Two Novel Residues in M2 of the γ-Aminobutyric Acid Type A Receptor Affecting Gating by GABA and Picrotoxin Affinity

Journal of Biological Chemistry

Volumn 276, Issue 11, 2001, Pages 7775-7781

  Buhr, Andreas ^a   Wagner, Clemens ^a   Fuchs, Karoline ^b   Sieghart, Werner ^b   Sigel, Erwin ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CHLORINE COMPOUNDS; ELECTROPHYSIOLOGY; IONS; MUTAGENESIS;

CHANNEL GATINGS; MUTANT RECEPTORS;

AMINO ACIDS;

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; AMINO ACID; CHLORIDE ION; PICROTOXIN; RECEPTOR SUBUNIT;

AMINO TERMINAL SEQUENCE; AMPLITUDE MODULATION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHANNEL GATING; CONCENTRATION RESPONSE; ELECTROPHYSIOLOGY; ION CURRENT; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; XENOPUS; AMINO ACID SEQUENCE; BIOLOGICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; METABOLISM; MOLECULAR GENETICS; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

AMINO ACID SEQUENCE; BINDING SITES; COMPUTER SIMULATION; GAMMA-AMINOBUTYRIC ACID; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PICROTOXIN; POINT MUTATION; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035896624     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008907200     Document Type: Article

References (32)

1. Sigel, E., Stephenson, F. A., Mamalaki, C., and Barnard, E. A. (1983) J. Biol. Chem. 258, 6965-6971
2. Schofield, P. R., Darlison, M. G., Fujita, N., Burt, D. R., Stephenson, F. A., Rodriguez, H., Rhee, L. M., Ramachandran, J., Reale, V., Glencorse, T. A., Seeburg, P. H., and Barnard, E. A. (1987) Nature 328, 221-227
3. Macdonald, R. L., and Olsen, R. W. (1994) Annu. Rev. Neurosci. 17, 569-602
4. Rabow, L. E., Russek, S. J., and Farb, D. H. (1995) Synapse 21, 189-274
5. Davies, P. A., Hanna, M. C., Hales, T. G., and Kirkness, E. F. (1997) Nature 385, 820-823
6. Barnard, E. A., Skolnick, P., Olsen, R. W., Möhler, H., Sieghart, W., Biggio, G., Braestrup, C., Bateson, A. N., and Langer, S. Z. (1998) Pharmacol. Rev. 50, 291-313
7. Hedblom, E., and Kirkness, E. F. (1997) J. Biol. Chem. 272, 15346-15350
8. Bonnert, T. P., McKernan, R. M., Farrar, S., Le Bourdellès, B., Heavens, R. P., Smith, D. W., Hewson, L., Rigby, M. R., Sirinathsinghji, D. J. S., Brown, N., Wafford, K. A., and Whiting. P. J. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 9891-9896
9. Sieghart, W. (1995) Pharmacol. Rev. 47, 181-233
10. Galzi, J.-L., and Changeux, J. P. (1994) Curr. Opin. Struct. Biol. 4, 554-565
11. Sigel, E., and Buhr, A. (1997) Trends Pharmacol. Sci. 18, 425-429
12. Xu, M., and Akabas, M. H. (1996) J. Gen. Physiol. 107, 195-205
13. Xu, M., Covey, D. F., and Akabas, M. H. (1995) Biophys. J. 69, 1858-1867
14. Perret, P., Sarda, X., Wolff, M., Wu, T.-T., Bushey, D., and Goeldner, M. (1999) J. Biol. Chem. 274, 25350-25354
15. Ffrench-Constant, R. H., Rocheleau, T. A., Steichen, J. C., and Chalmers, A. E. (1993) Nature 363, 449-451
16. Chang, Y., Wang, R., Barot, S., and Weiss, D. S. (1996) J. Neurosci. 16, 5415-5224
17. Tierney, M. L., Birnir, B., Pillai, N. P., Clements, J. D., Howitt, S. M., Cox, G. B., and Gage, P. W. (1996) J. Membr. Biol. 154, 11-21
18. Pan, Z.-H., Zhang, D., Zhang, X., and Lipton, S. A. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 6490-6495
19. Chang, Y., and Weiss, D. S. (1998) Mol. Pharmacol. 53, 511-523
20. Thompson, S.-A., Smith, M. Z., Wingrove, P. B., Whiting, P. J., and Wafford, K. A. (1999) Brit. J. Pharmacol. 127, 1349-1358
21. Dalziel, J. E., Cox, G. B., Gage, P. W., and Birnir, B. (2000) Mol. Pharmacol. 57, 875-882
22. Jursky, F., Fuchs, K., Buhr, A., Tretter, V., Sigel, E., and Sieghart, W. (2000) J. Neurochem. 74, 1310-1316
23. Lolait, S. J., O'Carroll, A.-M., Kusano, K., Muller, J.-M., Brownstein, M. J., and Mahan, L. C. (1989) FEBS Lett. 246, 145-148
24. Sigel, E. (1987) J. Physiol. 386, 73-90
25. Sigel, E., Baur, R., Trube, G., Möhler, H., and Malherbe, P. (1990) Neuron 5, 703-711
26. Hill, T. L. (1977) Free Energy Transduction in Biology: The Steady-state Kinetic and Thermodynamic Formalism, pp. 193-200 Academic Press, New York
27. Wingrove, P. B., Wafford, K. A., Bain, C. J., and Whiting, P. J. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 4569-4573
28. Sigel, E., Baur, R., Malherbe, P., and Möhler, H. (1989) FEBS Lett. 257, 377-379
29. Krishek, B. J., Moss, S. J., and Smart, T. G. (1996) Mol. Pharmacol. 49, 494-505
30. Wooltorton, J. R. A., Moss, S. J., and Smart, T. G. (1997) Eur. J. Neurosci. 9, 2225-2235
31. Khrestchatisky, M., MacLennan, A. J., Chiang, M. Y., Xu, W. T., Jackson, M. B., Brecha, N., Sternini, C., Olsen, R. W., and Tobin, A. J. (1989) Neuron 3, 745-753
32. Miyazawa, A., Fujiyoshi, Y., Stowell, M., and Unwin, N. J. (1999) J. Mol. Biol. 288, 765-786