Redox-active Cu(II)-Aβ causes substantial changes in axonal integrity in cultured cortical neurons in an oxidative-stress dependent manner

Experimental Neurology

Volumn 237, Issue 2, 2012, Pages 499-506

  Howells, Claire ^a   Saar, Katrina ^b   Eaton, Emma ^a   Ray, Shannon ^a   Palumaa, Peep ^b   Shabala, Lana ^a   Adlard, Paul A ^c   Bennett, William ^a   West, Adrian K ^a   Guillemin, Gilles J ^d   Chung, Roger S ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

^b TALLINN UNIVERSITY OF TECHNOLOGY   (Estonia)

^c FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

A ; AD; APP; Axon degeneration; Beta amyloid; DIV; MT; Neurodegeneration; Neurotoxicity; Oxidative stress; ROS

Indexed keywords

AMYLOID BETA PROTEIN; COPPER; MICROTUBULE ASSOCIATED PROTEIN 2; POTASSIUM ION;

ANIMAL CELL; ARTICLE; BRAIN CELL; CONTROLLED STUDY; DENDRITE; EMBRYO; LONG TERM EXPOSURE; NERVE CELL CULTURE; NERVE FIBER DEGENERATION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; AXONS; BLOTTING, WESTERN; CELLS, CULTURED; CEREBRAL CORTEX; COPPER; IMMUNOHISTOCHEMISTRY; NEURONS; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, WISTAR;

EID: 84865542064     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.06.002     Document Type: Article

References (27)

1. Adlard P.A., Cherny R.A., Finkelstein D.I., Gautier E., Robb E., Cortes M., Volitakis I., Liu X., Smith J.P., Perez K., Laughton K., Li Q.X., Charman S.A., Nicolazzo J.A., Wilkins S., Deleva K., Lynch T., Kok G., Ritchie C.W., Tanzi R.E., Cappai R., Masters C.L., Barnham K.J., Bush A.I. Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron 2008, 59:43-55.
2. Atwood C.S., Moir R.D., Huang X., Scarpa R.C., Bacarra N.M., Romano D.M., Hartshorn M.A., Tanzi R.E., Bush A.I. Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. J. Biol. Chem. 1998, 273:12817-12826.
3. Atwood C.S., Perry G., Zeng H., Kato Y., Jones W.D., Ling K.Q., Huang X., Moir R.D., Wang D., Sayre L.M., Smith M.A., Chen S.G., Bush A.I. Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta. Biochemistry 2004, 43:560-568.
4. Barnham K.J., Haeffner F., Ciccotosto G.D., Curtain C.C., Tew D., Mavros C., Beyreuther K., Carrington D., Masters C.L., Cherny R.A., Cappai R., Bush A.I. Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid. FASEB J. 2004, 18:1427-1429.
5. Blennow K., de Leon M.J., Zetterberg H. Alzheimer's disease. Lancet 2006, 368:387-403.
6. Bush A.I., Tanzi R.E. Therapeutics for Alzheimer's disease based on the metal hypothesis. Neurotherapeutics 2008, 5:421-432.
7. Butterfield D.A., Castegna A., Lauderback C.M., Drake J. Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death. Neurobiol. Aging 2002, 23:655-664.
8. Butterfield D.A., Reed T., Newman S.F., Sultana R. Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment. Free Radic. Biol. Med. 2007, 43:658-677.
9. Chung R.S., McCormack G.H., King A.E., West A.K., Vickers J.C. Glutamate induces rapid loss of axonal neurofilament proteins from cortical neurons in vitro. Exp. Neurol. 2005, 193:481-488.
10. Chung R.S., Howells C., Eaton E.D., Shabala L., Zovo K., Palumaa P., Sillard R., Woodhouse A., Bennett W.R., Ray S., Vickers J.C., West A.K. The native copper- and zinc-binding protein metallothionein blocks copper-mediated Abeta aggregation and toxicity in rat cortical neurons. PLoS One 2010, 5:e12030.
11. + channel oxidation in mammalian brain. J. Neurosci. 2012, 32(12):4133-4144.
12. Huang X., Cuajungco M.P., Atwood C.S., Hartshorn M.A., Tyndall J.D., Hanson G.R., Stokes K.C., Leopold M., Multhaup G., Goldstein L.E., Scarpa R.C., Saunders A.J., Lim J., Moir R.D., Glabe C., Bowden E.F., Masters C.L., Fairlie D.P., Tanzi R.E., Bush A.I. Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J. Biol. Chem. 1999, 274:37111-37116.
13. Leskovjan A.C., Lanzirotti A., Miller L.M. Amyloid plaques in PSAPP mice bind less metal than plaques in human Alzheimer's disease. Neuroimage 2009, 47:1215-1220.
14. + channel modulators as neuroprotective agents. Life Sci. 2010, 86(21-22):775-780.
15. Liu D., Pitta M., Lee J.H., Ray B., Lahiri D.K., Furukawa K., Mughal M., Jiang H., Villarreal J., Cutler R.G., Greig N.H., Mattson M.P. The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease. J. Alzheimers Dis. 2010, 22(2):443-457.
16. Lovell M.A., Robertson J.D., Teesdale W.J., Campbell J.L., Markesbery W.R. Copper, iron and zinc in Alzheimer's disease senile plaques. J. Neurol. Sci. 1998, 158:47-52.
17. Ma Q., Li Y., Du J., Liu H., Kanazawa K., Nemoto T., Nakanishi H., Zhao Y. Copper binding properties of a tau peptide associated with Alzheimer's disease studied by CD, NMR, and MALDI-TOF MS. Peptides 2006, 27(4):841-849.
18. Markesbery W.R. Oxidative stress hypothesis in Alzheimer's disease. Free Radic. Biol. Med. 1997, 23:134-147.
19. Meloni G., Sonois V., Delaine T., Guilloreau L., Gillet A., Teissie J., Faller P., Vasak M. Metal swap between Zn-7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity. Nat. Chem. Biol. 2008, 4:366-372.
20. (2). J. Biol. Chem. 2002, 277:40302-40308.
21. Praticò D., Uryu K., Leight S., Trojanoswki J.Q., Lee V.M.Y. Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J. Neurosci. 2001, 21:4183-4187.
22. Ritchie C.W., Bush A.I., Mackinnon A., Macfarlane S., Mastwyk M., MacGregor L., Kiers L., Cherny R., Li Q.X., Tammer A., Carrington D., Mavros C., Volitakis I., Xilinas M., Ames D., Davis S., Beyreuther K., Tanzi R.E., Masters C.L. Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch. Neurol. 2003, 60:1685-1691.
23. Selkoe, Podlisny M.B. Deciphering the genetic basis of Alzheimer's disease. Annu. Rev. Genomics Hum. Genet. 2002, 3:67-99.
24. 2+ homeostasis. Mol. Neurodegener. 2010, 5:30.
25. Tougu V., Karafin A., Zovo K., Chung R.S., Howells C., West A.K., Palumaa P. Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-beta (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators. J. Neurochem. 2009, 110:1784-1795.
26. (2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. J. Neurosci. 2010, 30(36):11938-11950.
27. Zhou L.X., Du J.T., Zeng Z.Y., Wu W.H., Zhao Y.F., Kanazawa K., Ishizuka Y., Nemoto T., Nakanishi H., Li Y.M. Copper(II) modulates in vitro aggregation of a tau peptide. Peptides 2007, 28(11):2229-2234.