897-905.
    • (1995) Am J Respir Crit Care Med , vol.152 , pp. 897-905
    • Wenzel, S.E.1    Trudeau, J.B.2    Kaminsky, D.A.3
  • 123
    • 0033456233 scopus 로고    scopus 로고
    • Induced sputum eicosanoid concentrations in asthma
    • Pavord I.D., Ward R., Woltmann G., et al. Induced sputum eicosanoid concentrations in asthma. Am J Respir Crit Care Med 1999, 160:1905-1909.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1905-1909
    • Pavord, I.D.1    Ward, R.2    Woltmann, G.3
  • 124
    • 0346041503 scopus 로고    scopus 로고
    • Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation
    • Miranda C., Busacker A., Balzar S., et al. Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation. J Allergy Clin Immunol 2004, 113:101-108.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 101-108
    • Miranda, C.1    Busacker, A.2    Balzar, S.3
  • 126
    • 47849086917 scopus 로고    scopus 로고
    • Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation
    • Haworth O., Cernadas M., Yang R., et al. Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation. Nat Immunol 2008, 9:873-879.
    • (2008) Nat Immunol , vol.9 , pp. 873-879
    • Haworth, O.1    Cernadas, M.2    Yang, R.3
  • 127
    • 51849153327 scopus 로고    scopus 로고
    • Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma
    • Planaguma A., Kazani S., Marigowda G., et al. Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma. Am J Respir Crit Care Med 2008, 178:574-582.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 574-582
    • Planaguma, A.1    Kazani, S.2    Marigowda, G.3
  • 129
    • 33846001661 scopus 로고    scopus 로고
    • Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness
    • Levy B.D., Kohli P., Gotlinger K., et al. Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness. J Immunol 2007, 178:496-502.
    • (2007) J Immunol , vol.178 , pp. 496-502
    • Levy, B.D.1    Kohli, P.2    Gotlinger, K.3
  • 130
    • 68849132219 scopus 로고    scopus 로고
    • Effects of the menstrual cycle on lung function variables in women with asthma
    • Farha S., Asosingh K., Laskowski D., et al. Effects of the menstrual cycle on lung function variables in women with asthma. Am J Respir Crit Care Med 2009, 180:304-310.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 304-310
    • Farha, S.1    Asosingh, K.2    Laskowski, D.3
  • 131
    • 48949092435 scopus 로고    scopus 로고
    • Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history
    • Tantisira K.G., Colvin R., Tonascia J., et al. Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history. Am J Respir Crit Care Med 2008, 178:325-331.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 325-331
    • Tantisira, K.G.1    Colvin, R.2    Tonascia, J.3
  • 132
    • 79957827092 scopus 로고    scopus 로고
    • Obesity and asthma: an association modified by age of asthma onset
    • e2
    • Holguin F., Bleecker E.R., Busse W.W., et al. Obesity and asthma: an association modified by age of asthma onset. J Allergy Clin Immunol 2011, 127:1486-1493. e2.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 1486-1493
    • Holguin, F.1    Bleecker, E.R.2    Busse, W.W.3
  • 133
    • 77949697927 scopus 로고    scopus 로고
    • Obesity, asthma, and oxidative stress
    • Holguin F., Fitzpatrick A. Obesity, asthma, and oxidative stress. J Appl Physiol 2010, 108:754-759.
    • (2010) J Appl Physiol , vol.108 , pp. 754-759
    • Holguin, F.1    Fitzpatrick, A.2
  • 134
    • 36148981436 scopus 로고    scopus 로고
    • A chitinase-like protein in the lung and circulation of patients with severe asthma
    • Chupp G.L., Lee C.G., Jarjour N., et al. A chitinase-like protein in the lung and circulation of patients with severe asthma. N Engl J Med 2007, 357:2016-2027.
    • (2007) N Engl J Med , vol.357 , pp. 2016-2027
    • Chupp, G.L.1    Lee, C.G.2    Jarjour, N.3
  • 135
    • 38949165471 scopus 로고    scopus 로고
    • Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation
    • Sorkness R.L., Bleecker E.R., Busse W.W., et al. Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J Appl Physiol 2008, 104:394-403.
    • (2008) J Appl Physiol , vol.104 , pp. 394-403
    • Sorkness, R.L.1    Bleecker, E.R.2    Busse, W.W.3
  • 136
    • 0036185622 scopus 로고    scopus 로고
    • High resolution computed tomographic assessment of airway wall thickness in chronic asthma: reproducibility and relationship with lung function and severity
    • Little S.A., Sproule M.W., Cowan M.D., et al. High resolution computed tomographic assessment of airway wall thickness in chronic asthma: reproducibility and relationship with lung function and severity. Thorax 2002, 57:247-253.
    • (2002) Thorax , vol.57 , pp. 247-253
    • Little, S.A.1    Sproule, M.W.2    Cowan, M.D.3
  • 137
    • 0041309886 scopus 로고    scopus 로고
    • Decreased computed tomographic lung density during exacerbation of asthma
    • Mitsunobu F., Ashida K., Hosaki Y., et al. Decreased computed tomographic lung density during exacerbation of asthma. Eur Respir J 2003, 22:106-112.
    • (2003) Eur Respir J , vol.22 , pp. 106-112
    • Mitsunobu, F.1    Ashida, K.2    Hosaki, Y.3
  • 138
    • 58249121587 scopus 로고    scopus 로고
    • A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis
    • Busacker A., Newell J.D., Keefe T., et al. A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis. Chest 2009, 135:48-56.
    • (2009) Chest , vol.135 , pp. 48-56
    • Busacker, A.1    Newell, J.D.2    Keefe, T.3
  • 139
    • 33750043741 scopus 로고    scopus 로고
    • Evaluation of asthma with hyperpolarized helium-3 MRI: correlation with clinical severity and spirometry
    • de Lange E.E., Altes T.A., Patrie J.T., et al. Evaluation of asthma with hyperpolarized helium-3 MRI: correlation with clinical severity and spirometry. Chest 2006, 130:1055-1062.
    • (2006) Chest , vol.130 , pp. 1055-1062
    • de Lange, E.E.1    Altes, T.A.2    Patrie, J.T.3


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