Mutations of charged amino acids in or near the transmembrane helices of the second membrane spanning domain differentially affect the substrate specificity and transport activity of the multidrug resistance protein MRP1 (ABCC1)

Molecular Pharmacology

Volumn 65, Issue 6, 2004, Pages 1375-1385

  Haimeur, Anass ^a   Conseil, Gwenaëlle ^a   Deeley, Roger G ^a   Cole, Susan P C ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ASPARTIC ACID; CARRIER PROTEIN; LEUKOTRIENE C4; LYSINE; MULTIDRUG RESISTANCE PROTEIN 1; NUCLEOTIDE BINDING PROTEIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CHEMICAL REACTION KINETICS; ENZYME SPECIFICITY; GENE MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN TRANSPORT;

AMINO ACIDS; ARGININE; ASPARTIC ACID; BIOLOGICAL TRANSPORT; CELLS, CULTURED; GLUTAMIC ACID; HUMANS; LYSINE; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; P-GLYCOPROTEINS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 2442660256     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.65.6.1375     Document Type: Article

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