-
1
-
-
0026639881
-
Unusual resistance of peptidyl transferase to protein extraction procedures
-
Noller, H.F., Hoffarth, V. & Zimniak, L. Unusual resistance of peptidyl transferase to protein extraction procedures. Science 256, 1416-1419 (1992).
-
(1992)
Science
, vol.256
, pp. 1416-1419
-
-
Noller, H.F.1
Hoffarth, V.2
Zimniak, L.3
-
2
-
-
0034637111
-
The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution
-
Ban, N., Nissen, P., Hansen, J., Moore, P.B. & Steitz, T.A. The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution. Science 289, 905-920 (2000).
-
(2000)
Science
, vol.289
, pp. 905-920
-
-
Ban, N.1
Nissen, P.2
Hansen, J.3
Moore, P.B.4
Steitz, T.A.5
-
3
-
-
0034637161
-
The structural basis of ribosome activity in peptide bond synthesis
-
Nissen, P., Hansen, J., Ban, N., Moore, P.B. & Steitz, T.A. The structural basis of ribosome activity in peptide bond synthesis. Science 289, 920-930 (2000).
-
(2000)
Science
, vol.289
, pp. 920-930
-
-
Nissen, P.1
Hansen, J.2
Ban, N.3
Moore, P.B.4
Steitz, T.A.5
-
4
-
-
0035977093
-
High resolution structure of the large ribosomal subunit from a mesophilic eubacterium
-
Harms, J. et al. High resolution structure of the large ribosomal subunit from a mesophilic eubacterium. Cell 107, 679-688 (2001).
-
(2001)
Cell
, vol.107
, pp. 679-688
-
-
Harms, J.1
-
5
-
-
0016405364
-
The mechanism of the aminolysis of acetate esters
-
Satterthwait, A.C. & Jencks, W.P. The mechanism of the aminolysis of acetate esters. J. Am. Chem. Soc. 96, 7018-7031 (1974).
-
(1974)
J. Am. Chem. Soc.
, vol.96
, pp. 7018-7031
-
-
Satterthwait, A.C.1
Jencks, W.P.2
-
6
-
-
0347763707
-
Catalytic roles for proton transfer and protonation in ribozymes
-
Bevilacqua, P.C., Brown, T.S., Nakano, S. & Yajima, R. Catalytic roles for proton transfer and protonation in ribozymes. Biopolymers 73, 90-109 (2004).
-
(2004)
Biopolymers
, vol.73
, pp. 90-109
-
-
Bevilacqua, P.C.1
Brown, T.S.2
Nakano, S.3
Yajima, R.4
-
7
-
-
0034757629
-
pH-dependent conformational flexibility within the ribosomal peptidyl transferase center
-
Muth, G.W., Chen, L., Kosek, A.B. & Strobel, S.A. pH-dependent conformational flexibility within the ribosomal peptidyl transferase center. RNA 7, 1403-1415 (2001).
-
(2001)
RNA
, vol.7
, pp. 1403-1415
-
-
Muth, G.W.1
Chen, L.2
Kosek, A.B.3
Strobel, S.A.4
-
9
-
-
0001349638
-
Molecular mechanisms of the ribosomal peptidyltransferase center
-
Nierhaus, K.H., Schulze, H. & Cooperman, B.S. Molecular mechanisms of the ribosomal peptidyltransferase center. Biochem. Int. 1, 185-192 (1980).
-
(1980)
Biochem. Int.
, vol.1
, pp. 185-192
-
-
Nierhaus, K.H.1
Schulze, H.2
Cooperman, B.S.3
-
10
-
-
27644557445
-
Structural insights into the roles of water and the 2′ hydroxyl of the P site tRNA in the peptidyl transferase reaction
-
Schmeing, T.M., Huang, K.S., Kitchen, D.E., Strobel, S.A. & Steitz, T.A. Structural insights into the roles of water and the 2′ hydroxyl of the P site tRNA in the peptidyl transferase reaction. Mol. Cell 20, 437-448 (2005).
-
(2005)
Mol. Cell
, vol.20
, pp. 437-448
-
-
Schmeing, T.M.1
Huang, K.S.2
Kitchen, D.E.3
Strobel, S.A.4
Steitz, T.A.5
-
11
-
-
23944472625
-
What are the roles of substrate-assisted catalysis and proximity effects in peptide bond formation by the ribosome?
-
Sharma, P.K., Xiang, Y., Kato, M. & Warshel, A. What are the roles of substrate-assisted catalysis and proximity effects in peptide bond formation by the ribosome? Biochemistry 44, 11307-11314 (2005).
-
(2005)
Biochemistry
, vol.44
, pp. 11307-11314
-
-
Sharma, P.K.1
Xiang, Y.2
Kato, M.3
Warshel, A.4
-
12
-
-
24644461086
-
Mechanism of peptide bond synthesis on the ribosome
-
Trobro, S. & Aqvist, J. Mechanism of peptide bond synthesis on the ribosome. Proc. Natl. Acad. Sci. USA 102, 12395-12400 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 12395-12400
-
-
Trobro, S.1
Aqvist, J.2
-
13
-
-
14844352639
-
Kinetic isotope effect analysis of the ribosomal peptidyl transferase reaction
-
Seila, A.C., Okuda, K., Nunez, S., Seila, A.F. & Strobel, S.A. Kinetic isotope effect analysis of the ribosomal peptidyl transferase reaction. Biochemistry 44, 4018-4027 (2005).
-
(2005)
Biochemistry
, vol.44
, pp. 4018-4027
-
-
Seila, A.C.1
Okuda, K.2
Nunez, S.3
Seila, A.F.4
Strobel, S.A.5
-
14
-
-
2542564300
-
The ribosome as an entropy trap
-
Sievers, A., Beringer, M., Rodnina, M.V. & Wolfenden, R. The ribosome as an entropy trap. Proc. Natl. Acad. Sci. USA 101, 7897-7901 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 7897-7901
-
-
Sievers, A.1
Beringer, M.2
Rodnina, M.V.3
Wolfenden, R.4
-
15
-
-
0037015037
-
Structural insights into peptide bond formation
-
Hansen, J.L., Schmeing, T.M., Moore, P.B. & Steitz, T.A. Structural insights into peptide bond formation. Proc. Natl. Acad. Sci. USA 99, 11670-11675 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 11670-11675
-
-
Hansen, J.L.1
Schmeing, T.M.2
Moore, P.B.3
Steitz, T.A.4
-
16
-
-
0035805213
-
Crystal structure of the ribosome at 5.5 Å resolution
-
Yusupov, M.M. et al. Crystal structure of the ribosome at 5.5 Å resolution. Science 292, 883-896 (2001).
-
(2001)
Science
, vol.292
, pp. 883-896
-
-
Yusupov, M.M.1
-
17
-
-
0037249473
-
Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression
-
Bashan, A. et al. Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression. Mol. Cell 11, 91-102 (2003).
-
(2003)
Mol. Cell
, vol.11
, pp. 91-102
-
-
Bashan, A.1
-
18
-
-
0033231562
-
Base-pairing between 23S rRNA and tRNA in the ribosomal A site
-
Kim, D.F. & Green, R. Base-pairing between 23S rRNA and tRNA in the ribosomal A site. Mol. Cell 4, 859-864 (1999).
-
(1999)
Mol. Cell
, vol.4
, pp. 859-864
-
-
Kim, D.F.1
Green, R.2
-
19
-
-
0032535207
-
Complete kinetic mechanism of elongation factor Tu-dependent binding of aminoacyl-tRNA to the A site of the E.coli ribosome
-
Pape, T., Wintermeyer, W. & Rodnina, M.V. Complete kinetic mechanism of elongation factor Tu-dependent binding of aminoacyl-tRNA to the A site of the E.coli ribosome. EMBO J. 17, 7490-7497 (1998).
-
(1998)
EMBO J.
, vol.17
, pp. 7490-7497
-
-
Pape, T.1
Wintermeyer, W.2
Rodnina, M.V.3
-
20
-
-
0036671344
-
Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome
-
Katunin, V.I., Muth, G.W., Strobel, S.A., Wintermeyer, W. & Rodnina, M.V. Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome. Mol. Cell 10, 339-346 (2002).
-
(2002)
Mol. Cell
, vol.10
, pp. 339-346
-
-
Katunin, V.I.1
Muth, G.W.2
Strobel, S.A.3
Wintermeyer, W.4
Rodnina, M.V.5
-
21
-
-
2542470615
-
The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release
-
Youngman, E.M., Brunelle, J.L., Kochaniak, A.B. & Green, R. The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release. Cell 117, 589-599 (2004).
-
(2004)
Cell
, vol.117
, pp. 589-599
-
-
Youngman, E.M.1
Brunelle, J.L.2
Kochaniak, A.B.3
Green, R.4
-
22
-
-
0141586316
-
The mechanism of hydrolysis of amino acyl RNA
-
Wolfenden, R. The mechanism of hydrolysis of amino acyl RNA. Biochemistry 338, 1090-1092 (1963).
-
(1963)
Biochemistry
, vol.338
, pp. 1090-1092
-
-
Wolfenden, R.1
-
23
-
-
0015212268
-
Synthesis by ribosomes of viral coat protein containing ester linkages
-
Fahnestock, S. & Rich, A. Synthesis by ribosomes of viral coat protein containing ester linkages. Nat. New Biol. 229, 8-10 (1971).
-
(1971)
Nat. New Biol.
, vol.229
, pp. 8-10
-
-
Fahnestock, S.1
Rich, A.2
-
24
-
-
0014938163
-
Ribosome-catalyzed ester formation
-
Fahnestock, S., Neumann, H., Shashoua, V. & Rich, A. Ribosome-catalyzed ester formation. Biochemistry 9, 2477-2483 (1970).
-
(1970)
Biochemistry
, vol.9
, pp. 2477-2483
-
-
Fahnestock, S.1
Neumann, H.2
Shashoua, V.3
Rich, A.4
-
25
-
-
28544452248
-
An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA
-
Schmeing, T.M., Huang, K.S., Strobel, S.A. & Steitz, T.A. An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA. Nature 438, 520-524 (2005).
-
(2005)
Nature
, vol.438
, pp. 520-524
-
-
Schmeing, T.M.1
Huang, K.S.2
Strobel, S.A.3
Steitz, T.A.4
-
26
-
-
0020646897
-
Phe with Escherichia coli elongation factor Tu
-
Phe with Escherichia coli elongation factor Tu. FEBS Lett. 151, 143-147 (1983).
-
(1983)
FEBS Lett.
, vol.151
, pp. 143-147
-
-
Derwenskus, K.H.1
Sprinzl, M.2
-
27
-
-
0024458904
-
Intermediate states in the movement of transfer RNA in the ribosome
-
Moazed, D. & Noller, H.F. Intermediate states in the movement of transfer RNA in the ribosome. Nature 342, 142-148 (1989).
-
(1989)
Nature
, vol.342
, pp. 142-148
-
-
Moazed, D.1
Noller, H.F.2
-
28
-
-
0037418547
-
Mechanistic considerations for general acid-base catalysis by RNA: Revisiting the mechanism of the hairpin ribozyme
-
Bevilacqua, P.C. Mechanistic considerations for general acid-base catalysis by RNA: revisiting the mechanism of the hairpin ribozyme. Biochemistry 42, 2259-2265 (2003).
-
(2003)
Biochemistry
, vol.42
, pp. 2259-2265
-
-
Bevilacqua, P.C.1
-
30
-
-
17844385296
-
a of the ribosomal peptidyl transferase reaction utilizing a fluorinated puromycin derivative
-
a of the ribosomal peptidyl transferase reaction utilizing a fluorinated puromycin derivative. Biochemistry 44, 6675-6684 (2005).
-
(2005)
Biochemistry
, vol.44
, pp. 6675-6684
-
-
Okuda, K.1
Seila, A.C.2
Strobel, S.A.3
-
31
-
-
0034637102
-
A single adenosine with a neutral pKa in the ribosomal peptidyl transferase center
-
Muth, G.W., Ortoleva-Donnelly, L. & Strobel, S.A. A single adenosine with a neutral pKa in the ribosomal peptidyl transferase center. Science 289, 947-950 (2000).
-
(2000)
Science
, vol.289
, pp. 947-950
-
-
Muth, G.W.1
Ortoleva-Donnelly, L.2
Strobel, S.A.3
-
32
-
-
0034768574
-
pKa of adenine 2451 in the ribosomal peptidyl transferase center remains elusive
-
Xiong, L., Polacek, N., Sander, P., Bottger, E.C. & Mankin, A. pKa of adenine 2451 in the ribosomal peptidyl transferase center remains elusive. RNA 7, 1365-1369 (2001).
-
(2001)
RNA
, vol.7
, pp. 1365-1369
-
-
Xiong, L.1
Polacek, N.2
Sander, P.3
Bottger, E.C.4
Mankin, A.5
-
33
-
-
0035964256
-
A conformational change in the ribosomal peptidyl transferase center upon active/inactive transition
-
Bayfield, M.A., Dahlberg, A.E., Schulmeister, U., Dorner, S. & Barta, A. A conformational change in the ribosomal peptidyl transferase center upon active/inactive transition. Proc. Natl. Acad. Sci. USA 98, 10096-10101 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10096-10101
-
-
Bayfield, M.A.1
Dahlberg, A.E.2
Schulmeister, U.3
Dorner, S.4
Barta, A.5
-
34
-
-
29844448116
-
The interaction between C75 of tRNA and the A loop of the ribosome stimulates peptidyl transferase activity
-
Brunelle, J.L., Youngman, E.M., Sharma, D. & Green, R. The interaction between C75 of tRNA and the A loop of the ribosome stimulates peptidyl transferase activity. RNA 12, 33-39 (2006).
-
(2006)
RNA
, vol.12
, pp. 33-39
-
-
Brunelle, J.L.1
Youngman, E.M.2
Sharma, D.3
Green, R.4
-
35
-
-
3142727548
-
Exploration of the conserved A+C wobble pair within the ribosomal peptidyl transferase center using affinity purified mutant ribosomes
-
Hesslein, A.E. et al. Exploration of the conserved A+C wobble pair within the ribosomal peptidyl transferase center using affinity purified mutant ribosomes. Nucleic Acids Res. 32, 3760-3770 (2004).
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 3760-3770
-
-
Hesslein, A.E.1
-
36
-
-
27744500865
-
Essential mechanisms in the catalysis of peptide bond formation on the ribosome
-
Beringer, M. et al. Essential mechanisms in the catalysis of peptide bond formation on the ribosome. J. Biol. Chem. 280, 36065-36072 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 36065-36072
-
-
Beringer, M.1
-
37
-
-
7544220590
-
Substrate-assisted catalysis of peptide bond formation by the ribosome
-
Weinger, J.S., Parnell, K.M., Dorner, S., Green, R. & Strobel, S.A. Substrate-assisted catalysis of peptide bond formation by the ribosome. Nat. Struct. Mol. Biol. 11, 1101-1106 (2004).
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 1101-1106
-
-
Weinger, J.S.1
Parnell, K.M.2
Dorner, S.3
Green, R.4
Strobel, S.A.5
-
38
-
-
0033592361
-
A possible mechanism of peptide bond formation on ribosome without mediation of peptidyl transferase
-
Das, G.K., Bhattacharyya, D. & Burma, D.P. A possible mechanism of peptide bond formation on ribosome without mediation of peptidyl transferase. J. Theor. Biol. 200, 193-205 (1999).
-
(1999)
J. Theor. Biol.
, vol.200
, pp. 193-205
-
-
Das, G.K.1
Bhattacharyya, D.2
Burma, D.P.3
-
39
-
-
0028918401
-
A proficient enzyme
-
Radzicka, A. & Wolfenden, R. A proficient enzyme. Science 267, 90-93 (1995).
-
(1995)
Science
, vol.267
, pp. 90-93
-
-
Radzicka, A.1
Wolfenden, R.2
-
40
-
-
0034923932
-
Fidelity of aminoacyl-tRNA selection on the ribosome: Kinetic and structural mechanisms
-
Rodnina, M.V. & Wintermeyer, W. Fidelity of aminoacyl-tRNA selection on the ribosome: kinetic and structural mechanisms. Annu. Rev. Biochem. 70, 415-435 (2001).
-
(2001)
Annu. Rev. Biochem.
, vol.70
, pp. 415-435
-
-
Rodnina, M.V.1
Wintermeyer, W.2
-
41
-
-
0028941626
-
GTP consumption of elongation factor Tu during translation of heteropolymeric mRNAs
-
Rodnina, M.V. & Wintermeyer, W. GTP consumption of elongation factor Tu during translation of heteropolymeric mRNAs. Proc. Natl. Acad. Sci. USA 92, 1945-1949 (1995).
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 1945-1949
-
-
Rodnina, M.V.1
Wintermeyer, W.2
-
42
-
-
0033578321
-
Thiostrepton inhibits turnover but not GTP hydrolysis by elongation factor G on the ribosome
-
Rodnina, M.V. et al. Thiostrepton inhibits turnover but not GTP hydrolysis by elongation factor G on the ribosome. Proc. Natl. Acad. Sci. USA 96, 9586-9590 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 9586-9590
-
-
Rodnina, M.V.1
-
43
-
-
0019972595
-
Distance moved by transfer RNA during translocation from the A site to the P site on the ribosome
-
Johnson, A.E., Adkins, H.J., Matthews, E.A. & Cantor, C.R. Distance moved by transfer RNA during translocation from the A site to the P site on the ribosome. J. Mol. Biol. 156, 113-140 (1982).
-
(1982)
J. Mol. Biol.
, vol.156
, pp. 113-140
-
-
Johnson, A.E.1
Adkins, H.J.2
Matthews, E.A.3
Cantor, C.R.4
-
44
-
-
0016010634
-
Assay of ester and polyester formation by the ribosomal peptidyltransferase
-
Fahnestock, S., Neumann, H. & Rich, A. Assay of ester and polyester formation by the ribosomal peptidyltransferase. Methods Enzymol. 30, 489-497 (1974).
-
(1974)
Methods Enzymol.
, vol.30
, pp. 489-497
-
-
Fahnestock, S.1
Neumann, H.2
Rich, A.3
-
45
-
-
0024241761
-
Structural analysis of RNA using chemical and enzymatic probing monitored by primer extension
-
Stern, S., Moazed, D. & Noller, H.F. Structural analysis of RNA using chemical and enzymatic probing monitored by primer extension. Methods Enzymol. 164, 481-489 (1988).
-
(1988)
Methods Enzymol.
, vol.164
, pp. 481-489
-
-
Stern, S.1
Moazed, D.2
Noller, H.F.3
|