Human and rat ABC transporter efflux of bisphenol A and bisphenol A glucuronide: Interspecies comparison and implications for pharmacokinetic assessment

Toxicological Sciences

Volumn 128, Issue 2, 2012, Pages 317-325

  Mazur, Christopher S ^a   Marchitti, Satori A ^a   Dimova, Mira ^b   Kenneke, John F ^a   Lumen, Annie ^c   Fisher, Jeff ^c  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Metabolism; Physiologically based pharmacokinetics; Xenobiotic transporters

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ABC TRANSPORTER; ADENOSINE TRIPHOSPHATASE; BISPHENOL A GLUCURONIDE; BREAST CANCER RESISTANCE PROTEIN; DRUG METABOLITE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; PROTEIN MDR1A; PROTEIN MDR1B; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; BILE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN; INTESTINE; METABOLISM; NONHUMAN; PHARMACOKINETICS; PORTAL VEIN BLOOD; RAT; RISK ASSESSMENT; SPECIES COMPARISON; SYSTEMIC CIRCULATION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BENZHYDRYL COMPOUNDS; GLUCURONIDES; HUMANS; PHENOLS; RATS; SPECIES SPECIFICITY;

EID: 84865366736     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs167     Document Type: Article

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