A role for the 2′ OH of peptidyl-tRNA substrate in peptide release on the ribosome revealed through RF-mediated rescue

Chemistry and Biology

Volumn 19, Issue 8, 2012, Pages 983-993

  Shaw, Jeffrey J ^a   Trobro, Stefan ^b   He, Shan L ^a   Qvist, Johan ^b   Green, Rachel ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINE; HYDROXYL GROUP; PEPTIDE DERIVATIVE; TRANSFER RNA; AMINOACYL TRANSFER RNA; HYDROXIDE; PEPTIDE; SOLVENT; TRANSLATION TERMINATION FACTOR; TRNA, PEPTIDYL; TRNA, PEPTIDYL-;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; HYDROGEN BOND; NONHUMAN; PEPTIDE ANALYSIS; RIBOSOME; RNA ANALYSIS; RNA STRUCTURE; STOP CODON; BIOCATALYSIS; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; GENETICS; METABOLISM; MOLECULAR DYNAMICS; PH;

AMINO ACID SUBSTITUTION; BIOCATALYSIS; CATALYTIC DOMAIN; CODON, TERMINATOR; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; HYDROXIDES; MOLECULAR DYNAMICS SIMULATION; PEPTIDE TERMINATION FACTORS; PEPTIDES; RIBOSOMES; RNA, TRANSFER, AMINO ACYL; SOLVENTS; SUBSTRATE SPECIFICITY;

EID: 84865501655     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2012.06.011     Document Type: Article

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