Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome

Molecular Cell

Volumn 10, Issue 2, 2002, Pages 339-346

  Katunin, Vladimir I ^a   Muth, Gregory W ^b   Strobel, Scott A ^b   Wintermeyer, Wolfgang ^c   Rodnina, Marina V ^c  

^a PETERSBURG NUCLEAR PHYSICS INSTITUTE   (Russian Federation)

^b YALE UNIVERSITY   (United States)

^c UNIVERSITY OF WITTEN HERDECKE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACID; BASE; PEPTIDE DERIVATIVE; PEPTIDYLTRANSFERASE; PUROMYCIN; RNA;

ARTICLE; CATALYSIS; CONFORMATION; CRYSTAL STRUCTURE; ENZYME MECHANISM; GENE MUTATION; KINETICS; PH; PROTON TRANSPORT; RIBOSOME; RIBOSOME SUBUNIT;

EID: 0036671344     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(02)00566-X     Document Type: Article

References (29)

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3. Solution structure of loop A from the hairpin ribozyme from tobacco ringspot virus satellite
4. Ribosomal protein L2 is involved in the association of the ribosomal subunits, tRNA binding to A and P sites and peptidyl transfer
5. Ribosome-catalyzed ester formation
6. The peptidyl transferase center
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8. Transition-state properties in acyl and methyl transfer
9. A one pot procedure for the synthesis of alpha-hydroxyamides from the corresponding alpha-hydroxyacids
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12. The peptidyltransferase center of ribosomes
13. Ribosome-catalyzed peptide-bond formation
14. Ribosome-catalyzed peptidyl transfer. Effects of cations and pH value
15. A single adenosine with a neutral pKa in the ribosomal peptidyl transferase center
16. PH-dependent conformational flexibility within the ribosomal peptidyl transferase center
17. Molecular mechanisms of the ribosomal peptidyltransferase center
18. The structural basis of ribosome activity in peptide bond synthesis
19. Unusual resistance of peptidyl transferase to protein extraction procedures
20. Complete kinetic mechanism of elongation factor Tu-dependent binding of aminoacyl-tRNA to the A site of the E. coli ribosome
21. Peptidyl-puromycin synthesis on polyribosomes from Escherichia coli
22. Ribosomal peptidyl transferase can withstand mutations at the putative catalytic nucleotide
23. GTP consumption of elongation factor Tu during translation of heteropolymeric mRNAs
24. A base pair between tRNA and 23S rRNA in the peptidyl transferase centre of the ribosome
25. Analysis of mutations at residues A2451 and G2447 of 23S rRNA in the peptidyltransferase active site of the 50S ribosomal subunit
26. The formation of dipeptides from amino acids and the 2′(3′)-glycyl ester of an adenylate
27. PKa of adenine 2451 in the ribosomal peptidyl transferase center remains elusive