Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors

Neuropharmacology

Volumn 63, Issue 6, 2012, Pages 1127-1139

  Huang, Shelley H ^a   Lewis, Trevor M ^b   Lummis, Sarah C R ^c   Thompson, Andrew J ^c   Chebib, Mary ^a   Johnston, Graham A R ^a   Duke, Rujee K ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

1 GABAC receptor; Bilobalide; GABA receptor; GABAC receptor; Ginkgolide; Mixed antagonism; Use dependent; Xenopus oocytes

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID C RECEPTOR; GINKGO BILOBA EXTRACT; GINKGOLIDE A; GINKGOLIDE B; GINKGOLIDE C;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHANNEL GATING; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; DRUG STRUCTURE; GINKGO BILOBA; NONHUMAN; OOCYTE; PLANT LEAF; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; RECEPTOR BLOCKING; VOLTAGE CLAMP; XENOPUS;

ALGORITHMS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GABA ANTAGONISTS; GINKGOLIDES; HUMANS; KINETICS; MODELS, MOLECULAR; OOCYTES; PATCH-CLAMP TECHNIQUES; RECEPTORS, GABA; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 84865275277     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.06.067     Document Type: Article

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