Economy of locomotion in high-altitude Tibetan migrants exposed to normoxia

Journal of Physiology

Volumn 569, Issue 2, 2005, Pages 667-675

  Maconi, Claudio ^a   Marzorati, Mauro ^a   Sciuto, Daniele ^a   Ferri, Alessandra ^a   Cerretelli, Paolo ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID; OXYGEN;

ADULT; AEROBIC METABOLISM; ALTITUDE; ALTITUDE ACCLIMATIZATION; ANAEROBIC METABOLISM; ARTICLE; CHINA; CONTROLLED STUDY; DATA ANALYSIS; ENERGY EXPENDITURE; ENVIRONMENTAL EXPOSURE; GLYCOLYSIS; HUMAN; HUMAN EXPERIMENT; HYPOXIA; LACTATE BLOOD LEVEL; LOADING TEST; LOCOMOTION; MALE; MIGRATION; NATIVE SPECIES; NEPAL; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RUNNING; STATISTICAL ANALYSIS; TREADMILL EXERCISE; WALKING; AEROBIC EXERCISE; GAS EXCHANGE; HEART RATE; MIGRANT; TIBETAN (PEOPLE);

ACCLIMATIZATION; ADAPTATION, PHYSIOLOGICAL; ADULT; ALTITUDE; ANOXIA; ENERGY METABOLISM; GLYCOLYSIS; HEART RATE; HEMOGLOBINS; HUMANS; LACTATES; LOCOMOTION; MALE; OXYGEN; OXYGEN CONSUMPTION; RESPIRATION; RUNNING; TIBET; TIME FACTORS; TRANSIENTS AND MIGRANTS; WALKING;

EID: 29244487094     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2005.094979     Document Type: Article

References (43)

1. Antunes F, Boveris A & Cadenas E (2004). On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide. PNAS 101, 16774-16779.
2. Avogadro P, Chaux C, Bourdin M, Dalleau G & Belli A (2004). The use of treadmill ergometers for extensive calculation of external work and leg stiffness during running. Eur J Appl Physiol 92, 182-185.
3. Bailey DM, Davies B, Romer L, Castell L, Newsholme E & Gandy G (1998). Implications of moderate altitude training for sea-level endurance in elite distance runners. Eur J Appl Physiol 78, 360-368.
4. Bastien GJ, Schepens B, Willems PA & Heglund NC (2005). Energetics of load carrying in Nepalese porters. Science 308, 1755.
5. Beall CM, Brittenham GM, Strohl KP, Blangero J, Williams-Blangero S, Goldstein MC, Decker MJ, Vargas E, Villena M, Soria R, Alarcon AM & Gonzales C (1998). Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara. Am J Phys Anthropol 106, 385-400.
6. 2 deficit and debt. Eur J Appl Physiol 53, 87-91.
7. Cerretelli P & Hoppeler H (1996). Morphologic and metabolic response to chronic hypoxia: the muscle system. In Handbook of Physiology, Section 4, Environmental Physiology, Vol. 4, ed Fregly MJ & Blatteis CM, pp. 1155-1181. Oxford University Press, New York.
8. Chen QH, Ge RL, Wang XZ, Chen HX, Wu TY, Kobayashi T & Yoshimura K (1997). Exercise performance of Tibetan and Han adolescents at altitude of 3,417 and 4,300 m. J Appl Physiol 83, 661-667.
9. Curran L, Zhuang J, Droma T & Moore LG (1998). Superior exercise performance in lifelong Tibetan residents of 4,400 m compared with Tibetan residents of 3,658 m. Am J Phys Anthropol 105, 21-31.
10. Dennell RW, Rendell HM & Hailwood E (1988). Late Pliocene artifacts from Northern Pakistan. Curr Anthropol 29, 495-498.
11. Favier R, Spielvogel H, Desplanches D, Ferretti G, Kayser B & Hoppeler H (1995). Maximal exercise performance in chronic hypoxia and acute normoxia in high-altitude natives. J Appl Physiol 78, 1868-1874.
12. O2max in Tibetan than Han residents at 4,700 m altitude. J Appl Physiol 77, 684-691.
13. Gelfi C, De Palma S, Ripamonti M, Wait R, Eberini I, Bajracharya A, Marconi C, Schneider A, Hoppeler H & Cerretelli P (2004). New aspects of altitude adaptation in Tibetans. A proteomic approach. FASEB J 18, 612-614.
14. Giuffrè A, Foret E, Brunori M & Sarti P (2005). Nitric oxide, cytochrome c oxidase and myoglobin: competition and reaction pathways. FEBS Lett 579, 2528-2532.
15. Gore CJ, Hahn AG, Aughey RJ, Martin DT, Ashenden MJ, Clark SA, Garnham AP, Roberts AD, Slater GJ & McKenna MJ (2001). Live high:train low increases muscle buffer capacity and submaximal cycling efficiency. Acta Physiol Scand 173, 275-286.
16. Grassi B, Marzorati M, Kayser B, Bordini M, Colombini A, Conti M, Marconi C & Cerretelli P (1996). Peak blood lactate and blood lactate vs. work load during acclimatization to 5,050 m and in deacclimatization. J App Physiol 80, 685-692.
17. +-ATPase following a 21-day expedition to 6,194 m. J Appl Physiol 88, 634-640.
18. Green H, Roy B, Grant S, Hughson R, Burnett M, Otto C, Pipe A, McKenzie D & Johnson M (2000b). Increases in submaximal cycling efficiency mediated by altitude acclimatization. J Appl Physiol 89, 1189-1197.
19. 2+-ATPase. High Alt Med Biol 1, 301-310.
20. Hochachka PW, Stanley C, Matheson GO, McKenzie DC, Allen PS & Parkhouse WS (1991). Metabolic and work efficiencies during exercise in Andean natives. J Appl Physiol 70, 1720-1730.
21. Huang SY, Sun S, Droma T, Zhuang J, Tao JX, McCullough RG, McCullough RE, Micco AJ, Reeves JT & Moore L (1992). Internal carotid arterial flow velocity during exercise in Tibetan and Han residents of Lhasa (3,658 m). J Appl Physiol 73, 2638-2642.
22. Julian CG, Gore CJ, Wilber RL, Daniels JT, Fredericson M, Stray-Gundersen J, Hahn AG, Parisotto R & Levine BD (2004). Intermittent normobaric hypoxia does not alter performance or erythropoietic markers in highly trained distance runners. J Appl Physiol 96, 1800-1807.
23. Katayama K, Sato Y, Matsuo H, Ishida K, Iwasaki K & Miyamura M (2004). Effect of intermittent hypoxia on oxygen uptake during submaximal exercise in endurance athletes. Eur J Appl Physiol 92, 75-83.
24. Kayser B, Hoppeler H, Claassen H & Cerretelli P (1991). Muscle structure and performance capacity of Himalayan Sherpas. J Appl Physiol 70, 1938-1942.
25. Kayser B, Hoppeler H, Desplanches D, Marconi C, Broers B & Cerretelli P (1996). Muscle ultrastructure and biochemistry of lowland Tibetans. J Appl Physiol 81, 419-425.
26. Kayser B, Marconi C, Amatya T, Basnyat B, Colombini A, Broers B & Cerretelli P (1994). The metabolic and ventilatory response to exercise in Tibetans born at low altitude. Respir Physiol 98, 15-26.
27. Marconi C, Marzorati M, Grassi B, Basnyat B, Colombini A, Kayser B & Cerretelli P (2004). Second generation Tibetan lowlanders acclimatise to high attitude more quickly than Caucasians. J Physiol 556, 661-671.
28. Margaria R (1938). Sulla fisiologia e specialmente sul consumo energetico della marcia e della corsa a varie velocità ed inclinazioni del terreno. Atti Reale Accad Naz Lincei 7, 299-368.
29. Margaria R, Cerretelli P, Aghemo P & Sassi G (1963). Energy cost of running. J Appl Physiol 18, 367-370.
30. 31P-NMR study of Andean natives and lowlanders. J Appl Physiol 70, 1963-1976.
31. Minetti AE, Ardigò LP & Saibene F (1993). Mechanical determinants of gradient walking energetics in man. J Physiol 471, 725-735.
32. Minetti AE, Ardigò LP & Saibene F (1994). Mechanical determinants of the minimum energy cost of gradient running in humans. J Exp Biol 195, 211-225.
33. Niu W, Wu Y, Li B, Chen N & Song S (1995). Effects of long-term acclimatization in lowlanders migrating to high altitude: comparison with high altitude residents. Eur J Appl Physiol 71, 543-548.
34. Rosser BW & Hochachka PW (1993). Metabolic capacity of muscle fibers from high-altitude natives. Eur J Appl Physiol 67, 513-517.
35. Saunders PU, Pyne DB, Telford RD & Hawley JA (2004a). Factors affecting running economy in trained distance runners. Sports Med 34, 465-485.
36. Saunders PU, Teford RD, Pyne DB, Cunningham RB, Gore CJ, Hahn AG & Hawley JA (2004b). Improved running economy in elite runners after 20 days of simulated moderate-altitude exposure. J Appl Physiol 96, 931-937.
37. Schepens B, Willems PA, Cavagna GA & Heglund NC (2001). Mechanical power and efficiency in running children. Pflugers Arch 442, 107-116.
38. Sheffield LT (1988). Exercise stress testing. Heart Disease. A Textbook of Cardiovascular Medicine, ed. Braunwald E, p. 224. W.B. Saunders Co, Philadelphia.
39. Stray-Gundersen J, Chapman RC & Levine BD (2001). 'Living high-training low' altitude training improves sea level performance in male and female elite runners. J Appl Physiol 91, 1113-1120.
40. 2 uptakes and vital capacities in Tibetan than Han residents of Lhasa. Respir Physiol 79, 151-162.
41. Terrados N, Mizuno M & Handersen H (1985). Reduction in maximal oxygen uptake at low altitude: role of training status and lung function. Clin Physiol 5 (Suppl. 3), 75-79.
42. Williams KR & Cavanagh PR (1987). Relationship between distance running mechanics, running economy, and performance. J Appl Physiol 63, 1236-1245.
43. 2 gradients in Tibetan than Han residents of Lhasa (3658 m). Respir Physiol 103, 75-82.