메뉴 건너뛰기




Volumn 4, Issue 8, 2009, Pages

Highly efficient differentiation and enrichment of spinal motor neurons derived from human and monkey embryonic stem cells

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; FIBROBLAST GROWTH FACTOR 2; NESTIN; NOGGIN; PROTEIN INHIBITOR; RETINOIC ACID; SONIC HEDGEHOG PROTEIN;

EID: 69249202573     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006722     Document Type: Article
Times cited : (92)

References (53)
  • 1
    • 0033560895 scopus 로고    scopus 로고
    • Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
    • Briscoe J, Sussel L, Serup P, Hartigan-O'Connor D, Jessell TM, et al. (1999) Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature 398: 622-627.
    • (1999) Nature , vol.398 , pp. 622-627
    • Briscoe, J.1    Sussel, L.2    Serup, P.3    Hartigan-O'Connor, D.4    Jessell, T.M.5
  • 2
    • 0030584081 scopus 로고    scopus 로고
    • Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity
    • Ericson J, Morton S, Kawakami A, Roelink H, Jessell TM (1996) Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Cell 87: 661-673.
    • (1996) Cell , vol.87 , pp. 661-673
    • Ericson, J.1    Morton, S.2    Kawakami, A.3    Roelink, H.4    Jessell, T.M.5
  • 3
    • 0029079893 scopus 로고
    • Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo
    • Marti E, Takada R, Bumcrot DA, Sasaki H, McMahon AP (1995) Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo. Development 121: 2537-2547.
    • (1995) Development , vol.121 , pp. 2537-2547
    • Marti, E.1    Takada, R.2    Bumcrot, D.A.3    Sasaki, H.4    McMahon, A.P.5
  • 4
    • 0029004233 scopus 로고
    • Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
    • Roelink H, Porter JA, Chiang C, Tanabe Y, Chang DT, et al. (1995) Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell 81: 445-455.
    • (1995) Cell , vol.81 , pp. 445-455
    • Roelink, H.1    Porter, J.A.2    Chiang, C.3    Tanabe, Y.4    Chang, D.T.5
  • 5
    • 0029311276 scopus 로고
    • Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation
    • Tanabe Y, Roelink H, Jessell TM (1995) Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation. Curr Biol 5: 651-658.
    • (1995) Curr Biol , vol.5 , pp. 651-658
    • Tanabe, Y.1    Roelink, H.2    Jessell, T.M.3
  • 6
    • 0032475837 scopus 로고    scopus 로고
    • Specification of motor neuron identity by the MNR2 homeodomain protein
    • Tanabe Y, William C, Jessell TM (1998) Specification of motor neuron identity by the MNR2 homeodomain protein. Cell 95: 67-80.
    • (1998) Cell , vol.95 , pp. 67-80
    • Tanabe, Y.1    William, C.2    Jessell, T.M.3
  • 7
    • 27744438009 scopus 로고    scopus 로고
    • Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells
    • Singh Roy N, Nakano T, Xuing L, Kang J, Nedergaard M, et al. (2005) Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells. Exp Neurol 196: 224-234.
    • (2005) Exp Neurol , vol.196 , pp. 224-234
    • Singh Roy, N.1    Nakano, T.2    Xuing, L.3    Kang, J.4    Nedergaard, M.5
  • 8
    • 34547186776 scopus 로고    scopus 로고
    • Easy and rapid differentiation of embryonic stem cells into functional motoneurons using sonic hedgehog-producing cells
    • Soundararajan P, Lindsey BW, Leopold C, Rafuse VF (2007) Easy and rapid differentiation of embryonic stem cells into functional motoneurons using sonic hedgehog-producing cells. Stem Cells 25: 1697-1706.
    • (2007) Stem Cells , vol.25 , pp. 1697-1706
    • Soundararajan, P.1    Lindsey, B.W.2    Leopold, C.3    Rafuse, V.F.4
  • 9
    • 38449122442 scopus 로고    scopus 로고
    • Neural stem cell engineering: Directed differentiation of adult and embryonic stem cells into neurons
    • Robertson MJ, Gip P, Schaffer DV (2008) Neural stem cell engineering: directed differentiation of adult and embryonic stem cells into neurons. Front Biosci 13: 21-50.
    • (2008) Front Biosci , vol.13 , pp. 21-50
    • Robertson, M.J.1    Gip, P.2    Schaffer, D.V.3
  • 10
    • 0037047320 scopus 로고    scopus 로고
    • Directed differentiation of embryonic stem cells into motor neurons
    • Wichterle H, Lieberam I, Porter JA, Jessell TM (2002) Directed differentiation of embryonic stem cells into motor neurons. Cell 110: 385-397.
    • (2002) Cell , vol.110 , pp. 385-397
    • Wichterle, H.1    Lieberam, I.2    Porter, J.A.3    Jessell, T.M.4
  • 11
    • 10744229091 scopus 로고    scopus 로고
    • Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice
    • Barberi T, Klivenyi P, Calingasan NY, Lee H, Kawamata H, et al. (2003) Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice. Nat Biotechnol 21: 1200-1207.
    • (2003) Nat Biotechnol , vol.21 , pp. 1200-1207
    • Barberi, T.1    Klivenyi, P.2    Calingasan, N.Y.3    Lee, H.4    Kawamata, H.5
  • 13
    • 34547858511 scopus 로고    scopus 로고
    • Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons
    • Lee H, Shamy GA, Elkabetz Y, Schofield CM, Harrsion NL, et al. (2007) Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons. Stem Cells 25: 1931-1939.
    • (2007) Stem Cells , vol.25 , pp. 1931-1939
    • Lee, H.1    Shamy, G.A.2    Elkabetz, Y.3    Schofield, C.M.4    Harrsion, N.L.5
  • 14
    • 34548591425 scopus 로고    scopus 로고
    • Embryonic stem cells and prospects for their use in regenerative medicine approaches to motor neurone disease
    • Christou YA, Moore HD, Shaw PJ, Monk PN (2007) Embryonic stem cells and prospects for their use in regenerative medicine approaches to motor neurone disease. Neuropathol Appl Neurobiol 33: 485-498.
    • (2007) Neuropathol Appl Neurobiol , vol.33 , pp. 485-498
    • Christou, Y.A.1    Moore, H.D.2    Shaw, P.J.3    Monk, P.N.4
  • 15
    • 0029983762 scopus 로고    scopus 로고
    • Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell
    • Reynolds BA, Weiss S (1996) Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell. Dev Biol 175: 1-13.
    • (1996) Dev Biol , vol.175 , pp. 1-13
    • Reynolds, B.A.1    Weiss, S.2
  • 16
    • 0035200623 scopus 로고    scopus 로고
    • In vitro differentiation of transplantable neural precursors from human embryonic stem cells
    • Zhang SC, Wernig M, Duncan ID, Brustle O, Thomson JA (2001) In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat Biotechnol 19: 1129-1133.
    • (2001) Nat Biotechnol , vol.19 , pp. 1129-1133
    • Zhang, S.C.1    Wernig, M.2    Duncan, I.D.3    Brustle, O.4    Thomson, J.A.5
  • 17
    • 0028908299 scopus 로고
    • Isolation, characterization, and use of stem cells from the CNS
    • Gage FH, Ray J, Fisher LJ (1995) Isolation, characterization, and use of stem cells from the CNS. Annu Rev Neurosci 18: 159-192.
    • (1995) Annu Rev Neurosci , vol.18 , pp. 159-192
    • Gage, F.H.1    Ray, J.2    Fisher, L.J.3
  • 18
    • 0030826603 scopus 로고    scopus 로고
    • Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma
    • Tropepe V, Craig CG, Morshead CM, van der Kooy D (1997) Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma. J Neurosci 17: 7850-7859.
    • (1997) J Neurosci , vol.17 , pp. 7850-7859
    • Tropepe, V.1    Craig, C.G.2    Morshead, C.M.3    van der Kooy, D.4
  • 19
    • 1642445643 scopus 로고    scopus 로고
    • Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon
    • Tropepe V, Sibilia M, Ciruna BG, Rossant J, Wagner EF, et al. (1999) Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon. Dev Biol 208: 166-188.
    • (1999) Dev Biol , vol.208 , pp. 166-188
    • Tropepe, V.1    Sibilia, M.2    Ciruna, B.G.3    Rossant, J.4    Wagner, E.F.5
  • 20
    • 1542674411 scopus 로고    scopus 로고
    • Growing and working with spinal motor neurons
    • Kuhn TB (2003) Growing and working with spinal motor neurons. Methods Cell Biol 71: 67-87.
    • (2003) Methods Cell Biol , vol.71 , pp. 67-87
    • Kuhn, T.B.1
  • 21
    • 0035025619 scopus 로고    scopus 로고
    • Direct neural fate specification from embryonic stem cells: A primitive mammalian neural stem cell stage acquired through a default mechanism
    • Tropepe V, Hitoshi S, Sirard C, Mak TW, Rossant J, et al. (2001) Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron 30: 65-78.
    • (2001) Neuron , vol.30 , pp. 65-78
    • Tropepe, V.1    Hitoshi, S.2    Sirard, C.3    Mak, T.W.4    Rossant, J.5
  • 22
    • 35448972941 scopus 로고    scopus 로고
    • Wnt3a regulates survival, expansion, and maintenance of neural progenitors derived from human embryonic stem cells
    • Davidson KC, Jamshidi P, Daly R, Hearn MT, Pera MF, et al. (2007) Wnt3a regulates survival, expansion, and maintenance of neural progenitors derived from human embryonic stem cells. Mol Cell Neurosci 36: 408-415.
    • (2007) Mol Cell Neurosci , vol.36 , pp. 408-415
    • Davidson, K.C.1    Jamshidi, P.2    Daly, R.3    Hearn, M.T.4    Pera, M.F.5
  • 23
    • 0034738979 scopus 로고    scopus 로고
    • Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
    • Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, et al. (2000) Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406: 1005-1009.
    • (2000) Nature , vol.406 , pp. 1005-1009
    • Taipale, J.1    Chen, J.K.2    Cooper, M.K.3    Wang, B.4    Mann, R.K.5
  • 24
    • 0030945871 scopus 로고    scopus 로고
    • Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors
    • Mohammadi M, McMahon G, Sun L, Tang C, Hirth P, et al. (1997) Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science 276: 955-960.
    • (1997) Science , vol.276 , pp. 955-960
    • Mohammadi, M.1    McMahon, G.2    Sun, L.3    Tang, C.4    Hirth, P.5
  • 25
    • 28244496603 scopus 로고    scopus 로고
    • Identification of a specific inhibitor of the dishevelled PDZ domain
    • Shan J, Shi DL, Wang J, Zheng J (2005) Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry 44: 15495-15503.
    • (2005) Biochemistry , vol.44 , pp. 15495-15503
    • Shan, J.1    Shi, D.L.2    Wang, J.3    Zheng, J.4
  • 26
    • 4544251998 scopus 로고    scopus 로고
    • Functional properties of motoneurons derived from mouse embryonic stem cells
    • Miles GB, Yohn DC, Wichterle H, Jessell TM, Rafuse VF, et al. (2004) Functional properties of motoneurons derived from mouse embryonic stem cells. J Neurosci 24: 7848-7858.
    • (2004) J Neurosci , vol.24 , pp. 7848-7858
    • Miles, G.B.1    Yohn, D.C.2    Wichterle, H.3    Jessell, T.M.4    Rafuse, V.F.5
  • 27
    • 34247475338 scopus 로고    scopus 로고
    • Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
    • Nagai M, Re DB, Nagata T, Chalazonitis A, Jessell TM, et al. (2007) Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci 10: 615-622.
    • (2007) Nat Neurosci , vol.10 , pp. 615-622
    • Nagai, M.1    Re, D.B.2    Nagata, T.3    Chalazonitis, A.4    Jessell, T.M.5
  • 28
    • 0017808464 scopus 로고
    • Enrichment of spinal cord cell cultures with motoneurons
    • Berg DK, Fischbach GD (1978) Enrichment of spinal cord cell cultures with motoneurons. J Cell Biol 77: 83-98.
    • (1978) J Cell Biol , vol.77 , pp. 83-98
    • Berg, D.K.1    Fischbach, G.D.2
  • 29
    • 34247562853 scopus 로고    scopus 로고
    • Optimized protocols for isolation of primary motor neurons, astrocytes and microglia from embryonic mouse spinal cord
    • Gingras M, Gagnon V, Minotti S, Durham HD, Berthod F (2007) Optimized protocols for isolation of primary motor neurons, astrocytes and microglia from embryonic mouse spinal cord. J Neurosci Methods 163: 111-118.
    • (2007) J Neurosci Methods , vol.163 , pp. 111-118
    • Gingras, M.1    Gagnon, V.2    Minotti, S.3    Durham, H.D.4    Berthod, F.5
  • 30
    • 0019794038 scopus 로고
    • Separation of cell types from embryonic chicken and rat spinal cord: Characterization of motoneuron-enriched fractions
    • Schnaar RI, Schaffner AE (1981) Separation of cell types from embryonic chicken and rat spinal cord: characterization of motoneuron-enriched fractions. J Neurosci 1: 204-217.
    • (1981) J Neurosci , vol.1 , pp. 204-217
    • Schnaar, R.I.1    Schaffner, A.E.2
  • 31
    • 33646851050 scopus 로고    scopus 로고
    • Efficient establishment of human embryonic stem cell lines and long-term maintenance with stable karyotype by enzymatic bulk passage
    • Suemori H, Yasuchika K, Hasegawa K, Fujioka T, Tsuneyoshi N, et al. (2006) Efficient establishment of human embryonic stem cell lines and long-term maintenance with stable karyotype by enzymatic bulk passage. Biochem Biophys Res Commun 345: 926-932.
    • (2006) Biochem Biophys Res Commun , vol.345 , pp. 926-932
    • Suemori, H.1    Yasuchika, K.2    Hasegawa, K.3    Fujioka, T.4    Tsuneyoshi, N.5
  • 32
    • 25844465546 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells to neural lineages in adherent culture by blocking bone morphogenetic protein signaling
    • Gerrard L, Rodgers L, Cui W (2005) Differentiation of human embryonic stem cells to neural lineages in adherent culture by blocking bone morphogenetic protein signaling. Stem Cells 23: 1234-1241.
    • (2005) Stem Cells , vol.23 , pp. 1234-1241
    • Gerrard, L.1    Rodgers, L.2    Cui, W.3
  • 33
    • 58049206540 scopus 로고    scopus 로고
    • Spatiotemporal recapitulation of central nervous system development by murine embryonic stem cell-derived neural stem/progenitor cells
    • Okada Y, Matsumoto A, Shimazaki T, Enoki R, Koizumi A, et al. (2008) Spatiotemporal recapitulation of central nervous system development by murine embryonic stem cell-derived neural stem/progenitor cells. Stem Cells 26: 3086-3098.
    • (2008) Stem Cells , vol.26 , pp. 3086-3098
    • Okada, Y.1    Matsumoto, A.2    Shimazaki, T.3    Enoki, R.4    Koizumi, A.5
  • 34
    • 33947105495 scopus 로고    scopus 로고
    • Nestin-GFP reporter expression defines the quiescent state of skeletal muscle satellite cells
    • Day K, Shefer G, Richardson JB, Enikolopov G, Yablonka-Reuveni Z (2007) Nestin-GFP reporter expression defines the quiescent state of skeletal muscle satellite cells. Dev Biol 304: 246-259.
    • (2007) Dev Biol , vol.304 , pp. 246-259
    • Day, K.1    Shefer, G.2    Richardson, J.B.3    Enikolopov, G.4    Yablonka-Reuveni, Z.5
  • 39
    • 50249103813 scopus 로고    scopus 로고
    • Requirement for COUPTFI and II in the temporal specification of neural stem cells in CNS development
    • Naka H, Nakamura S, Shimazaki T, Okano H (2008) Requirement for COUPTFI and II in the temporal specification of neural stem cells in CNS development. Nat Neurosci 11: 1014-1023.
    • (2008) Nat Neurosci , vol.11 , pp. 1014-1023
    • Naka, H.1    Nakamura, S.2    Shimazaki, T.3    Okano, H.4
  • 40
    • 0028070257 scopus 로고
    • Rapid purification of embryonic rat motoneurons: An in vitro model for studying MND/ALS pathogenesis
    • Camu W, Henderson CE (1994) Rapid purification of embryonic rat motoneurons: an in vitro model for studying MND/ALS pathogenesis. J Neurol Sci 124 Suppl: 73-74.
    • (1994) J Neurol Sci , vol.124 , Issue.SUPPL. , pp. 73-74
    • Camu, W.1    Henderson, C.E.2
  • 41
    • 0026630523 scopus 로고
    • Purification of embryonic rat motoneurons by panning on a monoclonal antibody to the low-affinity NGF receptor
    • Camu W, Henderson CE (1992) Purification of embryonic rat motoneurons by panning on a monoclonal antibody to the low-affinity NGF receptor. J Neurosci Methods 44: 59-70.
    • (1992) J Neurosci Methods , vol.44 , pp. 59-70
    • Camu, W.1    Henderson, C.E.2
  • 42
    • 0024450899 scopus 로고
    • Isolation of fetal mouse motor neurons on discontinuous Percoll density gradients
    • Strong MJ, Garruto RM (1989) Isolation of fetal mouse motor neurons on discontinuous Percoll density gradients. In Vitro Cell Dev Biol 25: 939-945.
    • (1989) In Vitro Cell Dev Biol , vol.25 , pp. 939-945
    • Strong, M.J.1    Garruto, R.M.2
  • 43
    • 0032948066 scopus 로고    scopus 로고
    • Cardiotrophin-1 requires LIFRbeta to promote survival of mouse motoneurons purified by a novel technique
    • Arce V, Garces A, de Bovis B, Filippi P, Henderson C, et al. (1999) Cardiotrophin-1 requires LIFRbeta to promote survival of mouse motoneurons purified by a novel technique. J Neurosci Res 55: 119-126.
    • (1999) J Neurosci Res , vol.55 , pp. 119-126
    • Arce, V.1    Garces, A.2    de Bovis, B.3    Filippi, P.4    Henderson, C.5
  • 45
    • 0036829397 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
    • Chen JK, Taipale J, Cooper MK, Beachy PA (2002) Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev 16: 2743-2748.
    • (2002) Genes Dev , vol.16 , pp. 2743-2748
    • Chen, J.K.1    Taipale, J.2    Cooper, M.K.3    Beachy, P.A.4
  • 46
    • 20944438598 scopus 로고    scopus 로고
    • Noggin and basic FGF were implicated in forebrain fate and caudal fate, respectively, of the neural tube-like structures emerging in mouse ES cell culture
    • Chiba S, Kurokawa MS, Yoshikawa H, Ikeda R, Takeno M, et al. (2005) Noggin and basic FGF were implicated in forebrain fate and caudal fate, respectively, of the neural tube-like structures emerging in mouse ES cell culture. Exp Brain Res 163: 86-99.
    • (2005) Exp Brain Res , vol.163 , pp. 86-99
    • Chiba, S.1    Kurokawa, M.S.2    Yoshikawa, H.3    Ikeda, R.4    Takeno, M.5
  • 47
    • 34748888919 scopus 로고    scopus 로고
    • Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations
    • Pruszak J, Sonntag KC, Aung MH, Sanchez-Pernaute R, Isacson O (2007) Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations. Stem Cells 25: 2257-2268.
    • (2007) Stem Cells , vol.25 , pp. 2257-2268
    • Pruszak, J.1    Sonntag, K.C.2    Aung, M.H.3    Sanchez-Pernaute, R.4    Isacson, O.5
  • 48
    • 56549096129 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation
    • Di Giorgio FP, Boulting GL, Bobrowicz S, Eggan KC (2008) Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. Cell Stem Cell 3: 637-648.
    • (2008) Cell Stem Cell , vol.3 , pp. 637-648
    • Di Giorgio, F.P.1    Boulting, G.L.2    Bobrowicz, S.3    Eggan, K.C.4
  • 49
    • 56549115885 scopus 로고    scopus 로고
    • Noncell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells
    • Marchetto MC, Muotri AR, Mu Y, Smith AM, Cezar GG, et al. (2008) Noncell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell 3: 649-657.
    • (2008) Cell Stem Cell , vol.3 , pp. 649-657
    • Marchetto, M.C.1    Muotri, A.R.2    Mu, Y.3    Smith, A.M.4    Cezar, G.G.5
  • 50
    • 69149108013 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS
    • Karumbayaram S, Kelly TK, Paucar AA, Roe AJ, Umbach JA, et al. (2009) Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS. Dis Model Mech 2: 189-195.
    • (2009) Dis Model Mech , vol.2 , pp. 189-195
    • Karumbayaram, S.1    Kelly, T.K.2    Paucar, A.A.3    Roe, A.J.4    Umbach, J.A.5
  • 52
    • 58249110796 scopus 로고    scopus 로고
    • Induced pluripotent stem cells from a spinal muscular atrophy patient
    • Ebert AD, Yu J, Rose FF Jr, Mattis VB, Lorson CL, et al. (2009) Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457: 277-280.
    • (2009) Nature , vol.457 , pp. 277-280
    • Ebert, A.D.1    Yu, J.2    Rose Jr, F.F.3    Mattis, V.B.4    Lorson, C.L.5
  • 53
    • 69249220421 scopus 로고    scopus 로고
    • Stem cell-based cell therapy in neurological diseases: A review
    • Kim SU, de Vellis J (2009) Stem cell-based cell therapy in neurological diseases: a review. J Neurosci Res 87: 2183-2200.
    • (2009) J Neurosci Res , vol.87 , pp. 2183-2200
    • Kim, S.U.1    de Vellis, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.