메뉴 건너뛰기




Volumn 23, Issue 5, 2012, Pages 773-779

Synthetic signaling networks for therapeutic applications

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR THERAPY; CLINICAL TRIAL; MOUSE MODELS; PERSONALIZED MEDICINES; PROCESSING ELEMENTS; SIGNALING NETWORKS; SIGNALING SYSTEMS; THERAPEUTIC APPLICATION;

EID: 84865284935     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2012.01.001     Document Type: Review
Times cited : (10)

References (46)
  • 1
    • 77951107086 scopus 로고    scopus 로고
    • Synthetic biology: applications come of age
    • Khalil A.S., Collins J.J. Synthetic biology: applications come of age. Nat Rev Genet 2010, 11:367-379.
    • (2010) Nat Rev Genet , vol.11 , pp. 367-379
    • Khalil, A.S.1    Collins, J.J.2
  • 2
    • 71849110893 scopus 로고    scopus 로고
    • Next-generation synthetic gene networks
    • Lu T.K., Khalil A.S., Collins J.J. Next-generation synthetic gene networks. Nat Biotechnol 2009, 27:1139-1150.
    • (2009) Nat Biotechnol , vol.27 , pp. 1139-1150
    • Lu, T.K.1    Khalil, A.S.2    Collins, J.J.3
  • 3
    • 80052484996 scopus 로고    scopus 로고
    • Synthetic biology moving into the clinic
    • Ruder W.C., Lu T., Collins J.J. Synthetic biology moving into the clinic. Science 2011, 333:1248-1252.
    • (2011) Science , vol.333 , pp. 1248-1252
    • Ruder, W.C.1    Lu, T.2    Collins, J.J.3
  • 5
    • 60949111303 scopus 로고    scopus 로고
    • A biotin-triggered genetic switch in mammalian cells and mice
    • Weber W., Lienhart C., Baba M.D., Fussenegger M. A biotin-triggered genetic switch in mammalian cells and mice. Metab Eng 2009, 11:117-124.
    • (2009) Metab Eng , vol.11 , pp. 117-124
    • Weber, W.1    Lienhart, C.2    Baba, M.D.3    Fussenegger, M.4
  • 6
    • 67650360436 scopus 로고    scopus 로고
    • A synthetic metabolite-based mammalian inter-cell signaling system
    • Weber W., Schuetz M., Denervaud N., Fussenegger M. A synthetic metabolite-based mammalian inter-cell signaling system. Mol Biosyst 2009, 5:757-763.
    • (2009) Mol Biosyst , vol.5 , pp. 757-763
    • Weber, W.1    Schuetz, M.2    Denervaud, N.3    Fussenegger, M.4
  • 7
    • 67649819663 scopus 로고    scopus 로고
    • Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin
    • Gitzinger M., Kemmer C., El-Baba M.D., Weber W., Fussenegger M. Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin. Proc Natl Acad Sci USA 2009, 106:10638-10643.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 10638-10643
    • Gitzinger, M.1    Kemmer, C.2    El-Baba, M.D.3    Weber, W.4    Fussenegger, M.5
  • 8
    • 85011936076 scopus 로고    scopus 로고
    • Riboswitch RNAs: regulation of gene expression by direct monitoring of a physiological signal
    • Smith A.M., Fuchs R.T., Grundy F.J., Henkin T.M. Riboswitch RNAs: regulation of gene expression by direct monitoring of a physiological signal. RNA Biol 2010, 7:104-110.
    • (2010) RNA Biol , vol.7 , pp. 104-110
    • Smith, A.M.1    Fuchs, R.T.2    Grundy, F.J.3    Henkin, T.M.4
  • 9
    • 65249122814 scopus 로고    scopus 로고
    • Artificial ribozyme switches containing natural riboswitch aptamer domains
    • Wieland M., Benz A., Klauser B., Hartig J.S. Artificial ribozyme switches containing natural riboswitch aptamer domains. Angew Chem Int Ed Engl 2009, 48:2715-2718.
    • (2009) Angew Chem Int Ed Engl , vol.48 , pp. 2715-2718
    • Wieland, M.1    Benz, A.2    Klauser, B.3    Hartig, J.S.4
  • 11
    • 84871957957 scopus 로고    scopus 로고
    • Rational design of a small molecule-responsive intramer controlling transgene expression in mammalian cells
    • Auslander D., Wieland M., Auslander S., Tigges M., Fussenegger M. Rational design of a small molecule-responsive intramer controlling transgene expression in mammalian cells. Nucleic Acids Res 2011, 39:e155.
    • (2011) Nucleic Acids Res , vol.39
    • Auslander, D.1    Wieland, M.2    Auslander, S.3    Tigges, M.4    Fussenegger, M.5
  • 12
    • 77952330657 scopus 로고    scopus 로고
    • A ligand-dependent hammerhead ribozyme switch for controlling mammalian gene expression
    • Auslander S., Ketzer P., Hartig J.S. A ligand-dependent hammerhead ribozyme switch for controlling mammalian gene expression. Mol Biosyst 2010, 6:807-814.
    • (2010) Mol Biosyst , vol.6 , pp. 807-814
    • Auslander, S.1    Ketzer, P.2    Hartig, J.S.3
  • 13
    • 77952318312 scopus 로고    scopus 로고
    • An RNA-based transcription activator derived from an inhibitory aptamer
    • Wang S., Shepard J.R., Shi H. An RNA-based transcription activator derived from an inhibitory aptamer. Nucleic Acids Res 2010, 38:2378-2386.
    • (2010) Nucleic Acids Res , vol.38 , pp. 2378-2386
    • Wang, S.1    Shepard, J.R.2    Shi, H.3
  • 14
    • 79961154112 scopus 로고    scopus 로고
    • De novo motif for kinase mediated signaling across the cell membrane
    • Petty R.T., Mrksich M. De novo motif for kinase mediated signaling across the cell membrane. Integr Biol (Camb) 2011, 3:816-822.
    • (2011) Integr Biol (Camb) , vol.3 , pp. 816-822
    • Petty, R.T.1    Mrksich, M.2
  • 19
    • 79951750301 scopus 로고    scopus 로고
    • Bionanoelectronics
    • Noy A. Bionanoelectronics. Adv Mater 2011, 23:807-820.
    • (2011) Adv Mater , vol.23 , pp. 807-820
    • Noy, A.1
  • 20
    • 70350070364 scopus 로고    scopus 로고
    • Spatiotemporal control of cell signalling using a light-switchable protein interaction
    • Levskaya A., Weiner O.D., Lim W.A., Voigt C.A. Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature 2009, 461:997-1001.
    • (2009) Nature , vol.461 , pp. 997-1001
    • Levskaya, A.1    Weiner, O.D.2    Lim, W.A.3    Voigt, C.A.4
  • 23
    • 78650896342 scopus 로고    scopus 로고
    • Multichromatic control of gene expression in Escherichia coli
    • Tabor J.J., Levskaya A., Voigt C.A. Multichromatic control of gene expression in Escherichia coli. J Mol Biol 2011, 405:315-324.
    • (2011) J Mol Biol , vol.405 , pp. 315-324
    • Tabor, J.J.1    Levskaya, A.2    Voigt, C.A.3
  • 24
    • 79959865302 scopus 로고    scopus 로고
    • Recording of mechanosensitive currents using piezoelectrically driven mechanostimulator
    • Hao J., Delmas P. Recording of mechanosensitive currents using piezoelectrically driven mechanostimulator. Nat Protoc 2011, 6:979-990.
    • (2011) Nat Protoc , vol.6 , pp. 979-990
    • Hao, J.1    Delmas, P.2
  • 25
    • 78649905517 scopus 로고    scopus 로고
    • A synthetic genetic circuit whose signal-response curve is temperature-tunable from band-detection to sigmoidal behaviour
    • Bagh S., McMillen D.R. A synthetic genetic circuit whose signal-response curve is temperature-tunable from band-detection to sigmoidal behaviour. Nat Comput 2010, 9:991-1006.
    • (2010) Nat Comput , vol.9 , pp. 991-1006
    • Bagh, S.1    McMillen, D.R.2
  • 26
    • 65549124451 scopus 로고    scopus 로고
    • Cold induces micro- and nano-scale reorganization of lipid raft markers at mounds of T-cell membrane fluctuations
    • Chen Y., Qin J., Cai J.Y., Chen Z.W. Cold induces micro- and nano-scale reorganization of lipid raft markers at mounds of T-cell membrane fluctuations. PLoS ONE 2009, 4.
    • (2009) PLoS ONE , vol.4
    • Chen, Y.1    Qin, J.2    Cai, J.Y.3    Chen, Z.W.4
  • 27
    • 73149084398 scopus 로고    scopus 로고
    • Making cellular memories
    • Burrill D.R., Silver P.A. Making cellular memories. Cell 2010, 140:13-18.
    • (2010) Cell , vol.140 , pp. 13-18
    • Burrill, D.R.1    Silver, P.A.2
  • 28
    • 79952214973 scopus 로고    scopus 로고
    • Synthetic circuit identifies subpopulations with sustained memory of DNA damage
    • Burrill D.R., Silver P.A. Synthetic circuit identifies subpopulations with sustained memory of DNA damage. Genes Dev 2011, 25:434-439.
    • (2011) Genes Dev , vol.25 , pp. 434-439
    • Burrill, D.R.1    Silver, P.A.2
  • 32
    • 79551599731 scopus 로고    scopus 로고
    • Synthetic in vitro transcriptional oscillators
    • Kim J., Winfree E. Synthetic in vitro transcriptional oscillators. Mol Syst Biol 2011, 7:465.
    • (2011) Mol Syst Biol , vol.7 , pp. 465
    • Kim, J.1    Winfree, E.2
  • 33
    • 79551586208 scopus 로고    scopus 로고
    • Programming an in vitro DNA oscillator using a molecular networking strategy
    • Montagne K., Plasson R., Sakai Y., Fujii T., Rondelez Y. Programming an in vitro DNA oscillator using a molecular networking strategy. Mol Syst Biol 2011, 7:466.
    • (2011) Mol Syst Biol , vol.7 , pp. 466
    • Montagne, K.1    Plasson, R.2    Sakai, Y.3    Fujii, T.4    Rondelez, Y.5
  • 35
    • 78751491498 scopus 로고    scopus 로고
    • Characterization of combinatorial patterns generated by multiple two-component sensors in E. coli that respond to many stimuli
    • Clarke E.J., Voigt C.A. Characterization of combinatorial patterns generated by multiple two-component sensors in E. coli that respond to many stimuli. Biotechnol Bioeng 2011, 108:666-675.
    • (2011) Biotechnol Bioeng , vol.108 , pp. 666-675
    • Clarke, E.J.1    Voigt, C.A.2
  • 36
    • 78649429678 scopus 로고    scopus 로고
    • Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins
    • Culler S.J., Hoff K.G., Smolke C.D. Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins. Science 2010, 330:1251-1255.
    • (2010) Science , vol.330 , pp. 1251-1255
    • Culler, S.J.1    Hoff, K.G.2    Smolke, C.D.3
  • 37
    • 80052456127 scopus 로고    scopus 로고
    • Multi-input RNAi-based logic circuit for identification of specific cancer cells
    • Xie Z., Wroblewska L., Prochazka L., Weiss R., Benenson Y. Multi-input RNAi-based logic circuit for identification of specific cancer cells. Science 2011, 333:1307-1311.
    • (2011) Science , vol.333 , pp. 1307-1311
    • Xie, Z.1    Wroblewska, L.2    Prochazka, L.3    Weiss, R.4    Benenson, Y.5
  • 38
    • 79960213497 scopus 로고    scopus 로고
    • Detection of multiple disease indicators by an autonomous biomolecular computer
    • Gil B., Kahan-Hanum M., Skirtenko N., Adar R., Shapiro E. Detection of multiple disease indicators by an autonomous biomolecular computer. Nano Lett 2011, 11:2989-2996.
    • (2011) Nano Lett , vol.11 , pp. 2989-2996
    • Gil, B.1    Kahan-Hanum, M.2    Skirtenko, N.3    Adar, R.4    Shapiro, E.5
  • 39
    • 79961051673 scopus 로고    scopus 로고
    • Separating intrinsic from extrinsic fluctuations in dynamic biological systems
    • Hilfinger A., Paulsson J. Separating intrinsic from extrinsic fluctuations in dynamic biological systems. Proc Natl Acad Sci USA 2011, 108:12167-12172.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 12167-12172
    • Hilfinger, A.1    Paulsson, J.2
  • 42
    • 77953359952 scopus 로고    scopus 로고
    • AG013, a mouth rinse formulation of Lactococcus lactis secreting human Trefoil Factor 1, provides a safe and efficacious therapeutic tool for treating oral mucositis
    • Caluwaerts S., Vandenbroucke K., Steidler L., Neirynck S., Vanhoenacker P., Corveleyn S., Watkins B., Sonis S., Coulie B., Rottiers P. AG013, a mouth rinse formulation of Lactococcus lactis secreting human Trefoil Factor 1, provides a safe and efficacious therapeutic tool for treating oral mucositis. Oral Oncol 2010, 46:564-570.
    • (2010) Oral Oncol , vol.46 , pp. 564-570
    • Caluwaerts, S.1    Vandenbroucke, K.2    Steidler, L.3    Neirynck, S.4    Vanhoenacker, P.5    Corveleyn, S.6    Watkins, B.7    Sonis, S.8    Coulie, B.9    Rottiers, P.10
  • 43
    • 79959514813 scopus 로고    scopus 로고
    • A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice
    • Ye H., Baba M.D.-E., Peng R.-W., Fussenegger M A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice. Science 2011, 332:1565-1568.
    • (2011) Science , vol.332 , pp. 1565-1568
    • Ye, H.1    Baba, M.D.-E.2    Peng, R.-W.3    Fussenegger, M.4
  • 44
    • 79951893203 scopus 로고    scopus 로고
    • A designer network coordinating bovine artificial insemination by ovulation-triggered release of implanted sperms
    • Kemmer C., Fluri D.A., Witschi U., Passeraub A., Gutzwiller A., Fussenegger M. A designer network coordinating bovine artificial insemination by ovulation-triggered release of implanted sperms. J Control Release 2011, 150:23-29.
    • (2011) J Control Release , vol.150 , pp. 23-29
    • Kemmer, C.1    Fluri, D.A.2    Witschi, U.3    Passeraub, A.4    Gutzwiller, A.5    Fussenegger, M.6
  • 45
    • 77950799444 scopus 로고    scopus 로고
    • Xylan-regulated delivery of human keratinocyte growth factor-2 to the inflamed colon by the human anaerobic commensal bacterium Bacteroides ovatus
    • Hamady Z.Z.R., Scott N., Farrar M.D., Lodge J.P.A., Holland K.T., Whitehead T., Carding S.R. Xylan-regulated delivery of human keratinocyte growth factor-2 to the inflamed colon by the human anaerobic commensal bacterium Bacteroides ovatus. Gut 2011, 59:461-469.
    • (2011) Gut , vol.59 , pp. 461-469
    • Hamady, Z.Z.R.1    Scott, N.2    Farrar, M.D.3    Lodge, J.P.A.4    Holland, K.T.5    Whitehead, T.6    Carding, S.R.7
  • 46
    • 77954920911 scopus 로고    scopus 로고
    • Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model
    • Duan F., March J.C. Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model. Proc Natl Acad Sci USA 2010, 107:11260-11264.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 11260-11264
    • Duan, F.1    March, J.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.