Effects of intermittent hypoxic training on amino and fatty acid oxidative combustion in human permeabilized muscle fibers

Journal of Applied Physiology

Volumn 102, Issue 1, 2007, Pages 79-86

  Roels, Belle ^a,b   Thomas, Claire ^c,d   Bentley, David J ^e,f   Mercier, Jacques ^b   Hayot, Maurice ^b   Millet, Grégoire ^a,g  

^a Unite Propre de Rech de l'Enseignement Sup Equipe d'Accueil 3759   (France)

^b BRUNEL UNIVERSITY   (United Kingdom)

^c Laboratory of Interaction Physiology   (France)

^d UNIVERSITÉ D EVRY VAL D ESSONNE   (France)

^e UNIVERSITY OF NEW SOUTH WALES   (Australia)

^f UNIVERSITY OF WESTMINSTER   (United Kingdom)

^g ASPIRE Academy for Sports Excellence   (Qatar)

Author keywords

Aerobic adaptation; Endurance exercise; Hypoxic stress; Muscle biopsy; Substrate preference

Indexed keywords

ADENOSINE DIPHOSPHATE; AMINO ACID; FATTY ACID; GLUTAMIC ACID; MALIC ACID; PALMITIC ACID;

ADULT; ARTICLE; ATHLETE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ENDURANCE; EXERCISE INTENSITY; FATTY ACID OXIDATION; HUMAN; HUMAN EXPERIMENT; HYPOXIA; MALE; MITOCHONDRIAL RESPIRATION; MUSCLE BIOPSY; MUSCLE CELL; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; VASTUS LATERALIS MUSCLE;

3-HYDROXYACYL COA DEHYDROGENASES; ADULT; AMINO ACIDS; ANOXIA; BIOPSY; CELL RESPIRATION; CITRATE (SI)-SYNTHASE; EXERCISE; FATTY ACIDS; GLUTAMIC ACID; HUMANS; MALATES; MALE; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; PHYSICAL ENDURANCE;

EID: 33846264003     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01319.2005     Document Type: Article

References (52)

1. Acevedo EO, Goldfarb AH. Increased training intensity effects on plasma lactate, ventilatory threshold, and endurance. Med Sci Sports Exerc 21: 563-568, 1989.
2. Chen J, Gollnick PD. Effect of exercise on hexokinase distribution and mitochondrial respiration in skeletal muscle. Pflügers Arch 427: 257-263, 1994.
3. Donovan CM, Brooks GA. Endurance training affects lactate clearance, not lactate production. Am J Physiol Endocrinol Metab 244: E83-E92, 1983.
4. Dubouchaud H, Butterfield GE, Wolfel EE, Bergman BC, Brooks GA. Endurance training, expression, and physiology of LDH, MCT1, and MCT4 in human skeletal muscle. Am J Physiol Endocrinol Metab 278: E571-E579, 2000.
5. Dyck DJ, Miskovic D, Code L, Luiken JJFP. Endurance training increases FFA oxidation and reduces triacylglycerol utilization in contracting rat soleus. Am J Physiol Endocrinol Metab 278: E778-E785, 2000.
6. Elder GC, Bradbury K, Roberts R. Variability of fiber type distributions within human muscles. J Appl Physiol 53: 1473-1480, 1982.
7. Erzen I, Pernus F, Sirca A. Muscle fibre types in the human vastus lateralis muscles: do symmetrical sites differ in their composition? Anat Anz 171: 55-63, 1990.
8. Essen B, Jansson E, Henriksson J, Taylor AW, Saltin B. Metabolic characteristics of fibre types in human skeletal muscle. Acta Physiol Scand 95: 153-165, 1975.
9. Fluck M, Hoppeler H. Molecular basis of skeletal muscle plasticity - from gene to form and function. Rev Physiol Biochem Pharmacol 146: 159-216, 2003.
10. Fulco CS, Rock PB, Cymerman A. Improving athletic performance: is altitude residence or altitude training helpful? Aviat Space Environ Med 71: 162-171, 2000.
11. Geiser J, Vogt M, Billeter R, Zuleger C, Belforti F, Hoppeler H. Training high-living low: changes of aerobic performance and muscle structure with training at simulated altitude. Int J Sports Med 22: 579-585, 2001.
12. Gollnick PD, Bertocci LA, Kelso TB, Witt EH, Hodgson DR. The effect of high-intensity exercise on the respiratory capacity of skeletal muscle. Pflügers Arch 415: 407-413, 1990.
13. Gracey AY, Troll JV, Somero GN. Hypoxia-induced gene expression profiling in the euryoxic fish Gillichthys mirabilis. Proc Natl Acad Sci USA 98: 1993-1998, 2001.
14. Green HJ, Sutton JR, Cymerman A, Young PM, Houston CS. Operation Everest II: adaptations in human skeletal muscle. J Appl Physiol 66: 2454-2461, 1989.
15. Hendriksen IJ, Meeuwsen T. The effect of intermittent training in hypobaric hypoxia on sea-level exercise: a cross-over study in humans. Eur J Appl Physiol 88: 396-403, 2003.
16. Holloszy JO, Coyle EF. Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol 56: 831-838, 1984.
17. Hoppeler H, Fluck M. Plasticity of skeletal muscle mitochondria: structure and function. Med Sci Sports Exerc 35: 95-104, 2003.
18. Hoppeler H, Howald H, Conley K, Lindstedt SL, Claassen H, Vock P, Weibel ER. Endurance training in humans: aerobic capacity and structure of skeletal muscle. J Appl Physiol 59: 320-327, 1985.
19. Hoppeler H, Vogt M, Weibel ER, Fluck M. Response of skeletal muscle mitochondria to hypoxia. Exp Physiol 88: 109-119, 2003.
20. Ishihara A, Itoh K, Itoh M, Hirofuji C, Hayashi H. Hypobaric-hypoxic exposure and histochemical responses of soleus muscle fibers in the rat. Acta Histochem 96: 74-80, 1994.
21. Itoh K, Itoh M, Ishihara A, Hirofuji C, Hayashi H. Influence of 12 weeks of hypobaric hypoxia on fibre type composition of the rat soleus muscle. Acta Physiol Scand 154: 417-418, 1995.
22. Jackman MR, Willis WT. Characteristics of mitochondria isolated from type I and type IIb skeletal muscle. Am J Physiol Cell Physiol 270: C673-C678, 1996.
23. Jones S, Passfield L. The Engineering of Sport. The Dynamic Calibration of Bicycle Power Measuring Cranks. Oxford, UK: Blackwell Science, 1998.
24. Julian CG, Gore CJ, Wilber RL, Daniels JT, Fredericson M, Stray-Gundersen J, Hahn AG, Parisotto R, Levine BD. Intermittent normobaric hypoxia does not alter performance or erythropoietic markers in highly trained distance runners. J Appl Physiol 96: 1800-1807, 2004.
25. MacDougall JD, Green HJ, Sutton JR, Coates G, Cymerman A, Young P, Houston CS. Operation Everest II: structural adaptations in skeletal muscle in response to extreme simulated altitude. Acta Physiol Scand 142: 421-427, 1991.
26. Madsen K, Ertbjerg P, Djurhuus MS, Pedersen PK. Calcium content and respiratory control index of skeletal muscle mitochondria during exercise and recovery. Am J Physiol Endocrinol Metab 271: E1044-E1050, 1996.
27. McGuigan MR, Kraemer WJ, Deschenes MR, Gordon SE, Kitaura T, Scheett TP, Sharman MJ, Staron RS. Statistical analysis of fiber area in human skeletal muscle. Can J Appl Physiol 27: 415-422, 2002.
28. Mettauer B, Zoll J, Sanchez H, Lampert E, Ribera F, Veksler V, Bigard X, Mateo P, Epailly E, Lonsdorfer J, Ventura-Clapier R. Oxidative capacity of skeletal muscle in heart failure patients versus sedentary or active control subjects. J Am Coll Cardiol 38: 947-954, 2001.
29. Mizuno M, Juel C, Bro-Rasmussen T, Mygind E, Schibye B, Rasmussen B, Saltin B. Limb skeletal muscle adaptation in athletes after training at altitude. J Appl Physiol 68: 496-502, 1990.
30. Mujika I, Busso T, Lacoste L, Barale F, Geyssant A, Chatard JC. Modeled responses to training and taper in competitive swimmers. Med Sci Sports Exerc 28: 251-258, 1996.
31. Pernus F, Erzen I. Arrangement of fiber types within fascicles of human vastus lateralis muscle. Muscle Nerve 14: 304-309, 1991.
32. Ponsot E, Dufour SP, Zoll J, Doutreleau S, N'Guessan B, Geny B, Hoppeler H, Lampert E, Mettauer B, Ventura-Clapier R, Richard R. Exercise training in normobaric hypoxia in endurance runners. II. Improvement of mitochondrial properties in skeletal muscle. J Appl Physiol 100: 1249-1257, 2006.
33. Roberts AC, Butterfield GE, Cymerman A, Reeves JT, Wolfel EE, Brooks GA. Acclimatization to 4,300-m altitude decreases reliance on fat as a substrate. J Appl Physiol 81: 1762-1771, 1996.
34. Roberts AC, Reeves JT, Butterfield GE, Mazzeo RS, Sutton JR, Wolfel EE, Brooks GA. Altitude and beta-blockade augment glucose utilization during submaximal exercise. J Appl Physiol 80: 605-615, 1996.
35. Roels B, Millet GP, Marcoux CJ, Coste O, Bentley DJ, Candau RB. Effects of hypoxic interval training on cycling performance. Med Sci Sports Exerc 37: 138-146, 2005.
36. Saks VA, Veksler VI, Kuznetsov AV, Kay L, Sikk P, Tiivel T, Tranqui L, Olivares J, Winkler K, Wiedemann F, Kunz WS. Permeabilized cell and skinned fiber techniques in studies of mitochondrial function in vivo. Mol Cell Biochem 184: 81-100, 1998.
37. Schwerzmann K, Hoppeler H, Kayar SR, Weibel ER. Oxidative capacity of muscle and mitochondria: correlation of physiological, biochemical, and morphometric characteristics. Proc Natl Acad Sci USA 86: 1583-1587, 1989.
38. Srere P. Citrate synthase. Methods Enzymol 13: 3-5, 1969.
39. Terjung RL, Baldwin KM, Mole PA, Klinkerfuss GH, Holloszy JO. Effect of running to exhaustion on skeletal muscle mitochondria: a biochemical study. Am J Physiol 223: 549-554, 1972.
40. Terrados N, Jansson E, Sylven C, Kaijser L. Is hypoxia a stimulus for synthesis of oxidative enzymes and myoglobin? J Appl Physiol 68: 2369-2372, 1990.
41. Thomas C, Sirvent P, Perrey S, Raynaud E, Mercier J. Relationships between maximal muscle oxidative capacity and blood lactate removal after supramaximal exercise and fatigue indexes in humans. J Appl Physiol 97: 2132-2138, 2004.
42. Tonkonogi M, Harris B, Sahlin K. Mitochondrial oxidative function in human saponin-skinned muscle fibres: effects of prolonged exercise. J Physiol 510: 279-286, 1998.
43. Truijens MJ, Toussaint HM, Dow J, Levine BD. Effect of high-intensity hypoxic training on sea-level swimming performances. J Appl Physiol 94: 733-743, 2003.
44. Veksler VI, Kuznetsov AV, Sharov VG, Kapelko VI, Saks VA. Mitochondrial respiratory parameters in cardiac tissue: a novel method of assessment by using saponin-skinned fibers. Biochim Biophys Acta 892: 191-196, 1987.
45. Vogt M, Puntschart A, Geiser J, Zuleger C, Billeter R, Hoppeler H. Molecular adaptations in human skeletal muscle to endurance training under simulated hypoxic conditions. J Appl Physiol 91: 173-182, 2001.
46. Walsh B, Tonkonogi M, Sahlin K. Effect of endurance training on oxidative and antioxidative function in human permeabilized muscle fibres. Pflügers Arch 442: 420-425, 2001.
47. Walsh B, Tonkonogi M, Soderlund K, Hultman E, Saks V, Sahlin K. The role of phosphorylcreatine and creatine in the regulation of mitochondrial respiration in human skeletal muscle. J Physiol 537: 971-978, 2001.
48. Wilber RL. Current trends in altitude training. Sports Med 31: 249-265, 2001.
49. Willis WT, Jackman MR. Mitochondrial function during heavy exercise. Med Sci Sports Exerc 26: 1347-1353, 1994.
50. Zammit VA, Newsholme EA. The maximum activities of hexokinase, phosphorylase, phosphofructokinase, glycerol phosphate dehydrogenases, lactate dehydrogenase, octopine dehydrogenase, phosphoenolpyruvate carboxykinase, nucleoside diphosphatekinase, glutamate-oxaloacetate transaminase and arginine kinase in relation to carbohydrate utilization in muscles from marine invertebrates. Biochem J 160: 447-462, 1976.
51. Zoll J, Koulmann N, Bahi L, Ventura-Clapier R, Bigard AX. Quantitative and qualitative adaptation of skeletal muscle mitochondria to increased physical activity. J Cell Physiol 194: 186-193, 2003.
52. Zoll J, Sanchez H, N'Guessan B, Ribera F, Lampert E, Bigard X, Serrurier B, Fortin D, Geny B, Veksler V, Ventura-Clapier R, Mettauer B. Physical activity changes the regulation of mitochondrial respiration in human skeletal muscle. J Physiol 543: 191-200, 2002.