A single amino acid in the second transmembrane domain of GABA ρ receptors regulates channel conductance

Neuroscience Letters

Volumn 418, Issue 2, 2007, Pages 205-209

  Zhu, Yujie ^a   Ripps, Harris ^a   Qian, Haohua ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Subunits; Bipolar cells; GABAC receptor; Noise analysis; Single channel conductance; White perch retina

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; AMINO ACID; PROLINE; RECEPTOR SUBTYPE; SERINE;

AMINO ACID SEQUENCE; ARTICLE; CELL LINE; GABAERGIC SYSTEM; GABAERGIC TRANSMISSION; HUMAN; HUMAN CELL; NOISE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; WILD TYPE;

AMINO ACID SUBSTITUTION; AMINO ACIDS; ANIMALS; BASS; CELL LINE; CELL MEMBRANE; CELLS, CULTURED; HUMANS; ION CHANNEL GATING; ION CHANNELS; MUTATION; PROLINE; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GABA; RECEPTORS, GABA-B; RETINAL BIPOLAR CELLS; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; SYNAPTIC TRANSMISSION;

EID: 34247394266     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.03.020     Document Type: Article

References (36)

1. C receptor ρ1- and ρ2-subunit genes in avian and rat brain. Eur. J. Neurosci. 9 (1997) 2414-2422
2. Barry P.H., and Lynch J.W. Ligand-gated channels. IEEE Trans. Nanobiosci. 4 (2005) 70-80
3. Boue-Grabot E., Roudbaraki M., Bascles L., Tramu G., Bloch B., and Garret M. Expression of GABA receptor rho subunits in rat brain. J. Neurochem. 70 (1998) 899-907
4. C ρ1 subunit alter agonist responses. Neuropharmacology 46 (2004) 770-781
5. Carland J.E., Moorhouse A.J., Barry P.H., Johnston G.A., and Chebib M. Charged residues at the 2′ position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability. J. Biol. Chem. (2004)
6. C receptor. Nat. Neurosci. 2 (1999) 219-225
7. C receptor antagonists differentiate between human ρ1 and ρ2 receptors expressed in Xenopus oocytes. Eur. J. Pharmacol. 357 (1998) 227-234
8. Cutting G.R., Lu L., O'Hara B.F., Kasch L.M., Montrose-Rafizadeh C., Donovan D.M., Shimada S., Antonarakis S.E., Guggino W.B., Uhl G.R., and Kazazian Jr. H.H. Cloning of the γ-aminobutyric acid (GABA) ρ1 cDNA: a GABA receptor subunit highly expressed in the retina. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 2673-2677
9. C receptor ρ subunits are heterogeneously expressed in the human CNS and form homo- and heterooligomers with distinct physical properties. Eur. J. Neurosci. 11 (1999) 41-50
10. Filippova N., Wotring V.E., and Weiss D.S. Evidence that the TM1-TM2 loop contributes to the rho1 GABA receptor pore. J. Biol. Chem. 279 (2004) 20906-20914
11. C receptor ρ1 and ρ2 subunits during development of the mouse retina. Eur. J. Neurosci. 12 (2000) 3575-3582
12. Johnston G.A.R. GABAc receptors: relatively simple transmitter-gated ion channels?. Trends Pharmacol. Sci. 17 (1996) 319-323
13. Kalloniatis M., and Tomisich G. Amino acid neurochemistry of the vertebrate retina. Prog. Retin. Eye Res. 18 (1999) 811-866
14. Knapp A.G., Schmidt K.F., and Dowling J.E. Dopamine modulates the kinetics of ion channels gated by excitatory amino acids in retinal horizontal cells. Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 767-771
15. C receptors in the vertebrate retina. Mol. Neurobiol. 12 (1996) 181-194
16. Luu T., Cromer B., Gage P.W., and Tierney M.L. A role for the 2′ residue in the second transmembrane helix of the GABA A receptor gamma2S subunit in channel conductance and gating. J. Membr. Biol. 205 (2005) 17-28
17. Martinez-Torres A., and Miledi R. A single amino acid change within the ion-channel domain of the γ-aminobutyric acid ρ1 receptor accelerates desensitization and increases taurine agonism. Arch. Med. Res. 35 (2004) 194-198
18. C receptor subunits in native central neurons. J. Neurosci. 24 (2004) 9241-9250
19. Palmer M.J. Functional segregation of synaptic GABAA and GABAC receptors in goldfish bipolar cell terminals. J. Physiol. 577 (2006) 45-53
20. C receptors: responses to agonists and antagonists distinguish A- and B-subtypes of homomeric rho receptors expressed in Xenopus oocytes. Neurosci. Lett. 376 (2005) 60-65
21. 2 subunits of the GABA receptor. J. Neurochem. 94 (2005) 482-490
22. 2S, glycine α1 and glycine α2 receptor subunits in vitro. Eur. J. Neurosci. 12 (2000) 3137-3145
23. C receptors on hybrid bass retinal bipolar cells. J. Neurophysiol. 74 (1995) 1920-1928
24. Qian H., Dowling J.E., and Ripps H. Molecular and pharmacological properties of GABA-ρ subunits from white perch retina. J. Neurobiol. 37 (1998) 305-320
25. C receptors. J. Neurobiol. 40 (1999) 67-76
26. 2-subunits. Proc. R. Soc. Lond. B Biol. Sci. 266 (1999) 2419-2425
27. C receptors of retinal neurons. In: Kolb H., Ripps H., and Wu S. (Eds). Progress in Brain Research vol. 131 (2001), Elsevier Science B.V. 295-308
28. Sivilotti L., and Nistri A. GABA receptor mechanisms in the central nervous system. Prog. Neurobiol. 36 (1991) 35-92
29. Wang T.L., Hackam A.S., Guggino W.B., and Cutting G.R. A single amino acid in γ-aminobutyric acid ρ1 receptors affects competitive and noncompetitive components of picrotoxin inhibition. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 11751-11755
30. Wegelius K., Pasternack M., Hiltunen J.O., Rivera C., Kaila K., Saarma M., and Reeben M. Distribution of GABA receptor rho subunit transcripts in the rat brain. Eur. J. Neurosci. 10 (1998) 350-357
31. C receptors. J. Physiol. (Lond.) 521 Pt 2 (1999) 327-336
32. Wotring V.E., Miller T.S., and Weiss D.S. Mutations at the GABA receptor selectivity filter: a possible role for effective charges. J. Physiol. 548 (2003) 527-540
33. Wu S.M. Functional organization of GABAergic circuitry in ectotherm retinas. Prog. Brain Res. 90 (1992) 93-106
34. Yazulla S. GABAergic mechanisms in the retina. Prog. Retin. Res. 5 (1986) 1-52
35. C receptors: a comparison of native versus recombinant receptors. Trends Pharmacol. Sci. 22 (2001) 121-132
36. Zhang D., Pan Z.H., Zhang X., Brideau A.D., and Lipton S.A. Cloning of a γ-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 11756-11760