Enhancing team-sport athlete performance: Is altitude training relevant?

Sports Medicine

Volumn 42, Issue 9, 2012, Pages 751-767

  Billaut, Franois ^a   Gore, Christopher J ^b,c   Aughey, Robert J ^a,d  

^a VICTORIA UNIVERSITY   (Australia)

^b AUSTRALIAN INSTITUTE OF SPORT   (Australia)

^c FLINDERS UNIVERSITY   (Australia)

^d WESTERN BULLDOGS FOOTBALL CLUB   (Australia)

Author keywords

Altitude; Exercise; Hypoxia; Running; Sports; Sports medicine; Training.

Indexed keywords

ACCLIMATIZATION; ALTITUDE; ATHLETE; ATHLETIC PERFORMANCE; ENDURANCE; HUMAN; MUSCLE FATIGUE; OXYGEN CONSUMPTION; PHYSIOLOGY; REVIEW; RUNNING; SKELETAL MUSCLE; SPORT;

ACCLIMATIZATION; ALTITUDE; ATHLETES; ATHLETIC PERFORMANCE; HUMANS; MUSCLE FATIGUE; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; PHYSICAL ENDURANCE; RUNNING; SPORTS;

EID: 84865475398     PISSN: 01121642     EISSN: 11792035     Source Type: Journal    
DOI: 10.2165/11634050-000000000-00000     Document Type: Review

References (170)

1. Farrow D, Pyne DB, Gabbett T. Skill and physiological demands of open and closed training drills in Australian football. In J Sports Sci Coach 2008; 3 (4): 489-99
2. Young W, Russell A, Burge P, et al. The use of sprint tests for assessment of speed qualities of elite Australian rules footballers.Int J Sports Physiol Perform 2008; 3 (2): 199-206
3. Young WB. Transfer of strength and power training to sports performance.Int J Sports Physiol Perform 2006; 1 (2): 74-83
4. Aughey RJ. Applications of GPS technologies to field sports.Int J Sports Physiol Perform 2011; 6 (3): 295-310
5. Osgnach C, Poser S, Bernardini R, et al. Energy cost and metabolic power in elite soccer: a new match analysis approach. Med Sci Sports and exercise 2010; 42 (1): 170-8
6. McGuigan MR, Cormack S, Newton RU. Long-term power performance of elite Australian rules football players. J Strength Cond Res 2009; 23 (1): 26-32
7. Portal S, Zadik Z, Rabinowitz J, et al. The effect of HMB supplementation on body composition, fitness, hormonal and inflammatory mediators in elite adolescent volleyball players: a prospective randomized, double-blind, placebocontrolled study.Eur J Appl Physiol 2011; 111 (9): 2261-9
8. Girard O, Mendez-Villanueva A, Bishop D. Repeatedsprint ability. Part I: factors contributing to fatigue. Sports Med 2011; 41 (8): 673-94
9. Spencer M, Bishop D, Dawson B, et al. Physiological and metabolic responses of repeated-sprint activities: specific to field-based team sports. Sports Med 2005; 35 (12): 1025-44 (Pubitemid 41803411)
10. Buchheit M. Repeated-sprint performance in team sport players: associations with measures of aerobic fitness, metabolic control and locomotor function.Int J Sports Med 2011; 32: 1-10
11. Rampinini E, Coutts AJ, Castagna C, et al. Variation in top level soccer match performance.Int J Sports Med 2007; 28 (12): 1018-24 (Pubitemid 350273335)
12. Bishop D, Girard O, Mendez-Villanueva A. Repeatedsprint ability. Part II: recommendations for training. Sports Med 2011; 41 (9): 741-56
13. Buchheit M. Should we be recommending repeated sprints to improve repeated-sprint performance? Sports Med 2012; 42 (2): 169-72
14. Buchheit M, Mendez-Villanueva A, Quod M, et al. Improving acceleration and repeated sprint ability in welltrained adolescent handball players: speed versus sprint interval training.Int J Sports Physiol Perform 2010; 5 (2): 152-64
15. Serpiello FR, McKenna MJ, Stepto NK, et al. Performance and physiological responses to repeated-sprint exercise: a novel multiple-set approach.Eur J Appl Physiol 2011; 111 (4) 669-78
16. Dawson B, Hopkinson R, Appleby B, et al.Comparison of training activities and game demands in the Australian Football League. J Sci Med Sport 2004; 7 (3): 292-301 (Pubitemid 40731862)
17. Ferrari Bravo D, Impellizzeri FM, Rampinini E, et al. Sprint vs.interval training in football.Int J Sports Med 2008; 29 (8): 668-74
18. Buchheit M, Ufland P. Effect of endurance training on performance and muscle reoxygenation rate during repeated-sprint running.Eur J Appl Physiol 2011; 111: 293-301
19. Impellizzeri FM, Marcora SM, Castagna C, et al. Physiological and performance effects of generic versus specific aerobic training in soccer players.Int J Sports Med 2006; 27 (6): 483-92 (Pubitemid 43938530)
20. Bartsch P, Saltin B, Dvorak J. Consensus statement on playing football at different altitude. Scand J Med Sci Sports 2008; 18 Suppl. 1: 96-9
21. Bonetti DL, Hopkins WG. Sea-level exercise performance following adaptation to hypoxia: a meta-analysis. Sports Med 2009; 39 (2): 107-27
22. Millet GP, Roels B, Schmitt L, et al.Combining hypoxic methods for peak performance. SportsMed 2010; 40 (1): 1-25
23. Hamlin MJ, Marshall HC, Hellemans J, et al. Effect of intermittent hypoxic training on 20 km time trial and 30 s anaerobic performance. Scand J Med Sci Sports 2010; 20 (4): 651-61
24. Wood MR, Dowson MN, Hopkins WG. Running performance after adaptation to accutely intermittent hypoxia.Eur J Sport Sci 2006; 6 (3): 163-72
25. Zoll J, Ponsot E, Dufour S, et al. Exercise training in normobaric hypoxia in endurance runners. III: muscular adjustments of selected gene transcripts. J Appl Physiol 2006; 100 (4): 1258-66 (Pubitemid 43671484)
26. Gore CJ, McSharry PE, Hewitt AJ, et al. Preparation for football competition at moderate to high altitude. Scand J Med Sci Sports 2008; 18 Suppl. 1: 85-95
27. Levine BD, Stray-Gundersen J, Mehta RD. Effect of altitude on football performance. Scand J Med Sci Sports 2008; 18 Suppl. 1: 76-84
28. Gore CJ, Little SC, Hahn AG, et al. Reduced performance of male and female athletes at 580m altitude.Eur J Appl Physiol Occup Physiol 1997; 75 (2): 136-43 (Pubitemid 27067481)
29. Wehrlin JP, Hallen J. Linear decrease in VO2max and performance with increasing altitude in endurance athletes.Eur J Appl Physiol 2006; 96 (4): 404-12
30. Gore CJ, Clark SA, Saunders PU. Nonhematological mechanisms of improved sea-level performance after hypoxic exposure. Med Sci Sports Exerc 2007; 39 (9): 1600-9 (Pubitemid 47360985)
31. Vogt M, Hoppeler H. Is hypoxia training good for muscles and exercise performance? Prog Cardiovasc Dis 2010; 52 (6): 525-33
32. Wilber RL. Current trends in altitude training. Sports Med 2001; 31 (4): 249-65 (Pubitemid 32328478)
33. Billaut F. A higher calling, but does altitude training work? The conversation. Melbourne (VIC): The Conversation Media Trust, 2011
34. Billaut F,Bishop D. Muscle fatigue inmales and females during multiple-sprint exercise. SportsMed 2009; 39 (4): 257-78
35. Deutsch MU, Kearney GA, Rehrer NJ. Time-motion analysis of professional rugby union players during match-play. J Sports Sci 2007; 25 (4): 461-72 (Pubitemid 46322846)
36. Aughey RJ. Australian football player work rate: evidence of fatigue and pacing? Int J Sports Physiol Perform 2010; 5 (3): 394-405
37. Bangsbo J, Norregaard L, Thorso F. Activity profile of competition soccer.Can J Sport Sci 1991; 16 (2): 110-6
38. Dawson B, Hopkinson R, Appleby B, et al. Player movement patterns and game activities in the Australian Football League. J Sci Med Sport 2004; 7 (3): 278-91 (Pubitemid 40731861)
39. Rampinini E, Impellizzeri FM, Castagna C, et al. Technical performance during soccer matches of the Italian Series A league: effect of fatigue and competitive level. J Sci Med Sport 2009; 12 (1): 227-33
40. Spencer M, Lawrence S, Rechichi C, et al. Time-motion analysis of elite field hockey, with special reference to repeated-sprint activity. J Sports Sci 2004; 22: 843-50 (Pubitemid 39335160)
41. Bangsbo J. The physiology of soccer: with special reference to intense intermittent exercise. Acta Physiol Scand Suppl 1994; 619: 1-155 (Pubitemid 2079452)
42. Bangsbo J, Mohr M, Krustrup P. Physical and metabolic demands of training and match-play in the elite football player. J Sports Sci 2006; 24 (7): 665-74 (Pubitemid 43675030)
43. Mohr M, Krustrup P, Bangsbo J. Match performance of high-standard soccer players with special reference to development of fatigue. J Sports Sci 2003; 21 (7): 519-28 (Pubitemid 36805772)
44. Aughey RJ. Increased high intensity activity in elite Australian football finals matches.Int J Sport Physiol Perform 2011; 6 (3): 367-79
45. Deutsch MU, Maw GJ, Jenkins D, et al. Heart rate, blood lactate and kinematic data of elite colts (under-19) rugby union players during competition. J Sports Sci 1998; 16 (6): 561-70 (Pubitemid 28420031)
46. Bradley PS, Sheldon W, Wooster B, et al. High-intensity running in English FA Premier League soccer matches. J Sports Sci 2009; 27 (2): 159-68
47. Krustrup P, Mohr M, Steensberg A, et al. Muscle and blood metabolites during a soccer game: implications for sprint performance. Med Sci Sports Exerc 2006; 38 (6): 1165-74 (Pubitemid 43902500)
48. Randers MB, Mujika I, Hewitt A, et al. Application of four different football match analysis systems: a comparative study. J Sports Sci 2010; 28 (2): 171-82
49. Rampinini E, Bosio A, Ferraresi I, et al. Match-related fatigue in soccer players. Med Sci Sports Exerc 2011; 43 (11): 2161-70
50. Varley MC, Aughey RJ. One minute rolling sampling periods: the most sensitive method for identifying transient fatigue in soccer [abstract]. Asics Conference of Science and Medicine in Sport (ACSMS); 2010 Nov 4-6; Port Douglas (QLD). Sports Med Australia 2010; e53
51. Balsom PD, Gaitanos GC, Ekblom B, et al. Reduced oxygen availability during high intensity intermittent exercise impairs performance. Acta Physiol Scand 1994; 152 (3): 279-85 (Pubitemid 24351955)
52. Billaut F, Smith KJ. Prolonged repeated-sprint ability is related to arterial O2 desaturation in man.Int J Sports Physiol Perform 2010; 5: 197-209
53. Smith KJ, Billaut F. Influence of cerebral and muscle oxygenation on repeated-sprint ability.Eur J Appl Physiol 2010; 109: 989-99
54. Billaut F, Buchheit M. Hypoxia lowers muscle reoxygenation during repeated sprints [abstract]. Med Sci Sports Exerc 2011; 43 (5 Suppl. ): 152
55. Hamlin MJ, Hinckson EA, Wood MR, et al. Simulated rugby performance at 1550-m altitude following adaptation to intermittent normobaric hypoxia. J Sci Med Sport 2008; 11 (6): 593-9
56. Weston AR, Mackenzie G, Tufts MA, et al. Optimal time of arrival for performance at moderate altitude (1700 m). Med Sci Sports Exerc 2001; 33 (2): 298-302 (Pubitemid 32142997)
57. Glaister M. Multiple-sprint work: methodological, physiological, and experimental issues.Int J Sports Physiol Perform 2008; 3 (1): 107-12
58. Buchheit M. Performance and physiological responses to repeated-sprint and jump sequences.Eur J Appl Physiol 2010; 110 (5): 1007-18
59. Jougla A, Micallef JP, Mottet D. Effects of active vs. passive recovery on repeated rugby-specific exercises. J Sci Med Sport 2010; 13 (3): 350-5
60. Meckel Y, Gottlieb R, Eliakim A. Repeated sprint tests in young basketball players at different game stages.Eur J Appl Physiol 2009; 107 (3): 273-9
61. Bogdanis GC, Nevill ME, Boobis LH, et al. Contribution of phosphocreatine and aerobic metabolism to energy supply during repeated sprint exercise. J Appl Physiol 1996; 80 (3): 876-84 (Pubitemid 26087253)
62. BogdanisGC,NevillME, Boobis LH, et al. Recovery of power output and muscle metabolites following 30 s of maximal sprint cycling in man. J Physiol 1995; 482 (Pt 2): 467-80
63. Dawson B, Goodman C, Lawrence S, et al. Muscle phosphocreatine repletion following single and repeated short sprint efforts. Scand J Med Sci Sports 1997; 7: 206-13 (Pubitemid 127524121)
64. Gaitanos GC, Williams C, Boobis LH, et al. Human muscle metabolism during intermittent maximal exercise. J Appl Physiol 1993; 75 (2): 712-9 (Pubitemid 23260212)
65. Harris R, Edwards R, Hultman E, et al. The time course of phosphorylcreatine resynthesis during recovery of the quadriceps muscle in man. Pflü gers Arch 1976; 367: 137-42 (Pubitemid 8007530)
66. Sahlin K, Harris R, Hultman E. Resynthesis of creatine phosphate in human muscle after exercise in relation to intramuscular pH and availability of oxygen. Scand J Clin Lab Invest 1979; 39: 551-8 (Pubitemid 10214738)
67. McCully KK, Iotti S, Kendrick K, et al. Simultaneous in vivo measurements of HbO2 saturation and PCr kinetics after exercise in normal humans. J Appl Physiol 1994; 77 (1): 5-10 (Pubitemid 24226107)
68. Buchheit M. Fatigue during Repeated sprints: precision needed. Sports Med 2012; 42 (2): 165-7
69. Bishop D, Edge J, Davis C, et al. Induced metabolic alkalosis affects muscle metabolism and repeated-sprint ability. Med Sci Sports Exerc 2004; 36 (5): 807-13 (Pubitemid 38596385)
70. Edge J, Bishop D, Goodman C. The effects of training intensity on muscle buffer capacity in females.Eur J Appl Physiol 2006; 96 (1): 97-105 (Pubitemid 43013296)
71. Overgaard K, Hojfeldt GW, Nielsen OB. Effects of acidification and increased extracellular potassium on dynamic muscle contractions in isolated rat muscles. J Physiol (Lond) 2010; 588 (Pt 24): 5065-76
72. Pedersen TH, Nielsen OB, Lamb GD, et al.Intracellular acidosis enhances the excitability of working muscle. Science 2004; 305 (5687): 1144-7 (Pubitemid 39100325)
73. Dupont G, Millet GP, Guinhouya C, et al. Relationship between oxygen uptake kinetics and performance in repeated running sprints.Eur J Appl Physiol 2005; 95 (1): 27-34 (Pubitemid 43008893)
74. McGawley K, Bishop D. Anaerobic and aerobic contribution to two, 5 x 6-s repeated-sprint bouts [abstract]. Proceedings of the Verona-Ghirada Team-Sport Conference; 2008 Jun 7-8; Treviso. Sundsvall: Coach Sport Sci J 2008; 3 (2) 52
75. Edge J, Bishop D, Goodman C, et al. Effects of high-and moderate-intensity training on metabolism and repeated sprints. Med Sci Sports Exerc 2005; 37 (11): 1975-82 (Pubitemid 41691842)
76. McMillan K, Helgerud J, Macdonald R, et al. Physiological adaptations to soccer specific endurance training in professional youth soccer players. Br J Sports Med 2005; 39 (5): 273-7 (Pubitemid 40598092)
77. Balsom PD, Ekblom B, Sjodin B. Enhanced oxygen availability during high intensity intermittent exercise decreases anaerobic metabolite concentrations in blood. Acta Physiol Scand 1994; 150 (4): 455-6 (Pubitemid 24231188)
78. Bishop D, Edge J. Determinants of repeated-sprint ability in females matched for single-sprint performance.Eur J Appl Physiol 2006; 97 (4): 373-9 (Pubitemid 43951024)
79. Hamilton A, Nevill M, Brooks S, et al. Physiological responses to maximal intermittent exercise: differences between endurance-trained runners and game players. J Sports Sci 1991; 9: 371-82
80. Tomlin DL, Wenger HA. The relationships between aerobic fitness, power maintenance and oxygen consumption during intense intermittent exercise. J Sci Med Sport 2002; 5 (3): 194-203 (Pubitemid 35190780)
81. Smith KJ, Billaut F. Tissue oxygenation in men and women during repeated-sprint exercise.Int J Sports Physiol Perform 2012; 7 (1): 59-67
82. Billaut F. Electromyography assessment ofmuscle recruitment strategies during high-intensity exercise. In: Mizrahi J, editor. Advances in applied electromyography rijeka. Croatia: In-Tech Open Access Publisher, 2011: 25-40
83. 2max. Sports Med 1993; 16 (1): 14-22 (Pubitemid 23217304)
84. Clark SA, Bourdon PC, Schmidt W, et al. The effect of acute simulated moderate altitude on power, performance and pacing strategies in well-trained cyclists.Eur J Appl Physiol 2007; 102 (1): 45-55 (Pubitemid 350090696)
85. Ekblom B. Applied physiology of soccer. Sports Med 1986; 3 (1): 50-60 (Pubitemid 16190213)
86. Billaut F, Smith K. Sex alters impact of repeated bouts of sprint exercise on neuromuscular activity in trained athletes. Appl Physiol Nutr Metab 2009; 34 (4): 689-99
87. Mendez-Villanueva A, Hamer P, Bishop D. Fatigue responses during repeated sprints matched for initial mechanical output. Med Sci Sports Exerc 2007; 39 (12): 2219-25 (Pubitemid 350211515)
88. Mendez-Villanueva A, Hamer P, Bishop D. Fatigue in repeated-sprint exercise is related to muscle power factors and reduced neuromuscular activity.Eur J Appl Physiol 2008; 103 (4): 411-9
89. Racinais S, Bishop D, Denis R, et al. Muscle deoxygenation and neural drive to the muscle during repeated sprint cycling. Med Sci Sports Exerc 2007; 39 (2): 268-74 (Pubitemid 46204293)
90. Amann M, Kayser B. Nervous system function during exercise in hypoxia. High Alt Med Biol 2009; 10 (2): 149-64
91. Perrey S, Rupp T. Altitude-induced changes in muscle contractile properties. High Alt Med Biol 2009; 10 (2): 175-82
92. Perrey S, Racinais S, Saimouaa K, et al. Neural and muscular adjustments following repeated running sprints.Eur J Appl Physiol 2010; 109 (6): 1027-36
93. Nieber K. Hypoxia and neuronal function under in vitro conditions. Pharmacol Ther 1999; 82 (1): 71-86 (Pubitemid 29134980)
94. Jain V, Langham MC, Wehrli FW. MRI estimation of global brain oxygen consumption rate. J Cereb Blood Flow Metab 2010; 30 (9): 1598-607
95. Amann M, Eldridge MW, Lovering AT, et al. Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humans. J Physiol 2006; 575 (Pt 3): 937-52 (Pubitemid 44323753)
96. Bigland-Ritchie BR, Dawson NJ, Johansson RS, et al. Reflex origin for the slowing of motoneurone firing rates in fatigue of human voluntary contractions. J Physiol 1986; 379: 451-9 (Pubitemid 17175929)
97. Dillon GH, Waldrop TG. In vitro responses of caudal hypothalamic neurons to hypoxia and hypercapnia. Neuroscience 1992; 51 (4): 941-50
98. Dousset E, Decherchi P, Grelot L, et al.Comparison between the effects of chronic and acute hypoxemia on muscle afferent activities from the tibialis anterior muscle. Exp Brain Res 2003; 148 (3): 320-7 (Pubitemid 36216489)
99. Amann M, Romer LM, Subudhi AW, et al. Severity of arterial hypoxaemia affects the relative contributions of peripheral muscle fatigue to exercise performance in healthy humans. J Physiol 2007; 581 (Pt 1): 389-403 (Pubitemid 46712047)
100. Subudhi AW, Dimmen AC, Roach RC. Effects of acute hypoxia on cerebral and muscle oxygenation during incremental exercise. J Appl Physiol 2007; 103 (1): 177-83 (Pubitemid 47092290)
101. Volianitis S, Fabricius-Bjerre A, Overgaard A, et al. The cerebral metabolic ratio is not affected by oxygen availability during maximal exercise in humans. J Physiol 2008; 586 (1): 107-12
102. Hoppeler H, Fluck M. Normal mammalian skeletal muscle and its phenotypic plasticity. J Exp Biol 2002; 205 (Pt 15): 2143-52
103. Hoppeler H, Klossner S, Vogt M. Training in hypoxia and its effects on skeletal muscle tissue. Scand J Med Sci Sports 2008; 18 Suppl. 1: 38-49
104. Hoppeler H, Howald H, Cerretelli P. Human muscle structure after exposure to extreme altitude. Experientia 1990; 46 (11-12): 1185-7
105. MacDougall JD, Green HJ, Sutton JR, et al. Operation Everest II: structural adaptations in skeletal muscle in response to extreme simulated altitude. Acta Physiol Scand 1991; 142 (3): 421-7
106. Levine BD, Stray-Gundersen J. "Living high-training low": effect of moderate-altitude acclimatization with low-altitude training on performance. J Appl Physiol 1997; 83 (1): 102-12 (Pubitemid 27304737)
107. Saunders PU Pyne DB, Gore CJ. Endurance training at altitude. High Alt Med Biol 2009; 10 (2): 135-48
108. Stray-Gundersen J, Levine BD. Live high, train low at natural altitude. Scand J Med Sci Sports 2008; 18 Suppl. 1: 21-8
109. Geiser J, Vogt M, Billeter R, et al. Training high-living low: changes of aerobic performance and muscle structure with training at simulated altitude.Int J Sports Med 2001; 22 (8): 579-85 (Pubitemid 33135114)
110. Julian CG, Gore CJ, Wilber RL, et al.Intermittent normobaric hypoxia does not alter performance or erythropoietic markers in highly trained distance runners. J Appl Physiol 2004; 96 (5): 1800-7 (Pubitemid 38580006)
111. Powell FL, Garcia N. Physiological effects of intermittent hypoxia. High Alt Med Biol 2000; 1 (2): 125-36
112. Tadibi V, Dehnert C, Menold E, et al. Unchanged anaerobic and aerobic performance after short-term intermittent hypoxia. Med Sci Sports Exerc 2007; 39 (5): 858-64 (Pubitemid 46789310)
113. Truijens MJ, Rodriguez FA, Townsend NE, et al. The effect of intermittent hypobaric hypoxic exposure and sea level training on submaximal economy in well-trained swimmers and runners. J Appl Physiol 2008; 104 (2): 328-37 (Pubitemid 351231479)
114. Hahn AG, Gore CJ. The effect of altitude on cycling performance: a challenge to traditional concepts. Sports Med 2001; 31 (7): 533-57 (Pubitemid 32575379)
115. Truijens MJ, Toussaint HM, Dow J, et al. Effect of highintensity hypoxic training on sea-level swimming performances. J Appl Physiol 2003; 94 (2): 733-43 (Pubitemid 36158253)
116. Nummela A, Rusko H. Acclimatization to altitude and normoxic training improve 400-m running performance at sea level. J Sports Sci 2000; 18 (6): 411-9 (Pubitemid 30391944)
117. Roberts AD, Clark SA, Townsend NE, et al. Changes in performance, maximal oxygen uptake and maximal accumulated oxygen deficit after 5, 10 and 15 days of live high: train low altitude exposure.Eur J Appl Physiol 2003; 88 (4-5): 390-5 (Pubitemid 36747990)
118. Juel C, Lundby C, Sander M, et al. Human skeletal muscle and erythrocyte proteins involved in acid-base homeostasis: adaptations to chronic hypoxia. J Physiol 2003; 548 (Pt 2): 639-48
119. Gore CJ, Hahn AG, Aughey RJ, et al. Live high:train low increases muscle buffer capacity and submaximal cycling efficiency. Acta Physiol Scand 2001; 173 (3): 275-86 (Pubitemid 33071044)
120. Basset FA, Joanisse DR, Boivin F, et al. Effects of short-term normobaric hypoxia on haematology, muscle phenotypes and physical performance in highly trained athletes. Exp Physiol 2006; 91 (2): 391-402 (Pubitemid 43356964)
121. Clark SA, Aughey RJ, Gore CJ, et al. Effects of live high, train low hypoxic exposure on lactate metabolism in trained humans. J Appl Physiol 2004; 96 (2): 517-25 (Pubitemid 38140151)
122. Mizuno M, Juel C, Bro-Rasmussen T, et al. Limb skeletal muscle adaptation in athletes after training at altitude. J Appl Physiol 1990; 68 (2): 496-502 (Pubitemid 20088878)
123. Saltin B, Kim CK, Terrados N, et al. Morphology, enzyme activities and buffer capacity in leg muscles of Kenyan and Scandinavian runners. Scand J Med Sci Sports 1995; 5 (4): 222-30
124. Mizuno M, Savard GK, Areskog NH, et al. Skeletal muscle adaptations to prolonged exposure to extreme altitude: a role of physical activity? High Alt Med Biol 2008; 9 (4): 311-7
125. Vogt M, Puntschart A, Geiser J, et al. Molecular adaptations in human skeletal muscle to endurance training under simulated hypoxic conditions. J Appl Physiol 2001; 91 (1): 173-82 (Pubitemid 32574722)
126. Melissa L, MacDougall JD, Tarnopolsky MA, et al. Skeletal muscle adaptations to training under normobaric hypoxic versus normoxic conditions. Med Sci Sports Exerc 1997; 29 (2): 238-43 (Pubitemid 27113520)
127. Hendriksen IJ, Meeuwsen T. The effect of intermittent training in hypobaric hypoxia on sea-level exercise: a cross-over study in humans.Eur J Appl Physiol 2003; 88 (4-5): 396-403 (Pubitemid 36747991)
128. Meeuwsen T, Hendriksen IJ, Holewijn M. Traininginduced increases in sea-level performance are enhanced by acute intermittent hypobaric hypoxia.Eur J Appl Physiol 2001; 84 (4): 283-90 (Pubitemid 32372436)
129. Morton JP, Cable NT. Effects of intermittent hypoxic training on aerobic and anaerobic performance. Ergonomics 2005; 48 (11-14): 1535-46 (Pubitemid 43347823)
130. Hinckson EA, Hamlin MJ, Wood MR, et al. Game performance and intermittent hypoxic training. Br J Sports Med 2007; 41 (8): 537-9 (Pubitemid 47216969)
131. Hamlin MJ, Hellemans J. Effect of intermittent normobaric hypoxic exposure at rest on haematological, physiological, and performance parameters in multi-sport athletes. J Sports Sci 2007; 25 (4): 431-41 (Pubitemid 46322843)
132. Bonetti DL, Hopkins WG, Kilding AE. High-intensity kayak performance after adaptation to intermittent hypoxia.Int J Sports Physiol Perform 2006; 1 (3): 246-60
133. Bakkman L, Sahlin K, Holmberg HC, et al. Quantitative and qualitative adaptation of human skeletal muscle mitochondria to hypoxic compared with normoxic training at the same relative work rate. Acta Physiol (Oxf) 2007; 190 (3): 243-51 (Pubitemid 46934658)
134. Terrados N, Melichna J, Sylven C, et al. Effects of training at simulated altitude on performance and muscle metabolic capacity in competitive road cyclists.Eur J Appl Physiol Occup Physiol 1988; 57 (2): 203-9 (Pubitemid 18048481)
135. Terrados N, Jansson E, Sylven C, et al. Is hypoxia a stimulus for synthesis of oxidative enzymes and myoglobin? J Appl Physiol 1990; 68 (6): 2369-72 (Pubitemid 20212625)
136. Green H, MacDougall J, Tarnopolsky M, et al. Downregulation of Na+K+ATPase pumps in skeletal muscle with training in normobaric hypoxia. J Appl Physiol 1999; 86 (5): 1745-8 (Pubitemid 29230324)
137. Hoppeler H, Vogt M, Weibel ER, et al. Response of skeletal muscle mitochondria to hypoxia. Exp Physiol 2003; 88 (1): 109-19 (Pubitemid 36150064)
138. Roels B, Thomas C, Bentley DJ, et al. Effects of intermittent hypoxic training on amino and fatty acid oxidative combustion in human permeabilized muscle fibers. J Appl Physiol 2007; 102 (1): 79-86 (Pubitemid 46091592)
139. Roels B, Bentley DJ, Coste O, et al. Effects of intermittent hypoxic training on cycling performance in well-trained athletes.Eur J Appl Physiol 2007; 101 (3): 359-68 (Pubitemid 47377540)
140. Dufour SP, Ponsot E, Zoll J, et al. Exercise training in normobaric hypoxia in endurance runners. I: improvement in aerobic performance capacity. J Appl Physiol 2006; 100 (4): 1238-48 (Pubitemid 43671482)
141. Katayama K, Matsuo H, Ishida K, et al.Intermittent hypoxia improves endurance performance and submaximal exercise efficiency. High Alt Med Biol 2003; 4 (3): 291-304 (Pubitemid 37259234)
142. Green HJ, Roy B, Grant S, et al. Increases in submaximal cycling efficiency mediated by altitude acclimatization. J Appl Physiol 2000; 89 (3): 1189-97 (Pubitemid 32125423)
143. Katayama K, Sato K, Matsuo H, et al. Effect of intermittent hypoxia on oxygen uptake during submaximal exercise in endurance athletes.Eur J Appl Physiol 2004; 92 (1-2): 75-83 (Pubitemid 38885864)
144. Marconi C, Marzorati M, Sciuto D, et al. Economy of locomotion in high-altitude Tibetan migrants exposed to normoxia. J. Physiol. (Lond. ) 2005; 569 (Pt 2): 667-75 (Pubitemid 41830130)
145. Saunders PU, Telford RD, Pyne DB, et al. Improved running economy in elite runners after 20 days of simulated moderate-altitude exposure. J Appl Physiol 2004; 96 (3): 931-7 (Pubitemid 38248665)
146. Saunders PU, Telford RD, Pyne DB, et al. Improved running economy and increased hemoglobin mass in elite runners after extended moderate altitude exposure. J Sci Med Sport 2009; 12 (1): 67-72
147. Schmitt L, Millet G, Robach P, et al. Influence of "living high-training low" on aerobic performance and economy of work in elite athletes.Eur J Appl Physiol 2006; 97 (5): 627-36
148. Lundby C, Calbet JA, Sander M, et al. Exercise economy does not change after acclimatization to moderate to very high altitude. Scand J Med Sci Sports 2007; 17 (3): 281-91
149. Siebenmann C, Robach P, Jacobs RA, et al. "Live high-train low" using normobaric hypoxia: a double-blinded, placebocontrolled study. J Appl Physiol 2012; 112 (1): 106-17
150. Schuler B, Thomsen JJ, Gassmann M, et al. Timing the arrival at 2340m altitude for aerobic performance. Scand J Med Sci Sports 2007; 17 (5): 588-94
151. Garvican L, Martin D, Quod M, et al. Time course of the hemoglobin mass response to natural altitude training in elite endurance cyclists. Scand J Med Sci Sports 2012; 22 (1): 95-103
152. Clark SA, Quod MJ, Clark MA, et al. Time course of haemoglobin mass during 21 days live high: train low simulated altitude.Eur J Appl Physiol 2009; 106 (3): 399-406
153. Abellan R, Remacha AF, Ventura R, et al. Hematologic response to four weeks of intermittent hypobaric hypoxia in highly trained athletes. Haematologica 2005; 90 (1): 126-7 (Pubitemid 40193763)
154. Ebert TR, Brothers MD, Nelson JL, et al. Effects of moderate altitude training on total hemoglobin mass and hematology in world class sprint cyclists. Med Sci Sports Exerc 2011; 43 (5 Suppl. ): 284-5
155. Desplanches D, Hoppeler H, Linossier MT, et al. Effects of training in normoxia and normobaric hypoxia on human muscle ultrastructure. Pflugers Arch 1993; 425 (3-4): 263-7 (Pubitemid 23338844)
156. 2max is limited primarily by cardiac output and locomotor muscle blood flow. J Appl Physiol 2006; 100 (2): 745-7; discussion 7-8
157. Hamlin MJ, Marshall HC, Hellemans J, et al. Effect of intermittent hypoxia on muscle and cerebral oxygenation during a 20-km time trial in elite athletes: a preliminary report. Appl Physiol Nutr Metab 2010; 35 (4): 548-59
158. Buchheit M, Cormie P, Abbiss CR, et al. Muscle deoxygenation during repeated sprint running: effect of active vs. passive recovery.Int J Sports Med 2009; 30 (6): 418-25
159. Faulkner JA, Kollias J, Favour CB, et al. Maximum aerobic capacity and running performance at altitude. J Appl Physiol 1968; 24 (5): 685-91
160. Bartsch P, Saltin B. General introduction to altitude adaptation and mountain sickness. Scand J Med Sci Sports 2008; 18 Suppl. 1: 1-10
161. Pyne DB, Mujika I, Reilly T. Peaking for optimal performance: research limitations and future directions. J Sports Sci 2009; 27 (3): 195-202
162. Burtscher M, Gatterer H, Faulhaber M, et al. Effects of intermittent hypoxia on running economy.Int J Sports Med 2010; 31 (9): 644-50
163. Cormack SJ, Newton RU, McGuigan MR, et al. Neuromuscular and endocrine responses of elite players during an Australian rules football season.Int J Sports Physiol Perform 2008; 3 (4): 439-53
164. Mendez-Villanueva A, Buchheit M. Physical capacity-match physical performance relationships in soccer: simply, more complex.Eur J Appl Physiol 2011; 111 (9): 2387-9
165. Chapman RF, Stray-Gundersen J, Levine BD. Individual variation in response to altitude training. J Appl Physiol 1998; 85 (4): 1448-56 (Pubitemid 28465076)
166. Robertson EY, Saunders PU, Pyne DB, et al. Effectiveness of intermittent training in hypoxia combined with live high/train low.Eur J Appl Physiol 2010; 110 (2): 379-87
167. Julian CG, Subudhi AW, Wilson MJ, et al. Acute mountain sickness, inflammation, and permeability: new insights from a blood biomarker study. J Appl Physiol 2011; 111 (2): 392-9
168. Subudhi AW, Dimmen AC, Julian CG, et al. Effects of acetazolamide and dexamethasone on cerebral hemodynamics in hypoxia. J Appl Physiol 2011; 110 (5): 1219-25
169. Buchheit M, Mendez-Villanueva A, Simpson BM, et al. Match running performance and fitness in youth soccer.Int J Sports Med 2010; 31 (11): 818-25
170. Lago C. The influence of match location, quality of opposition, and match status on possession strategies in professional association football. J Sports Sci 2009; 27 (13): 1463-9