The native copper- and zinc- binding protein metallothionein blocks copper-mediated aβ aggregation and toxicity in rat cortical neurons

PLoS ONE

Volumn 5, Issue 8, 2010, Pages

  Chung, Roger S ^a   Howells, Claire ^a   Eaton, Emma D ^a   Shabala, Lana ^a   Zovo, Kairit ^b   Palumaa, Peep ^b   Sillard, Rannar ^b   Woodhouse, Adele ^a   Bennett, William R ^a   Ray, Shannon ^a   Vickers, James C ^a   West, Adrian K ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

^b TALLINN UNIVERSITY OF TECHNOLOGY   (Estonia)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; CALCIUM ION; COPPER; METALLOTHIONEIN II; POTASSIUM ION; REACTIVE OXYGEN METABOLITE; ZINC; AMYLOID BETA PROTEIN; DODECYL SULFATE SODIUM; METALLOTHIONEIN; MT2A PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BRAIN CELL; CALCIUM TRANSPORT; CONTROLLED STUDY; HOMEOSTASIS; IN VITRO STUDY; IONIC BALANCE; METAL BINDING; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; POTASSIUM TRANSPORT; PROTEIN AGGREGATION; RAT; AMINO ACID SEQUENCE; ANIMAL; BRAIN CORTEX; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; HUMAN; METABOLISM; MOLECULAR GENETICS; NERVE CELL; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; SOLUBILITY;

RATTUS;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; COPPER; HUMANS; METALLOTHIONEIN; MOLECULAR SEQUENCE DATA; NEURONS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; RATS; SODIUM DODECYL SULFATE; SOLUBILITY; ZINC;

EID: 77957774530     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012030     Document Type: Article

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