Complexity generation in fungal peptidyl alkaloid biosynthesis: Oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from aspergillus fumigatus

Biochemistry

Volumn 50, Issue 40, 2011, Pages 8756-8769

  Ames, Brian D ^a   Haynes, Stuart W ^a   Gao, Xue ^b   Evans, Bradley S ^c   Kelleher, Neil L ^d   Tang, Yi ^b   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID BIOSYNTHESIS; ANTHRANILATE; ASPERGILLUS FUMIGATUS; BUILDING BLOCKES; DIASTEREOMERS; FLAVOENZYMES; GENE CLUSTERS; HUMAN PATHOGENS; OXIDATIVE ANNULATION; REGIOCHEMISTRY; SIDE-CHAINS; SUBSTRATE STRUCTURE; SYNTHETASES;

AMIDES; AMINO ACIDS; BIOCHEMISTRY; BIOSYNTHESIS; CYCLIZATION; ENZYMES; GENES; METABOLITES; NITROGEN COMPOUNDS; SCAFFOLDS (BIOLOGY);

ASPERGILLUS;

ALKALOID; AMINE OXIDASE (FLAVIN CONTAINING); FLAVOPROTEIN; FLAVOPROTEIN AF12070; FUMIQUINAZOLINE A; FUMIQUINAZOLINE C; IMINE; PYRAZINE DERIVATIVE; QUINAZOLINE DERIVATIVE; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS FUMIGATUS; BIOSYNTHESIS; CATALYSIS; CYCLIZATION; DIASTEREOISOMER; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; PRIORITY JOURNAL; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

ALKALOIDS; ASPERGILLUS FUMIGATUS; FLAVOPROTEINS; FUNGAL PROTEINS; OXIDATION-REDUCTION; OXIDOREDUCTASES; PEPTIDE SYNTHASES; QUINAZOLINES;

ASPERGILLUS FUMIGATUS;

EID: 80053579138     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201302w     Document Type: Article

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