Skeletal muscle adaptations to prolonged exposure to extreme altitude: A role of physical activity?

High Altitude Medicine and Biology

Volumn 9, Issue 4, 2008, Pages 311-317

  Mizuno, Masao ^a   Savard, Gabrielle K ^a   Areskog, Nils Holger ^b   Lundby, Carsten ^a,c   Saltin, Bengt ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b LINKÖPING UNIVERSITY   (Sweden)

^c Rigshospitalet   (Denmark)

Author keywords

Buffer; Enzyme; Hypoxia; Morphology

Indexed keywords

3 HYDROXYL COENZYME A DEHYDROGENASE; CITRATE SYNTHASE; COENZYME A; UNCLASSIFIED DRUG;

ADAPTATION; ADULT; ALTITUDE; ALTITUDE ACCLIMATIZATION; ARTICLE; BICEPS BRACHII MUSCLE; CAPILLARY; CELL SIZE; CONTROLLED STUDY; ENZYME ACTIVITY; EXPOSURE; HUMAN; HUMAN TISSUE; LEG MUSCLE; LONG TERM EXPOSURE; MALE; MITOCHONDRION; MUSCLE BIOPSY; MUSCLE CELL; PHYSICAL ACTIVITY; PRIORITY JOURNAL; QUADRICEPS FEMORIS MUSCLE; SEA LEVEL; SKELETAL MUSCLE;

3-HYDROXYACYL COA DEHYDROGENASES; ACCLIMATIZATION; ADULT; ALTITUDE; BIOPSY; CAPILLARIES; CITRATE (SI)-SYNTHASE; ENVIRONMENTAL MONITORING; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; PHYSICAL ENDURANCE;

EID: 58149236983     PISSN: 15270297     EISSN: None     Source Type: Journal    
DOI: 10.1089/ham.2008.1009     Document Type: Article

References (30)

1. Andersen P. (1975). Capillary density in skeletal muscle in man. Acta. Physiol. Scand. 95:203-205.
2. Brooke, M.H. and Kaiser K.K. (1970). Three "myosin ATPase" systems: the nature of their pH liability and sulphydryl dependence. J. Histocehem. Cytochem. 18:670-672.
3. Butterfield G.E., Gates J., Fleming S., Brooks G.A., Sutton J.R., and Reeves J.T. (1992). Increased energy intake minimizes weight loss in men at high altitude. J. Appl. Physiol. 72:1741-1748.
4. Essén-Gustafsson B. and Henriksson J. (1984). Enzyme levels in pools of microdissected human muscle fibres of identified typ. Adaptive responses to exercise. Acta. Scand. Physiol. 120:505-515.
5. Gore C.J., Hahn A.G., Aughey R.J., Martin D.T., Ashenden M.J., Clark S.A., Garnham A.P., Roberts A.D., Slater G.J., and McKenna M.J. (2001). Live high:train low increases muscle buffer capacity and submaximal cycling efficiency. Acta. Physiol. Scand. 173:275-286.
6. Green H., Roy B., Grant S., Burnett M., Tupling R., Otto C., Pipe A., and McKenzie D. (2000). Downregulation in muscle Na(+)-K(+)-ATPase following a 21-day expedition to 6,194 m. J. Appl. Physiol. 88:634-640.
7. Green H.J., Sutton J.R., Cymerman A., Young P.M., and Houston C.S. (1989). Operation Everest II: adaptations in human skeletal muscle. J. Appl. Physiol. 66:2454-2461.
8. Green H.J., Sutton J.R., Wolfel E.E., Reeves J.T., Butterfield G.E., and Brooks G.A. (1992). Altitude acclimatization and energy metabolic adaptations in skeletal muscle during exercise. J. Appl. Physiol. 73:2701-2708.
9. Hochachka P.W., Buck L.T., Doll C.J., and Land S.C. (1996). Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack. Proc. Natl. Acad. Sci. USA. 93:9493-9498.
10. Hoppeler H., Kleinert E., Schlegel C., Claassen H., Howald H., Kayar S.R., and Cerretelli P. (1990). Morphological adaptations of human skeletal muscle to chronic hypoxia. Int. J. Sports. Med. 11 Suppl 1:S3-S9.
11. Howald H., Pette D., Simoneau J.A., Uber A., Hoppeler H., and Cerretelli P. (1990). Effect of chronic hypoxia on muscle enzyme activities. Int. J. Sports. Med. 11 Suppl 1:S10-S14.
12. Imoberdorf R, Garlick PJ, McNurlan MA, Casella GA, Marini JC, Turgay M, Bartsch P and Ballmer PE. (2006). Skeletal muscle protein synthesis after active or passive ascent to high altitude. Med Sci Sports Exerc 38:1082-1087.
13. Kayser B. (1994). Nutrition and energetics of exercise at altitude. Theory and possible practical implications. Sports. Med. 17:309-323.
14. Kayser B, Narici M, Milesi S, Grassi B and Cerretelli P. (1993). Body composition and maximum alactic anaerobic performance during a one month stay at high altitude. Int J Sports Med 14:244-247.
15. Kayser B., Acheson K., Decombaz J., Fern E., and Cerretelli P. (1992). Protein absorption and energy digestibility at high altitude. J. Appl. Physiol. 73:2425-2431.
16. Krogh A. (1919). The supply of oxygen to the tissue and the regulation of the capillary circulation. J. Physiol. 52:457.
17. Lundby C., Pilegaard H., Andersen J.L., van Hall G., Sander M., and Calbet J.A. (2004). Acclimatization to 4100 m does not change capillary density or mRNA expression of potential angiogenesis regulatory factors in human skeletal muscle. J. Exp. Biol. 207:3865-3871.
18. Lundby C and van Hall G. (2002). Substrate utilization in sea level residents during exercise in acute hypoxia and after 4 weeks of acclimatization to 4100 m. Acta Physiol Scand 176:195-201.
19. MacDougall J.D., Green H.J., Sutton J.R., Coates G., Cymerman A., Young P., and Houston C.S. (1991). Operation Everest II: structural adaptations in skeletal muscle in response to extreme simulated altitude. Acta. Physiol. Scand. 142:421-427.
20. Mizuno M., Juel C., Bro-Rasmussen T., Mygind E., Schibye B., Rasmussen B., and Saltin B. (1990). Limb skeletal muscle adaptation in athletes after training at altitude. J. Appl. Physiol. 68:496-502.
21. Narici M and Kayser B. (1995). Hypertropic response of human skeletal muscle to strenght training in hypoxia and normoxia. Eur J Appl Physiol Occup Physiol 70:213-219.
22. Reynolds RD, Lickteig JA, Howard MP and Deuster PA. (1998). Intakes of high fat and high carbohydrate foods by humans increased with exposure to increasing altitude during an expedition to Mt.Everest. J Nutr 128:50-55.
23. Robach P, Cairo G, Gelfi C, Bernuzzi F, Pilegaard H, Vigano A, Santambrogio P, Cerretelli P, Calbet JAL, Moutereau S and Lundby C. (2007). Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle. Blood 109:4724-4731.
24. Saltin B and Gollnick P. Skeletal muscle adaptability: significance for metabolism and performance. In: Handbook of Physiology, edited by Peachery LD, Adrian RH and Geiger SR. Bethesda: American Physiological Society, 1983, p. 555-631.
25. Saltin B., Kim C.K., Terrados N., Larsen H., Svedenhag J., and Rolf C.J. (1995). Morphology, enzyme activities and buffer capacity in leg muscles of Kenyan and Scandinavian runners. Scand. J. Med. Sci. Sports. 5:222-230.
26. Westerterp KR and Kayser B. (2006). Body mass regulation at altitude. Eur J Gastroenterol Hepatol 18:1-3.
27. Westerterp KR, Kayser B, Brouns F, Herry JP and Saris WH. (1992). Energy expenditure climbing Mt.Everest. J Appl Physiol 73:1815-1819.
28. Westerterp KR, Kayser B, Wouters L, Le Trong JL and Richalet JP. (1994). Energy balance at high altitude of 6,542 m. J Appl Physiol 77:862-866.
29. Westerterp KR, Meijer EP, Rubbens M, Robach P and Richalet JP. (2004). Operation Everest III: energy and water balance. Pflügers Arch 439:483-488.
30. Westerterp-Plantenga MS, Westerterp KR, Rubbins M, Verwegen CRT, Richalet JP and Gardette B. (1999). Appetite at "high altitude" [Operation Everest III (Comes-'97)]: a simulated ascent of Mount Everest. J Appl Physiol 87:391-399.