메뉴 건너뛰기




Volumn 30, Issue 9, 2012, Pages 1787-1792

Concise review: Human pluripotent stem cells in the treatment of spinal cord injury

Author keywords

Embryonic stem cells; Induced pluripotent stem cells; Spinal cord injury; Stem cell transplantation; Tissue regeneration

Indexed keywords

OLIGODENDROCYTE TRANSCRIPTION FACTOR 2;

EID: 84865312600     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1159     Document Type: Short Survey
Times cited : (49)

References (75)
  • 1
    • 75349094565 scopus 로고    scopus 로고
    • Challenges of stem cell therapy for spinal cord injury: Human embryonic stem cells, endogenous neural stem cells, or induced pluripotent stem cells?
    • Ronaghi M, Erceg S, Moreno-Manzano V et al. Challenges of stem cell therapy for spinal cord injury: Human embryonic stem cells, endogenous neural stem cells, or induced pluripotent stem cells? Stem Cells 2010;28:93-99.
    • (2010) Stem Cells , vol.28 , pp. 93-99
    • Ronaghi, M.1    Erceg, S.2    Moreno-Manzano, V.3
  • 2
    • 0036904245 scopus 로고    scopus 로고
    • Recent advances in pathophysiology and treatment of spinal cord injury
    • Hulsebosch CE. Recent advances in pathophysiology and treatment of spinal cord injury. Adv Physiol Educ 2002;26:238-255.
    • (2002) Adv Physiol Educ , vol.26 , pp. 238-255
    • Hulsebosch, C.E.1
  • 3
    • 0032146758 scopus 로고    scopus 로고
    • Selective chemokine mRNA accumulation in the rat spinal cord after contusion injury
    • McTigue DM, Tani M, Krivacic K et al. Selective chemokine mRNA accumulation in the rat spinal cord after contusion injury. J Neurosci Res 1998;53:368-376.
    • (1998) J Neurosci Res , vol.53 , pp. 368-376
    • McTigue, D.M.1    Tani, M.2    Krivacic, K.3
  • 4
    • 0035074297 scopus 로고    scopus 로고
    • Temporal-spatial pattern of acute neuronal and glial loss after spinal cord contusion
    • Grossman SD, Rosenberg LJ, Wrathall JR. Temporal-spatial pattern of acute neuronal and glial loss after spinal cord contusion. Exp Neurol 2001;168:273-282.
    • (2001) Exp Neurol , vol.168 , pp. 273-282
    • Grossman, S.D.1    Rosenberg, L.J.2    Wrathall, J.R.3
  • 5
    • 0033001836 scopus 로고    scopus 로고
    • The applied neuropathology of human spinal cord injury
    • Kakulas BA. The applied neuropathology of human spinal cord injury. Spinal Cord 1999;37:79-88.
    • (1999) Spinal Cord , vol.37 , pp. 79-88
    • Kakulas, B.A.1
  • 6
    • 0034589060 scopus 로고    scopus 로고
    • Cell death and plasticity after experimental spinal cord injury
    • Beattie MS, Li Q, Bresnahan JC. Cell death and plasticity after experimental spinal cord injury. Prog Brain Res 2000;128:9-21.
    • (2000) Prog Brain Res , vol.128 , pp. 9-21
    • Beattie, M.S.1    Li, Q.2    Bresnahan, J.C.3
  • 7
    • 63849340879 scopus 로고    scopus 로고
    • Current status of acute spinal cord injury pathophysiology and emerging therapies: Promise on the horizon
    • Rowland JW, Hawryluk GW, Kwon B et al. Current status of acute spinal cord injury pathophysiology and emerging therapies: Promise on the horizon. Neurosurg Focus 2008;25:E2.
    • (2008) Neurosurg Focus , vol.25
    • Rowland, J.W.1    Hawryluk, G.W.2    Kwon, B.3
  • 8
    • 0037651916 scopus 로고    scopus 로고
    • Slit and glypican-1 mRNAs are coexpressed in the reactive astrocytes of the injured adult brain
    • Hagino S, Iseki K, Mori T et al. Slit and glypican-1 mRNAs are coexpressed in the reactive astrocytes of the injured adult brain. Glia 2003;42:130-138.
    • (2003) Glia , vol.42 , pp. 130-138
    • Hagino, S.1    Iseki, K.2    Mori, T.3
  • 9
    • 0042320614 scopus 로고    scopus 로고
    • Ephrin-B2 and EphB2 regulation of astrocyte-meningeal fibroblast interactions in response to spinal cord lesions in adult rats
    • Bundesen LQ, Scheel TA, Bregman BS et al. Ephrin-B2 and EphB2 regulation of astrocyte-meningeal fibroblast interactions in response to spinal cord lesions in adult rats. J Neurosci 2003;23:7789-7800.
    • (2003) J Neurosci , vol.23 , pp. 7789-7800
    • Bundesen, L.Q.1    Scheel, T.A.2    Bregman, B.S.3
  • 10
    • 0031817692 scopus 로고    scopus 로고
    • Spinal cord injury in the rat
    • Taoka Y, Okajima K. Spinal cord injury in the rat. Prog Neurobiol 1998;56:341-358.
    • (1998) Prog Neurobiol , vol.56 , pp. 341-358
    • Taoka, Y.1    Okajima, K.2
  • 11
    • 77958144300 scopus 로고    scopus 로고
    • Transplanted oligodendrocytes and motoneuron progenitors generated from human embryonic stem cells promote locomotor recovery after spinal cord transection
    • Erceg S, Ronaghi M, Oria M et al. Transplanted oligodendrocytes and motoneuron progenitors generated from human embryonic stem cells promote locomotor recovery after spinal cord transection. Stem Cells 2010;28:1541-1549.
    • (2010) Stem Cells , vol.28 , pp. 1541-1549
    • Erceg, S.1    Ronaghi, M.2    Oria, M.3
  • 12
    • 47749108736 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells to regional specific neural precursors in chemically defined medium conditions
    • Erceg S, Lainez S, Ronaghi M et al. Differentiation of human embryonic stem cells to regional specific neural precursors in chemically defined medium conditions. PLoS One 2008;3:e2122.
    • (2008) PLoS One , vol.3
    • Erceg, S.1    Lainez, S.2    Ronaghi, M.3
  • 13
    • 18644384444 scopus 로고    scopus 로고
    • Human embryonic stem cellderived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury
    • Keirstead HS, Nistor G, Bernal G et al. Human embryonic stem cellderived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci 2005;25:4694-4705.
    • (2005) J Neurosci , vol.25 , pp. 4694-4705
    • Keirstead, H.S.1    Nistor, G.2    Bernal, G.3
  • 14
    • 34547858511 scopus 로고    scopus 로고
    • Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons
    • Lee H, Shamy GA, Elkabetz Y et al. Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons. Stem Cells 2007;25:1931-1939.
    • (2007) Stem Cells , vol.25 , pp. 1931-1939
    • Lee, H.1    Shamy, G.A.2    Elkabetz, Y.3
  • 15
    • 59849107734 scopus 로고    scopus 로고
    • Human embryonic stem cell differentiation toward regional specific neural precursors
    • Erceg S, Ronaghi M, Stojkovic M. Human embryonic stem cell differentiation toward regional specific neural precursors. Stem Cells 2009;27:78-87.
    • (2009) Stem Cells , vol.27 , pp. 78-87
    • Erceg, S.1    Ronaghi, M.2    Stojkovic, M.3
  • 16
    • 13544264789 scopus 로고    scopus 로고
    • Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation
    • Nistor GI, Totoiu MO, Haque N et al. Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation. Glia 2005;49:385-396.
    • (2005) Glia , vol.49 , pp. 385-396
    • Nistor, G.I.1    Totoiu, M.O.2    Haque, N.3
  • 17
    • 80054744525 scopus 로고    scopus 로고
    • Derivation of oligodendrocyte progenitor cells from human embryonic stem cells
    • Sharp J, Hatch M, Nistor G et al. Derivation of oligodendrocyte progenitor cells from human embryonic stem cells. Methods Mol Biol 2011;767:399-409.
    • (2011) Methods Mol Biol , vol.767 , pp. 399-409
    • Sharp, J.1    Hatch, M.2    Nistor, G.3
  • 18
    • 75349113016 scopus 로고    scopus 로고
    • Human embryonic stem cellderived oligodendrocyte progenitor cell transplants improve recovery after cervical spinal cord injury
    • Sharp J, Frame J, Siegenthaler M et al. Human embryonic stem cellderived oligodendrocyte progenitor cell transplants improve recovery after cervical spinal cord injury. Stem Cells 2010;28:152-163.
    • (2010) Stem Cells , vol.28 , pp. 152-163
    • Sharp, J.1    Frame, J.2    Siegenthaler, M.3
  • 19
    • 65249176820 scopus 로고    scopus 로고
    • Activated spinal cord ependymal stem cells rescue neurological function
    • Moreno-Manzano V, Rodriguez-Jimenez FJ, Garcia-Rosello M et al. Activated spinal cord ependymal stem cells rescue neurological function. Stem Cells 2009;27:733-743.
    • (2009) Stem Cells , vol.27 , pp. 733-743
    • Moreno-Manzano, V.1    Rodriguez-Jimenez, F.J.2    Garcia-Rosello, M.3
  • 20
    • 80053172088 scopus 로고    scopus 로고
    • What is the potential of oligodendrocyte progenitor cells to successfully treat human spinal cord injury?
    • Watson RA, Yeung TM. What is the potential of oligodendrocyte progenitor cells to successfully treat human spinal cord injury? BMC Neurol 2011;11:113.
    • (2011) BMC Neurol , vol.11 , pp. 113
    • Watson, R.A.1    Yeung, T.M.2
  • 21
    • 77950816148 scopus 로고    scopus 로고
    • Efficient differentiation of human embryonic stem cells into oligodendrocyte progenitors for application in a rat contusion model of spinal cord injury
    • Kerr CL, Letzen BS, Hill CM et al. Efficient differentiation of human embryonic stem cells into oligodendrocyte progenitors for application in a rat contusion model of spinal cord injury. Int J Neurosci 2010;120:305-313.
    • (2010) Int J Neurosci , vol.120 , pp. 305-313
    • Kerr, C.L.1    Letzen, B.S.2    Hill, C.M.3
  • 22
    • 77649133015 scopus 로고    scopus 로고
    • Transplantation of ciliary neurotrophic factor-expressing adult oligodendrocyte precursor cells promotes remyelination and functional recovery after spinal cord injury
    • Cao Q, He Q, Wang Y et al. Transplantation of ciliary neurotrophic factor-expressing adult oligodendrocyte precursor cells promotes remyelination and functional recovery after spinal cord injury. J Neurosci 2010;30:2989-3001.
    • (2010) J Neurosci , vol.30 , pp. 2989-3001
    • Cao, Q.1    He, Q.2    Wang, Y.3
  • 23
    • 0033767315 scopus 로고    scopus 로고
    • Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system
    • Lu QR, Yuk D, Alberta JA et al. Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron 2000;25:317-329.
    • (2000) Neuron , vol.25 , pp. 317-329
    • Lu, Q.R.1    Yuk, D.2    Alberta, J.A.3
  • 24
    • 0033764232 scopus 로고    scopus 로고
    • Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors
    • Zhou Q, Wang S, Anderson DJ. Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron 2000;25:331-343.
    • (2000) Neuron , vol.25 , pp. 331-343
    • Zhou, Q.1    Wang, S.2    Anderson, D.J.3
  • 25
    • 67649212160 scopus 로고    scopus 로고
    • Human oligodendrocytes from embryonic stem cells: Conserved SHH signaling networks and divergent FGF effects
    • Hu BY, Du ZW, Li XJ et al. Human oligodendrocytes from embryonic stem cells: Conserved SHH signaling networks and divergent FGF effects. Development 2009;136:1443-1452.
    • (2009) Development , vol.136 , pp. 1443-1452
    • Hu, B.Y.1    Du, Z.W.2    Li, X.J.3
  • 26
    • 0037023529 scopus 로고    scopus 로고
    • Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection
    • Lu QR, Sun T, Zhu Z et al. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell 2002;109:75-86.
    • (2002) Cell , vol.109 , pp. 75-86
    • Lu, Q.R.1    Sun, T.2    Zhu, Z.3
  • 27
    • 0037023492 scopus 로고    scopus 로고
    • The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification
    • Zhou Q, Anderson DJ. The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell 2002;109:61-73.
    • (2002) Cell , vol.109 , pp. 61-73
    • Zhou, Q.1    Anderson, D.J.2
  • 28
    • 0029559654 scopus 로고
    • Host-guided migration allows targeted introduction of neurons into the embryonic brain
    • Brustle O, Maskos U, McKay RD. Host-guided migration allows targeted introduction of neurons into the embryonic brain. Neuron 1995;15:1275-1285.
    • (1995) Neuron , vol.15 , pp. 1275-1285
    • Brustle, O.1    Maskos, U.2    McKay, R.D.3
  • 29
    • 0034548865 scopus 로고    scopus 로고
    • Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus
    • Shihabuddin LS, Horner PJ, Ray J et al. Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. J Neurosci 2000;20:8727-8735.
    • (2000) J Neurosci , vol.20 , pp. 8727-8735
    • Shihabuddin, L.S.1    Horner, P.J.2    Ray, J.3
  • 30
    • 22444450988 scopus 로고    scopus 로고
    • Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism
    • Pluchino S, Zanotti L, Rossi B et al. Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism. Nature 2005;436:266-271.
    • (2005) Nature , vol.436 , pp. 266-271
    • Pluchino, S.1    Zanotti, L.2    Rossi, B.3
  • 31
    • 33745012950 scopus 로고    scopus 로고
    • Neural subtype specification from embryonic stem cells
    • Zhang SC. Neural subtype specification from embryonic stem cells. Brain Pathol 2006;16:132-142.
    • (2006) Brain Pathol , vol.16 , pp. 132-142
    • Zhang, S.C.1
  • 32
    • 34249750476 scopus 로고    scopus 로고
    • Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?
    • Courtine G, Bunge MB, Fawcett JW et al. Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans? Nat Med 2007;13:561-566.
    • (2007) Nat Med , vol.13 , pp. 561-566
    • Courtine, G.1    Bunge, M.B.2    Fawcett, J.W.3
  • 33
    • 76349111372 scopus 로고    scopus 로고
    • Translational research in spinal cord injury: A survey of opinion from the SCI community
    • Kwon BK, Hillyer J, Tetzlaff W. Translational research in spinal cord injury: A survey of opinion from the SCI community. J Neurotrauma 2010;27:21-33.
    • (2010) J Neurotrauma , vol.27 , pp. 21-33
    • Kwon, B.K.1    Hillyer, J.2    Tetzlaff, W.3
  • 34
    • 79955699569 scopus 로고    scopus 로고
    • Target populations for first-inhuman embryonic stem cell research in spinal cord injury
    • Bretzner F, Gilbert F, Baylis F et al. Target populations for first-inhuman embryonic stem cell research in spinal cord injury. Cell Stem Cell 2011;8:468-475.
    • (2011) Cell Stem Cell , vol.8 , pp. 468-475
    • Bretzner, F.1    Gilbert, F.2    Baylis, F.3
  • 35
    • 79955681182 scopus 로고    scopus 로고
    • Response to Frederic Bretzner et al. "Target populations for first-in-human embryonic stem cell research in spinal cord injury"
    • Wirth E, 3rd, Lebkowski JS, Lebacqz K. Response to Frederic Bretzner et al. "Target populations for first-in-human embryonic stem cell research in spinal cord injury". Cell Stem Cell 2011;8:476-478.
    • (2011) Cell Stem Cell , vol.8 , pp. 476-478
    • Wirth III, E.1    Lebkowski, J.S.2    Lebacqz, K.3
  • 36
    • 79955676993 scopus 로고    scopus 로고
    • The tragedy of translation: The case of "first use" in human embryonic stem cell research
    • Solbakk JH, Zoloth L. The tragedy of translation: The case of "first use" in human embryonic stem cell research. Cell Stem Cell 2011;8:479-481.
    • (2011) Cell Stem Cell , vol.8 , pp. 479-481
    • Solbakk, J.H.1    Zoloth, L.2
  • 37
    • 84857643783 scopus 로고    scopus 로고
    • Embryonic stem cell trials for macular degeneration: A preliminary report
    • Schwartz SD, Hubschman JP, Heilwell G et al. Embryonic stem cell trials for macular degeneration: A preliminary report. Lancet 2010;379:713-720.
    • (2010) Lancet , vol.379 , pp. 713-720
    • Schwartz, S.D.1    Hubschman, J.P.2    Heilwell, G.3
  • 38
    • 0034303585 scopus 로고    scopus 로고
    • Neuronal specification in the spinal cord: Inductive signals and transcriptional codes
    • Jessell TM. Neuronal specification in the spinal cord: Inductive signals and transcriptional codes. Nat Rev Genet 2000;1:20-29.
    • (2000) Nat Rev Genet , vol.1 , pp. 20-29
    • Jessell, T.M.1
  • 39
    • 0037047320 scopus 로고    scopus 로고
    • Directed differentiation of embryonic stem cells into motor neurons
    • Wichterle H, Lieberam I, Porter JA et al. Directed differentiation of embryonic stem cells into motor neurons. Cell 2002;110:385-397.
    • (2002) Cell , vol.110 , pp. 385-397
    • Wichterle, H.1    Lieberam, I.2    Porter, J.A.3
  • 40
    • 78651358721 scopus 로고    scopus 로고
    • Inhibition of Sirt1 promotes neural progenitors toward motoneuron differentiation from human embryonic stem cells
    • Zhang Y, Wang J, Chen G et al. Inhibition of Sirt1 promotes neural progenitors toward motoneuron differentiation from human embryonic stem cells. Biochem Biophys Res commun 2011;404:610-614.
    • (2011) Biochem Biophys Res Commun , vol.404 , pp. 610-614
    • Zhang, Y.1    Wang, J.2    Chen, G.3
  • 41
    • 78149467339 scopus 로고    scopus 로고
    • Human motor neuron generation from embryonic stem cells and induced pluripotent stem cells
    • Nizzardo M, Simone C, Falcone M et al. Human motor neuron generation from embryonic stem cells and induced pluripotent stem cells. Cell Mol Life Sci 2010;67:3837-3847.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 3837-3847
    • Nizzardo, M.1    Simone, C.2    Falcone, M.3
  • 42
    • 69249202573 scopus 로고    scopus 로고
    • Highly efficient differentiation and enrichment of spinal motor neurons derived from human and monkey embryonic stem cells
    • Wada T, Honda M, Minami I et al. Highly efficient differentiation and enrichment of spinal motor neurons derived from human and monkey embryonic stem cells. PLoS One 2009;4:e6722.
    • (2009) PLoS One , vol.4
    • Wada, T.1    Honda, M.2    Minami, I.3
  • 43
    • 45849146018 scopus 로고    scopus 로고
    • Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules
    • Dayton, Ohio
    • Li XJ, Hu BY, Jones SA et al. Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem Cells (Dayton, Ohio) 2008;26:886-893.
    • (2008) Stem Cells , vol.26 , pp. 886-893
    • Li, X.J.1    Hu, B.Y.2    Jones, S.A.3
  • 44
    • 27744438009 scopus 로고    scopus 로고
    • Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells
    • Singh Roy N, Nakano T, Xuing L et al. Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells. Exp Neurol 2005;196:224-234.
    • (2005) Exp Neurol , vol.196 , pp. 224-234
    • Singh Roy, N.1    Nakano, T.2    Xuing, L.3
  • 45
    • 21244485072 scopus 로고    scopus 로고
    • Human motor neuron differentiation from human embryonic stem cells
    • Shin S, Dalton S, Stice SL. Human motor neuron differentiation from human embryonic stem cells. Stem Cells Dev 2005;14:266-269.
    • (2005) Stem Cells Dev , vol.14 , pp. 266-269
    • Shin, S.1    Dalton, S.2    Stice, S.L.3
  • 46
    • 70249133666 scopus 로고    scopus 로고
    • Differentiation of spinal motor neurons from pluripotent human stem cells
    • Hu BY, Zhang SC. Differentiation of spinal motor neurons from pluripotent human stem cells. Nat Protocls 2009;4:1295-1304.
    • (2009) Nat Protocls , vol.4 , pp. 1295-1304
    • Hu, B.Y.1    Zhang, S.C.2
  • 47
    • 13844271605 scopus 로고    scopus 로고
    • Specification of motoneurons from human embryonic stem cells
    • Li XJ, Du ZW, Zarnowska ED et al. Specification of motoneurons from human embryonic stem cells. Nat Biotechnol 2005;23:215-221.
    • (2005) Nat Biotechnol , vol.23 , pp. 215-221
    • Li, X.J.1    Du, Z.W.2    Zarnowska, E.D.3
  • 48
    • 77954312775 scopus 로고    scopus 로고
    • Preparation of the acellular scaffold of the spinal cord and the study of biocompatibility
    • Guo SZ, Ren XJ, Wu B et al. Preparation of the acellular scaffold of the spinal cord and the study of biocompatibility. Spinal Cord 2010;48:576-581.
    • (2010) Spinal Cord , vol.48 , pp. 576-581
    • Guo, S.Z.1    Ren, X.J.2    Wu, B.3
  • 49
    • 67649231458 scopus 로고    scopus 로고
    • Laminin and fibronectin scaffolds enhance neural stem cell transplantation into the injured brain
    • Tate CC, Shear DA, Tate MC et al. Laminin and fibronectin scaffolds enhance neural stem cell transplantation into the injured brain. J Tissue Eng Regen Med 2009;3:208-217.
    • (2009) J Tissue Eng Regen Med , vol.3 , pp. 208-217
    • Tate, C.C.1    Shear, D.A.2    Tate, M.C.3
  • 50
    • 70849118272 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived neural precursor transplants in collagen scaffolds promote recovery in injured rat spinal cord
    • Hatami M, Mehrjardi NZ, Kiani S et al. Human embryonic stem cell-derived neural precursor transplants in collagen scaffolds promote recovery in injured rat spinal cord. Cytotherapy 2009;11:618-630.
    • (2009) Cytotherapy , vol.11 , pp. 618-630
    • Hatami, M.1    Mehrjardi, N.Z.2    Kiani, S.3
  • 51
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3
  • 52
    • 67650095306 scopus 로고    scopus 로고
    • Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells
    • Raya A, Rodriguez-Piza I, Guenechea G et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 2009;460:53-59.
    • (2009) Nature , vol.460 , pp. 53-59
    • Raya, A.1    Rodriguez-Piza, I.2    Guenechea, G.3
  • 53
    • 50149098605 scopus 로고    scopus 로고
    • Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
    • Dimos JT, Rodolfa KT, Niakan KK et al. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 2008;321:1218-1221.
    • (2008) Science , vol.321 , pp. 1218-1221
    • Dimos, J.T.1    Rodolfa, K.T.2    Niakan, K.K.3
  • 54
    • 69149108013 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS
    • Karumbayaram S, Kelly TK, Paucar AA et al. Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS. Dis Model Mech 2009;2:189-195.
    • (2009) Dis Model Mech , vol.2 , pp. 189-195
    • Karumbayaram, S.1    Kelly, T.K.2    Paucar, A.A.3
  • 55
    • 65649115029 scopus 로고    scopus 로고
    • Directed differentiation of human-induced pluripotent stem cells generates active motor neurons
    • Karumbayaram S, Novitch BG, Patterson M et al. Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells 2009;27:806-811.
    • (2009) Stem Cells , vol.27 , pp. 806-811
    • Karumbayaram, S.1    Novitch, B.G.2    Patterson, M.3
  • 56
    • 42649130264 scopus 로고    scopus 로고
    • Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease
    • Wernig M, Zhao JP, Pruszak J et al. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci USA 2008;105:5856-5861.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 5856-5861
    • Wernig, M.1    Zhao, J.P.2    Pruszak, J.3
  • 57
    • 65449121435 scopus 로고    scopus 로고
    • Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency
    • Hotta A, Cheung AY, Farra N et al. Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency. Nat Methods 2009;6:370-376.
    • (2009) Nat Methods , vol.6 , pp. 370-376
    • Hotta, A.1    Cheung, A.Y.2    Farra, N.3
  • 58
    • 58249110796 scopus 로고    scopus 로고
    • Induced pluripotent stem cells from a spinal muscular atrophy patient
    • Ebert AD, Yu J, Rose FF, Jr. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 2009;457:277-280.
    • (2009) Nature , vol.457 , pp. 277-280
    • Ebert, A.D.1    Yu, J.2    Rose Jr., F.F.3
  • 59
    • 84873337576 scopus 로고    scopus 로고
    • Characterization of human Huntington's disease cell model from induced pluripotent stem cells
    • Zhang N, An MC, Montoro D et al. Characterization of human Huntington's disease cell model from induced pluripotent stem cells. PLoS Curr 2010;2:RRN1193.
    • (2010) PLoS Curr , vol.2
    • Zhang, N.1    An, M.C.2    Montoro, D.3
  • 60
    • 78049512763 scopus 로고    scopus 로고
    • Friedreich's ataxia induced pluripotent stem cells model intergenerational GAATTC triplet repeat instability
    • Ku S, Soragni E, Campau E et al. Friedreich's ataxia induced pluripotent stem cells model intergenerational GAATTC triplet repeat instability. Cell Stem Cell 2010;7:631-637.
    • (2010) Cell Stem Cell , vol.7 , pp. 631-637
    • Ku, S.1    Soragni, E.2    Campau, E.3
  • 61
    • 61349100729 scopus 로고    scopus 로고
    • Parkinson's disease patientderived induced pluripotent stem cells free of viral reprogramming factors
    • Soldner F, Hockemeyer D, Beard C et al. Parkinson's disease patientderived induced pluripotent stem cells free of viral reprogramming factors. Cell 2009;136:964-977.
    • (2009) Cell , vol.136 , pp. 964-977
    • Soldner, F.1    Hockemeyer, D.2    Beard, C.3
  • 62
    • 77958536106 scopus 로고    scopus 로고
    • Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
    • Warren L, Manos PD, Ahfeldt T et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 2010;7:618-630.
    • (2010) Cell Stem Cell , vol.7 , pp. 618-630
    • Warren, L.1    Manos, P.D.2    Ahfeldt, T.3
  • 63
    • 66049135249 scopus 로고    scopus 로고
    • Generation of induced pluripotent stem cells using recombinant proteins
    • Zhou H, Wu S, Joo JY et al. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem cell 2009;4:381-384.
    • (2009) Cell Stem Cell , vol.4 , pp. 381-384
    • Zhou, H.1    Wu, S.2    Joo, J.Y.3
  • 64
    • 79957807595 scopus 로고    scopus 로고
    • Immunogenicity of induced pluripotent stem cells
    • Zhao T, Zhang ZN, Rong Z et al. Immunogenicity of induced pluripotent stem cells. Nature 2011;474:212-215.
    • (2011) Nature , vol.474 , pp. 212-215
    • Zhao, T.1    Zhang, Z.N.2    Rong, Z.3
  • 65
    • 79958271514 scopus 로고    scopus 로고
    • Stem cells: iPS cells under attack
    • Apostolou E, Hochedlinger K. Stem cells: iPS cells under attack. Nature 2011;474:165-166.
    • (2011) Nature , vol.474 , pp. 165-166
    • Apostolou, E.1    Hochedlinger, K.2
  • 66
    • 67649222358 scopus 로고    scopus 로고
    • Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures
    • Chin MH, Mason MJ, Xie W et al. Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell 2009;5:111-123.
    • (2009) Cell Stem Cell , vol.5 , pp. 111-123
    • Chin, M.H.1    Mason, M.J.2    Xie, W.3
  • 67
    • 77953912037 scopus 로고    scopus 로고
    • Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity
    • Kim DS, Lee JS, Leem JW et al. Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity. Stem Cell Rev 2010;6:270-281.
    • (2010) Stem Cell Rev , vol.6 , pp. 270-281
    • Kim, D.S.1    Lee, J.S.2    Leem, J.W.3
  • 68
    • 79953058250 scopus 로고    scopus 로고
    • The tumorigenicity of human embryonic and induced pluripotent stem cells
    • Ben-David U, Benvenisty N. The tumorigenicity of human embryonic and induced pluripotent stem cells. Nature Rev 2011;11:268-277.
    • (2011) Nature Rev , vol.11 , pp. 268-277
    • Ben-David, U.1    Benvenisty, N.2
  • 69
    • 77955454021 scopus 로고    scopus 로고
    • Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury
    • Tsuji O, Miura K, Okada Y et al. Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury. Proc Natl Acad Sci USA 2010;107:12704-12709.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 12704-12709
    • Tsuji, O.1    Miura, K.2    Okada, Y.3
  • 70
    • 80053628732 scopus 로고    scopus 로고
    • Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice
    • Nori S, Okada Y, Yasuda A et al. Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice. Proc Natl Acad Sci USA 2011;108:16825-16830.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 16825-16830
    • Nori, S.1    Okada, Y.2    Yasuda, A.3
  • 71
    • 84861839572 scopus 로고    scopus 로고
    • Treatment of a mouse model of spinal cord injury by transplantation of human iPS cell-derived long-term self-renewing neuroepithelial-like stem cells
    • Fujimoto Y, Abematsu M, Falk A et al. Treatment of a mouse model of spinal cord injury by transplantation of human iPS cell-derived long-term self-renewing neuroepithelial-like stem cells. Stem Cells 2012;30:1163-1173.
    • (2012) Stem Cells , vol.30 , pp. 1163-1173
    • Fujimoto, Y.1    Abematsu, M.2    Falk, A.3
  • 72
    • 39949083205 scopus 로고    scopus 로고
    • Critical issues of clinical human embryonic stem cell therapy for brain repair
    • Li JY, Christophersen NS, Hall V et al. Critical issues of clinical human embryonic stem cell therapy for brain repair. Trends Neurosci 2008;31:146-153.
    • (2008) Trends Neurosci , vol.31 , pp. 146-153
    • Li, J.Y.1    Christophersen, N.S.2    Hall, V.3
  • 73
    • 61449171881 scopus 로고    scopus 로고
    • Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient
    • Amariglio N, Hirshberg A, Scheithauer BW et al. Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. PLoS Med 2009;6:e1000029.
    • (2009) PLoS Med , vol.6
    • Amariglio, N.1    Hirshberg, A.2    Scheithauer, B.W.3
  • 74
    • 77649162059 scopus 로고    scopus 로고
    • Direct conversion of fibroblasts to functional neurons by defined factors
    • Vierbuchen T, Ostermeier A, Pang ZP et al. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010;463:1035-1041.
    • (2010) Nature , vol.463 , pp. 1035-1041
    • Vierbuchen, T.1    Ostermeier, A.2    Pang, Z.P.3
  • 75
    • 79958264182 scopus 로고    scopus 로고
    • Cell fate plug and play: Direct reprogramming and induced pluripotency
    • Chambers SM, Studer L. Cell fate plug and play: Direct reprogramming and induced pluripotency. Cell 2011;145:827-830.
    • (2011) Cell , vol.145 , pp. 827-830
    • Chambers, S.M.1    Studer, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.