Translational research in spinal cord injury: A survey of opinion from the SCI community

Journal of Neurotrauma

Volumn 27, Issue 1, 2010, Pages 21-33

  Kwon, Brian K ^a   Hillyer, Jessica ^a   Tetzlaff, Wolfram ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Secondary insult; Spinal cord injury; Surgery

Indexed keywords

ARTICLE; CELL THERAPY; CELL TRANSPLANTATION; CERVICAL SPINE INJURY; HUMAN; INJURY SEVERITY; MEDICAL RESEARCH; NEUROPROTECTION; NONHUMAN; SPINAL CORD INJURY; STROKE;

ANIMALS; CLINICAL PROTOCOLS; CLINICAL TRIALS AS TOPIC; DRUG EVALUATION, PRECLINICAL; EVIDENCE-BASED MEDICINE; HUMANS; MODELS, ANIMAL; NEUROSCIENCES; QUESTIONNAIRES; SPINAL CORD INJURIES; TRANSLATIONAL RESEARCH;

EID: 76349111372     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2009.1048     Document Type: Article

References (43)

1. Assina, R., Sankar, T., Theodore, N., Javedan, S.P., Gibson, A.R., Horn, K.M., Berens, M., Sonntag, V.K., and Preul, M.C. (2008). Activated autologous macrophage implantation in a largeanimal model of spinal cord injury. Neurosurg. Focus 25, E3.
2. Blesch, A., and Tuszynski, M.H. (2009). Spinal cord injury: Plasticity, regeneration and the challenge of translational drug development. Trends Neurosci. 32, 41-47.
3. Bomstein, Y., Marder, J.B., Vitner, K., Smirnov, I., Lisaey, G., Butovsky, O., Fulga, V., and Yoles, E. (2003). Features of skincoincubated macrophages that promote recovery from spinal cord injury. J. Neuroimmunol. 142, 10-16.
4. Bracken, M.B., Shepard, M.J., Collins, W.F., Holford, T.R., Young, W., Baskin, D.S., Eisenberg, H.M., Flamm, E., Leo-Summers, L., Maroon, J., Marshall, L.F., Perot, P.L., Jr., Piepmeier, J., Sonntag, V.K.H., Wagner, F.C., Wilberger, J.E., and Winn, H.R. (1990). A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury. Results of the Second National Acute Spinal Cord Injury Study. N. Engl. J. Med. 322, 1405-1411.
5. Bracken, M.B., Shepard, M.J., Holford, T.R., Leo-Summers, L., Aldrich, E.F., Fazl, M., Fehlings, M., Herr, D.L., Hitchon, P.W., Marshall, L.F., Nockels, R.P., Pascale, V., Perot, P.L., Jr., Piepmeier, J., Sonntag, V.K., Wagner, F., Wilberger, J.E., Winn, H.R., and Young, W. (1997). Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA 277, 1597-1604.
6. Cardenas, D.D., Ditunno, J., Graziani, V., Jackson, A.B., Lammertse, D., Potter, P., Sipski, M., Cohen, R., and Blight, A.R. (2007). Phase 2 trial of sustained-release fampridine in chronic spinal cord injury. Spinal Cord 45, 158-168.
7. Courtine, G., Bunge, M.B., Fawcett, J.W., Grossman, R.G., Kaas, J.H., Lemon, R., Maier, I., Martin, J., Nudo, R.J., Ramon-Cueto, A., Rouiller, E.M., Schnell, L., Wannier, T., Schwab, M.E., and Edgerton, V.R. (2007). Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans? Nat. Med. 13, 561-566.
8. Couzin, J. (2009). Biotechnology. Celebration and concern over U.S. trial of embryonic stem cells. Science 323, 568.
9. Dergham, P., Ellezam, B., Essagian, C., Avedissian, H., Lubell, W.D., and McKerracher, L. (2002). Rho signaling pathway targeted to promote spinal cord repair. J Neurosci. 22, 6570-6577.
10. Dobkin, B.H., Curt, A., and Guest, J. (2006). Cellular transplants in China: Observational study from the largest human experiment in chronic spinal cord injury. Neurorehabil. Neural Repair 20, 5-13.
11. Fawcett, J.W., Curt, A., Steeves, J.D., Coleman, W.P., Tuszynski, M.H., Lammertse, D., Bartlett, P.F., Blight, A.R., Dietz, V., Ditunno, J., Dobkin, B.H., Havton, L.A., Ellaway, P.H., Fehlings, M.G., Privat, A., Grossman, R., Guest, J.D., Kleitman, N., Nakamura, M., Gaviria, M., and Short, D. (2007). Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: Spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials. Spinal Cord 45, 190-205.
12. Fisher, M., Feuerstein, G., Howells, D.W., Hurn, P.D., Kent, T.A., Savitz, S.I., and Lo, E.H. (2009). Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke 40, 2244-2250.
13. Fisher, M., Hanley, D.F., Howard, G., Jauch, E.C., and Warach, S. (2007). Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes. Stroke 38, 245-248.
14. Freund, P., Schmidlin, E., Wannier, T., Bloch, J., Mir, A., Schwab, M.E., and Rouiller, E.M. (2006). Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates. Nat. Med. 12, 790-792.
15. Geisler, F.H., Coleman, W.P., Grieco, G., and Poonian, D. (2001). The Sygen multicenter acute spinal cord injury study. Spine 26, S87-S98.
16. Geisler, F.H., Dorsey, F.C., and Coleman, W.P. (1990). GM1 gangliosides in the treatment of spinal cord injury: Report of preliminary data analysis. Acta Neurobiol. Exp. (Wars.) 50, 515-521.
17. Goodman, A.D., Brown, T.R., Krupp, L.B., Schapiro, R.T., Schwid, S.R., Cohen, R., Marinucci, L.N., and Blight, A.R. (2009). Sustained-release oral fampridine in multiple sclerosis: a randomised, double-blind, controlled trial. Lancet 373, 732-738.
18. Grijalva, I., Guizar-Sahagun, G., Castaneda-Hernandez, G., Mino, D., Maldonado-Julian, H., Vidal-Cantu, G., Ibarra, A., Serra, O., Salgado-Ceballos, H., and renas-Hernandez, R. (2003). Efficacy and safety of 4-aminopyridine in patients with long-term spinal cord injury: A randomized, double-blind, placebo-controlled trial. Pharmacotherapy 23, 823-834.
19. Hauben, E., Butovsky, O., Nevo, U., Yoles, E., Moalem, G., Agranov, E., Mor, F., Leibowitz-Amit, R., Pevsner, E., Akselrod, S., Neeman, M., Cohen, I.R., and Schwartz, M. (2000a). Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion. J. Neurosci. 20, 6421-6430.
20. Hauben, E., Nevo, U., Yoles, E., Moalem, G., Agranov, E., Mor, F., Akselrod, S., Neeman, M., Cohen, I.R., and Schwartz, M. (2000b). Autoimmune T cells as potential neuroprotective therapy for spinal cord injury. Lancet 355, 286-287.
21. Hayes, K.C. (2007). Fampridine-SR for multiple sclerosis and spinal cord injury. Expert. Rev. Neurother. 7, 453-461.
22. Hofstetter, C.P., Holmstrom, N.A., Lilja, J.A., Schweinhardt, P., Hao, J., Spenger, C., Wiesenfeld-Hallin, Z., Kurpad, S.N., Frisen, J., and Olson, L. (2005). Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome. Nat. Neurosci. 8, 346-353.
23. Hurlbert, R.J., and Hamilton, M.G. (2008). Methylprednisolone for acute spinal cord injury: 5-year practice reversal. Can. J. Neurol. Sci. 35, 41-45.
24. Iwanami, A., Yamane, J., Katoh, H., Nakamura, M., Momoshima, S., Ishii, H., Tanioka, Y., Tamaoki, N., Nomura, T., Toyama, Y., and Okano, H. (2005). Establishment of graded spinal cord injury model in a nonhuman primate: The common marmoset. J. Neurosci. Res. 80, 172-181.
25. Karimi-Abdolrezaee, S., Eftekharpour, E., Wang, J., Morshead, C.M., and Fehlings, M.G. (2006). Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury. J. Neurosci. 26, 3377-3389.
26. Keirstead, H.S., Nistor, G., Bernal, G., Totoiu, M., Cloutier, F., Sharp, K., and Steward, O. (2005). Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J. Neurosci. 25, 4694-4705.
27. Knoller, N., Auerbach, G., Fulga, V., Zelig, G., Attias, J., Bakimer, R., Marder, J.B., Yoles, E., Belkin, M., Schwartz, M., and Hadani, M. (2005). Clinical experience using incubated autologous macrophages as a treatment for complete spinal cord injury: Phase I study results. J. Neurosurg. Spine 3, 173-181.
28. Lammertse, D., Tuszynski, M.H., Steeves, J.D., Curt, A., Fawcett, J.W., Rask, C., Ditunno, J.F., Fehlings, M.G., Guest, J.D., Ellaway, P.H., Kleitman, N., Blight, A.R., Dobkin, B.H., Grossman, R., Katoh, H., Privat, A., and Kalichman, M. (2007). Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: Clinical trial design. Spinal Cord 45, 232-242.
29. Layden, T. (2007). Kevin Everett, The Road Back. Sports Illustrated 107, 56-67.
30. Lord-Fontaine, S., Yang, F., Diep, Q., Dergham, P., Munzer, S., Tremblay, P., and McKerracher, L. (2008). Local inhibition of Rho signaling by cell-permeable recombinant protein BA-210 prevents secondary damage and promotes functional recovery following acute spinal cord injury. J. Neurotrauma 25, 1309-1322.
31. O'Collins, V.E., Macleod, M.R., Donnan, G.A., Horky, L.L., van der Worp, B.H., and Howells, D.W. (2006). 1,026 experimental treatments in acute stroke. Ann. Neurol. 59, 467-477.
32. PBS (2004). Innovation, Life Inspired. Miracle Cell.
33. Pinzon, A., Marcillo, A., Quintana, A., Stamler, S., Bunge, M.B., Bramlett, H.M., and Dietrich, W.D. (2008). A re-assessment of minocycline as a neuroprotective agent in a rat spinal cord contusion model. Brain Res. 1243, 146-151.
34. Rapalino, O., Lazarov-Spiegler, O., Agranov, E., Velan, G.J., Yoles, E., Fraidakis, M., Solomon, A., Gepstein, R., Katz, A., Belkin, M., Hadani, M., and Schwartz, M. (1998). Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nat. Med. 4, 814-821.
35. Rosenzweig, E.S., Brock, J.H., Culbertson, M.D., Lu, P., Moseanko, R., Edgerton, V.R., Havton, L.A., and Tuszynski, M.H. (2009). Extensive spinal decussation and bilateral termination of cervical corticospinal projections in rhesus monkeys. J. Comp. Neurol. 513, 151-163.
36. Schwartz, M. (2000). Autoimmune involvement in CNS trauma is beneficial if well controlled. Prog. Brain Res. 128, 259-263.
37. Schwartz, M., and Yoles, E. (2006). Immune-based therapy for spinal cord repair: Autologous macrophages and beyond. J. Neurotrauma 23, 360-370.
38. Steeves, J., Fawcett, J., and Tuszynski, M. (2004). Report of international clinical trials workshop on spinal cord injury February 20-21, 2004, Vancouver, Canada. Spinal Cord 42, 591-597.
39. Steeves, J.D., Lammertse, D., Curt, A., Fawcett, J.W., Tuszynski, M.H., Ditunno, J.F., Ellaway, P.H., Fehlings, M.G., Guest, J.D., Kleitman, N., Bartlett, P.F., Blight, A.R., Dietz, V., Dobkin, B.H., Grossman, R., Short, D., Nakamura, M., Coleman, W.P., Gaviria, M., and Privat, A. (2007). Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: Clinical trial outcome measures. Spinal Cord 45, 206-221.
40. Steward, O., Sharp, K., Yee, K.M., and Hofstadter, M. (2008). A re-assessment of the effects of a Nogo-66 receptor antagonist on regenerative growth of axons and locomotor recovery after spinal cord injury in mice. Exp. Neurol. 209, 446-468.
41. Tator, C.H. (2006). Review of treatment trials in human spinal cord injury: Issues, difficulties, and recommendations. Neurosurgery 59, 957-982.
42. Tuszynski, M.H., Steeves, J.D., Fawcett, J.W., Lammertse, D., Kalichman, M., Rask, C., Curt, A., Ditunno, J.F., Fehlings, M.G., Guest, J.D., Ellaway, P.H., Kleitman, N., Bartlett, P.F., Blight, A.R., Dietz, V., Dobkin, B.H., Grossman, R., and Privat, A. (2007). Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP Panel: Clinical trial inclusion=exclusion criteria and ethics. Spinal Cord 45, 222-231.
43. Yoles, E., Hauben, E., Palgi, O., Agranov, E., Gothilf, A., Cohen, A., Kuchroo, V., Cohen, I.R., Weiner, H., and Schwartz, M. (2001). Protective autoimmunity is a physiological response to CNS trauma. J. Neurosci. 21, 3740-3748.