A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin

Biochemistry

Volumn 50, Issue 25, 2011, Pages 5680-5692

  Giessen, Tobias W ^a   Kraas, Femke I ^a   Marahiel, Mohamed A ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRANILATE; ANTI-TUMOR ACTIVITIES; ANTITUMOR ANTIBIOTICS; ANTITUMOR PROPERTY; BENZODIAZEPINES; BIOSYNTHETIC ENZYMES; BUILDING BLOCKES; DNA BINDING AFFINITY; GLYCOSYLATED; HYDROXYLASES; IN-VITRO; METHYLTRANSFERASES; REACTION SEQUENCES; SUBSTRATE SPECIFICITY; THIOLATION;

BINDING ENERGY; BIOCHEMISTRY; BIOSYNTHESIS; BUDGET CONTROL; CATALYSTS; ENZYMES; MACHINERY; SUBSTRATES;

ANTIBIOTICS;

3 HYDROXYKYNURENINE; 3,5 DIHYDROXY 4 METHYLANTHRANILIC ACID; ANTHRANILIC ACID; ANTHRANILIC ACID DERIVATIVE; FLAVINE ADENINE NUCLEOTIDE; KYNURENINASE; KYNURENINE; METHYLTRANSFERASE; OXYGENASE; PHOSPHATE; PYRIDOXYL 5' PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SIBIROMYCIN; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; BIOSYNTHESIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; ENZYME SPECIFICITY; GENE EXPRESSION; HYDROLYSIS; HYDROXYLATION; NONHUMAN; PRIORITY JOURNAL; PURIFICATION; SEQUENCE ANALYSIS; SIBE GENE; SIBE PCP GENE; SIBG GENE; SIBL GENE; SIBQ GENE; STEREOCHEMISTRY; SUBSTITUTION REACTION; THIOLATION;

ACTINOMYCETALES; AMINOGLYCOSIDES; ANTHRANILIC ACIDS; ANTIBIOTICS, ANTINEOPLASTIC; BENZODIAZEPINES; GLYCOSYLATION; HYDROLASES; KYNURENINE; METHYLTRANSFERASES; PYROPHOSPHATASES; PYRROLES; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

ACTINOBACTERIA (CLASS);

EID: 79959459977     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2006114     Document Type: Article

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