The effect of HMB supplementation on body composition, fitness, hormonal and inflammatory mediators in elite adolescent volleyball players: A prospective randomized, double-blind, placebo-controlled study

European Journal of Applied Physiology

Volumn 111, Issue 9, 2011, Pages 2261-2269

  Portal, Shawn ^a,b   Zadik, Zvi ^a   Rabinowitz, Jonathan ^c   Pilz Burstein, Ruty ^b   Adler Portal, Dana ^b   Meckel, Yoav ^b   Cooper, Dan M ^d   Eliakim, Alon ^e   Nemet, Dan ^e  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b WINGATE INSTITUTE   (Israel)

^c BAR ILAN UNIVERSITY   (Israel)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e TEL AVIV UNIVERSITY   (Israel)

Author keywords

Athletes; Cytokines; Growth; Supplements; Youth

Indexed keywords

3 HYDROXYISOVALERIC ACID; AUTACOID; BETA-HYDROXYISOVALERIC ACID; HORMONE; PLACEBO; VALERIC ACID DERIVATIVE;

ADOLESCENT; ARTICLE; ATHLETE; BLOOD; BODY COMPOSITION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EXERCISE TEST; FEMALE; FITNESS; HUMAN; MALE; MUSCLE STRENGTH; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; VOLLEYBALL;

ADOLESCENT; ATHLETES; BODY COMPOSITION; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; EXERCISE TEST; FEMALE; HORMONES; HUMANS; INFLAMMATION MEDIATORS; MALE; MUSCLE STRENGTH; PHYSICAL FITNESS; PLACEBOS; VALERATES; VOLLEYBALL;

EID: 80053900683     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-011-1855-x     Document Type: Article

References (27)

1. Bar-Or O (1987) The Wingate anaerobic test. An update on methodology, reliability and validity. Sports Med 4: 381-394
2. Castro-Pinero J, Artero EG, Espana-Romero V, Ortega FB, Sjostrom M, Suni J, Ruiz JR (2009) Criterion-related validity of field-based fitness tests in youth: a systematic review. Br J Sports Med 30(9): 658-662
3. Crawford PB, Obarzanek E, Morrison J, Sabry ZI (1994) Comparative advantage of 3-day food records over 24-hour recall and 5-day food frequency validated by observation of 9- and 10-year-old girls. J Am Diet Assoc 94: 626-630
4. Decombaz J, Bury A, Hager C (2003) HMB meta-analysis and the clustering of data sources. J Appl Physiol 95: 2180-2182
5. Eliakim A, Nemet D, Bar-Sela S, Higer Y, Falk B (2002) Changes in circulating IGF-I and their correlation with self-assessment and fitness among elite athletes. Int J Sports Med 23: 600-603
6. Eliakim A, Nemet D, Cooper DM (2005) Exercise, training and the GH->IGF-I axis. In: Kraemer WJ, Rogol AD (eds) The endocrine system in sports and exercise, 1. Wiley-Blackwell, Oxford, pp 165-179
7. Gallagher PM, Carrithers JA, Godard MP, Schulze KE, Trappe SW (2000) Beta-hydroxy-beta-methylbutyrate ingestion, part I: effects on strength and fat free mass. Med Sci Sports Exerc 32: 2109-2115
8. Godin G, Shephard RJ (1985) A simple method to assess exercise behavior in the community. Can J Appl Sport Sci 10: 141-146
9. Hoffman JR, Cooper J, Wendell M, Im J, Kang J (2004) Effects of beta-hydroxy beta-methylbutyrate on power performance and indices of muscle damage and stress during high-intensity training. J Strength Cond Res 18: 747-752
10. Koziris LP, Hickson RC, Chatterton RT Jr, Groseth RT, Christie JM, Goldflies DG, Unterman TG (1999) Serum levels of total and free IGF-I and IGFBP-3 are increased and maintained in longterm training. J Appl Physiol 86: 1436-1442
11. Kraemer WJ, Hatfield DL, Volek JS, Fragala MS, Vingren JL, Anderson JM, Spiering BA, Thomas GA, Ho JY, Quann EE, Izquierdo M, Hakkinen K, Maresh CM (2009) Effects of amino acids supplement on physiological adaptations to resistance training. Med Sci Sports Exerc 41: 1111-1121
12. Kreider RB, Ferreira M, Wilson M, Almada AL (1999) Effects of calcium beta-hydroxy-beta-methylbutyrate (HMB) supplementation during resistance-training on markers of catabolism, body composition and strength. Int J Sports Med 20: 503-509
13. Lamboley CR, Royer D, Dionne IJ (2007) Effects of beta-hydroxybeta- methylbutyrate on aerobic-performance components and body composition in college students. Int J Sport Nutr Exerc Metab 17: 56-69
14. Molnar GE, Alexander J (1974) Development of quantitative standards for muscle strength in children. Arch Phys Med Rehabil 55: 490-493
15. Nemet D, Eliakim A (2007) Protein and amino acid supplementation in sport. Int SportMed J 8: 11-23
16. Nemet D, Connolly PH, Pontello-Pescatello AM, Rose-Gottron C, Larson JK, Galassetti P, Cooper DM (2004a) Negative energy balance plays a major role in the IGF-I response to exercise training. J Appl Physiol 96: 276-282
17. Nemet D, Pontello AM, Rose-Gottron C, Cooper DM (2004b) Cytokines and growth factors during and after a wrestling season in adolescent boys. Med Sci Sports Exerc 36: 794-800
18. Nemet D, Wolach B, Eliakim A (2005) Proteins and amino acid supplementation in sports: are they truly necessary? Isr Med Assoc J 7: 328-332
19. Nissen S, Sharp R, Ray M, Rathmacher JA, Rice D, Fuller JC Jr, Connelly AS, Abumrad N (1996) Effect of leucine metabolite beta-hydroxy-beta- methylbutyrate on muscle metabolism during resistance-exercise training. J Appl Physiol 81: 2095-2104
20. Rowlands DS, Thomson JS (2009) Effects of beta-hydroxy-betamethylbutyrate supplementation during resistance training on strength, body composition, and muscle damage in trained and untrained young men: a meta-analysis. J Strength Cond Res 23: 836-846
21. Slater GJ, Jenkins D (2000) Beta-hydroxy-beta-methylbutyrate (HMB) supplementation and the promotion of muscle growth and strength. Sports Med 30: 105-116
22. Slaughter MH, Lohman TG, Boileau RA, Horswill CA, Stillman RJ, Van Loan MD, Bemben DA (1988) Skinfold equations for estimation of body fatness in children and youth. Hum Biol 60: 709-723
23. St Clair GA, Broomhead S, Lambert MI, Hawley JA (1998) Prediction of maximal oxygen uptake from a 20-m shuttle run as measured directly in runners and squash players. J Sports Sci 16: 331-335
24. Thomson JS, Watson PE, Rowlands DS (2009) Effects of nine weeks of beta-hydroxy-beta-methylbutyrate supplementation on strength and body composition in resistance trained men. J Strength Cond Res 23: 827-835
25. Vukovich MD, Dreifort GD (2001) Effect of beta-hydroxy betamethylbutyrate on the onset of blood lactate accumulation and V(O)(2) peak in endurance-trained cyclists. J Strength Cond Res 15: 491-497
26. Wilson GJ, Wilson JM, Manninen AH (2008) Effects of betahydroxy-beta- methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: a review. Nutr Metab (Lond) 5: 1
27. Zanchi NE, Gerlinger-Romero F, Guimaraes-Ferreira L, de Siqueira Filho MA, Felitti V, Lira FS, Seelaender M, Lancha AH, Jr (2010) HMB supplementation: clinical and athletic performance-related effects and mechanisms of action. Amino Acids, Epub ahead of print