Characterization of inducible nitric oxide synthase expression in human airway epithelium

Environmental Health Perspectives

Volumn 106, Issue SUPPL. 5, 1998, Pages 1119-1124

  Guo, Fuhua H ^a   Erzurum, Serpil C ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Airway epithelium; Gene expression regulation; Nitric oxide; Nitric oxide synthase; Signal transduction

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; STAT1 PROTEIN; TRANSCRIPTION FACTOR;

BLOOD VESSEL TONE; BRONCHUS TONE; CELL CULTURE; CONFERENCE PAPER; CONTROLLED STUDY; CULTURE MEDIUM; EPITHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; LUNG BLOOD VESSEL; LUNG FLUID; MEDIATOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION;

BRONCHUS;

EID: 0031761402     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.98106s51119     Document Type: Conference Paper

References (35)

1. .NO at work. Cell 78:919-925 (1994).
2. Steuhr DJ, Griffith OW. Mammalian nitric oxide synthases. Adv Enzymol Relat Areas Mol Biol 65:287-346 (1992).
3. Nathan C, Xie Q-W. Regulation of biosynthesis of nitric oxide. J Biol Chem 269:13725-13728 (1994).
4. .NO synthase in human lung. Am J Physiol 266:L722-L727 (1994).
5. Kobzik L, Bredt DS, Lowenstein CJ, Drazen J, Gaston B, Sugarbaker D, Stamler JS. Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am J Respir Cell Mol Biol 9:371-377 (1993).
6. Chao C-C, Park S-H, Aust AE. Participation of nitric oxide and iron in the oxidation of DNA in asbestos-treated human lung epithelial cells. Arch Biochem Biophys 326:152-157 (1996).
7. Barnes PJ. Nitric oxide and airway disease. Ann Med 27:389-393 (1995).
8. Beckman JS, Koppenol WH. Nitric oxide, Superoxide, and peroxynitrite: the good, the bad and the ugly. Am J Physiol 271:C1424-C1437 (1996).
9. Akaike T, Noguchi Y, Ijiri S, Setoguchi K, Suga M, Zheng YM, Dirtzschold B, Maeda H. Pathogenesis of influenza virusinduced pneumonia: involvement of both nitric oxide and oxygen radicals. Proc Natl Acad Sci USA 93:2448-2453 (1996).
10. Pietraforte D, Tritarelli E, Testa U, Minetti M. gp120 HIV envelope glycoprotein increases the production of nitric oxide in human monocyte-derived macrophages. J Leukoc Biol 55:175-182 (1994).
11. Guo FH, De Raeve HR, Rice TW, Steuhr DJ, Thunnissen FBJM, Erzurum SC. Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo. Proc Natl Acad Sci USA 92:7809-7813 (1995).
12. Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, Nakayama DK, Simmons RL, Snyder SH, Billiar TR. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc Natl Acad Sci USA 90:3491-3495 (1993).
13. Charles IG, Palmer MJ, Hickery MS, Bayliss MT, Chubb AP, Hall VS, Moss DW, Moncada S. Cloning, characterization, and expression of a cDNA encoding and inducible nitric oxide synthase from the human chondrocyte. Proc Natl Acad Sci USA 90:11419-11423 (1993).
14. Sherman PA, Laubach VE, Reep BR, Wood ER. Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line. Biochemistry 32:11600-11605 (1993).
15. Maier R, Bilbe G, Rediske J, Lotz M. Inducible nitric oxide synthase from human articular chondrocytes: cDNA cloning and analysis of mRNA expression. Biochem Biophys Acta 1208:145-150 (1994).
16. Janssens SP, Shimouchi A, Quertermous T, Bloch DB, Bloch KD. Cloning and expression of cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J Biol Chem 267:14519-14522 (1992).
17. Robbins RA, Sprineall DR, Warren JB, Kwon OJ, Buttery LDK, Wilson AJ, Adcock IM, Riveros-Moreno V, Moncada S, Polak JM, et al. Inducible nitric oxide synthase is increased in murine lung epithelial cells by cytokine stimulation. Biochem Biophys Res Commun 198(3):835-843 (1994).
18. Asano K, Chee CBE, Gaston B, Lilly C, Gerard C, Drazen JM, Stamler JS. Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc Natl Acad Sci USA 91:10089-10093 (1994).
19. Robbins RA, Barnes PJ, Springall DR, Warren JB, Kwon OJ, Buttery LDK, Wilson AJ, Geller DA, Polak JM. Expression of inducible nitric oxide in human lung epithelial cells. Biochem Biophys Res Commun 203:209-218 (1994).
20. Guo FH, Uetani K, Haque SJ, Williams BRG, Dweik RA, Thunnissen FBJM, Calhoun W, Erzurum SC. Interferon y and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators. J Clin Invest 100 (4):829-835 (1997).
21. De Vera ME, Shapiro RA, Nussler AK, Mudgett JS, Simmons RL, Morris SM Jr, Billiar TR, Geller DA. Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter. Proc Natl Acad Sci USA 93:1054-1059 (1996).
22. Sands WA, Bulut V, Severn A, Xu D, Liew FY. Inhibition of nitric oxide synthesis by interleukin-4 may involve inhibiting the activation of protein kinase C ε. Eur J Immunol 24:2345-2350 (1994).
23. Kolb JP, Paul-Eugene N, Damais C, Yamaoke K, Drapier JC, Dugas B. Interleukin-4 stimulates cGMP production by IFNγ-activated human monocytes. J Biol Chem 269:9811-9816 (1994).
24. Iademarco MF, Barks JL, Dean DC. Regulation of vascular cell adhesion molecule-1 expression by IL-4 and TNF-α in cultured endothelial cells. J Clin Invest 95:264-271 (1995).
25. .NO synthase gene expression in macrophages during activation by interferon-γ and bacterial lipopolysaccharide. J Biol Chem 269:8324-8333 (1994).
26. Haque SJ, Flati V, Deb A, Williams BRG. Roles of proteintyrosine phosphatases in STAT1 alpha-mediated cell signaling. J Biol Chem 270:25709-25714 (1995).
27. .NO synthase induction in macrophages. Science 263:1612-1615 (1994).
28. Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL. An interleukin-4-induced transcription factor: IL-4 STAT. Science 265:1701-1706 (1994).
29. Zhane X, Laubach VE, Alley EW, Edwards KA, Sherman PA, Russell SW, Murphy WJ. Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide/interferon-γ. J Leukoc Biol 59:575-585 (1996).
30. Darnell JE Jr, Kerr IM, Stark GR. JAK-STAT Pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1420 (1994).
31. Look DC, Pelletier MR, Holtzman MJ. Selective interaction of a subset of interferon-gamma response element-binding proteins with the intercellular adhesion molecule-1 (ICAM-1) gene promoter controls the pattern of expression on epithelial cells. J Biol Chem 269:8952-8958 (1994).
32. Williams BRG. Transcriptional regulation of interferon-stimulated genes. Eur J Immunol 200:1-11 (1991).
33. Marshall CJ. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-185 (1995).
34. Hill CS, Treisman R. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 80:199-211 (1995).
35. Schindler C, Darnell JE Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 64:621-651 (1995).