Cysteinyl leukotriene receptors

Prostaglandins and Other Lipid Mediators

Volumn 68-69, Issue , 2002, Pages 587-597

  Evans, Jilly F ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cysteinyl leukotriene; Intracellular signaling; Receptors

Indexed keywords

6 (4 CARBOXYPHENYLTHIO) 5 HYDROXY 7,9,11,14 ICOSATETRAENOIC ACID; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; LEUKOTRIENE C4; LEUKOTRIENE D4; LEUKOTRIENE E4; LEUKOTRIENE RECEPTOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MEMBRANE RECEPTOR; MONTELUKAST; POBILUKAST; PRANLUKAST; RECEPTOR SUBTYPE; VERLUKAST; ZAFIRLUKAST;

ADRENAL MEDULLA; ARTICLE; ASTHMA; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; EOSINOPHIL; HEART; HUMAN; INFLAMMATION; LEUKOCYTE; LUNG ALVEOLUS MACROPHAGE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORTHOLOGY; PLACENTA; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SPLEEN; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; CLASSIFICATION; GENETICS; METABOLISM; MOLECULAR GENETICS; PHYLOGENY; REVIEW; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ANIMALS; HUMANS; LEUKOTRIENE C4; LEUKOTRIENE D4; LEUKOTRIENE E4; MOLECULAR SEQUENCE DATA; PHYLOGENY; RECEPTORS, LEUKOTRIENE; SEQUENCE ALIGNMENT;

EID: 0036669868     PISSN: 00906980     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-6980(02)00057-6     Document Type: Article

References (46)

1. Kellaway W., Trewethie E.R. The liberation of a slow reacting smooth-muscle stimulating substance in anaphylaxis. Q. J. Exp. Physiol. 30:1940;121-145.
2. Samuelsson B. Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science. 220:1983;568-575.
3. Dahlen S-E., Hedqvist P., Hammarstrom S., Samuelsson B. Leukotrienes are potent constrictors of human bronchi. Nature. 288:1980;484-486.
4. Weiss J.W., Drazen J.M., Coles N., McFadden E.R.J., Weler P.J., Corey E.J.et al. Bronchoconstrictor effects of leukotriene C in humans. Science. 216:1982;196-198.
5. 4. Proc. Natl. Acad. Sci. U.S.A. 80:1983;1712-1716.
6. Piper P.J. Formation and actions of leukotrienes. Physiol. Rev. 64:1984;744-761.
7. 4 effects on human eosinophil and neutrophil motility in vitro. J. Leukoc. Biol. 55:1994;183-191.
8. 1. Blood 97:3433-40.
9. Coleman R.A., Eglen R.M., Jones R.L., Narumiya S., Shimizu T., Smith W.L.et al. Prostanoid and leukotriene receptors: a progress report from the IUPHAR working parties on classification and nomenclature. Adv. Prostaglandin Thromboxan Leukot. Res. 23:1995;283-285.
10. Lefkowitz R.J., Stadel J.M., Caron M.G. Adenylate cyclase-coupled beta-adrenergic receptors: structure and mechanisms of activation and desensitization. Annu. Rev. Biochem. 52:1983;159-186.
11. Metters K.M. Leukotriene receptors. J. Lipid Mediators Cell Signal. 12:1995;413-427.
12. 4 receptor in guinea-pig lung. Proc. Natl. Acad. Sci. U.S.A. 80:1983;7415-7419.
13. 4 receptor in guinea pig lung membranes: interconversion of agonist-receptor binding affinity states. Mol. Pharmacol. 35:1989;795-802.
14. 4 receptor in guinea pig lung. J. Biol. Chem. 268:1993;6487-6495.
15. 4 binding protein in cellular membranes. J. Biol. Chem. 269:1994;12816-12823.
16. 4 receptor in human lung and guinea-pig lung. Eur. J. Pharmacol. 244:1993;239-250.
17. Suissa S., Dennis R., Ernst P., Sheehy O., Wood-Dauphinee S. Effectiveness of the leukotriene receptor antagonist zafirlukast for mild-moderate asthma. Ann. Int. Med. 126:1997;177-183.
18. Grossman J., Faiferman I., Dubb J.W., Tompsom D.J., Busse W., Bronsky E.et al. Results of the first US double-blind, placebo-controlled multicenter clinical study in asthma with pranlukast, a novel leukotriene receptor antagonist. J. Asthma. 34:1997;321-328.
19. Reiss T.F., Chervinsky P., Dockhorn R.J., Shingo S., Seidenberg B., Edwards T.B. Montelukast, a once-daily leukotriene receptor antagonist in the treatment of chromic asthma: a multicenter, randomized, double-blind trial: Montelukast Clinical Research Study Group. Arch. Int. Med. 158:1998;1213-1220.
20. Crooke S.T., Mattern M., Sarau H.M., Winkler J.D., Balcarek J., Wong A. The signal transduction system of the leukotriene receptor. Trends Pharmacol. Sci. 10:1989;103-107.
21. 4 receptor antagonists. J. Pharmacol. Exp. Ther. 269:1994;891-896.
22. Krell R.D., Aharony D., Buckner C.K., Kusner E.J. Peptide leukotriene receptors and antagonists. Adv. Prostaglandin Thromboxan Leukot. Res. 20:1990;119-126.
23. Gardiner P.J., Abram T.S., Cuthbert N.J. Evidence for two leukotriene receptor types in the guinea-pig isolated ileum. Eur. J. Pharmacol. 182:1990;291-299.
24. Labat C., Ortiz J.L., Norel X., Gorenne I., Verley J., Abram T.S.et al. A second cysteinyl leukotriene receptor in human lung. J. Pharm. Exp. Ther. 263:1992;800-805.
25. Charette L., Jones T.R. Effects of L-serine borate on antagonism of leukotriene C4-induced contractions of guinea pig trachea. Br. J. Pharmacol. 91:1987;179-188.
26. Tudhope S.R., Cuthburt N.J., Abram T.S., Jennings M.A., Maxey R.J., Thompson A.M.et al. BAY u9773, a novel antagonist of cysteinyl leukotrienes with activity against two receptor subtypes. Eur. J. Pharmacol. 264:1994;317-323.
27. Back M., Norel X., Walch L., Gascard J., de Montpreville V., Dahlen S.et al. Prostacyclin modulation of contractions of the human pulmonary artery by cysteinyl-leukotrienes. Eur. J. Pharmacol. 401(3):2000;389-395.
28. 4-induced endothelium-dependent vasomotor relaxation and cGMP. J. Pharmacol. Exp. Ther. 245:1988;47-52.
29. 4 on human isolated saphenous veins. Br. J. Clin. Pharmacol. 34:1992;409-414.
30. + exchanger-mediated response. Am. J. Physiol. 257:1989;C232-C239.
31. 4 on human airway smooth muscle cell proliferation, matrix expression, and contraction in vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists. Am. J. Respir. Cell Mol. Biol. 19:1998;453-461.
32. 1 receptor. Nature. 399:1999;789-793.
33. Sarau H.M., Ames R.S., Chambers J., Ellis C., Elshourbagy N., Foley J.J.et al. Identification, molecular cloning, expression and characterization of a cysteinyl leukotriene receptor. Mol. Pharmacol. 56:1999;657-663.
34. 4 and regulation of vascular and inflammatory responses. Am. J. Pathol. 158:2001;3-9.
35. 1) receptor in normal human lung and peripheral blood leukocytes. Am. J. Respir. Crit. Care. 163:2001;226-233.
36. Thivierge M., Doty M., Johnson J., Stankova J., Rola-Pleszczynski M. IL-5 upregulates the CysLT1 receptor in HL-60 cells differentiated into eosinophils. J. Immunol. 165:2000;5221-5226.
37. Thivierge M., Stankova J., Rola-Pleszczynski M. IL-13 and IL-4 up-regulate cysteinyl leukotriene 1 receptor expression in human monocytes and macrophages. J. Immunol. 167:2001;2855-2860.
38. Mellor E.A., Maekawa A., Austen K.F., Boyce J.A. Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells. Proc. Natl. Acad. Sci. U.S.A. 98:2001;7964-7969.
39. 1 receptor. Eur. J. Biochem. 268:2001;2578-2586.
40. Heise C.E., O'Dowd B.F., Figueora D.J., Sawyer N., Nguyen T., Im D.-S.et al. Characterization of the human cysteinyl leukotriene 2 receptor. J. Biol. Chem. 275:2000;30531-30536.
41. 2 receptor. Biochem. Biophys. Res. Commun. 274:2000;316-322.
42. Nothacker H.P., Wang Z., Zhu Y., Reinscheid R.K., Lin S.H.S., Civelli O. Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. Mol. Pharmacol. 58:2000;1601-1608.
43. Daniels S.E., Bhattacharrya S., James A., Leaves N.I., Young A., Hill M.R.et al. A genome-wide search for quantitative trait loci underlying asthma. Nature. 383:1996;247-250.
44. Kimura K., Noguchi E., Shibasaki M., Arinami T., Yokouchi Y., Takeda K.et al. Linkage and association of atopic asthma to markers on chromosome 13 in the Japanese population. Human Mol. Genet. 8(8):1999;1487-1490.
45. Maekawa A., Kanaoka Y., Lam B.K., Austen K.F. Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing. Proc. Natl. Acad. Sci. U.S.A. 98:2001;2256-2261.
46. Hui Y, Yang G, Galczenski H, Figueroa DJ, Austin CP, Copeland NG, et al. The murine cysteinyl leukotriene 2 (CysLT2) receptor, cDNA and genomic cloning, alternative splicing, and in vitro characterization. J Biol Chem 2001:276(50):47489-95.