Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53

Toxicology in Vitro

Volumn 25, Issue 7, 2011, Pages 1302-1309

  Rudolf, Emil ^a   Červinka, Miroslav ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Colon cancer; Cytotoxicity; Lysosomes; Mitochondria; Sulforaphane

Indexed keywords

BIM PROTEIN; CASPASE 3; CYTOCHROME C; JANUS KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN P53; SULFORAPHANE;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CELL DIVISION; CELL PROLIFERATION; CELL STRAIN HCT116; COLON CANCER; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; DRUG CYTOTOXICITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LYSOSOME; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

ANTICARCINOGENIC AGENTS; BCL-2-ASSOCIATED X PROTEIN; CELL PROLIFERATION; CELL SURVIVAL; COLONIC NEOPLASMS; DNA DAMAGE; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HEAT-SHOCK PROTEINS; HUMANS; LYSOSOMES; MAP KINASE KINASE 4; MITOCHONDRIA; STRESS, PHYSIOLOGICAL; THIOCYANATES; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 80051910138     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.04.019     Document Type: Article

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