Local release of eosinophil peroxidase following segmental allergen provocation in asthma

Clinical and Experimental Allergy

Volumn 33, Issue 3, 2003, Pages 331-336

  Erpenbeck, V J ^a,b   Hohlfeld, J M ^a,b   Petschallies, J ^b   Eklund, E ^c   Peterson, C G B ^c   Fabel, H ^b   Krug, N ^a  

^a FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c Thermo Fisher Scientific   (United States)

Author keywords

Asthma; Eosinophil; Eosinophil peroxidase

Indexed keywords

ALLERGEN; EOSINOPHIL PEROXIDASE;

ADULT; ALLERGENICITY; ALLERGIC ASTHMA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME BLOOD LEVEL; ENZYME RELEASE; EOSINOPHIL; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOASSAY; LEUKOCYTE COUNT; LUNG; LUNG LAVAGE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROVOCATION TEST; SERUM;

ADULT; ASTHMA; BRONCHIAL PROVOCATION TESTS; BRONCHOALVEOLAR LAVAGE FLUID; CASE-CONTROL STUDIES; EOSINOPHIL PEROXIDASE; EOSINOPHILS; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; LEUKOCYTE COUNT; MALE; PEROXIDASES; SKIN TESTS; STATISTICS, NONPARAMETRIC;

EID: 0037335804     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2003.01580.x     Document Type: Article

References (24)

1. Ackerman SJ, Loegering DA, Venge P et al. Distinctive cationic proteins of the human eosinophil granule: major basic protein, eosinophil cationic protein, and eosinophil-derived neurotrophin. J Immunol 1983; 131:2977-82.
2. Rothenberg ME. Eosinophilia. N Engl J Med 1998; 338:1592-600.
3. Erjefalt JS, Greiff L, Andersson M, Adelroth E, Jeffery PK, Persson CG. Degranulation patterns of eosinophil granulocytes as determinants of eosinophil driven disease. Thorax 2001; 56:341-4.
4. Parra A, Sanz ML, Vila L, Prieto I, Dieguez I, Oehling AK. Eosinophil soluble protein levels, eosinophil peroxidase and eosinophil cationic protein in asthmatic patients. J Invest Allergol Clin Immunol 1999; 9:27-34.
5. Carlson MG, Peterson CG, Venge P. Human eosinophil peroxidase: purification and characterization. J Immunol 1985; 134:1875-9.
6. Metso T, Venge P, Haahtela T, Peterson CG, Seveus L. Cell specific markers for eosinophils and neutrophils in sputum and bronchoalveolar lavage fluid of patients with respiratory conditions and healthy subjects. Thorax 2002; 57:449-51.
7. Wu W, Chen Y, Hazen SL. Eosinophil peroxidase nitrates protein tyrosyl residues. Implications for oxidative damage by nitrating intermediates in eosinophilic inflammatory disorders. J Biol Chem 1999; 274:25933-44.
8. Wu W, Chen Y, d'Avignon A, Hazen SL. 3-Bromotyrosine and 3,5-dibromotyrosine are major products of protein oxidation by eosinophil peroxidase: potential markers for eosinophil-dependent tissue injury in vivo. Biochemistry 1999; 38:3538-48.
9. MacPherson JC, Comhair SA, Erzurum SC et al. Eosinophils are a major source of nitric oxide-derived oxidants in asthma: characterization of pathways available to eosinophils for generating reactive nitrogen species. J Immunol 2001; 166:5763-72.
10. Wu W, Samoszuk MK, Comhair SA, Thomassen MJ et al. Eosinophils generate brominating oxidants in allergen-induced asthma. J Clin Invest 2000; 105:1455-63.
11. Erjefalt JS, Greiff L, Andersson M et al. Allergen-induced eosinophil cytolysis is a primary mechanism for granule protein release in human upper airways. Am J Respir Crit Care Med 1999; 160:304-12.
12. Sedgwick JB, Calhoun WJ, Gleich GJ et al. Immediate and late airway response of allergic rhinitis patients to segmental antigen challenge. Characterization of eosinophil and mast cell mediators. Am Rev Respir Dis 1991; 144:1274-81.
13. Sanz ML, Parra A, Prieto I, Dieguez I, Oehling AK. Serum eosinophil peroxidase (EPO) levels in asthmatic patients. Allergy 1997; 52:417-22.
14. Krug N, Napp U, Enander I, Eklund E, Rieger CH, Schauer U. Intracellular expression and serum levels of eosinophil peroxidase and eosinophil cationic protein in asthmatic children. Clin Exp Allergy 1999; 29:1507-15.
15. International Consensus Report on Diagnosis and Treatment of Asthma. Clin Exp Allergy 1992; 22 (Suppl. 1):1-72.
16. Krug N, Erpenbeck VJ, Balke K et al. Cytokine profile of bronchoalveolar lavage-derived CD4(+), CD8(+), and gammadelta T cells in people with asthma after segmental allergen challenge. Am J Respir Cell Mol Biol 2001; 25:125-31.
17. Nielsen LP, Bjerke T, Christensen MB et al. Eosinophil markers in seasonal allergic rhinitis. Intranasal fluticasone propionate inhibits local and systemic increases during the pollen season. Allergy 1998; 53:778-85.
18. Krug N, Thurau AM, Lackie P et al. A flow cytometric method for the detection of intracellular basic protein in unseparated peripheral blood and bone marrow eosinophils. J Immunol Meth 1996; 190:245-54.
19. Bjork A, Venge P, Peterson CG. Measurements of ECP in serum and the impact of plasma coagulation. Allergy 2000; 55:442-8.
20. Fukuda T, Dunnette SL, Reed CE, Ackerman SJ, Peters MS, Gleich GJ. Increased numbers of hypodense eosinophils in the blood of patients with bronchial asthma. Am Rev Respir Dis 1985; 132:981-5.
21. Karawajczyk M, Seveus L, Garcia R et al. Piecemeal degranulation of peripheral blood eosinophils: a study of allergic subjects during and out of the pollen season. Am J Respir Cell Mol Biol 2000; 23:521-9.
22. Khalife J, Capron M, Cesbron JY et al. Role of specific IgE antibodies in peroxidase (EPO) release from human eosinophils. J Immunol 1986; 137:1659-64.
23. Capron M. Eosinophils: receptors and mediators in hypersensitivity. Clin Exp Allergy 1989; 19 (Suppl. 1):3-8.
24. Tomassini M, Tsicopoulos A, Tai PC et al. Release of granule proteins by eosinophils from allergic and nonallergic patients with eosinophilia on immunoglobulin-dependent activation. J Allergy Clin Immunol 1991; 88:365-75.