Time course of haemoglobin mass during 21 days live high:train low simulated altitude

European Journal of Applied Physiology

Volumn 106, Issue 3, 2009, Pages 399-406

  Clark, Sally A ^a   Quod, M J ^a   Clark, M A ^a   Martin, D T ^a   Saunders, P U ^a   Gore, C J ^b  

^a AUSTRALIAN INSTITUTE OF SPORT   (Australia)

^b FLINDERS UNIVERSITY   (Australia)

Author keywords

Haemoglobin mass; Simulated altitude

Indexed keywords

ERYTHROPOIETIN; HEMOGLOBIN;

ADULT; ALTITUDE; ARTICLE; CYCLING; ERYTHROPOIESIS; HEMATOLOGICAL PARAMETERS; HEMOGLOBIN DETERMINATION; HEMOGLOBIN MASS; HUMAN; HUMAN EXPERIMENT; HYPOXIA; MALE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SIMULATION; TIME; TRAINING;

ADOLESCENT; ADULT; ALTITUDE; ANOXIA; BICYCLING; ERYTHROPOIESIS; EXERCISE; HEMOGLOBINS; HUMANS; MALE; OXYGEN; OXYGEN CONSUMPTION; PHYSICAL FITNESS; TIME FACTORS; YOUNG ADULT;

EID: 67349270348     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-009-1027-4     Document Type: Article

References (48)

1. Alfrey CP, Udden MM, Huntoon CL, Driscoll T (1996) Destruction of newly released red blood cells in space flight. Med Sci Sports Exerc 28:S42-S44. doi: 10.1097/00005768-199610000-00032
2. Ashenden MJ, Gore CJ, Dobson GP, Hahn AG (1999a) "Live high, train low" does not change the total haemoglobin mass of male endurance athletes sleeping at a simulated altitude of 3000 m for 23 nights. Eur J Appl Physiol Occup Physiol 80:479-484. doi: 10.1007/s004210050621
3. Ashenden MJ, Gore CJ, Martin DT, Dobson GP, Hahn AG (1999b) Effects of a 12-day "live high, train low" camp on reticulocyte production and haemoglobin mass in elite female road cyclists. Eur J Appl Physiol Occup Physiol 80:472-478. doi: 10.1007/s004210050620
4. Ashenden MJ, Gore CJ, Dobson GP, Boston TT, Parisotto R, Emslie KR, Trout GJ, Hahn AG (2000) Simulated moderate altitude elevates serum erythropoietin but does not increase reticulocyte production in well-trained runners. Eur J Appl Physiol 81:428-435. doi: 10.1007/ s004210050064
5. Brugniaux JV, Schmitt L, Robach P, Nicolet G, Fouillot JP, Moutereau S, Lasne F, Pialoux V, Saas P, Chorvot MC, Cornolo J, Olsen NV, Richalet JP (2006) Eighteen days of "living high, training low" stimulate erythropoiesis and enhance aerobic performance in elite middle-distance runners. J Appl Physiol 100:203-211. doi: 10.1152/japplphysiol.00808.2005
6. Celsing F, Svedenhag J, Pihlstedt P, Ekblom B (1987) Effects of anaemia and stepwise-induced polycythaemia on maximal aerobic power in individuals with high and low haemoglobin concentrations. Acta Physiol Scand 129(1):47-54. doi: 10.1111/j.1748-1716.1987.tb08038.x
7. Chapman RF, Stray-Gundersen J, Levine BD (1988) Individual variation in response to altitude training. J Appl Physiol 85(4):1448-1456
8. Cohen J (1988) Statistical power analysis for the behavioural sciences. Lawrence Erlbaum Associates Incorporation, Hillsdale
9. Dehnert C, Hutler M, Liu Y, Menold E, Netzer C, Schick R, Kubanek B, Lehmann M, Boning D, Steinacker JM (2002) Erythropoiesis and performance after two weeks of living high and training low in well trained triathletes. Int J Sports Med 23:561-566. doi: 10.1055/s-2002-35533
10. Friedmann B, Frese F, Menold E, Kauper F, Jost J, Bärtsch P (2005) Individual variation in the erythropoietic response to altitude training in elite junior swimmers. Br J Sports Med 39(3):148-153. doi: 10.1136/ bjsm.2003.011387
11. Garvican LA, Martin DT, Clark SA, Schmidt W, Gore CJ (2007) Variability of EPO response to sleeping at altitude: A cycling case study. Int J Sports Physiol Perform 2(3):329-333
12. Ge RL, Witkowski S, Zhang Y, Alfrey C, Sivieri M, Karlsen T, Resaland GK, Harber M, Stray-Gundersen J, Levine BD (2002) Determinants of erythropoietin release in response to short-term hypobaric hypoxia. J Appl Physiol 92(6):2361-2367
13. Gore CJ, Hopkins WG (2005) Counterpoint: Positive effects of intermittent hypoxia (live high:tRain low) on exercise performance are not mediated primarily by augmented red cell volume. J Appl Physiol 99(5):2055-2057. doi: 10.1152/japplphysiol.00820.2005
14. 2max and haemoglobin mass of trained athletes during high intensity training. Int J Sports Med 18:477-482. doi: 10.1055/s-2007-972667
15. Gore CJ, Hopkins WG, Burge CM (2005) Errors of measurement for blood volume parameters: A meta-analysis. J Appl Physiol 99(5):1745-1758. doi: 10.1152/japplphysiol.00505.2005
16. Gore CJ, Rodriguez FA, Truijens MJ, Townsend NE, Stray-Gundersen J, Levine BD (2006a) Increased serum erythropoietin but not red cell production after 4 wk of intermittent hypobaric hypoxia (4000-5500 m). J Appl Physiol 101:1386-1393. doi: 10.1152/japplphysiol.00342.2006
17. Gore CJ, Bourdon PC, Woolford SM, Ostler LM, Eastwood A, Scroop GC (2006b) Time and sample site dependency of the optimized CO-rebreathing method. Med Sci Sports Exerc 38:1187-1193. doi: 10.1249/ 01.mss.0000222848.35004.41
18. Gore CJ, Clark SA, Saunders PU (2007) Nonhematological mechanisms of improved sea-level performance after hypoxic exposure. Med Sci Sports Exerc 39(9):1600-1609. doi: 10.1249/mss.0b013e3180de49d3
19. Green HJ, Sutton JR, Coates G, Ali M, Jones S (1991) Response of red cell and plasma volume to prolonged training in humans. J Appl Physiol 70:1810-1815
20. Hahn AG, Gore CJ (2001) The effect of altitude on cycling performance: A challenge to traditional concepts. Sports Med 31:533-557. doi: 10.2165/ 00007256-200131070-00008
21. Hahn AG, Gore CJ, Martin DT, Ashenden MJ, Roberts AD, Logan PA (2001) An evaluation of the concept of living at moderate altitude and training at sea level. Comp Biochem Physiol A Mol Integr Physiol 128:777-789. doi: 10.1016/S1095-6433(01)00283-5
22. Hopkins WG (2002) A scale of magnitudes for effect statistics. Sportscience. http://www.sportsci.org/resource/stats/effectmag.html
23. Hopkins WG (2003) A spreadsheet for analysis of straightforward controlled trials. Sportscience. http://www.sportsci.org/jour/03/ wghtrials.htm
24. Hopkins WG, Marshall SW, Batterham AM, Hanin J (2009) Progressive statistics for studies in sports medicine and exercise science. Med Sci Sports Exerc 41(1):3-13
25. Julian CG, Gore CJ, Wilber RL, Daniels JT, Fredericson M, Stray-Gundersen J, Hahn AG, Parisotto R, Levine BD (2004) Intermittent normobaric hypoxia does not alter performance or erythropoietic markers in highly trained distance runners. J Appl Physiol 96:1800-1807. doi: 10.1152/japplphysiol.00969.2003
26. Laitinen H, Alopaeus K, Heikkinen R, Hietanen H, Mikkelsson L, Tikkanen H, Rusko HK (1995) Acclimatisation to living in normobaric hypoxia and training at sea level in runners. Med Sci Sport Exerc 27(5):S109
27. Levine BD, Stray-Gundersen J (1997) "Living high-training low": Effect of moderate-altitude acclimatization with low-altitude training on performance. J Appl Physiol 83:102-112
28. Levine BD, Stray-Gundersen J, Duhaime G, Snell PG, Friedman DB (1991) "Live high-train low": The effect of altitude acclimatisation/ normoxic training in trained runners. Med Sci Sport Exerc 23(4):S25
29. Levine BD, Stray-Gundersen J, Gore CJ, Hopkins WG (2005) Point:cPunterpoint: positive effects of intermittent hypoxia (live high:tRain low) on exercise are/are not mediated primarily by augmented red cell volume. J Appl Physiol 99:2053-2055. doi: 10.1152/ japplphysiol.00877.2005 (discussion 2055-2058)
30. Maxwell BF, Withers RT, Ilsley AH, Wakin MJ, Woods GF, Day L (1998) Dynamic calibration of mechanically air- and electromagnetically braked cycle ergometers. Eur J Appl Physiol 78:346-352. doi: 10.1007/ s004210050430
31. Myhre LG, Muir IH, Salazar AB, Dahms T (2003) Effect of 40 days sleeping in normobaric hypoxia on total hemoglobin mass in competitive runners. Med Sci Sports Exerc 35(5):S115. doi: 10.1097/00005768-200305001-00622
32. Neya M, Enoki T, Kumai Y, Sugoh T, Tawahaia T (2007) The effects of nightly normobaric hypoxia and high intensity training under intermittent normobaric hypoxia on running economy and hemoglobin mass. J Appl Physiol 103(3):828-834. doi: 10.1152/japplphysiol.00265.2007
33. Parisotto R, Wu M, Ashenden MJ, Emslie KR, Gore CJ, Howe C, Kazlauskas R, Sharpe K, Trout GJ, Xie M (2001) Detection of recombinant human erythropoietin abuse in athletes utilizing markers of altered erythropoiesis. Haematologica 86:128-137
34. Piehl-Aulin K, Svedenhag J, Wide L, Berglund B, Saltin B (1998) Short-term intermittent normobaric hypoxia - haematological, physiological and mental effects. Scand J Med Sci Sports 8(3):132-137
35. Prommer N, Schmidt W (2007) Loss of CO from the intravascular bed and its impact on the optimised CO-rebreathing method. Eur J Appl Physiol 100(4):383-391. doi: 10.1007/s00421-007-0439-2
36. Remes K (1979) Effect of long-term physical training on total red cell volume. Scand J Clin Lab Invest 39:311-319. doi: 10.3109/ 00365517909106114
37. Rice L, Ruiz W, Driscoll T, Whitley CE, Tapia R, Hachey DL, Gonzales GF, Alfrey CP (2001) Neocytolysis on descent from altitude: A newly recognized mechanism for the control of red cell mass. Ann Intern Med 134(8):652-656
38. Robach P, Schmitt L, Brugniaux JV, Roels B, Millet G, Hellard P, Nicolet G, Duvallet A, Fouillot JP, Moutereau S, Lasne F, Pialoux V, Olsen NV, Richalet JP (2006a) Living high-training low: Effect on erythropoiesis and aerobic performance in highly-trained swimmers. Eur J Appl Physiol 96:423-433. doi: 10.1007/s00421-005-0089-1
39. Robach P, Schmitt L, Brugniaux JV, Nicolet G, Duvallet A, Fouillot JP, Moutereau S, Lasne F, Pialoux V, Olsen NV, Richalet JP (2006b) Living high-training low: Effect on erythropoiesis and maximal aerobic performance in elite Nordic skiers. Eur J Appl Physiol 97(6):695-705. doi: 10.1007/s00421-006-0240-7
40. 2max and red cell mass. Med Sci Sport Exerc 31(5):S86
41. Rusko HK, Tikkanen HO, Peltonen JE (2004) Altitude and endurance training. J Sports Sci 22:928-944. doi: 10.1080/02640410400005933 (discussion 945)
42. Saunders PU, Telford RD, Pyne DB, Cunningham RB, Gore CJ, Hahn AG, Hawley JA (2004) Improved running economy in elite runners after 20 days of simulated moderate-altitude exposure. J Appl Physiol 96:931-937. doi: 10.1152/japplphysiol.00725.2003
43. Saunders PU, Telford RD, Pyne DB, Hahn AG, Gore CJ (2009) Improved running economy and increased hemoglobin mass in elite runners after extended moderate altitude exposure. J Sci Med Sport 12(1):67-72
44. Schmidt W, Prommer N (2008) Effects of various training modalities on blood volume. Scand J Med Sci Sports 18(Suppl 1):57-69
45. Stray-Gundersen J, Chapman RF, Levine BD (2001) "Living high-training low" altitude training improves sea level performance in male and female elite runners. J Appl Physiol 91:1113-1120
46. Wehrlin JP, Marti B (2006) Live high-train low associated with increased haemoglobin mass as preparation for the 2003 World Championships in two native world class runners. Br J Sports Med 40(2):e3. doi: 10.1136/ bjsm.2005.019729 (discussion e3)
47. Wehrlin JP, Zuest P, Hallen J, Marti B (2006) Live high-train low for 24 days increases hemoglobin mass and red cell volume in elite endurance athletes. J Appl Physiol 100:1938-1945. doi: 10.1152/ japplphysiol.01284.2005
48. Weil JV, Jamieson G, Brown DW, Grover RF (1968) The red cell mass - arterial oxygen relationship in normal man. Application to patients with chronic obstructive airway disease. J Clin Invest 47:1627-1639