Structural model for γ-aminobutyric acid receptor noncompetitive antagonist binding: Widely diverse structure fit the same site

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 13, 2006, Pages 5185-5190

  Chen, Ligong ^a   Durkin, Kathleen A ^b   Casida, John E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

3 homopentamer; Disulfide trapping; Insecticide; Receptor model; Transmembrane 2

Indexed keywords

1 (4 ETHYNYLPHENYL) 4 N PROPYL 2,6,7 TRIOXABICYCLO[2.2.2]OCTANE; 3,3 BISTRIFLUOROMETHYLBICYCLO[2.2.1]HEPTANE 2,2 DICARBONITRILE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; AMINO ACID; CHLORIDE CHANNEL; CYSTEINE; DISULFIDE; ENDOSULFAN; FIPRONIL; HYDROXYL GROUP; INSECTICIDE; LINDANE; PICROTOXININ; SERINE; TERT BUTYLBICYCLOPHOSPHOROTHIOATE; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BETA CHAIN; BINDING SITE; CONTROLLED STUDY; CROSS LINKING; CROSS RESISTANCE; DRUG RECEPTOR BINDING; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR MODEL; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; BICYCLO COMPOUNDS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; CELL LINE; DROSOPHILA; GABA ANTAGONISTS; GENE EXPRESSION; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NITRILES; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN SUBUNITS; RATS; RECEPTORS, GABA; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; HEXAPODA; INSECTA; MAMMALIA;

EID: 33645511221     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0600370103     Document Type: Article

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