Charged residues at the 2′ position of human GABAC ρ1 receptors invert ion selectivity and influence open state probability

Journal of Biological Chemistry

Volumn 279, Issue 52, 2004, Pages 54153-54160

  Carland, Jane E ^a   Moorhouse, Andrew J ^c   Barry, Peter H ^c   Johnston, Graham A R ^b   Chebib, Mary ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b University of Sydney   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; MEMBRANES; MUTAGENESIS; NEGATIVE IONS; NEUROLOGY; POSITIVE IONS;

CENTRAL NERVOUS SYSTEM; CHARGED RESIDUES; NICOTINICOID; TRANSMEMBRANES;

PROTEINS;

3 PIPERIDEINE DERIVATIVE; 4 AMINOBUTYRIC ACID C RECEPTOR; 4 AMINOBUTYRIC ACID C RHO1 RECEPTOR; ANION; ARGININE; CATION; GLUTAMIC ACID; ION CHANNEL; METHYLPHOSPHONIC ACID; PROLINE; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CENTRAL NERVOUS SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; GABAERGIC SYSTEM; HILL REACTION; HUMAN; ION CONDUCTANCE; ION CURRENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION;

ANIMALIA;

EID: 11144230053     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M410625200     Document Type: Article

References (47)

1. Chebib, M., and Johnston, G. A. R. (2000) J. Med. Chem. 43, 1427-1447
2. Cully, D. F., Vassilatis, D. K., Liu, K. K., Paress, P. S., Van der Ploeg, L. H. T., Schaeffer, J. M., and Arena, J. P. (1994) Nature 371, 707-711
3. Davies, P. A., Wang, W., Hales, T. G., and Kirness, E. F. (2003) J. Biol. Chem. 278, 712-717
4. Lester, H. A., Dibas, M. I., Dahan, D., Leite, J. F., and Dougherty, D. A. (2004) Trends Neurosci. 27, 329-336
5. Miyazawa, A., Fujiyoshi, Y., and Unwin, N. (2003) Nature 423, 949-955
6. Imoto, K., Busch, C., Sakmann, B., Mishina, M., Konno, T., Nakai, J., Bujo, H., Mori, Y., Fukuda, K., and Numa, S. (1988) Nature 335, 645-648
7. Corringer, P.-J., Le Novère, N., and Changeux, J.-P. (2000) Annu. Rev. Pharmacol. Toxicol. 40, 431-458
8. Keramidas, A., Moorhouse, A. J., Schofield, P. R., and Barry, P. H. (2004) Prog. Biophys. Mol. Biol. 86, 161-204
9. Galzi, J.-L., Devillers-Thiéry, A., Hussy, N., Betrand, S., Changeux, J.-P., and Bertrand, D. (1992) Nature 359, 500-505
10. Auerbach, A., and Akk, G. (1998) J. Gen. Physiol. 112, 181-197
11. Wilson, G. G., and Karlin, A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 1241-1248
12. Unwin, N. (2000) Proc. R. Soc. Lond. B Biol. Sci. 355, 1813-1829
13. Dani, J. A. (1986) Biophys. J. 49, 607-618
14. Gunthorpe, M. J., and Lummis, S. C. R. (2001) J. Biol. Chem. 276, 10977-10983
15. Jensen, M. L., Timmermann, D. B., Johansen, T. H., Schousboe, A., Varming, T., and Ahring, P. K. (2002) J. Biol. Chem. 277, 41438-41447
16. Keramidas, A., Moorhouse, A. J., French, C. R., Schofield, P. R., and Barry, P. H. (2000) Biophys. J. 78, 247-259
17. Keramidas, A., Moorhouse, A. J., Pierce, K. D., Schofield, P. R., and Barry, P. H. (2002) J. Gen. Physiol. 119, 393-410
18. Moorhouse, A. J., Keramidas, A., Zaykin, A., Schofield, P. R., and Barry, P. H. (2002) J. Gen. Physiol. 119, 411-425
19. Wotring, V. E., Miller, T. S., and Weiss, D. S. (2003) J. Physiol. 2003, 527-540
20. Carland, J. E., Moore, A. M., Hanrahan, J. R., Mewett, K. N., Johnston, G. A. R., and Chebib, M. (2004) Neuropharmacology 46, 770-781
21. Chebib, M., Mewett, K. N., and Johnston, G. A. R. (1998) Eur. J. Pharmacol. 357, 227-234
22. Wolf, A. V., Brown, M. G., and Prentiss, P. G. (1980) in CRC Handbook of Chemistry and Physics (Weast, R. C., and Astle, M. J., eds) pp. D261-D270, Chemical Rubber Publishing Co., Florida
23. Hanrahan, J. R., Mewett, K. N., Chebib, M., Burden, P. M., and Johnston, G. A. R. (2001) J. Chem. Soc. Perkins Trans. 1 19, 2389-2392
24. Duke, R. K., Chebib, M., Allan, R. D., Mewett, K. N., and Johnston, G. A. R. (2000) J. Neurochem. 75, 2602-2610
25. Barry, P. H. (1994) J. Neurosci. Methods 51, 107-116
26. Hodgkin, A. L., and Katz, B. (1949) J. Physiol. 108, 37-77
27. Goldman, D. E. (1943) J. Gen. Physiol. 27, 37-60
28. Robinson, R. A., and Stokes, R. H. (1965) Activity Coefficients of Electrolytes at 25 °C, Electrolyte Solutions, Butterworths, London
29. Barish, M. E. (1983) J. Physiol. 342, 309-325
30. Corringer, P.-J., Bertrand, S., Galzi, J.-L., Devillers-Thiéry, A., Changeux, J.-P., and Bertrand, D. (1999) Neuron 22, 831-843
31. Enz, R., and Bormann, J. (1995) Neuroreport 6, 1569-1572
32. Wang, T.-L., Hackam, A. S., Guggino, W. B., and Cutting, G. R. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 11751-11755
33. Thompson, S-A., Smith, M. Z., Wingrove, P. R., Whiting, P. J., and Wafford, K. A. (1999) Br. J. Pharmacol. 127, 1349-1358
34. Pan, Z.-H., Zhang, D., Zhang, X., and Lipton, S. A. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 6490-6495
35. Colquhoun, D. (1998) Br. J. Pharmacol. 125, 924-947
36. Lewis, T. M., Sivilotti, L. G., Colquhoun, D., Gardiner, R. M., Schoepfer, R., and Rees, M. (1998) J. Physiol. 507, 25-40
37. Ueno, S., Lin, A., Nikolaeva, N., Trudell, J. R., Mihic, S. J., Harris, R. A., and Harrison, N. L. (2000) Br. J. Pharmacol. 131, 296-302
38. Chang, Y., and Weiss, D. S. (1999) Nat. Neurosci. 2, 219-225
39. Xu, M., Covey, D. F., and Akabas, M. H. (1995) Biophys. J. 69, 1858-1867
40. Shan, Q., Haddrill, J. L., and Lynch, J. W. (2001) J. Neurochem. 76, 1109-1120
41. Filippova, N., Wotring, V. E., and Weiss, D. S. (2004) J. Biol. Chem, 279, 20906-20914
42. Kelley, S. P., Dunlop, J. I., Kirkness, E. F., Lambert, J. J., and Peters, J. A. (2003) Nature 424, 321-324
43. Zamyatnin, A. A. (1972) Prog. Biophys. Mol. Biol. 24, 109-123
44. Cutting, G. R., Curristin, S., Zoghbl, H., O'Hara, B. F., Seldin, M. F., and Uhl, G. R. (1992) Genomics 12, 801-806
45. Cutting, G. R., Lu, L., O'Hara, B. F., Kasch, L. M., Montrose-Rafizadeh, C., Donovan, D. M., Shimada, S., Antonarakis, S. E., Guggino, W. B., Uhl, G. R., and Kazazian, H. H., Jr. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 2673-2677
46. Ogurusu, T., and Shingai, R. (1996) Biochim. Biophys. Acta 1305, 15-18
47. Zhang, D., Pan, Z-H., Zhang, X., Brideau, A. D., and Lipton, S. A. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 11756-11760