메뉴 건너뛰기




Volumn 55, Issue 6, 2012, Pages 1813-1823

Ghrelin contributes to derangements of glucose metabolism induced by rapamycin in mice

Author keywords

Ghrelin; Glucose metabolism; Rapamycin

Indexed keywords

GHRELIN; GHRELIN RECEPTOR; GLUCOSE; GLUCOSE TRANSPORTER 4; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; PROTEIN INHIBITOR; PROTEIN S6; RAPAMYCIN; STRESS ACTIVATED PROTEIN KINASE; GHRP 6, LYS(3); GHRP-6, LYS(3)-; OLIGOPEPTIDE;

EID: 84865424560     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2509-1     Document Type: Article
Times cited : (33)

References (49)
  • 1
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660 (Pubitemid 129516334)
    • (1999) Nature , vol.402 , Issue.6762 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 2
    • 15444371950 scopus 로고    scopus 로고
    • Ghrelin and energy balance: Focus on current controversies
    • Cummings DE, Foster-Schubert KE, Overduin J (2005) Ghrelin and energy balance: focus on current controversies. Curr Drug Targets 6:153-169 (Pubitemid 40394311)
    • (2005) Current Drug Targets , vol.6 , Issue.2 , pp. 153-169
    • Cummings, D.E.1    Foster-Schubert, K.E.2    Overduin, J.3
  • 3
    • 15544385058 scopus 로고    scopus 로고
    • Ghrelin: Structure and function
    • DOI 10.1152/physrev.00012.2004
    • Kojima M, Kangawa K (2005) Ghrelin: structure and function. Physiol Rev 85:495-522 (Pubitemid 40404635)
    • (2005) Physiological Reviews , vol.85 , Issue.2 , pp. 495-522
    • Kojima, M.1    Kangawa, K.2
  • 4
    • 58149352421 scopus 로고    scopus 로고
    • Ghrelin infusion in humans induces acute insulin resistance and lipolysis independent of growth hormone signaling
    • Vestergaard ET, Gormsen LC, Jessen N et al (2008) Ghrelin infusion in humans induces acute insulin resistance and lipolysis independent of growth hormone signaling. Diabetes 57:3205-3210
    • (2008) Diabetes , vol.57 , pp. 3205-3210
    • Vestergaard, E.T.1    Gormsen, L.C.2    Jessen, N.3
  • 5
    • 9444264700 scopus 로고    scopus 로고
    • 2+ signaling in β-cells: Implication in the glycemic control in rodents
    • DOI 10.2337/diabetes.53.12.3142
    • Dezaki K, Hosoda H, Kakei M et al (2004) Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents. Diabetes 53:3142-3151 (Pubitemid 39564489)
    • (2004) Diabetes , vol.53 , Issue.12 , pp. 3142-3151
    • Dezaki, K.1    Hosoda, H.2    Kakei, M.3    Hashiguchi, S.4    Watanabe, M.5    Kangawa, K.6    Yada, T.7
  • 6
    • 33845534952 scopus 로고    scopus 로고
    • Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance
    • DOI 10.2337/db06-0878
    • Dezaki K, Sone H, Koizumi M et al (2006) Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance. Diabetes 55:3486-3493 (Pubitemid 44923609)
    • (2006) Diabetes , vol.55 , Issue.12 , pp. 3486-3493
    • Dezaki, K.1    Sone, H.2    Koizumi, M.3    Nakata, M.4    Kakei, M.5    Nagai, H.6    Hosoda, H.7    Kangawa, K.8    Yada, T.9
  • 9
    • 78149450776 scopus 로고    scopus 로고
    • Modulation of ghrelin O-acyltransferase expression in pancreatic islets
    • An W, Li Y, Xu G et al (2010) Modulation of ghrelin O-acyltransferase expression in pancreatic islets. Cell Physiol Biochem 26:707-716
    • (2010) Cell Physiol Biochem , vol.26 , pp. 707-716
    • An, W.1    Li, Y.2    Xu, G.3
  • 11
    • 63749105226 scopus 로고    scopus 로고
    • MTOR and the control of whole body metabolism
    • Polak P, Hall MN (2009) mTOR and the control of whole body metabolism. Curr Opin Cell Biol 21:209-218
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 209-218
    • Polak, P.1    Hall, M.N.2
  • 12
    • 33745052121 scopus 로고    scopus 로고
    • MTOR tells the brain that the body is hungry
    • DOI 10.1038/nm0606-615, PII N0606615
    • Kahn BB, Myers MG Jr (2006) mTOR tells the brain that the body is hungry. Nat Med 12:615-617 (Pubitemid 43869941)
    • (2006) Nature Medicine , vol.12 , Issue.6 , pp. 615-617
    • Kahn, B.B.1    Myers Jr., M.G.2
  • 14
    • 77953218866 scopus 로고    scopus 로고
    • Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue
    • Houde VP, Brule S, Festuccia WT et al (2010) Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. Diabetes 59:1338-1348
    • (2010) Diabetes , vol.59 , pp. 1338-1348
    • Houde, V.P.1    Brule, S.2    Festuccia, W.T.3
  • 16
    • 42449104351 scopus 로고    scopus 로고
    • MTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
    • Fraenkel M, Ketzinel-Gilad M, Ariav Y et al (2008) mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes. Diabetes 57:945-957
    • (2008) Diabetes , vol.57 , pp. 945-957
    • Fraenkel, M.1    Ketzinel-Gilad, M.2    Ariav, Y.3
  • 17
    • 48149112155 scopus 로고    scopus 로고
    • Sirolimus is associated with new-onset diabetes in kidney transplant recipients
    • Johnston O, Rose CL, Webster AC, Gill JS (2008) Sirolimus is associated with new-onset diabetes in kidney transplant recipients. J Am Soc Nephrol 19:1411-1418
    • (2008) J Am Soc Nephrol , vol.19 , pp. 1411-1418
    • Johnston, O.1    Rose, C.L.2    Webster, A.C.3    Gill, J.S.4
  • 18
    • 0021928110 scopus 로고
    • Posttransplant diabetes in kidney transplant recipients
    • Friedman EA, Shyh TP, Beyer MM, Manis T, Butt KM (1985) Posttransplant diabetes in kidney transplant recipients. Am J Nephrol 5:196-202 (Pubitemid 15120354)
    • (1985) American Journal of Nephrology , vol.5 , Issue.3 , pp. 196-202
    • Friedman, E.A.1    Shyh, T.P.2    Beyer, M.M.3
  • 21
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTORmediated translational control
    • Ma XM, Blenis J (2009) Molecular mechanisms of mTORmediated translational control. Nat Rev Mol Cell Biol 10:307-318
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 22
    • 14244256097 scopus 로고    scopus 로고
    • Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance
    • DOI 10.1210/en.2004-0921
    • Khamzina L, Veilleux A, Bergeron S, Marette A (2005) Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats, possible involvement in obesitylinked insulin resistance. Endocrinology 146:1473-1481 (Pubitemid 40289337)
    • (2005) Endocrinology , vol.146 , Issue.3 , pp. 1473-1481
    • Khamzina, L.1    Veilleux, A.2    Bergeron, S.3    Marette, A.4
  • 24
    • 4544343980 scopus 로고    scopus 로고
    • Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
    • DOI 10.1016/j.cub.2004.08.026, PII S0960982204006116
    • Shah OJ, Wang Z, Hunter T (2004) Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol 14:1650-1656 (Pubitemid 39239362)
    • (2004) Current Biology , vol.14 , Issue.18 , pp. 1650-1656
    • Shah, O.J.1    Wang, Z.2    Hunter, T.3
  • 28
    • 54849431380 scopus 로고    scopus 로고
    • Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration
    • Polak P, Cybulski N, Feige JN, Auwerx J, Ruegg MA, Hall MN (2008) Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab 8:399-410
    • (2008) Cell Metab , vol.8 , pp. 399-410
    • Polak, P.1    Cybulski, N.2    Feige, J.N.3    Auwerx, J.4    Ruegg, M.A.5    Hall, M.N.6
  • 29
    • 78049463961 scopus 로고    scopus 로고
    • Regulation of gastric hormones by systemic rapamycin
    • Xu G, Li Y, An W et al (2010) Regulation of gastric hormones by systemic rapamycin. Peptides 31:2185-2192
    • (2010) Peptides , vol.31 , pp. 2185-2192
    • Xu, G.1    Li, Y.2    An, W.3
  • 30
    • 67651177691 scopus 로고    scopus 로고
    • Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake
    • Xu G, Li Y, An W et al (2009) Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake. Endocrinology 150:3637-3644
    • (2009) Endocrinology , vol.150 , pp. 3637-3644
    • Xu, G.1    Li, Y.2    An, W.3
  • 31
    • 84866385335 scopus 로고    scopus 로고
    • Generation of mouse embryonic stem cell clones for ghrelin receptor gene knock out
    • Wang W, Wang Z, Zhang Y, Fei J, Zheng Q (2008) Generation of mouse embryonic stem cell clones for ghrelin receptor gene knock out. Chin J Bases Clin General Surg 15:733-736
    • (2008) Chin J Bases Clin General Surg , vol.15 , pp. 733-736
    • Wang, W.1    Wang, Z.2    Zhang, Y.3    Fei, J.4    Zheng, Q.5
  • 32
    • 0026758928 scopus 로고
    • Abundance, localization, and insulin-induced translocation of glucose transporters in red and white muscle
    • Marette A, Richardson JM, Ramlal T et al (1992) Abundance, localization, and insulin-induced translocation of glucose transporters in red and white muscle. Am J Physiol 263:C443-C452
    • (1992) Am J Physiol , vol.263
    • Marette, A.1    Richardson, J.M.2    Ramlal, T.3
  • 33
    • 0024592462 scopus 로고
    • Molecular cloning and characterization of an insulin-regulatable glucose transporter
    • DOI 10.1038/338083a0
    • James DE, Strube M, Mueckler M (1989) Molecular cloning and characterization of an insulin-regulatable glucose transporter. Nature 338:83-87 (Pubitemid 19076789)
    • (1989) Nature , vol.338 , Issue.6210 , pp. 83-87
    • James, D.E.1    Strube, M.2    Mueckler, M.3
  • 35
    • 43049170316 scopus 로고    scopus 로고
    • Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis
    • Dezaki K, Sone H, Yada T (2008) Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis. Pharmacol Ther 118:239-249
    • (2008) Pharmacol Ther , vol.118 , pp. 239-249
    • Dezaki, K.1    Sone, H.2    Yada, T.3
  • 36
    • 34547907805 scopus 로고    scopus 로고
    • Expanding mTOR signaling
    • DOI 10.1038/cr.2007.64, PII CR200764
    • Yang Q, Guan KL (2007) Expanding mTOR signaling. Cell Res 17:666-681 (Pubitemid 47255937)
    • (2007) Cell Research , vol.17 , Issue.8 , pp. 666-681
    • Yang, Q.1    Guan, K.-L.2
  • 37
    • 34249679614 scopus 로고    scopus 로고
    • MTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer
    • DOI 10.1016/j.molmed.2007.04.002, PII S1471491407000664
    • Dann SG, Selvaraj A, Thomas G (2007) mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol Med 13:252-259 (Pubitemid 46836871)
    • (2007) Trends in Molecular Medicine , vol.13 , Issue.6 , pp. 252-259
    • Dann, S.G.1    Selvaraj, A.2    Thomas, G.3
  • 38
    • 0035851205 scopus 로고    scopus 로고
    • Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
    • Tremblay F, Marette A (2001) Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem 276:38052-38060
    • (2001) J Biol Chem , vol.276 , pp. 38052-38060
    • Tremblay, F.1    Marette, A.2
  • 40
    • 77951298589 scopus 로고    scopus 로고
    • Ghrelin inhibits insulin secretion through the AMPK-UCP2 pathway in beta cells
    • Wang Y, Nishi M, Doi A et al (2010) Ghrelin inhibits insulin secretion through the AMPK-UCP2 pathway in beta cells. FEBS Lett 584:1503-1508
    • (2010) FEBS Lett , vol.584 , pp. 1503-1508
    • Wang, Y.1    Nishi, M.2    Doi, A.3
  • 42
    • 33646141847 scopus 로고    scopus 로고
    • Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice
    • Sun Y, Asnicar M, Saha PK, Chan L, Smith RG (2006) Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab 3:379-386
    • (2006) Cell Metab , vol.3 , pp. 379-386
    • Sun, Y.1    Asnicar, M.2    Saha, P.K.3    Chan, L.4    Smith, R.G.5
  • 44
    • 77954107681 scopus 로고    scopus 로고
    • Melanocortin signaling in the CNS directly regulates circulating cholesterol
    • Perez-Tilve D, Hofmann SM, Basford J et al (2010) Melanocortin signaling in the CNS directly regulates circulating cholesterol. Nat Neurosci 13:877-882
    • (2010) Nat Neurosci , vol.13 , pp. 877-882
    • Perez-Tilve, D.1    Hofmann, S.M.2    Basford, J.3
  • 49
    • 50949132040 scopus 로고    scopus 로고
    • Hypothalamic protein kinase C regulates glucose production
    • Ross R, Wang PY, Chari M et al (2008) Hypothalamic protein kinase C regulates glucose production. Diabetes 57:2061-2065
    • (2008) Diabetes , vol.57 , pp. 2061-2065
    • Ross, R.1    Wang, P.Y.2    Chari, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.